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Search results 801 to 878 out of 878 for Hspa5

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Type Details Score
Publication
27626380 | J:236599
First Author: Dickinson ME
Year: 2016
Journal: Nature
Title: High-throughput discovery of novel developmental phenotypes.
Volume: 537
Issue: 7621
Pages: 508-514
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Publication
- | J:94790
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Mouse Synonym Curation
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
- | J:188991
     
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
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Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Allele
Hspa5<em1Smoc> | MGI:7290267
Name: heat shock protein 5; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:7623392 | C57BL/6JSmoc-Hspa5<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
2766926 | -
First Author: Heschl MF
Year: 1989
Journal: DNA
Title: Characterization of the hsp70 multigene family of Caenorhabditis elegans.
Volume: 8
Issue: 4
Pages: 233-43
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Publication
2661018 | -
First Author: Rose MD
Year: 1989
Journal: Cell
Title: KAR2, a karyogamy gene, is the yeast homolog of the mammalian BiP/GRP78 gene.
Volume: 57
Issue: 7
Pages: 1211-21
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Publication
20886215 | -
First Author: Morrow MW
Year: 2011
Journal: Curr Genet
Title: The Candida albicans Kar2 protein is essential and functions during the translocation of proteins into the endoplasmic reticulum.
Volume: 57
Issue: 1
Pages: 25-37
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Publication
20430899 | -
First Author: Hale SJ
Year: 2010
Journal: J Biol Chem
Title: Interactions between Kar2p and its nucleotide exchange factors Sil1p and Lhs1p are mechanistically distinct.
Volume: 285
Issue: 28
Pages: 21600-6
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Publication
30563838 | -
First Author: Pobre KFR
Year: 2019
Journal: J Biol Chem
Title: The endoplasmic reticulum (ER) chaperone BiP is a master regulator of ER functions: Getting by with a little help from ERdj friends.
Volume: 294
Issue: 6
Pages: 2098-2108
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Publication
18285827 | -
First Author: Anttonen AK
Year: 2008
Journal: Eur J Hum Genet
Title: Novel SIL1 mutations and exclusion of functional candidate genes in Marinesco-Sjögren syndrome.
Volume: 16
Issue: 8
Pages: 961-9
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Protein Domain
IPR042050 | BIP_NBD
Type: Domain
Description: This entry includes human endoplasmic reticulum chaperone BIP (also known as 70kDa heat shock protein 5, HSPA5, glucose-regulated protein 78/GRP78, and immunoglobulin heavy chain-binding protein), yeast Kar2p (also known as Grp78p) [, ], hsp-3 from C. elegans []and related proteins. BIP/HSPA5 belongs to the heat shock protein 70 (HSP70) family of chaperones that assist in protein folding and assembly and can direct incompetent 'client' proteins towards degradation. HSPA5 and Kar2p are chaperones of the endoplasmic reticulum (ER). Typically, HSP70s have a nucleotide-binding domain (NBD) and a substrate-binding domain (SBD). The nucleotide sits in a deep cleft formed between the two lobes of the NBD. The two subdomains of each lobe change conformation between ATP-bound, ADP-bound, and nucleotide-free states. ATP binding opens up the substrate-binding site; substrate-binding increases the rate of ATP hydrolysis. HSP70 chaperone activity is regulated by various co-chaperones: J-domain proteins and nucleotide exchange factors (NEFs). Multiple ER DNAJ domain proteins have been identified and may exist in distinct complexes with HSPA5 in various locations in the ER, for example DNAJC3-p58IPK in the lumen []. HSPA5-NEFs include SIL1, whose disruption causes the Marinesco-Sjogren syndrome, and an atypical HSP70 family protein HYOU1/ORP150 [, ]. The ATPase activity of Kar2p is stimulated by the NEFs: Sil1p and Lhs1p [].
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Publication
37421621 | J:338470
First Author: Mun SH
Year: 2023
Journal: Cell Rep
Title: Marchf6 E3 ubiquitin ligase critically regulates endoplasmic reticulum stress, ferroptosis, and metabolic homeostasis in POMC neurons.
Volume: 42
Issue: 7
Pages: 112746
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Publication
31492921 | J:284061
First Author: Bensellam M
Year: 2019
Journal: Sci Rep
Title: Phlda3 regulates beta cell survival during stress.
Volume: 9
Issue: 1
Pages: 12827
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Publication
22083493 | J:320710
First Author: Ciocca DR
Year: 2012
Journal: Histochem Cell Biol
Title: Absence of caveolin-1 alters heat shock protein expression in spontaneous mammary tumors driven by Her-2/neu expression.
Volume: 137
Issue: 2
Pages: 187-94
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Publication
30045879 | J:300042
First Author: Hegyi E
Year: 2019
Journal: Gut
Title: Human CPA1 mutation causes digestive enzyme misfolding and chronic pancreatitis in mice.
Volume: 68
Issue: 2
Pages: 301-312
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Publication
22128176 | J:181385
First Author: Jurczak MJ
Year: 2012
Journal: J Biol Chem
Title: Dissociation of inositol-requiring enzyme (IRE1α)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out mice.
Volume: 287
Issue: 4
Pages: 2558-67
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Publication
36322628 | J:335296
First Author: Zhang Y
Year: 2022
Journal: Sci Transl Med
Title: Hormonal therapies up-regulate MANF and overcome female susceptibility to immune checkpoint inhibitor myocarditis.
Volume: 14
Issue: 669
Pages: eabo1981
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Publication
25545477 | J:219198
First Author: Luo H
Year: 2015
Journal: Lab Invest
Title: Extracellular deposition of mouse senile AApoAII amyloid fibrils induced different unfolded protein responses in the liver, kidney, and heart.
Volume: 95
Issue: 3
Pages: 320-33
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Publication
25926690 | J:222774
First Author: Alam SM
Year: 2015
Journal: Reproduction
Title: Identification of target genes for a prolactin family paralog in mouse decidua.
Volume: 149
Issue: 6
Pages: 625-32
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Publication
36233305 | J:330157
 
First Author: Hyde LF
Year: 2022
Journal: Int J Mol Sci
Title: A Dpagt1 Missense Variant Causes Degenerative Retinopathy without Myasthenic Syndrome in Mice.
Volume: 23
Issue: 19
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Publication
32116022 | J:300037
First Author: Orekhova A
Year: 2020
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Ethanol feeding accelerates pancreatitis progression in CPA1 N256K mutant mice.
Volume: 318
Issue: 4
Pages: G694-G704
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Publication
37807968 | J:342349
First Author: Gurri S
Year: 2023
Journal: EMBO Mol Med
Title: NRF3 suppresses squamous carcinogenesis, involving the unfolded protein response regulator HSPA5.
Volume: 15
Issue: 11
Pages: e17761
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Publication
22581041 | J:186441
First Author: Sims-Robinson C
Year: 2012
Journal: Diabetologia
Title: Central nervous system endoplasmic reticulum stress in a murine model of type 2 diabetes.
Volume: 55
Issue: 8
Pages: 2276-84
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Publication
17268797 | J:119770
First Author: Laybutt DR
Year: 2007
Journal: Diabetologia
Title: Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes.
Volume: 50
Issue: 4
Pages: 752-63
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Publication
34185677 | J:309416
First Author: Enriquez C
Year: 2021
Journal: Cancer Res
Title: Castration-Induced Downregulation of SPARC in Stromal Cells Drives Neuroendocrine Differentiation of Prostate Cancer.
Volume: 81
Issue: 16
Pages: 4257-4274
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Publication
21358806 | J:171086
First Author: Audouard C
Year: 2011
Journal: PLoS One
Title: Oocyte-targeted deletion reveals that hsp90b1 is needed for the completion of first mitosis in mouse zygotes.
Volume: 6
Issue: 2
Pages: e17109
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Publication
23108377 | J:191742
First Author: Baird M
Year: 2013
Journal: Lab Invest
Title: The unfolded protein response is activated in Helicobacter-induced gastric carcinogenesis in a non-cell autonomous manner.
Volume: 93
Issue: 1
Pages: 112-22
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Publication
28274919 | J:241580
First Author: Mahmassani ZS
Year: 2017
Journal: Am J Physiol Cell Physiol
Title: α7β1 Integrin regulation of gene transcription in skeletal muscle following an acute bout of eccentric exercise.
Volume: 312
Issue: 5
Pages: C638-C650
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Publication
37983263 | J:344734
First Author: Jani PK
Year: 2023
Journal: PLoS Biol
Title: The miR-221/222 cluster regulates hematopoietic stem cell quiescence and multipotency by suppressing both Fos/AP-1/IEG pathway activation and stress-like differentiation to granulocytes.
Volume: 21
Issue: 11
Pages: e3002015
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Protein
P20029
Organism: Mus musculus/domesticus
Length: 655  
Fragment?: false
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Protein
Q3TI47
Organism: Mus musculus/domesticus
Length: 655  
Fragment?: false
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Protein
Q3TKF8
Organism: Mus musculus/domesticus
Length: 655  
Fragment?: false
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Protein
Q3UEM8
Organism: Mus musculus/domesticus
Length: 520  
Fragment?: true
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Protein
Q9DC41
Organism: Mus musculus/domesticus
Length: 655  
Fragment?: false
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Protein
Q3TWF2
Organism: Mus musculus/domesticus
Length: 655  
Fragment?: false
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Protein
Q3U9G2
Organism: Mus musculus/domesticus
Length: 655  
Fragment?: false
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Protein
Q3U7T8
Organism: Mus musculus/domesticus
Length: 619  
Fragment?: true
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Protein
Q3U6V3
Organism: Mus musculus/domesticus
Length: 655  
Fragment?: false
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Publication
32673694 | J:321007
First Author: Stengel ST
Year: 2020
Journal: Gastroenterology
Title: Activating Transcription Factor 6 Mediates Inflammatory Signals in Intestinal Epithelial Cells Upon Endoplasmic Reticulum Stress.
Volume: 159
Issue: 4
Pages: 1357-1374.e10
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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