Type |
Details |
Score |
Publication |
First Author: |
Almrud JJ |
Year: |
2002 |
Journal: |
Biochemistry |
Title: |
The crystal structure of YdcE, a 4-oxalocrotonate tautomerase homologue from Escherichia coli, confirms the structural basis for oligomer diversity. |
Volume: |
41 |
Issue: |
40 |
Pages: |
12010-24 |
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Protein Domain |
Type: |
Homologous_superfamily |
Description: |
Tautomerase superfamily members have a (beta-α-β)2 structure in two layers, and use a similar mechanism of action involving an amino-terminal proline as a general base in a ket-enol tautomerisation reaction []. Members of this superfamily include macrophage migration inhibitory factor (MIF) and related proteins such as D-dopachrome tautomerase; 4-oxalocrotonoate tautomerase and related enzymes such as trans-3-chloroacrylic acid dehalogenase; and 5-carboxymethyl-2-hydroxymuconate Delta-isomerase (CHMI).Macrophage migration inhibitory factor (MIF) is a key regulatory cytokine within innate and adaptive immune responses, capable of promoting and modulating the magnitude of the response []. MIF is released from T-cells and macrophages, and it can regulate cytokine secretion and the expression of receptors involved in the immune response. MIF has been linked to various inflammatory diseases, such as rheumatoid arthritis and atherosclerosis [].4-Oxalocrotonate tautomerase (4-OT) is a plasmid-encoded enzyme that catalyzes the isomerisation of beta,gamma-unsaturated enones to their alpha,beta-isomers. This enzyme is part of the plasmid-encoded catechol meta-fission pathway, which enables the bacteria to use various aromatic hydrocarbons as their sole sources of carbon and energy [].5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme involved in the homoprotocatechuate pathway in Escherichia coli []. This enzyme catalyses the isomerisation of 5-carboxymethyl-2-hydroxymuconate (CHM) to 5-carboxymethyl-2-oxo-3-hexene-1,6-dioate (COHED). |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
252
 |
Fragment?: |
true |
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Publication |
First Author: |
Subramanya HS |
Year: |
1996 |
Journal: |
Biochemistry |
Title: |
Enzymatic ketonization of 2-hydroxymuconate: specificity and mechanism investigated by the crystal structures of two isomerases. |
Volume: |
35 |
Issue: |
3 |
Pages: |
792-802 |
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•
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Publication |
First Author: |
Whitman CP |
Year: |
2002 |
Journal: |
Arch Biochem Biophys |
Title: |
The 4-oxalocrotonate tautomerase family of enzymes: how nature makes new enzymes using a beta-alpha-beta structural motif. |
Volume: |
402 |
Issue: |
1 |
Pages: |
1-13 |
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Publication |
First Author: |
Cuthbert RJ |
Year: |
2009 |
Journal: |
Eur J Cancer |
Title: |
Differential CD74 (major histocompatibility complex Class II invariant chain) expression in mouse and human intestinal adenomas. |
Volume: |
45 |
Issue: |
9 |
Pages: |
1654-63 |
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•
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Publication |
First Author: |
Zaidi T |
Year: |
2011 |
Journal: |
Sci Rep |
Title: |
CD74 deficiency ameliorates Pseudomonas aeruginosa-induced ocular infection. |
Volume: |
1 |
|
Pages: |
58 |
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•
•
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Publication |
First Author: |
Israelson A |
Year: |
2015 |
Journal: |
Neuron |
Title: |
Macrophage migration inhibitory factor as a chaperone inhibiting accumulation of misfolded SOD1. |
Volume: |
86 |
Issue: |
1 |
Pages: |
218-32 |
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•
•
•
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Publication |
First Author: |
Hou L |
Year: |
2024 |
Journal: |
Front Immunol |
Title: |
Integrin CD11c regulates B cell homeostasis. |
Volume: |
15 |
|
Pages: |
1359608 |
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•
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•
•
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Publication |
First Author: |
Yoshihisa Y |
Year: |
2021 |
Journal: |
FASEB J |
Title: |
Overexpression of D-dopachrome tautomerase increases ultraviolet B irradiation-induced skin tumorigenesis in mice. |
Volume: |
35 |
Issue: |
7 |
Pages: |
e21671 |
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•
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Publication |
First Author: |
Hudson JD |
Year: |
1999 |
Journal: |
J Exp Med |
Title: |
A proinflammatory cytokine inhibits p53 tumor suppressor activity. |
Volume: |
190 |
Issue: |
10 |
Pages: |
1375-82 |
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•
•
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•
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Publication |
First Author: |
Kobayashi S |
Year: |
1998 |
Journal: |
Gene |
Title: |
DNA sequence motifs are associated with aberrant homologous recombination in the mouse macrophage migration inhibitory factor (Mif) locus. |
Volume: |
215 |
Issue: |
1 |
Pages: |
85-92 |
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•
•
•
•
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Publication |
First Author: |
Jüttner S |
Year: |
1998 |
Journal: |
J Immunol |
Title: |
Migration inhibitory factor induces killing of Leishmania major by macrophages: dependence on reactive nitrogen intermediates and endogenous TNF-alpha. |
Volume: |
161 |
Issue: |
5 |
Pages: |
2383-90 |
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•
•
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•
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Publication |
First Author: |
Kyaw T |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
BAFF receptor mAb treatment ameliorates development and progression of atherosclerosis in hyperlipidemic ApoE(-/-) mice. |
Volume: |
8 |
Issue: |
4 |
Pages: |
e60430 |
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•
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•
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Publication |
First Author: |
Gregory JL |
Year: |
2006 |
Journal: |
J Immunol |
Title: |
Macrophage migration inhibitory factor induces macrophage recruitment via CC chemokine ligand 2. |
Volume: |
177 |
Issue: |
11 |
Pages: |
8072-9 |
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•
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•
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Publication |
First Author: |
Tagliabue A |
Year: |
1978 |
Journal: |
J Immunol |
Title: |
Refractoriness to migration inhibitory factor of macrophages of LPS nonresponder mouse strains. |
Volume: |
121 |
Issue: |
4 |
Pages: |
1223-6 |
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•
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Publication |
First Author: |
Ohkawara T |
Year: |
2005 |
Journal: |
Clin Exp Immunol |
Title: |
Macrophage migration inhibitory factor contributes to the development of acute dextran sulphate sodium-induced colitis in Toll-like receptor 4 knockout mice. |
Volume: |
141 |
Issue: |
3 |
Pages: |
412-21 |
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•
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•
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Publication |
First Author: |
Cohen S |
Year: |
2012 |
Journal: |
J Immunol |
Title: |
The cytokine midkine and its receptor RPTPζ regulate B cell survival in a pathway induced by CD74. |
Volume: |
188 |
Issue: |
1 |
Pages: |
259-69 |
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•
•
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Publication |
First Author: |
Yang L |
Year: |
2019 |
Journal: |
Biochim Biophys Acta Mol Basis Dis |
Title: |
CD74 knockout attenuates alcohol intake-induced cardiac dysfunction through AMPK-Skp2-mediated regulation of autophagy. |
Volume: |
1865 |
Issue: |
9 |
Pages: |
2368-2378 |
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•
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•
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Publication |
First Author: |
Ma Y |
Year: |
2015 |
Journal: |
Cardiovasc Res |
Title: |
Deriving a cardiac ageing signature to reveal MMP-9-dependent inflammatory signalling in senescence. |
Volume: |
106 |
Issue: |
3 |
Pages: |
421-31 |
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•
•
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•
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Publication |
First Author: |
Rittirsch D |
Year: |
2008 |
Journal: |
J Immunol |
Title: |
Acute lung injury induced by lipopolysaccharide is independent of complement activation. |
Volume: |
180 |
Issue: |
11 |
Pages: |
7664-72 |
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•
•
•
•
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Publication |
First Author: |
Traggiai E |
Year: |
2010 |
Journal: |
PLoS One |
Title: |
Selective preservation of bone marrow mature recirculating but not marginal zone B cells in murine models of chronic inflammation. |
Volume: |
5 |
Issue: |
6 |
Pages: |
e11262 |
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•
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•
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Publication |
First Author: |
Wilson C |
Year: |
2022 |
Journal: |
JCI Insight |
Title: |
Sine oculis homeobox homolog 1 plays a critical role in pulmonary fibrosis. |
Volume: |
7 |
Issue: |
10 |
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|
•
•
•
•
•
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Publication |
First Author: |
Jia H |
Year: |
2016 |
Journal: |
PLoS One |
Title: |
The Effects of Pharmacological Inhibition of Histone Deacetylase 3 (HDAC3) in Huntington's Disease Mice. |
Volume: |
11 |
Issue: |
3 |
Pages: |
e0152498 |
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•
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•
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Publication |
First Author: |
Fujihara Y |
Year: |
2010 |
Journal: |
Biomaterials |
Title: |
Immunological response to tissue-engineered cartilage derived from auricular chondrocytes and a PLLA scaffold in transgenic mice. |
Volume: |
31 |
Issue: |
6 |
Pages: |
1227-34 |
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•
•
•
•
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Publication |
First Author: |
Thavayogarajah T |
Year: |
2022 |
Journal: |
Exp Hematol |
Title: |
CXCR4 and CD74 together enhance cell survival in response to macrophage migration-inhibitory factor in chronic lymphocytic leukemia. |
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•
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Publication |
First Author: |
Chen D |
Year: |
2015 |
Journal: |
Circulation |
Title: |
Expression of human tissue factor pathway inhibitor on vascular smooth muscle cells inhibits secretion of macrophage migration inhibitory factor and attenuates atherosclerosis in ApoE-/- mice. |
Volume: |
131 |
Issue: |
15 |
Pages: |
1350-60 |
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•
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•
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Publication |
First Author: |
COFFEY JW |
Year: |
1965 |
Journal: |
Arch Biochem Biophys |
Title: |
STUDIES ON THE INTERACTION OF VITAMIN B12: INTRINSIC FACTOR AND RECEPTORS. 3. CHEMICAL AND BIOLOGICAL PROPERTIES OF VITAMIN B12 COMBINING SUBSTANCES FROM THE STOMACH, SERUM, AND ASCITES FLUID OF THE MOUSE. |
Volume: |
110 |
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Pages: |
117-23 |
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•
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•
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Publication |
First Author: |
Galat A |
Year: |
1994 |
Journal: |
Eur J Biochem |
Title: |
A diversified family of 12-kDa proteins with a high amino acid sequence similarity to macrophage migration-inhibitory factor (MIF). |
Volume: |
224 |
Issue: |
2 |
Pages: |
417-21 |
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•
•
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•
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Publication |
First Author: |
Pastrana DV |
Year: |
1998 |
Journal: |
Infect Immun |
Title: |
Filarial nematode parasites secrete a homologue of the human cytokine macrophage migration inhibitory factor. |
Volume: |
66 |
Issue: |
12 |
Pages: |
5955-63 |
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•
•
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•
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Publication |
First Author: |
Chesney J |
Year: |
1999 |
Journal: |
Mol Med |
Title: |
An essential role for macrophage migration inhibitory factor (MIF) in angiogenesis and the growth of a murine lymphoma. |
Volume: |
5 |
Issue: |
3 |
Pages: |
181-91 |
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•
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Publication |
First Author: |
Takagi D |
Year: |
2006 |
Journal: |
Int J Mol Med |
Title: |
Natural killer T cells ameliorate antibody-induced arthritis in macrophage migration inhibitory factor transgenic mice. |
Volume: |
18 |
Issue: |
5 |
Pages: |
829-36 |
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•
•
•
•
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Publication |
First Author: |
Torii M |
Year: |
2010 |
Journal: |
Eur J Immunol |
Title: |
Thioredoxin suppresses airway inflammation independently of systemic Th1/Th2 immune modulation. |
Volume: |
40 |
Issue: |
3 |
Pages: |
787-96 |
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•
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Publication |
First Author: |
Choudhary S |
Year: |
2013 |
Journal: |
Carcinogenesis |
Title: |
Macrophage migratory inhibitory factor promotes bladder cancer progression via increasing proliferation and angiogenesis. |
Volume: |
34 |
Issue: |
12 |
Pages: |
2891-9 |
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Publication |
First Author: |
Hauser JT |
Year: |
2014 |
Journal: |
J Leukoc Biol |
Title: |
Coalescence of B cell receptor and invariant chain MHC II in a raft-like membrane domain. |
Volume: |
96 |
Issue: |
5 |
Pages: |
843-55 |
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•
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•
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Publication |
First Author: |
Baumeier C |
Year: |
2015 |
Journal: |
Biochim Biophys Acta |
Title: |
Caloric restriction and intermittent fasting alter hepatic lipid droplet proteome and diacylglycerol species and prevent diabetes in NZO mice. |
Volume: |
1851 |
Issue: |
5 |
Pages: |
566-76 |
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Publication |
First Author: |
Zhang W |
Year: |
2017 |
Journal: |
Neuroscience |
Title: |
Macrophage migration inhibitory factor mediates viability and apoptosis of PVM/Ms through PI3K/Akt pathway. |
Volume: |
360 |
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Pages: |
220-229 |
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Publication |
First Author: |
Chen H |
Year: |
2017 |
Journal: |
Sci Rep |
Title: |
MircroRNA-19a promotes vascular inflammation and foam cell formation by targeting HBP-1 in atherogenesis. |
Volume: |
7 |
Issue: |
1 |
Pages: |
12089 |
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•
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Publication |
First Author: |
Li S |
Year: |
2019 |
Journal: |
Neuroscience |
Title: |
Macrophage Migration Inhibitory Factor Mediates Neuroprotective Effects by Regulating Inflammation, Apoptosis and Autophagy in Parkinson's Disease. |
Volume: |
416 |
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Pages: |
50-62 |
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Publication |
First Author: |
Wang W |
Year: |
2018 |
Journal: |
Am J Physiol Renal Physiol |
Title: |
Endogenous H2S sensitizes PAR4-induced bladder pain. |
Volume: |
314 |
Issue: |
6 |
Pages: |
F1077-F1086 |
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Publication |
First Author: |
Morimoto Y |
Year: |
2022 |
Journal: |
Neurochem Res |
Title: |
TPT1 Supports Proliferation of Neural Stem/Progenitor Cells and Brain Tumor Initiating Cells Regulated by Macrophage Migration Inhibitory Factor (MIF). |
Volume: |
47 |
Issue: |
9 |
Pages: |
2741-2756 |
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•
•
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Publication |
First Author: |
Sinning J |
Year: |
2023 |
Journal: |
Front Immunol |
Title: |
The aging kidney is characterized by tubuloinflammaging, a phenotype associated with MHC-II gene expression. |
Volume: |
14 |
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Pages: |
1222339 |
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Publication |
First Author: |
Mladenova DN |
Year: |
2015 |
Journal: |
Dis Model Mech |
Title: |
HIF1α deficiency reduces inflammation in a mouse model of proximal colon cancer. |
Volume: |
8 |
Issue: |
9 |
Pages: |
1093-103 |
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•
•
•
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Publication |
First Author: |
Cheng J |
Year: |
2020 |
Journal: |
Autophagy |
Title: |
Microglial autophagy defect causes parkinson disease-like symptoms by accelerating inflammasome activation in mice. |
Volume: |
16 |
Issue: |
12 |
Pages: |
2193-2205 |
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Publication |
First Author: |
Woolbright BL |
Year: |
2023 |
Journal: |
J Pathol |
Title: |
Role of MIF1/MIF2/CD74 interactions in bladder cancer. |
Volume: |
259 |
Issue: |
1 |
Pages: |
46-55 |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
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Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
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Title: |
MGI Sequence Curation Reference |
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Publication |
First Author: |
Peters J |
Year: |
1996 |
Journal: |
Mouse Genome |
Title: |
New Gene Symbols |
Volume: |
94 |
Issue: |
4 |
Pages: |
700-14 |
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Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
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Title: |
Nomenclature Committee Use |
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