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Search results 801 to 900 out of 1089 for Jak2

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Type Details Score
Interaction Experiment
Weiler SR (1996)
Description: JAK2 is associated with the c-kit proto-oncogene product and is phosphorylated in response to stem cell factor.
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Interaction Experiment
Szente BE (1995)
Description: Identification of IFN-gamma receptor binding sites for JAK2 and enhancement of binding by IFN-gamma and its C-terminal peptide IFN-gamma(95-133).
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Publication
19783980 | -
First Author: Dawson MA
Year: 2009
Journal: Nature
Title: JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin.
Volume: 461
Issue: 7265
Pages: 819-22
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Publication
16810614 | -
First Author: Bellucci S
Year: 2006
Journal: Semin Thromb Hemost
Title: The role of JAK2 V617F mutation, spontaneous erythropoiesis and megakaryocytopoiesis, hypersensitive platelets, activated leukocytes, and endothelial cells in the etiology of thrombotic manifestations in polycythemia vera and essential thrombocythemia.
Volume: 32
Issue: 4 Pt 2
Pages: 381-98
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Publication
16239216 | -
First Author: Staerk J
Year: 2005
Journal: J Biol Chem
Title: JAK1 and Tyk2 activation by the homologous polycythemia vera JAK2 V617F mutation: cross-talk with IGF1 receptor.
Volume: 280
Issue: 51
Pages: 41893-9
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Interaction Experiment
Hackett RH (1997)
Description: Mapping of a cytoplasmic domain of the human growth hormone receptor that regulates rates of inactivation of Jak2 and Stat proteins.
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Publication
20098430 | J:157074
First Author: Guilluy C
Year: 2010
Journal: Nat Med
Title: The Rho exchange factor Arhgef1 mediates the effects of angiotensin II on vascular tone and blood pressure.
Volume: 16
Issue: 2
Pages: 183-90
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Publication
8068943 | -
First Author: Miura O
Year: 1994
Journal: Blood
Title: Erythropoietin induces association of the JAK2 protein tyrosine kinase with the erythropoietin receptor in vivo.
Volume: 84
Issue: 5
Pages: 1501-7
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Publication
9343427 | -
First Author: Rui L
Year: 1997
Journal: Mol Cell Biol
Title: Identification of SH2-Bbeta as a substrate of the tyrosine kinase JAK2 involved in growth hormone signaling.
Volume: 17
Issue: 11
Pages: 6633-44
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Publication
12552091 | -
First Author: Leung KC
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2.
Volume: 100
Issue: 3
Pages: 1016-21
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Publication
15143188 | -
First Author: Feener EP
Year: 2004
Journal: Mol Cell Biol
Title: Tyrosine phosphorylation of Jak2 in the JH2 domain inhibits cytokine signaling.
Volume: 24
Issue: 11
Pages: 4968-78
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Publication
9363897 | -
First Author: Yamauchi T
Year: 1997
Journal: Nature
Title: Tyrosine phosphorylation of the EGF receptor by the kinase Jak2 is induced by growth hormone.
Volume: 390
Issue: 6655
Pages: 91-6
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Publication
15988755 | -
First Author: Huang HM
Year: 2005
Journal: J Cell Biochem
Title: Simultaneous activation of JAK1 and JAK2 confers IL-3 independent growth on Ba/F3 pro-B cells.
Volume: 96
Issue: 2
Pages: 361-75
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Publication
10757801 | -
First Author: Rui L
Year: 2000
Journal: Mol Cell Biol
Title: Differential binding to and regulation of JAK2 by the SH2 domain and N-terminal region of SH2-bbeta.
Volume: 20
Issue: 9
Pages: 3168-77
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Publication
8702385 | -
First Author: Fuhrer DK
Year: 1996
Journal: Biochem Biophys Res Commun
Title: Complex formation of JAK2 with PP2A, P13K, and Yes in response to the hematopoietic cytokine interleukin-11.
Volume: 224
Issue: 2
Pages: 289-96
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Allele
Jak2<em1Smoc> | MGI:7290626
Name: Janus kinase 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Allele
Jak2<em3Smoc> | MGI:7290628
Name: Janus kinase 2; endonuclease-mediated mutation 3, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready
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Allele
Jak2<em2Smoc> | MGI:7292357
Name: Janus kinase 2; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Not Specified
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HT Experiment
E-MTAB-3774 | Hepatic Deletion of Janus Kinase 2 Counteracts Inflammation, Oxidative Stress and Liver Cancer Formation in Growth Hormone Transgenic Mice
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Protein
A0A494BBB9
Organism: Mus musculus/domesticus
Length: 638  
Fragment?: true
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GO Term
GO:0042976 | activation of Janus kinase activity
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Publication
- | J:72448
     
First Author: Sjoling A
Year: 2001
Journal: MGI Direct Data Submission
Title: Analysis of chromosomal aberrations involving rat chromosome 1q31-q51 in a DMBA-induced rat fibrosarcoma cell line: amplification and over-expression of Jak2
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Publication
8611693 | -
First Author: Weiler SR
Year: 1996
Journal: Blood
Title: JAK2 is associated with the c-kit proto-oncogene product and is phosphorylated in response to stem cell factor.
Volume: 87
Issue: 9
Pages: 3688-93
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Publication
7499845 | -
First Author: Szente BE
Year: 1995
Journal: J Immunol
Title: Identification of IFN-gamma receptor binding sites for JAK2 and enhancement of binding by IFN-gamma and its C-terminal peptide IFN-gamma(95-133).
Volume: 155
Issue: 12
Pages: 5617-22
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Publication
16914724 | -
First Author: Kurzer JH
Year: 2006
Journal: Mol Cell Biol
Title: Binding of SH2-B family members within a potential negative regulatory region maintains JAK2 in an active state.
Volume: 26
Issue: 17
Pages: 6381-94
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Allele
Lepr<tm4Mgmj> | MGI:4843181
 
Name: leptin receptor; targeted mutation 4, Martin G Myers, Jr
Allele Type: Targeted
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Strain
MGI:7623410 | C57BL/6JSmoc-Jak2<em3Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:7623411 | C57BL/6JSmoc-Jak2<em2Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
9111009 | -
First Author: Hackett RH
Year: 1997
Journal: J Biol Chem
Title: Mapping of a cytoplasmic domain of the human growth hormone receptor that regulates rates of inactivation of Jak2 and Stat proteins.
Volume: 272
Issue: 17
Pages: 11128-32
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Strain
MGI:4843271 | B6.Cg-Lepr<tm4Mgmj>
Attribute String: congenic, mutant strain, targeted mutation
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Allele
Tg(Jak2-EGFP)FW203Gsat | MGI:4847167
Name: transgene insertion FW203, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
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Genotype
Genotype
Symbol: Lepr/Lepr
Background: B6.Cg-Lepr
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dcc/Dcc<+>
Background: involves: C57BL/6 * DBA/2
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(H2-K-Jak2*V617F)2Shmd/?
Background: involves: C57BL/6 * DBA/2
Zygosity: ot
Has Mutant Allele: true
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Publication
22019628 | J:191404
First Author: Majumder A
Year: 2012
Journal: Exp Hematol
Title: A46, a benzothiophene-derived compound, suppresses Jak2-mediated pathologic cell growth.
Volume: 40
Issue: 1
Pages: 22-34
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Publication
22796437 | J:188525
First Author: Kirabo A
Year: 2012
Journal: Am J Pathol
Title: The small molecule inhibitor G6 significantly reduces bone marrow fibrosis and the mutant burden in a mouse model of Jak2-mediated myelofibrosis.
Volume: 181
Issue: 3
Pages: 858-65
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Publication
27401345 | J:236468
First Author: Sashida G
Year: 2016
Journal: J Exp Med
Title: The loss of Ezh2 drives the pathogenesis of myelofibrosis and sensitizes tumor-initiating cells to bromodomain inhibition.
Volume: 213
Issue: 8
Pages: 1459-77
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Publication
17133099 | -
First Author: Levine RL
Year: 2007
Journal: Curr Opin Hematol
Title: JAK-2 mutations and their relevance to myeloproliferative disease.
Volume: 14
Issue: 1
Pages: 43-7
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Protein Domain
IPR035588 | PTK_Jak2_rpt1
Type: Domain
Description: Jak2 is widely expressed in many tissues. It is essential for the signaling of hormone-like cytokines such as growth hormone, erythropoietin, thrombopoietin, and prolactin, as well as some IFNs and cytokines that signal through the IL-3 and gp130 receptors []. Disruption of Jak2 in mice results in an embryonic lethal phenotype with multiple defects including erythropoietic and cardiac abnormalities []. It is the only Jak gene that results in a lethal phenotype when disrupted in mice. A mutation in the pseudokinase domain of Jak2, V617F, is present in many myeloproliferative diseases, including almost all patients with polycythemia vera, and 50% of patients with essential thrombocytosis and myelofibrosis [, , , ].Jak2 is a cytoplasmic (or nonreceptor) PTK containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal tyr kinase domain. The pseudokinase domain shows similarity to tyr kinases but lacks crucial residues for catalytic activity and ATP binding. Despite this, the presumed pseudokinase (repeat 1) domain of Jak2 exhibits dual-specificity kinase activity, phosphorylating two negative regulatory sites in Jak2: Ser523 and Tyr570. Inactivation of the repeat 1 domain increased Jak2 basal activity, suggesting that it modulates the kinase activity of the C-terminal catalytic (repeat 2) domain [].This entry represents the pseudokinase domain of Jak2.
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Protein Domain
IPR035589 | PTKc_Jak2_rpt2
Type: Domain
Description: Jak2 is widely expressed in many tissues. It is essential for the signaling of hormone-like cytokines such as growth hormone, erythropoietin, thrombopoietin, and prolactin, as well as some IFNs and cytokines that signal through the IL-3 and gp130 receptors []. Disruption of Jak2 in mice results in an embryonic lethal phenotype with multiple defects including erythropoietic and cardiac abnormalities []. It is the only Jak gene that results in a lethal phenotype when disrupted in mice. A mutation in the pseudokinase domain of Jak2, V617F, is present in many myeloproliferative diseases, including almost all patients with polycythemia vera, and 50% of patients with essential thrombocytosis and myelofibrosis [, , , ].Jak2 is a cytoplasmic (or nonreceptor) PTK containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal tyr kinase domain. The pseudokinase domain shows similarity to tyr kinases but lacks crucial residues for catalytic activity and ATP binding. Despite this, the presumed pseudokinase (repeat 1) domain of Jak2 exhibits dual-specificity kinase activity, phosphorylating two negative regulatory sites in Jak2: Ser523 and Tyr570. Inactivation of the repeat 1 domain increased Jak2 basal activity, suggesting that it modulates the kinase activity of the C-terminal catalytic (repeat 2) domain [].This entry represents the C-terminal catalytic domain.
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Publication
11340172 | J:69504
First Author: Yamada M
Year: 2001
Journal: Mol Cell Biol
Title: Loss of hippocampal CA3 pyramidal neurons in mice lacking STAM1.
Volume: 21
Issue: 11
Pages: 3807-19
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Strain
MGI:5003650 | STOCK Tg(Jak2-EGFP)FW203Gsat/Mmucd
Attribute String: mutant stock, transgenic
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Allele
Tg(Vav1-JAK2*V617F)AZjz | MGI:5441310
Name: transgene insertion A, Zhizhuang Joe Zhao
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Publication
34497325 | J:319703
First Author: Shinoda D
Year: 2022
Journal: Leukemia
Title: Insufficiency of non-canonical PRC1 synergizes with JAK2V617F in the development of myelofibrosis.
Volume: 36
Issue: 2
Pages: 452-463
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Allele
Tg(JAK2*)N1Rsko | MGI:7327623
Name: transgene insertion N1, Radek C Skoda
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Publication
25395421 | J:330937
First Author: Kameda T
Year: 2015
Journal: Blood
Title: Loss of TET2 has dual roles in murine myeloproliferative neoplasms: disease sustainer and disease accelerator.
Volume: 125
Issue: 2
Pages: 304-15
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Publication
35286385 | J:326022
First Author: Li L
Year: 2022
Journal: Blood
Title: HMGA1 chromatin regulators induce transcriptional networks involved in GATA2 and proliferation during MPN progression.
Volume: 139
Issue: 18
Pages: 2797-2815
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Publication
18334677 | J:135993
First Author: Xing S
Year: 2008
Journal: Blood
Title: Transgenic expression of JAK2V617F causes myeloproliferative disorders in mice.
Volume: 111
Issue: 10
Pages: 5109-17
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Publication
32294178 | J:301286
First Author: Matsuura S
Year: 2020
Journal: Blood
Title: Adhesion to fibronectin via α5β1 integrin supports expansion of the megakaryocyte lineage in primary myelofibrosis.
Volume: 135
Issue: 25
Pages: 2286-2291
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Publication
24391943 | J:209831
First Author: Jin X
Year: 2013
Journal: PLoS One
Title: Generation of a new congenic mouse strain with enhanced chymase expression in mast cells.
Volume: 8
Issue: 12
Pages: e84340
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Genotype
Genotype
Symbol: Tg(Vav1-JAK2*V617F)AZjz/?
Background: involves: C57BL/6 * DBA/2
Zygosity: ot
Has Mutant Allele: true
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Publication
31511238 | J:282109
First Author: Rao TN
Year: 2019
Journal: Blood
Title: JAK2-mutant hematopoietic cells display metabolic alterations that can be targeted to treat myeloproliferative neoplasms.
Volume: 134
Issue: 21
Pages: 1832-1846
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Publication
15561980 | -
First Author: Horvath CM
Year: 2004
Journal: Sci STKE
Title: The Jak-STAT pathway stimulated by interferon gamma.
Volume: 2004
Issue: 260
Pages: tr8
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Protein Domain
IPR035860 | JAK2_SH2
Type: Domain
Description: Jak2 is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constitutively associated with the prolactin receptor []and is required for responses to gamma interferon []. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis []. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites [, , ].
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Allele
Tg(JAK2*V617F)FF1Rsko | MGI:5553468
Name: transgene insertion FF1, Radek C Skoda
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Publication
12446783 | J:80617
First Author: Yamada M
Year: 2002
Journal: Mol Cell Biol
Title: Signal-transducing adaptor molecules STAM1 and STAM2 are required for T-cell development and survival.
Volume: 22
Issue: 24
Pages: 8648-58
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Publication
21187078 | -
First Author: Lim J
Year: 2011
Journal: Biochem Biophys Res Commun
Title: Solution structure of UIM and interaction of tandem ubiquitin binding domains in STAM1 with ubiquitin.
Volume: 405
Issue: 1
Pages: 24-30
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Publication
26101075 | J:226940
 
First Author: Kapuralin K
Year: 2015
Journal: Mol Cell Neurosci
Title: STAM2, a member of the endosome-associated complex ESCRT-0 is highly expressed in neurons.
Volume: 67
Pages: 104-15
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Protein Domain
IPR035657 | STAM1_SH3
Type: Domain
Description: This entry represents the SH3 domain of STAM1 (signal transducing adapter molecule 1). STAM1 is part of the endosomal sorting complex required for transport (ESCRT-0) and is involved in sorting ubiquitinated cargo proteins from the endosome []. It may also be involved in the regulation of IL2 and GM-CSF mediated signaling, and has been implicated in neural cell survival [, ]. STAMs were discovered as proteins that are highly phosphorylated following cytokine and growth factor stimulation []. They function in cytokine signaling and surface receptor degradation, as well as regulate Golgi morphology. They associate with many proteins including Jak2 and Jak3 tyrosine kinases [], Hrs, AMSH, and UBPY. STAM adaptor proteins contain VHS (Vps27, Hrs, STAM homology), ubiquitin interacting (UIM), and SH3 domains [].
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Protein Domain
IPR035675 | STAM2_SH3
Type: Domain
Description: This entry represents the SH3 domain of STAM2 (signal transducing adapter molecule 2). STAM2, a subunit of the ESCRT-0 complex, is an endosomal protein acting as a regulator of receptor signaling and trafficking. It contains an N-terminal VHS domain (Vps-27/Hrs/Stam), UIM (ubiquitin-interacting motif), SH3 (Src homology 3), CC ("coiled coil"), SSM (STAM-specific motif) and C-terminal ITAM (immunoreceptor tyrosine-based activation motif) domain. It may play a regulatory role in the endosomal sorting of ubiquitinated membrane proteins []. STAMs were discovered as proteins that are highly phosphorylated following cytokine and growth factor stimulation []. They function in cytokine signaling and surface receptor degradation, as well as regulate Golgi morphology. They associate with many proteins including Jak2 and Jak3 tyrosine kinases [], Hrs, AMSH, and UBPY. STAM adaptor proteins contain VHS (Vps27, Hrs, STAM homology), ubiquitin interacting (UIM), and SH3 domains [].
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Publication
9407053 | J:44869
First Author: Asao H
Year: 1997
Journal: J Biol Chem
Title: Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth.
Volume: 272
Issue: 52
Pages: 32785-91
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Publication
11728436 | -
First Author: Lohi O
Year: 2001
Journal: FEBS Lett
Title: STAM/EAST/Hbp adapter proteins--integrators of signalling pathways.
Volume: 508
Issue: 3
Pages: 287-90
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Publication
10899310 | -
First Author: Endo K
Year: 2000
Journal: FEBS Lett
Title: STAM2, a new member of the STAM family, binding to the Janus kinases.
Volume: 477
Issue: 1-2
Pages: 55-61
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Publication
29296743 | J:303417
First Author: Ueda K
Year: 2017
Journal: Blood Adv
Title: Hmga2 collaborates with JAK2V617F in the development of myeloproliferative neoplasms.
Volume: 1
Issue: 15
Pages: 1001-1015
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Strain
MGI:7327621 | C57BL/6-Tg(JAK2*V617F)FF1Rsko/J
Attribute String: coisogenic, mutant strain, transgenic
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Publication
36873934 | J:343719
 
First Author: Aini W
Year: 2023
Journal: Front Genet
Title: Exploration and identification of anoikis-related genes in polycythemia vera.
Volume: 14
Pages: 1139351
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Genotype
Genotype
Symbol: Tg(JAK2*V617F)FF1Rsko/? Tg(Tek-cre)1Arnd/?
Background: involves: C57BL/6 * CBA * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Publication
28550162 | J:244489
First Author: Kim E
Year: 2017
Journal: J Exp Med
Title: Rb family proteins enforce the homeostasis of quiescent hematopoietic stem cells by repressing Socs3 expression.
Volume: 214
Issue: 7
Pages: 1901-1912
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Publication
24820309 | J:211277
First Author: Duek A
Year: 2014
Journal: Blood
Title: Loss of Stat1 decreases megakaryopoiesis and favors erythropoiesis in a JAK2-V617F-driven mouse model of MPNs.
Volume: 123
Issue: 25
Pages: 3943-50
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Publication
27133820 | J:237878
First Author: Zhan H
Year: 2016
Journal: Leukemia
Title: JAK2V617F-mutant megakaryocytes contribute to hematopoietic stem/progenitor cell expansion in a model of murine myeloproliferation.
Volume: 30
Issue: 12
Pages: 2332-2341
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Genotype
Genotype
Symbol: Tg(JAK2*V617F)FF1Rsko/? Commd10/Commd10<+>
Background: involves: C57BL/6 * C57BL/10 * CBA/Ca
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(JAK2*V617F)FF1Rsko/? Tg(Mx1-cre)1Cgn/?
Background: involves: C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(JAK2*V617F)FF1Rsko/? Tg(Pf4-icre)Q3Rsko/?
Background: involves: C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Publication
16905102 | J:201263
First Author: Bergamin E
Year: 2006
Journal: Structure
Title: Structural basis for phosphotyrosine recognition by suppressor of cytokine signaling-3.
Volume: 14
Issue: 8
Pages: 1285-92
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Publication
16098827 | J:129837
First Author: Ren D
Year: 2005
Journal: Cell Metab
Title: Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in mice.
Volume: 2
Issue: 2
Pages: 95-104
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Publication
28912580 | J:255767
First Author: Shintani T
Year: 2017
Journal: Sci Rep
Title: PTPRJ Inhibits Leptin Signaling, and Induction of PTPRJ in the Hypothalamus Is a Cause of the Development of Leptin Resistance.
Volume: 7
Issue: 1
Pages: 11627
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Publication
25194569 | J:227594
First Author: Price FD
Year: 2014
Journal: Nat Med
Title: Inhibition of JAK-STAT signaling stimulates adult satellite cell function.
Volume: 20
Issue: 10
Pages: 1174-81
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Publication
16966486 | J:114638
First Author: Samardzija M
Year: 2006
Journal: FASEB J
Title: Differential role of Jak-STAT signaling in retinal degenerations.
Volume: 20
Issue: 13
Pages: 2411-3
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Publication
29168692 | J:254972
   
First Author: Klisch TJ
Year: 2017
Journal: Elife
Title: Jak2-mediated phosphorylation of Atoh1 is critical for medulloblastoma growth.
Volume: 6
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Publication
32160545 | J:288284
First Author: Viaud M
Year: 2020
Journal: Cell Rep
Title: ABCA1 Exerts Tumor-Suppressor Function in Myeloproliferative Neoplasms.
Volume: 30
Issue: 10
Pages: 3397-3410.e5
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Publication
30254368 | J:268393
First Author: Balcerek J
Year: 2018
Journal: Nat Commun
Title: Lnk/Sh2b3 deficiency restores hematopoietic stem cell function and genome integrity in Fancd2 deficient Fanconi anemia.
Volume: 9
Issue: 1
Pages: 3915
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Publication
34433042 | J:350601
First Author: Qian Y
Year: 2021
Journal: Cell Rep
Title: ZEB1 promotes pathogenic Th1 and Th17 cell differentiation in multiple sclerosis.
Volume: 36
Issue: 8
Pages: 109602
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