MouseMine: Keyword Search

Publication

First Author:	Oliver TG
Year:	2011
Journal:	Mol Cell
Title:	Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop.
Volume:	43
Issue:	1
Pages:	57-71

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Publication

15927364 | J:100601

First Author:	Slack A
Year:	2005
Journal:	Cancer Lett
Title:	MDM2 as MYCN transcriptional target: implications for neuroblastoma pathogenesis.
Volume:	228
Issue:	1-2
Pages:	21-7

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Publication

23327795 | J:320712

First Author:	Xiong S
Year:	2013
Journal:	Chin J Cancer
Title:	Mouse models of Mdm2 and Mdm4 and their clinical implications.
Volume:	32
Issue:	7
Pages:	371-5

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Publication

32561413 | J:298223

First Author:	Kim JE
Year:	2020
Journal:	Exp Neurol
Title:	PLPP/CIN-mediated Mdm2 dephosphorylation increases seizure susceptibility via abrogating PSD95 ubiquitination.
Volume:	331

Pages:	113383

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Publication

10085066 | J:53947

First Author:	Sionov RV
Year:	1999
Journal:	J Biol Chem
Title:	c-Abl neutralizes the inhibitory effect of Mdm2 on p53.
Volume:	274
Issue:	13
Pages:	8371-4

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Publication

9878046 | J:51904

First Author:	Honda R
Year:	1999
Journal:	EMBO J
Title:	Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.
Volume:	18
Issue:	1
Pages:	22-7

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HT Experiment

GSE157356 | Mis-splicing of Mdm2 leads to Increased P53-Activity and Craniofacial Defects in a MFDM Eftud2 Mutant Mouse Model


Experiment Type:	RNA-Seq
Study Type:	WT vs. Mutant
Source:	GEO

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Publication

25809483 | J:222582

First Author:	Leslie PL
Year:	2015
Journal:	J Biol Chem
Title:	The MDM2 RING domain and central acidic domain play distinct roles in MDM2 protein homodimerization and MDM2-MDMX protein heterodimerization.
Volume:	290
Issue:	20
Pages:	12941-50

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Publication

25088421 | -

First Author:	Yoshihara S
Year:	2014
Journal:	Cell Rep
Title:	Npas4 regulates Mdm2 and thus Dcx in experience-dependent dendritic spine development of newborn olfactory bulb interneurons.
Volume:	8
Issue:	3
Pages:	843-57

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Publication

26832969 | J:236289

First Author:	Kwon DH
Year:	2016
Journal:	Nat Commun
Title:	MDM2 E3 ligase-mediated ubiquitination and degradation of HDAC1 in vascular calcification.
Volume:	7

Pages:	10492

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Publication

19372219 | J:183215

First Author:	Li X
Year:	2009
Journal:	J Biol Chem
Title:	Mdm2 directs the ubiquitination of beta-arrestin-sequestered cAMP phosphodiesterase-4D5.
Volume:	284
Issue:	24
Pages:	16170-82

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Publication

19648273 | J:151868

First Author:	Zhou JX
Year:	2009
Journal:	J Immunol
Title:	IFN regulatory factor 8 regulates MDM2 in germinal center B cells.
Volume:	183
Issue:	5
Pages:	3188-94

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Publication

22710720 | J:198026

First Author:	Xu E
Year:	2013
Journal:	Oncogene
Title:	MDM2 expression is repressed by the RNA-binding protein RNPC1 via mRNA stability.
Volume:	32
Issue:	17
Pages:	2169-78

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Publication

20305689 | J:162036

First Author:	Odvody J
Year:	2010
Journal:	Oncogene
Title:	A deficiency in Mdm2 binding protein inhibits Myc-induced B-cell proliferation and lymphomagenesis.
Volume:	29
Issue:	22
Pages:	3287-96

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Publication

14757843 | J:88006

First Author:	Bartel F
Year:	2004
Journal:	Mol Cancer Res
Title:	MDM2 and its splice variant messenger RNAs: expression in tumors and down-regulation using antisense oligonucleotides.
Volume:	2
Issue:	1
Pages:	29-35

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Publication

19147532 | J:205255

First Author:	Wade M
Year:	2009
Journal:	Mol Cancer Res
Title:	Targeting Mdm2 and Mdmx in cancer therapy: better living through medicinal chemistry?
Volume:	7
Issue:	1
Pages:	1-11

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Publication

9136986 | J:39458

First Author:	Marechal V
Year:	1997
Journal:	Oncogene
Title:	Conservation of structural domains and biochemical activities of the MDM2 protein from Xenopus laevis.
Volume:	14
Issue:	12
Pages:	1427-33

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Publication

27122614 | J:250364

First Author:	Li Y
Year:	2016
Journal:	Sci Transl Med
Title:	MDM2 inhibition rescues neurogenic and cognitive deficits in a mouse model of fragile X syndrome.
Volume:	8
Issue:	336
Pages:	336ra61

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Publication

20089965 | J:160270

First Author:	Asslaber D
Year:	2010
Journal:	Blood
Title:	microRNA-34a expression correlates with MDM2 SNP309 polymorphism and treatment-free survival in chronic lymphocytic leukemia.
Volume:	115
Issue:	21
Pages:	4191-7

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Publication

16982679 | J:118109

First Author:	Limesand KH
Year:	2006
Journal:	Mol Cell Biol
Title:	MDM2 is required for suppression of apoptosis by activated Akt1 in salivary acinar cells.
Volume:	26
Issue:	23
Pages:	8840-56

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Publication

7651818 | J:28003

First Author:	Zauberman A
Year:	1995
Journal:	Nucleic Acids Res
Title:	A functional p53-responsive intronic promoter is contained within the human mdm2 gene.
Volume:	23
Issue:	14
Pages:	2584-92

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Publication

9840926 | J:51321

First Author:	Pochampally R
Year:	1998
Journal:	Oncogene
Title:	A 60 kd MDM2 isoform is produced by caspase cleavage in non-apoptotic tumor cells.
Volume:	17
Issue:	20
Pages:	2629-36

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Publication

16757884 | J:110065

First Author:	Wu H
Year:	2006
Journal:	J Vet Med Sci
Title:	Immunohistochemical analysis for Mdm2 and p53 proteins in methylcholanthrene-induced mouse rhabdomyosarcomas.
Volume:	68
Issue:	5
Pages:	427-31

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Publication

19541936 | J:149982

First Author:	Hwang YC
Year:	2009
Journal:	Am J Pathol
Title:	NOLC1, an enhancer of nasopharyngeal carcinoma progression, is essential for TP53 to regulate MDM2 expression.
Volume:	175
Issue:	1
Pages:	342-54

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Publication

21419099 | J:171930

First Author:	Matsushima S
Year:	2011
Journal:	Biochem Biophys Res Commun
Title:	An Mdm2 antagonist, Nutlin-3a, induces p53-dependent and proteasome-mediated poly(ADP-ribose) polymerase1 degradation in mouse fibroblasts.
Volume:	407
Issue:	3
Pages:	557-61

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Publication

22377766 | J:185216

First Author:	Manfé V
Year:	2012
Journal:	J Invest Dermatol
Title:	MDM2 inhibitor nutlin-3a induces apoptosis and senescence in cutaneous T-cell lymphoma: role of p53.
Volume:	132
Issue:	5
Pages:	1487-96

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Publication

26124108 | J:223726

First Author:	Malonia SK
Year:	2015
Journal:	Proc Natl Acad Sci U S A
Title:	F-box protein FBXO31 directs degradation of MDM2 to facilitate p53-mediated growth arrest following genotoxic stress.
Volume:	112
Issue:	28
Pages:	8632-7

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Publication

19166840 | J:201310

First Author:	Ochocka AM
Year:	2009
Journal:	FEBS Lett
Title:	FKBP25, a novel regulator of the p53 pathway, induces the degradation of MDM2 and activation of p53.
Volume:	583
Issue:	4
Pages:	621-6

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Publication

7590734 | J:27751

First Author:	Bureau JF
Year:	1995
Journal:	Genomics
Title:	The gene coding for interferon-gamma is linked to the D12S335 and D12S313 microsatellites and to the MDM2 gene.
Volume:	28
Issue:	1
Pages:	109-12

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Publication

29762656 | J:266016

First Author:	Wang W
Year:	2018
Journal:	Carcinogenesis
Title:	Prevention of prostate cancer by natural product MDM2 inhibitor GS25: In vitro and in vivo activities and molecular mechanisms.

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Publication

22383580 | J:197696

First Author:	Lessard F
Year:	2012
Journal:	Nucleic Acids Res
Title:	The cellular abundance of the essential transcription termination factor TTF-I regulates ribosome biogenesis and is determined by MDM2 ubiquitinylation.
Volume:	40
Issue:	12
Pages:	5357-67

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Protein

Q3UB74

Organism:	Mus musculus/domesticus
Length:	406
Fragment?:	false

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Publication

33414453 | J:327679

First Author:	Kim JE
Year:	2021
Journal:	Cell Death Dis
Title:	PLPP/CIN-mediated NF2-serine 10 dephosphorylation regulates F-actin stability and Mdm2 degradation in an activity-dependent manner.
Volume:	12
Issue:	1
Pages:	37

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Publication

23946421 | J:200986

First Author:	Chang YS
Year:	2013
Journal:	Proc Natl Acad Sci U S A
Title:	Stapled α-helical peptide drug development: a potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy.
Volume:	110
Issue:	36
Pages:	E3445-54

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Interaction Experiment

Lee MH (2006)

Description:

SUMO-specific protease SUSP4 positively regulates p53 by promoting Mdm2 self-ubiquitination.

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Interaction Experiment

Li X (2009)

Description:

Mdm2 directs the ubiquitination of beta-arrestin-sequestered cAMP phosphodiesterase-4D5.

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Interaction Experiment

Wang X (2011)

Description:

MdmX protein is essential for Mdm2 protein-mediated p53 polyubiquitination.

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Interaction Experiment

Clegg HV (2012)

Description:

Mdm2 RING Mutation Enhances p53 Transcriptional Activity and p53-p300 Interaction.

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Interaction Experiment

Juven-Gershon T (1998)

Description:

The Mdm2 oncoprotein interacts with the cell fate regulator Numb.

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Interaction Experiment

Yamauchi T (2014)

Description:

MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24.

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Interaction Experiment

Hallenborg P (2016)

Description:

MDM2 facilitates adipocyte differentiation through CRTC-mediated activation of STAT3.

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Interaction Experiment

Tsai NP (2016)

Description:

FMRP-dependent Mdm2 dephosphorylation is required for MEF2-induced synapse elimination.

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Interaction Experiment

Zheng H (2020)

Description:

Mdm2 Promotes Odontoblast-like Differentiation by Ubiquitinating Dlx3 and p53.

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Publication

11588219 | -

First Author:	Shenoy SK
Year:	2001
Journal:	Science
Title:	Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin.
Volume:	294
Issue:	5545
Pages:	1307-13

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Publication

10713175 | -

First Author:	Weber JD
Year:	2000
Journal:	Mol Cell Biol
Title:	Cooperative signals governing ARF-mdm2 interaction and nucleolar localization of the complex.
Volume:	20
Issue:	7
Pages:	2517-28

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Publication

14642282 | -

First Author:	Colledge M
Year:	2003
Journal:	Neuron
Title:	Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression.
Volume:	40
Issue:	3
Pages:	595-607

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Interaction Experiment

Pant V (2011)

Description:

Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability.

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Publication

10360174 | J:55192

First Author:	Zhang Y
Year:	1999
Journal:	Mol Cell
Title:	Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53.
Volume:	3
Issue:	5
Pages:	579-91

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Publication

14707287 | J:87255

First Author:	Hernandez I
Year:	2003
Journal:	Mol Cancer Res
Title:	Prostate-specific expression of p53(R172L) differentially regulates p21, Bax, and mdm2 to inhibit prostate cancer progression and prolong survival.
Volume:	1
Issue:	14
Pages:	1036-47

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GXD Expression

Probe:	MGI:7531826
Assay Type:	Immunohistochemistry
Annotation Date:	2023-10-04
Strength:	Present
Sex:	Not Specified
Emaps:	EMAPS:3288928
Pattern:	Regionally restricted
Stage:	TS28
Assay Id:	MGI:7532785
Age:	postnatal day 14
Image:	7Fd
Note:	Proximity ligation assay indicated that the interaction between MDM2 and DLX3 was enhanced in the secretory odontoblasts.
Specimen Label:	7Fd
Detected:	true
Specimen Num:	8

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GXD Expression

Probe:	MGI:7531826
Assay Type:	Immunohistochemistry
Annotation Date:	2023-10-04
Strength:	Weak
Sex:	Not Specified
Emaps:	EMAPS:3289428
Pattern:	Regionally restricted
Stage:	TS28
Assay Id:	MGI:7532785
Age:	postnatal day 14
Image:	7Fc
Note:	Proximity ligation assay indicated that the interaction between MDM2 and DLX3 was weak in undifferentiated dental mesenchymal cells.
Specimen Label:	7Fc
Detected:	true
Specimen Num:	7

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Publication

35747386 | J:341509

First Author:	Zhao W
Year:	2022
Journal:	iScience
Title:	Murine double minute 2 aggravates adipose tissue dysfunction through ubiquitin-mediated six-transmembrane epithelial antigen of prostate 4 degradation.
Volume:	25
Issue:	7
Pages:	104544

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Publication

12016060 | -

First Author:	Bennett-Lovsey R
Year:	2002
Journal:	Bioinformatics
Title:	The SWIB and the MDM2 domains are homologous and share a common fold.
Volume:	18
Issue:	4
Pages:	626-30

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Interaction Experiment

Masuhara M (2003)

Description:

Enhanced degradation of MDM2 by a nuclear envelope component, mouse germ cell-less.

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Interaction Experiment

Song MS (2008)

Description:

The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex.

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Interaction Experiment

Tompkins VS (2007)

Description:

A novel nuclear interactor of ARF and MDM2 (NIAM) that maintains chromosomal stability.

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Interaction Experiment

Alt JR (2005)

Description:

Mdm2 binds to Nbs1 at sites of DNA damage and regulates double strand break repair.

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Interaction Experiment

Lee D (2012)

Description:

Mdm2 associates with Ras effector NORE1 to induce the degradation of oncoprotein HIPK1.

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Interaction Experiment

Vlatkovic N (2000)

Description:

MDM2 interacts with the C-terminus of the catalytic subunit of DNA polymerase epsilon.

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Interaction Experiment

Dias SS (2009)

Description:

Polo-like kinase-1 phosphorylates MDM2 at Ser260 and stimulates MDM2-mediated p53 turnover.

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Interaction Experiment

Gu J (2002)

Description:

Mutual dependence of MDM2 and MDMX in their functional inactivation of p53.

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Interaction Experiment

Reed SM (2014)

Description:

Nuclear interactor of ARF and Mdm2 regulates multiple pathways to activate p53.

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Interaction Experiment

Fu D (2015)

Description:

Mdm2 promotes myogenesis through the ubiquitination and degradation of CCAAT/enhancer-binding protein .

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Interaction Experiment

Wienken M (2016)

Description:

MDM2 Associates with Polycomb Repressor Complex 2 and Enhances Stemness-Promoting Chromatin Modifications Independent of p53.

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Interaction Experiment

Malek R (2011)

Description:

The p53 inhibitor MDM2 facilitates Sonic Hedgehog-mediated tumorigenesis and influences cerebellar foliation.

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Interaction Experiment

Michelsen K (2012)

Description:

Ordering of the N-terminus of human MDM2 by small molecule inhibitors.

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Interaction Experiment

Guo Q (2023)

Description:

LncRNA NRON promotes tumorigenesis by enhancing MDM2 activity toward tumor suppressorsubstrates.

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Allele

Tg(Mdm2)1Snj | MGI:2182249

Name:	transgene insertion 1, Stephen N Jones
Allele Type:	Transgenic
Attribute String:	Inserted expressed sequence

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Allele

Igs2<em1(Adipoq-Mdm2)Xliu> | MGI:7540641

Name:	intergenic site 2; endonuclease-mediated mutation 1, Xiaojun Liu
Allele Type:	Endonuclease-mediated
Attribute String:	Inserted expressed sequence

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Publication

21132010 | -

First Author:	Meng L
Year:	2011
Journal:	Oncogene
Title:	GNL3L depletion destabilizes MDM2 and induces p53-dependent G2/M arrest.
Volume:	30
Issue:	14
Pages:	1716-26

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Publication

17086174 | -

First Author:	Lee MH
Year:	2006
Journal:	Nat Cell Biol
Title:	SUMO-specific protease SUSP4 positively regulates p53 by promoting Mdm2 self-ubiquitination.
Volume:	8
Issue:	12
Pages:	1424-31

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Publication

20153724 | -

First Author:	Tang J
Year:	2010
Journal:	Biochem Biophys Res Commun
Title:	Daxx is reciprocally regulated by Mdm2 and Hausp.
Volume:	393
Issue:	3
Pages:	542-5

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Publication

21572037 | -

First Author:	Wang X
Year:	2011
Journal:	J Biol Chem
Title:	MdmX protein is essential for Mdm2 protein-mediated p53 polyubiquitination.
Volume:	286
Issue:	27
Pages:	23725-34

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Publication

27362806 | -

First Author:	Hallenborg P
Year:	2016
Journal:	Cell Death Dis
Title:	MDM2 facilitates adipocyte differentiation through CRTC-mediated activation of STAT3.
Volume:	7
Issue:	6
Pages:	e2289

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Publication

31847675 | -

First Author:	Zheng H
Year:	2020
Journal:	J Dent Res
Title:	Mdm2 Promotes Odontoblast-like Differentiation by Ubiquitinating Dlx3 and p53.
Volume:	99
Issue:	3
Pages:	320-328

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Interaction Experiment

Itahana K (2007)

Description:

Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation.

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Interaction Experiment

Giono LE (2007)

Description:

Mdm2 is required for inhibition of Cdk2 activity by p21, thereby contributing to p53-dependent cell cycle arrest.

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Interaction Experiment

Picksley SM (1994)

Description:

Immunochemical analysis of the interaction of p53 with MDM2;--fine mapping of the MDM2 binding site on p53 using synthetic peptides.

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Interaction Experiment

Knights CD (2003)

Description:

Defective p53 post-translational modification required for wild type p53 inactivation in malignant epithelial cells with mdm2 gene amplification.

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Strain

MGI:5898470 | B6.129S7-Tg(Mdm2)1Snj/Nci

Attribute String:

congenic, mutant strain, transgenic

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Allele

Mdm2<tm1Smoc> | MGI:7291014

Name:	transformed mouse 3T3 cell double minute 2; targeted mutation 1, Shanghai Model Organisms Center
Allele Type:	Targeted
Attribute String:	Conditional ready, No functional change

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Genotype

Symbol:	Tg(Mdm2)1Snj/?
Background:	involves: 129S7/SvEvBrd * C57BL/6
Zygosity:	ot
Has Mutant Allele:	true

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Genotype

Symbol:	Tg(Mdm2)1Snj/Tg(Mdm2)1Snj
Background:	involves: 129S7/SvEvBrd * C57BL/6
Zygosity:	hm
Has Mutant Allele:	true

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Interaction Experiment

Girnita L (2005)

Description:

{beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase.

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Publication

9529248 | -

First Author:	Pomerantz J
Year:	1998
Journal:	Cell
Title:	The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53.
Volume:	92
Issue:	6
Pages:	713-23

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Publication

17226766 | -

First Author:	Shin S
Year:	2007
Journal:	J Cell Biochem
Title:	Concerted activation of the Mdm2 promoter by p72 RNA helicase and the coactivators p300 and P/CAF.
Volume:	101
Issue:	5
Pages:	1252-65

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Publication

24621507 | -

First Author:	Reed SM
Year:	2014
Journal:	Cell Cycle
Title:	Nuclear interactor of ARF and Mdm2 regulates multiple pathways to activate p53.
Volume:	13
Issue:	8
Pages:	1288-98

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Publication

18566590 | -

First Author:	Song MS
Year:	2008
Journal:	EMBO J
Title:	The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex.
Volume:	27
Issue:	13
Pages:	1863-74

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Publication

10982879 | -

First Author:	Vlatkovic N
Year:	2000
Journal:	Nucleic Acids Res
Title:	MDM2 interacts with the C-terminus of the catalytic subunit of DNA polymerase epsilon.
Volume:	28
Issue:	18
Pages:	3581-6

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Publication

11953423 | -

First Author:	Gu J
Year:	2002
Journal:	J Biol Chem
Title:	Mutual dependence of MDM2 and MDMX in their functional inactivation of p53.
Volume:	277
Issue:	22
Pages:	19251-4

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Publication

22991965 | -

First Author:	Michelsen K
Year:	2012
Journal:	J Am Chem Soc
Title:	Ordering of the N-terminus of human MDM2 by small molecule inhibitors.
Volume:	134
Issue:	41
Pages:	17059-67

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Publication

37382239 | -

First Author:	Guo Q
Year:	2023
Journal:	EMBO J
Title:	LncRNA NRON promotes tumorigenesis by enhancing MDM2 activity toward tumor suppressor substrates.
Volume:	42
Issue:	16
Pages:	e112414

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Publication

23623661 | -

First Author:	Lu M
Year:	2013
Journal:	Cancer Cell
Title:	Restoring p53 function in human melanoma cells by inhibiting MDM2 and cyclin B1/CDK1-phosphorylated nuclear iASPP.
Volume:	23
Issue:	5
Pages:	618-33

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Publication

24003224 | -

First Author:	Iwasa H
Year:	2013
Journal:	J Biol Chem
Title:	The RASSF6 tumor suppressor protein regulates apoptosis and the cell cycle via MDM2 protein and p53 protein.
Volume:	288
Issue:	42
Pages:	30320-9

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Publication

17371838 | -

First Author:	Giono LE
Year:	2007
Journal:	Mol Cell Biol
Title:	Mdm2 is required for inhibition of Cdk2 activity by p21, thereby contributing to p53-dependent cell cycle arrest.
Volume:	27
Issue:	11
Pages:	4166-78

•

Publication

8058315 | -

First Author:	Picksley SM
Year:	1994
Journal:	Oncogene
Title:	Immunochemical analysis of the interaction of p53 with MDM2;--fine mapping of the MDM2 binding site on p53 using synthetic peptides.
Volume:	9
Issue:	9
Pages:	2523-9

•

Publication

14555661 | -

First Author:	Knights CD
Year:	2003
Journal:	J Biol Chem
Title:	Defective p53 post-translational modification required for wild type p53 inactivation in malignant epithelial cells with mdm2 gene amplification.
Volume:	278
Issue:	52
Pages:	52890-900