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Search results 801 to 900 out of 964 for Lrrk2

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Type Details Score
UniProt Feature
UniProt Feature
Begin: 72
Description: Phosphothreonine; by LRRK2
Type: modified residue
End: 72
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UniProt Feature
UniProt Feature
Begin: 72
Description: Phosphothreonine; by LRRK2
Type: modified residue
End: 72
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Allele
Lrrk2<tm1Hmgu> | MGI:6273237
Name: leucine-rich repeat kinase 2; targeted mutation 1, Wolfgang Wurst
Allele Type: Targeted
Attribute String: Conditional ready, Hypomorph
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Allele
Tg(LRRK2)1Cjli | MGI:3847810
Name: transgene insertion 1, Chenjian Li
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Interaction Experiment
Shin N (2008)
Description: LRRK2 regulates synaptic vesicle endocytosis.
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Publication
24075941 | J:204058
First Author: Häbig K
Year: 2013
Journal: Biochim Biophys Acta
Title: LRRK2 guides the actin cytoskeleton at growth cones together with ARHGEF7 and Tropomyosin 4.
Volume: 1832
Issue: 12
Pages: 2352-67
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Publication
28973420 | J:251668
First Author: Chen Z
Year: 2017
Journal: Hum Mol Genet
Title: LRRK2 interacts with ATM and regulates Mdm2-p53 cell proliferation axis in response to genotoxic stress.
Volume: 26
Issue: 22
Pages: 4494-4505
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Publication
26341487 | J:237016
First Author: Melrose HL
Year: 2015
Journal: Biochem J
Title: LRRK2 and ubiquitination: implications for kinase inhibitor therapy.
Volume: 470
Issue: 3
Pages: e21-4
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Publication
25899482 | J:244388
First Author: Wallings R
Year: 2015
Journal: FEBS J
Title: Cellular processes associated with LRRK2 function and dysfunction.
Volume: 282
Issue: 15
Pages: 2806-26
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Author
Canadian Lrrk2 in Inflammation Team (CLINT).
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Author
CLINT (Canadian LRRK2 in inflammation team).
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Publication
- | J:169825
     
First Author: Li C
Year: 2011
Journal: MGI Direct Data Submission
Title: A new transgenic mouse expressing mutant human LRRK2 (G2019S), a model for Parkinson's disease
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Publication
24830390 | J:214322
 
First Author: Chou JS
Year: 2014
Journal: Neurobiol Dis
Title: (G2019S) LRRK2 causes early-phase dysfunction of SNpc dopaminergic neurons and impairment of corticostriatal long-term depression in the PD transgenic mouse.
Volume: 68
Pages: 190-9
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Publication
20659558 | J:163737
First Author: Melrose HL
Year: 2010
Journal: Neurobiol Dis
Title: Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice.
Volume: 40
Issue: 3
Pages: 503-17
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Publication
34515301 | J:315839
First Author: Tasegian A
Year: 2021
Journal: Biochem J
Title: Impact of Type II LRRK2 inhibitors on signaling and mitophagy.
Volume: 478
Issue: 19
Pages: 3555-3573
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Publication
33720852 | J:347644
First Author: Henderson MX
Year: 2021
Journal: J Parkinsons Dis
Title: LRRK2 Kinase Activity Does Not Alter Cell-Autonomous Tau Pathology Development in Primary Neurons.
Volume: 11
Issue: 3
Pages: 1187-1196
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Publication
26930193 | J:259816
First Author: Shu Y
Year: 2016
Journal: PLoS One
Title: Parkinson-Related LRRK2 Mutation R1628P Enables Cdk5 Phosphorylation of LRRK2 and Upregulates Its Kinase Activity.
Volume: 11
Issue: 3
Pages: e0149739
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Publication
25804954 | J:221597
First Author: Mikhail F
Year: 2015
Journal: Hum Mol Genet
Title: Lack of exacerbation of neurodegeneration in a double transgenic mouse model of mutant LRRK2 and tau.
Volume: 24
Issue: 12
Pages: 3545-56
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UniProt Feature
UniProt Feature
Begin: 743
Description: Phosphothreonine; by CDK5 and MAPK10 and LRRK2
Type: modified residue
End: 743
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Publication
38227290 | J:344326
 
First Author: Eguchi T
Year: 2024
Journal: J Cell Biol
Title: The V-ATPase-ATG16L1 axis recruits LRRK2 to facilitate the lysosomal stress response.
Volume: 223
Issue: 3
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Publication
20173330 | J:196352
First Author: Hsu CH
Year: 2010
Journal: Neurodegener Dis
Title: LRRK2 and the stress response: interaction with MKKs and JNK-interacting proteins.
Volume: 7
Issue: 1-3
Pages: 68-75
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Publication
28958936 | J:253289
First Author: Kim J
Year: 2017
Journal: Biochem Biophys Res Commun
Title: Suppression of neuroinflammation by matrix metalloproteinase-8 inhibitor in aged normal and LRRK2 G2019S Parkinson's disease model mice challenged with lipopolysaccharide.
Volume: 493
Issue: 2
Pages: 879-886
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Allele
Tg(tetO-LRRK2*G2019S)E3Cai | MGI:4420755
Name: transgene insertion E3, Huaibin Cai
Allele Type: Transgenic
Attribute String: Humanized sequence, Inducible, Inserted expressed sequence
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Publication
- | J:314235
     
First Author: Mazza MC
Year: 2020
Journal: bioRxiv
Title: Combined knockout of Lrrk2 and Rab29 does not result in behavioral abnormalities in vivo
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Interaction Experiment
Moehle MS (2015)
Description: The G2019S LRRK2 mutation increases myeloid cell chemotactic responses and enhances LRRK2 binding to actin-regulatory proteins.
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Publication
24993787 | J:215453
First Author: Li T
Year: 2014
Journal: Hum Mol Genet
Title: Novel LRRK2 GTP-binding inhibitors reduced degeneration in Parkinson's disease cell and mouse models.
Volume: 23
Issue: 23
Pages: 6212-22
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Publication
28321439 | J:255948
 
First Author: Xiong Y
Year: 2017
Journal: eNeuro
Title: Overexpression of Parkinson's Disease-Associated Mutation LRRK2 G2019S in Mouse Forebrain Induces Behavioral Deficits and α-Synuclein Pathology.
Volume: 4
Issue: 2
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Publication
30808409 | J:278978
First Author: Henderson MX
Year: 2019
Journal: Acta Neuropathol Commun
Title: LRRK2 inhibition does not impart protection from α-synuclein pathology and neuron death in non-transgenic mice.
Volume: 7
Issue: 1
Pages: 28
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Publication
22649237 | J:184970
First Author: Friedman LG
Year: 2012
Journal: J Neurosci
Title: Disrupted autophagy leads to dopaminergic axon and dendrite degeneration and promotes presynaptic accumulation of α-synuclein and LRRK2 in the brain.
Volume: 32
Issue: 22
Pages: 7585-93
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Publication
25174890 | J:218456
 
First Author: Tsika E
Year: 2014
Journal: Neurobiol Dis
Title: Conditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegeneration.
Volume: 71
Pages: 345-58
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Publication
35776681 | J:327105
 
First Author: Lara Ordóñez AJ
Year: 2022
Journal: Biol Open
Title: The LRRK2 signaling network converges on a centriolar phospho-Rab10/RILPL1 complex to cause deficits in centrosome cohesion and cell polarization.
Volume: 11
Issue: 8
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Publication
33653948 | J:304788
 
First Author: Sobu Y
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Pathogenic LRRK2 regulates ciliation probability upstream of tau tubulin kinase 2 via Rab10 and RILPL1 proteins.
Volume: 118
Issue: 10
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Publication
25076905 | J:310233
 
First Author: Alvarez-Castelao B
Year: 2014
Journal: Front Aging Neurosci
Title: Epitope Mapping of Antibodies to Alpha-Synuclein in LRRK2 Mutation Carriers, Idiopathic Parkinson Disease Patients, and Healthy Controls.
Volume: 6
Pages: 169
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Publication
27890708 | -
 
First Author: Ding X
Year: 2017
Journal: Neurobiol Dis
Title: Fbxl18 targets LRRK2 for proteasomal degradation and attenuates cell toxicity.
Volume: 98
Pages: 122-136
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Transgene
MGI:5559902 | Tg(PDGFB-LRRK2*G2019S)32Hlw
Type: transgene
Organism: mouse, laboratory
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Transgene
MGI:5800407 | Tg(PDGFB-LRRK2*R1441C)31Hlw
Type: transgene
Organism: mouse, laboratory
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Publication
26407721 | J:302951
First Author: Fell MJ
Year: 2015
Journal: J Pharmacol Exp Ther
Title: MLi-2, a Potent, Selective, and Centrally Active Compound for Exploring the Therapeutic Potential and Safety of LRRK2 Kinase Inhibition.
Volume: 355
Issue: 3
Pages: 397-409
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Publication
18650931 | -
First Author: Gotthardt K
Year: 2008
Journal: EMBO J
Title: Structure of the Roc-COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase.
Volume: 27
Issue: 16
Pages: 2239-49
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Publication
34530877 | J:313813
First Author: Kadgien CA
Year: 2021
Journal: Mol Brain
Title: Endosomal traffic and glutamate synapse activity are increased in VPS35 D620N mutant knock-in mouse neurons, and resistant to LRRK2 kinase inhibition.
Volume: 14
Issue: 1
Pages: 143
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Allele
Lrrk2<em2Smoc> | MGI:7290880
Name: leucine-rich repeat kinase 2; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Not Specified
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Publication
16532471 | -
First Author: Galter D
Year: 2006
Journal: Ann Neurol
Title: LRRK2 expression linked to dopamine-innervated areas.
Volume: 59
Issue: 4
Pages: 714-9
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Interaction Experiment
Stafa K (2012)
Description: GTPase activity and neuronal toxicity of Parkinsons disease-associated LRRK2 is regulated by ArfGAP1.
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Interaction Experiment
Li X (2011)
Description: Phosphorylation-dependent 14-3-3 binding to LRRK2 is impaired by common mutations of familial Parkinsons disease.
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Interaction Experiment
Berwick DC (2012)
Description: LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6.
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Interaction Experiment
Jaleel M (2007)
Description: LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinsons disease mutants affect kinase activity.
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Interaction Experiment
Nichols RJ (2010)
Description: 14-3-3 binding to LRRK2 is disrupted by multiple Parkinsons disease-associated mutations and regulates cytoplasmic localization.
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Interaction Experiment
Imai Y (2015)
Description: The Parkinsons Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway.
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Interaction Experiment
Nucifora FC (2016)
Description: Ubiqutination via K27 and K29 chains signals aggregation and neuronal protection of LRRK2 by WSB1.
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Interaction Experiment
Shanley MR (2015)
Description: LRRK2 Facilitates tau Phosphorylation through Strong Interaction with tau and cdk5.
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Interaction Experiment
Stafa K (2014)
Description: Functional interaction of Parkinsons disease-associated LRRK2 with members of the dynamin GTPase superfamily.
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Transgene
MGI:4420754 | Tg(tetO-LRRK2*G2019S)E3Cai
Type: transgene
Organism: mouse, laboratory
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Transgene
MGI:3847809 | Tg(LRRK2)1Cjli
Type: transgene
Organism: mouse, laboratory
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Allele
Lrrk2<em3Smoc> | MGI:7290881
Name: leucine-rich repeat kinase 2; endonuclease-mediated mutation 3, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:7623420 | C57BL/6J-Lrrk2<em2Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Interaction Experiment
Zach S (2010)
Description: Signal transduction protein array analysis links LRRK2 to Ste20 kinases and PKC zeta that modulate neuronal plasticity.
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Interaction Experiment
Dzamko N (2010)
Description: Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization.
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Publication
15541309 | -
First Author: Zimprich A
Year: 2004
Journal: Neuron
Title: Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology.
Volume: 44
Issue: 4
Pages: 601-7
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Publication
29212815 | -
First Author: Purlyte E
Year: 2018
Journal: EMBO J
Title: Rab29 activation of the Parkinson's disease-associated LRRK2 kinase.
Volume: 37
Issue: 1
Pages: 1-18
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Publication
- | J:177258
     
First Author: Ouyang Y
Year: 2011
Journal: MGI Direct Data Submission
Title: Creation of a transgenic mouse expressing human LRRK2
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Publication
25360523 | -
First Author: Waschbüsch D
Year: 2014
Journal: PLoS One
Title: LRRK2 transport is regulated by its novel interacting partner Rab32.
Volume: 9
Issue: 10
Pages: e111632
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Strain
MGI:6429125 | C57BL/6J-Lrrk2<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Publication
16487147 | -
First Author: Simón-Sánchez J
Year: 2006
Journal: Eur J Neurosci
Title: LRRK2 is expressed in areas affected by Parkinson's disease in the adult mouse brain.
Volume: 23
Issue: 3
Pages: 659-66
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Publication
17447891 | -
First Author: Jaleel M
Year: 2007
Journal: Biochem J
Title: LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity.
Volume: 405
Issue: 2
Pages: 307-17
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Publication
20642453 | -
First Author: Nichols RJ
Year: 2010
Journal: Biochem J
Title: 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization.
Volume: 430
Issue: 3
Pages: 393-404
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Publication
26268594 | -
First Author: Shanley MR
Year: 2015
Journal: Biochemistry
Title: LRRK2 Facilitates tau Phosphorylation through Strong Interaction with tau and cdk5.
Volume: 54
Issue: 33
Pages: 5198-208
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Publication
20876399 | -
First Author: Meixner A
Year: 2011
Journal: Mol Cell Proteomics
Title: A QUICK screen for Lrrk2 interaction partners--leucine-rich repeat kinase 2 is involved in actin cytoskeleton dynamics.
Volume: 10
Issue: 1
Pages: M110.001172
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Publication
21850687 | -
First Author: Angeles DC
Year: 2011
Journal: Hum Mutat
Title: Mutations in LRRK2 increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal death.
Volume: 32
Issue: 12
Pages: 1390-7
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Publication
23183827 | -
First Author: Guerreiro PS
Year: 2013
Journal: J Mol Med (Berl)
Title: LRRK2 interactions with α-synuclein in Parkinson's disease brains and in cell models.
Volume: 91
Issue: 4
Pages: 513-22
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Allele
Tg(LRRK2*Y1699C)C7.11HMjfa | MGI:5488984
Name: transgene insertion C7.11H, Matthew Farrer
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Lrrk2<em1Smoc> | MGI:7290879
Name: leucine-rich repeat kinase 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Publication
32422864 | J:302660
 
First Author: Sim H
Year: 2020
Journal: Int J Mol Sci
Title: Iroquois Homeobox Protein 2 Identified as a Potential Biomarker for Parkinson's Disease.
Volume: 21
Issue: 10
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Publication
20949042 | -
First Author: Zach S
Year: 2010
Journal: PLoS One
Title: Signal transduction protein array analysis links LRRK2 to Ste20 kinases and PKC zeta that modulate neuronal plasticity.
Volume: 5
Issue: 10
Pages: e13191
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Strain
MGI:5488986 | B6.FVB-Tg(LRRK2*Y1699C)C7.11HMjfa/J
Attribute String: congenic, mutant strain, transgenic
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Publication
18230735 | -
First Author: Deng J
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase.
Volume: 105
Issue: 5
Pages: 1499-504
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Protein Domain
IPR032171 | COR
Type: Domain
Description: The C-terminal of Roc domain, or COR domain, functions along with Roc as a putative regulator of kinase activity. It functions as a proper GTP-binding protein with a low GTPase activity somehow stimulating the kinase activity []. The Roc-COR tandem is found in bacterial and eukaryotic proteins. Its most prominent member is the leucine-rich repeat kinase LRRK2 [].
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Publication
27063942 | J:230487
 
First Author: Palomo-Garo C
Year: 2016
Journal: Pharmacol Res
Title: Targeting the cannabinoid CB2 receptor to attenuate the progression of motor deficits in LRRK2-transgenic mice.
Volume: 110
Pages: 181-192
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Publication
31346295 | J:279709
First Author: Henderson MX
Year: 2019
Journal: Nat Neurosci
Title: Spread of α-synuclein pathology through the brain connectome is modulated by selective vulnerability and predicted by network analysis.
Volume: 22
Issue: 8
Pages: 1248-1257
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Publication
19503083 | J:149135
First Author: Li Y
Year: 2009
Journal: Nat Neurosci
Title: Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease.
Volume: 12
Issue: 7
Pages: 826-8
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Allele
Tg(LRRK2*G2019S)2AMjff | MGI:5502368
Name: transgene insertion 2A, The Michael J Fox Foundation
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(tetO-LRRK2)C7874Cai | MGI:4420758
Name: transgene insertion C7874, Huaibin Cai
Allele Type: Transgenic
Attribute String: Humanized sequence, Inducible, Inserted expressed sequence
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Allele
Gt(ROSA)26Sor<tm9(RNAi:Lrrk2)Rkuhn> | MGI:4353633
 
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 9, Ralf Kuhn
Allele Type: Targeted
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Allele
Tg(Lrrk2-EGFP)KJ162Gsat | MGI:4847209
Name: transgene insertion KJ162, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
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Allele
Tg(tetO-LRRK2)C77Cai | MGI:4420821
Name: transgene insertion C77, Huaibin Cai
Allele Type: Transgenic
Attribute String: Inducible, Inserted expressed sequence
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Strain
MGI:4942385 | FVB/N-Tg(LRRK2*G2019S)1Cjli/J
Attribute String: coisogenic, mutant strain, transgenic
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Allele
Tg(tetO-LRRK2*)D10Cai | MGI:4420818
Name: transgene insertion D10, Huaibin Cai
Allele Type: Transgenic
Attribute String: Inducible, Inserted expressed sequence
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Genotype
Genotype
Symbol: Tg(LRRK2*G2019S)1Cjli/?
Background: FVB/N-Tg(LRRK2*G2019S)1Cjli/J
Zygosity: ot
Has Mutant Allele: true
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Publication
31148170 | J:277683
First Author: Marte A
Year: 2019
Journal: J Neurochem
Title: Leucine-rich repeat kinase 2 phosphorylation on synapsin I regulates glutamate release at pre-synaptic sites.
Volume: 150
Issue: 3
Pages: 264-281
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Publication
21494637 | J:171645
First Author: Ramonet D
Year: 2011
Journal: PLoS One
Title: Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.
Volume: 6
Issue: 4
Pages: e18568
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Publication
22342962 | J:184728
 
First Author: Gillardon F
Year: 2012
Journal: Neuroscience
Title: Parkinson's disease-linked leucine-rich repeat kinase 2(R1441G) mutation increases proinflammatory cytokine release from activated primary microglial cells and resultant neurotoxicity.
Volume: 208
Pages: 41-8
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Publication
26192625 | J:222393
 
First Author: Tagliaferro P
Year: 2015
Journal: Neurobiol Dis
Title: An early axonopathy in a hLRRK2(R1441G) transgenic model of Parkinson disease.
Volume: 82
Pages: 359-371
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Publication
25654763 | -
 
First Author: Liu Y
Year: 2015
Journal: Cell Death Dis
Title: F-box protein Fbxl18 mediates polyubiquitylation and proteasomal degradation of the pro-apoptotic SCF subunit Fbxl7.
Volume: 6
Pages: e1630
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Protein Domain
IPR045627 | FBXL18_LRR
Type: Domain
Description: In general, F-box proteins share a F-box motif and also have either WD40 repeat domains, LRR domains or various other domains. F-box proteins recruit specific substrates for ubiquitination via different protein-protein interaction domains, such as WD40 repeats and leucine rich repeats (LRRs) [, ]. This entry represents the leucine-rich repeats (LRR) domain of F-box/LRR repeat protein 18 (FBXL18). This protein is a component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The SCF-Fbxl18 complex has been shown to ubiquitinate Fbxl7 and LRRK2 and promote their degradation through the proteasome pathway [, ].
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Strain
MGI:5560147 | FVB/N-Tg(PDGFB-LRRK2*G2019S)32Hlw
Attribute String: coisogenic, mutant strain, transgenic
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Strain
MGI:5502369 | C57BL/6J-Tg(LRRK2*G2019S)2AMjff/J
Attribute String: coisogenic, mutant strain, transgenic
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Publication
36671436 | J:347452
 
First Author: Yao N
Year: 2022
Journal: Biomolecules
Title: Age- and Sex-Dependent Behavioral and Neurochemical Alterations in hLRRK2-G2019S BAC Mice.
Volume: 13
Issue: 1
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Strain
MGI:5293637 | B6.Cg-Tg(tetO-LRRK2)C7874Cai/J
Attribute String: congenic, transgenic, mutant strain
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Strain
MGI:4421046 | STOCK Tg(teto-LRRK2)C7874Cai/J
Attribute String: transgenic, mutant strain
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Allele
Tg(PDGFB-LRRK2*R1441C)574Djmo | MGI:4950673
Name: transgene insertion 574, Darren Moore
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Strain
MGI:4950692 | B6;C3-Tg(PDGFB-LRRK2*R1441C)574Djmo/J
Attribute String: mutant stock, transgenic
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Strain
MGI:3847894 | FVB/N-Tg(LRRK2)1Cjli/J
Attribute String: coisogenic, transgenic
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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