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Search results 801 to 900 out of 1119 for Htt

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Type Details Score
Publication
35023827 | J:323770
   
First Author: Shenoy SA
Year: 2022
Journal: Elife
Title: A novel and accurate full-length HTT mouse model for Huntington's disease.
Volume: 11
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Publication
16135087 | J:129784
First Author: Jenkins BG
Year: 2005
Journal: J Neurochem
Title: Effects of CAG repeat length, HTT protein length and protein context on cerebral metabolism measured using magnetic resonance spectroscopy in transgenic mouse models of Huntington's disease.
Volume: 95
Issue: 2
Pages: 553-62
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Interaction Experiment
Franco-Iborra S (2020)
Description: Mutant HTT (huntingtin) impairs mitophagy in a cellular model of Huntington disease.
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Protein
Q60857
Organism: Mus musculus/domesticus
Length: 630  
Fragment?: false
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Publication
32093570 | -
   
First Author: Franco-Iborra S
Year: 2020
Journal: Autophagy
Title: Mutant HTT (huntingtin) impairs mitophagy in a cellular model of Huntington disease.
Pages: 1-18
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Publication
30120269 | J:279276
First Author: Bretin A
Year: 2018
Journal: Sci Rep
Title: AIEC infection triggers modification of gut microbiota composition in genetically predisposed mice, contributing to intestinal inflammation.
Volume: 8
Issue: 1
Pages: 12301
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Publication
38818900 | J:354221
First Author: Salesse L
Year: 2024
Journal: Autophagy
Title: ATG16L1 in myeloid cells limits colorectal tumor growth in Apc(Min/+) mice infected with colibactin-producing Escherichia coli via decreasing inflammasome activation.
Volume: 20
Issue: 10
Pages: 2186-2204
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Publication
33249136 | J:302737
 
First Author: Kong G
Year: 2021
Journal: Neurobiol Dis
Title: An integrated metagenomics and metabolomics approach implicates the microbiota-gut-brain axis in the pathogenesis of Huntington's disease.
Volume: 148
Pages: 105199
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Protein Coding Gene
MGI:96285 | Slc6a4
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
31917256 | J:294842
First Author: Lucas C
Year: 2020
Journal: Gastroenterology
Title: Autophagy of Intestinal Epithelial Cells Inhibits Colorectal Carcinogenesis Induced by Colibactin-Producing Escherichia coli in ApcMin/+ Mice.
Volume: 158
Issue: 5
Pages: 1373-1388
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Publication
28074064 | J:245798
First Author: Freund P
Year: 2017
Journal: Leukemia
Title: O-GlcNAcylation of STAT5 controls tyrosine phosphorylation and oncogenic transcription in STAT5-dependent malignancies.
Volume: 31
Issue: 10
Pages: 2132-2142
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Publication
29422532 | J:263002
First Author: Komori T
Year: 2018
Journal: Sci Rep
Title: Type IV collagen α6 chain is a regulator of keratin 10 in keratinization of oral mucosal epithelium.
Volume: 8
Issue: 1
Pages: 2612
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Publication
21562226 | -
First Author: Wang Y
Year: 2011
Journal: Mol Biol Cell
Title: Dictyostelium huntingtin controls chemotaxis and cytokinesis through the regulation of myosin II phosphorylation.
Volume: 22
Issue: 13
Pages: 2270-81
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Publication
22932724 | -
 
First Author: Cisbani G
Year: 2012
Journal: Cell Death Dis
Title: An in vitro perspective on the molecular mechanisms underlying mutant huntingtin protein toxicity.
Volume: 3
Pages: e382
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Protein Domain
IPR028426 | Huntingtin_fam
Type: Family
Description: The huntingtin family consists of huntingtin proteins, including Dictyostelium HD protein homologue. Abnormalities in the huntingtin protein (Htt) are associated with Huntington's disease [], but despite its importance the function of Htt is largely unknown. In Dictyostelium discoideum Htt is required for normal chemotaxis and cytokinesis [].
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Publication
24081492 | J:201806
First Author: Xu Q
Year: 2013
Journal: J Cell Biol
Title: Synaptic mutant huntingtin inhibits synapsin-1 phosphorylation and causes neurological symptoms.
Volume: 202
Issue: 7
Pages: 1123-38
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Allele
Htt<em1Smoc> | MGI:7290285
Name: huntingtin; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Allele
Tg(YAC18)18Hay | MGI:3829789
Name: transgene insertion 18, Michael Hayden
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(HTT*/EGFP)150Nn | MGI:5052379
Name: transgene insertion 150, Nobuyuki Nukina
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(Prnp-SNAP25/HTT*150Q)8Xjl | MGI:5575507
Name: transgene insertion 8, Xiao-Jiang Li
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(HTT*/EGFP)120Nn | MGI:7382938
Name: transgene insertion 120, Nobuyuki Nukina
Allele Type: Transgenic
Attribute String: Inserted expressed sequence, Reporter
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Allele
Htt<tm7Szi> | MGI:7431214
Name: huntingtin; targeted mutation 7, Scott Zeitlin
Allele Type: Targeted
Attribute String: Epitope tag
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Publication
33323974 | J:302562
First Author: Swoboda A
Year: 2021
Journal: Oncogene
Title: STAT3 promotes melanoma metastasis by CEBP-induced repression of the MITF pathway.
Volume: 40
Issue: 6
Pages: 1091-1105
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Publication
31420552 | J:279428
First Author: Arrojo E Drigo R
Year: 2019
Journal: Nat Commun
Title: Structural basis for delta cell paracrine regulation in pancreatic islets.
Volume: 10
Issue: 1
Pages: 3700
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Publication
31175292 | J:283551
First Author: de Araujo ED
Year: 2019
Journal: Nat Commun
Title: Structural and functional consequences of the STAT5BN642H driver mutation.
Volume: 10
Issue: 1
Pages: 2517
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Publication
29466333 | -
First Author: Guo Q
Year: 2018
Journal: Nature
Title: The cryo-electron microscopy structure of huntingtin.
Volume: 555
Issue: 7694
Pages: 117-120
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Publication
32668197 | -
First Author: Jung T
Year: 2020
Journal: Structure
Title: The Polyglutamine Expansion at the N-Terminal of Huntingtin Protein Modulates the Dynamic Configuration and Phosphorylation of the C-Terminal HEAT Domain.
Volume: 28
Issue: 9
Pages: 1035-1050.e8
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Protein Domain
IPR024613 | Huntingtin_middle-repeat
Type: Repeat
Description: This repeated domain is less than 40 amino acids in length and is present in huntingtin protein (Htt). Htt is expressed in many tissues, with various expression levels and is involved in a number of cellular functions. However, its exact function is not yet clear. An abnormal polyglutamine (polyQ) expansion in this protein causes Huntington's disease (HD), a progressive autosomal-dominant neurodegenerative disease characterised by an uncontrolled motor movement known as chorea, cognitive disorder and depression []. Htt consists of multiple HEAT repeats organised in N-terminal, bridge and C-terminal domains [, ], which function as a scaffold that mediates interactions with binding partners. This domain connects the N- and C-HEAT domains.
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Publication
23810380 | J:206691
First Author: Cheng PH
Year: 2013
Journal: Am J Hum Genet
Title: miR-196a ameliorates phenotypes of Huntington disease in cell, transgenic mouse, and induced pluripotent stem cell models.
Volume: 93
Issue: 2
Pages: 306-12
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Publication
22422149 | J:209055
First Author: Cheng PH
Year: 2013
Journal: Brain Struct Funct
Title: Significantly differential diffusion of neuropathological aggregates in the brain of transgenic mice carrying N-terminal mutant huntingtin fused with green fluorescent protein.
Volume: 218
Issue: 1
Pages: 283-94
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Publication
31123029 | J:358408
First Author: Maurer B
Year: 2020
Journal: Haematologica
Title: High activation of STAT5A drives peripheral T-cell lymphoma and leukemia.
Volume: 105
Issue: 2
Pages: 435-447
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Allele
Htt<tm6Mem> | MGI:3697905
Name: huntingtin; targeted mutation 6, Marcy E MacDonald
Allele Type: Targeted
Attribute String: Humanized sequence
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Allele
Del(5D5Mit388-D5Mit351)4Jcs | MGI:3798167
 
Name: deletion, Chr 5, John C. Schimenti 4; deletion, Chr 5, John C Schimenti 4
Allele Type: Radiation induced
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Allele
Del(5D5Mit73-D5Mit351)5Jcs | MGI:3798174
 
Name: deletion, Chr 5, John C. Schimenti 5; deletion, Chr 5, John C Schimenti 5
Allele Type: Radiation induced
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Allele
Del(5Letm1-Htt)1Jcs | MGI:3798071
 
Name: deletion, Chr 5, John C Schimenti; deletion, Chr 5, John C Schimenti 1
Allele Type: Radiation induced
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Allele
Del(5D5Mit148-Qdpr)2Jcs | MGI:3798083
 
Name: deletion, Chr 5, John C. Schimenti 2; deletion, Chr 5, John C Schimenti 2
Allele Type: Chemically induced (ENU)
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Allele
Del(5Letm1-D5Mit81)3Jcs | MGI:3798084
 
Name: deletion, Chr 5, John C. Schimenti 3; deletion, Chr 5, John C Schimenti 3
Allele Type: Radiation induced
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Allele
Tg(Ppp1r1b-HTT*)1Meeh | MGI:3813481
Name: transgene insertion 1, Michelle E Erlich
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(HTT*/EGFP)190Nn | MGI:5052377
Name: transgene insertion 190, Nobuyuki Nukina
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence, Reporter
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Strain
MGI:7386802 | B6;D2-Tg(HTT*/EGFP)150Nn/Nn
Attribute String: mutant stock, transgenic
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Allele
Htt<tm1(HTT)Arte> | MGI:5426926
Name: huntingtin; targeted mutation 1, TaconicArtemis
Allele Type: Targeted
Attribute String: Inserted expressed sequence, Null/knockout
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Allele
Tg(Plp1-HTT*150Q)4aXjl | MGI:5700344
Name: transgene insertion 4a, Xiao-Jiang Li
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Htt<tm1.1Mfc> | MGI:5789600
Name: huntingtin; targeted mutation 1.1, Marie-Francoise Chesselet
Allele Type: Targeted
Attribute String: Humanized sequence
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Strain
MGI:7718094 | C57BL/6JSmoc-Htt<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:7386801 | B6;D2-Tg(HTT*/EGFP)120Nn/Nn
Attribute String: mutant stock, transgenic
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Allele
Htt<em2(HTT)Chdi> | MGI:7576151
Name: huntingtin; endonuclease-mediated mutation 2, David Howland
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence
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Allele
Htt<em3(HTT)Chdi> | MGI:7576152
Name: huntingtin; endonuclease-mediated mutation 3, David Howland
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence
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Allele
Htt<em1(HTT)Chdi> | MGI:7576089
Name: huntingtin; endonuclease-mediated mutation 1, David Howland
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence
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Genotype
Genotype
Symbol: Tg(YAC18)18Hay/?
Background: involves: FVB/N
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(HTT*/EGFP)150Nn/?
Background: involves: C57BL/6 * DBA/2
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(YAC18)18Hay/?
Background: involves: FVB/N
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Prnp-SNAP25/HTT*150Q)8Xjl/?
Background: involves: FVB
Zygosity: ot
Has Mutant Allele: true
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HT Experiment
E-GEOD-3248 | Transcription profiling of cerebellum from transgenic mice with nuclear and extranuclear polyQ to investigate the role of polyQ in Huntingtons disease
Series Id: GSE3248
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
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HT Experiment
GSE209893 | Proteolysis resistant huntingtin isoform induced by antisense oligonucleotide maintains normal huntingtin function in mouse
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
E-GEOD-50379 | Expression data from striatum of a mouse model of Huntington's disease (HD) (HdhQ111/Q111) crossed with mGluR5 knockout mice (mGluR5-/-) and their respective controls (HdhQ20/Q20 and mGluR5+/+)
Series Id: GSE50379
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
26920069 | J:233017
First Author: Oliveira AO
Year: 2016
Journal: Hum Mol Genet
Title: αB-Crystallin overexpression in astrocytes modulates the phenotype of the BACHD mouse model of Huntington's disease.
Volume: 25
Issue: 9
Pages: 1677-89
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Publication
25160573 | J:218460
 
First Author: Doria JG
Year: 2015
Journal: Neurobiol Dis
Title: The mGluR5 positive allosteric modulator, CDPPB, ameliorates pathology and phenotypic signs of a mouse model of Huntington's disease.
Volume: 73
Pages: 163-73
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Publication
31648394 | J:316238
First Author: Wu TT
Year: 2020
Journal: Stem Cells
Title: Mesenchymal stem cells alleviate AQP-4-dependent glymphatic dysfunction and improve brain distribution of antisense oligonucleotides in BACHD mice.
Volume: 38
Issue: 2
Pages: 218-230
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Publication
25271967 | J:223482
First Author: Baldo B
Year: 2014
Journal: PLoS One
Title: Effects of deletion of mutant huntingtin in steroidogenic factor 1 neurons on the psychiatric and metabolic phenotype in the BACHD mouse model of Huntington disease.
Volume: 9
Issue: 10
Pages: e107691
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Publication
21997870 | J:179024
First Author: Shirendeb UP
Year: 2012
Journal: Hum Mol Genet
Title: Mutant huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's disease.
Volume: 21
Issue: 2
Pages: 406-20
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Strain
MGI:3813644 | C57BL/6J-Tg(Ppp1r1b-HTT*)1Meeh
Attribute String: transgenic, coisogenic
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Publication
18632688 | J:139807
First Author: Brown TB
Year: 2008
Journal: Hum Mol Genet
Title: Neocortical expression of mutant huntingtin is not required for alterations in striatal gene expression or motor dysfunction in a transgenic mouse.
Volume: 17
Issue: 20
Pages: 3095-104
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Allele
Tg(HTT*97Q)LXwy | MGI:4438228
Name: transgene insertion L, X William Yang
Allele Type: Transgenic
Attribute String: Conditional ready, Humanized sequence, Inserted expressed sequence
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Allele
Tg(HTT*)BXwy | MGI:4438229
Name: transgene insertion B, X William Yang
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(HTT*)1Xwy | MGI:4438230
Name: transgene insertion 1, X William Yang
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Strain
MGI:7386803 | B6;D2-Tg(HTT*/EGFP)190Nn/Nn
Attribute String: mutant stock, transgenic
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Strain
MGI:6294730 | B6.Cg-Htt<tm1(HTT)Arte>/ChdiJ
Attribute String: targeted mutation, mutant strain, congenic
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Allele
Tg(UBC-GFP/HTT*84Q)22Shya | MGI:5565690
Name: transgene insertion 22, Shang-Hsun Yang
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence, Reporter
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Strain
MGI:6294721 | B6.129S1-Htt<tm1.1Mfc>/190ChdiJ
Attribute String: congenic, mutant strain, targeted mutation
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Strain
MGI:7576746 | B6.129S1-Htt<em2(HTT)Chdi>/J
Attribute String: congenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Ift172/Ift172<+> Del(5D5Mit73-D5Mit351)5Jcs/?
Background: involves: 129S4/SvJae * C3HeB/FeJ * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Del(5D5Mit73-D5Mit351)5Jcs/+
Background: mixed
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Htt/Htt
Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Del(5D5Mit148-Qdpr)2Jcs/+
Background: involves: 129S4/SvJae * C57BL/6J
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Del(5D5Mit73-D5Mit351)5Jcs/+
Background: involves: 129S4/SvJae * C57BL/6J
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Del(5Letm1-D5Mit81)3Jcs/+
Background: involves: 129S4/SvJae * C57BL/6J
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Del(5Letm1-D5Mit81)3Jcs/+
Background: involves: 129S4/SvJae * C3H * C57BL/6J
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Del(5D5Mit73-D5Mit351)5Jcs/+
Background: involves: 129S4/SvJae * C3H * C57BL/6J
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Del(5D5Mit148-Qdpr)2Jcs/+
Background: involves: 129S4/SvJae * C3H * C57BL/6J
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Del(5Letm1-Htt)1Jcs/+
Background: involves: 129S4/SvJae * C57BL/6J
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Del(5D5Mit388-D5Mit351)4Jcs/+
Background: involves: 129S4/SvJae * C57BL/6J
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Ppp1r1b-HTT*)1Meeh/?
Background: C57BL/6J-Tg(Ppp1r1b-HTT*)1Meeh
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(HTT*/EGFP)190Nn/?
Background: involves: C57BL/6 * DBA/2
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Plp1-HTT*150Q)4aXjl/?
Background: Not Specified
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Htt/Htt<+>
Background: Not Specified
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Htt/Htt<+>
Background: B6.129S1-Htt/190ChdiJ
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Htt/Htt<+>
Background: involves: 129S1/Sv * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Publication
24042107 | J:202019
   
First Author: Kudwa AE
Year: 2013
Journal: PLoS Curr
Title: Increased Body Weight of the BAC HD Transgenic Mouse Model of Huntington's Disease Accounts for Some but Not All of the Observed HD-like Motor Deficits.
Volume: 5
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Publication
28171570 | J:288462
First Author: Simmons DA
Year: 2016
Journal: Hum Mol Genet
Title: A small molecule p75NTR ligand normalizes signalling and reduces Huntington's disease phenotypes in R6/2 and BACHD mice.
Volume: 25
Issue: 22
Pages: 4920-4938
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Publication
21177255 | J:168853
First Author: Thomas EA
Year: 2011
Journal: Hum Mol Genet
Title: In vivo cell-autonomous transcriptional abnormalities revealed in mice expressing mutant huntingtin in striatal but not cortical neurons.
Volume: 20
Issue: 6
Pages: 1049-60
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Publication
22219281 | J:179364
First Author: Waldron-Roby E
Year: 2012
Journal: J Neurosci
Title: Transgenic mouse model expressing the caspase 6 fragment of mutant huntingtin.
Volume: 32
Issue: 1
Pages: 183-93
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Publication
18550760 | J:137345
First Author: Gray M
Year: 2008
Journal: J Neurosci
Title: Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice.
Volume: 28
Issue: 24
Pages: 6182-95
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Publication
30150378 | J:265875
First Author: Siebzehnrübl FA
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Early postnatal behavioral, cellular, and molecular changes in models of Huntington disease are reversible by HDAC inhibition.
Volume: 115
Issue: 37
Pages: E8765-E8774
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Publication
22649225 | J:184973
First Author: Gafni J
Year: 2012
Journal: J Neurosci
Title: Caspase-6 activity in a BACHD mouse modulates steady-state levels of mutant huntingtin protein but is not necessary for production of a 586 amino acid proteolytic fragment.
Volume: 32
Issue: 22
Pages: 7454-65
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Publication
20097678 | J:158346
First Author: Pouladi MA
Year: 2010
Journal: Hum Mol Genet
Title: Full-length huntingtin levels modulate body weight by influencing insulin-like growth factor 1 expression.
Volume: 19
Issue: 8
Pages: 1528-38
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Publication
25305080 | J:218299
First Author: Kurosawa M
Year: 2015
Journal: Hum Mol Genet
Title: Depletion of p62 reduces nuclear inclusions and paradoxically ameliorates disease phenotypes in Huntington's model mice.
Volume: 24
Issue: 4
Pages: 1092-105
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Publication
23160193 | J:193974
First Author: Kwan W
Year: 2012
Journal: J Clin Invest
Title: Mutant huntingtin impairs immune cell migration in Huntington disease.
Volume: 122
Issue: 12
Pages: 4737-47
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Publication
16417581 | J:144917
First Author: Leavitt BR
Year: 2006
Journal: J Neurochem
Title: Wild-type huntingtin protects neurons from excitotoxicity.
Volume: 96
Issue: 4
Pages: 1121-9
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Strain
MGI:5753064 | FVB/N-Tg(HTT*97Q)LXwy/ChdiJ
Attribute String: coisogenic, mutant strain, transgenic
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Strain
MGI:5300537 | FVB-Tg(HTT*97Q)LXwy/J
Attribute String: transgenic, mutant strain, coisogenic
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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