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Search results 801 to 867 out of 867 for Pak1

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Type Details Score
Publication
12176334 | -
First Author: Banerjee M
Year: 2002
Journal: Curr Biol
Title: Pak1 phosphorylation on t212 affects microtubules in cells undergoing mitosis.
Volume: 12
Issue: 14
Pages: 1233-9
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Strain
MGI:6260851 | C57BL/6NCrl-Pak1ip1<em1(IMPC)Tcp>/Tcp
Attribute String: coisogenic, targeted mutation
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Strain
MGI:6334863 | C57BL/6N-Pak1ip1<em1(IMPC)Tcp>
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Strain
MGI:6866525 | C57BL/6NCrl-Pak1ip1<em1(IMPC)Tcp>/TcpMmucd
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Pak1ip1/Pak1ip1
Background: C57BL/6NCrl-Pak1ip1/Tcp
Zygosity: hm
Has Mutant Allele: true
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Publication
10975528 | -
First Author: Lei M
Year: 2000
Journal: Cell
Title: Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch.
Volume: 102
Issue: 3
Pages: 387-97
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Protein Coding Gene
MGI:108022 | Pkn1
Type: protein_coding_gene
Organism: mouse, laboratory
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Genotype
Genotype
Symbol: Pak1ip1/Pak1ip1<+>
Background: C57BL/6NCrl-Pak1ip1/Tcp
Zygosity: ht
Has Mutant Allele: true
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Protein Domain
IPR035064 | STK_PAK2
Type: Domain
Description: PAK2 plays a role in pro-apoptotic signaling. It is cleaved and activated by caspases leading to morphological changes during apoptosis []. PAK2 is also activated in response to a variety of stresses including DNA damage, hyperosmolarity, serum starvation, and contact inhibition, and may play a role in coordinating the stress response []. PAK2 also contributes to cancer cell invasion through a mechanism distinct fromthat of PAK1 []. PAK2 belongs to the group I PAKs.Group I PAKs contain a PBD (p21-binding domain) overlapping with an AID (autoinhibitory domain), a C-terminal catalytic domain, SH3 binding sites and a non-classical SH3 binding site for PIX (PAK-interacting exchange factor). PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac [].This entry corresponds to the PAK2 C-terminal catalytic domain.
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Protein Domain
IPR035065 | PAK2
Type: Family
Description: PAK2 plays a role in pro-apoptotic signaling. It is cleaved and activated by caspases leading to morphological changes during apoptosis []. PAK2 is also activated in response to a variety of stresses including DNA damage, hyperosmolarity, serum starvation, and contact inhibition, and may play a role in coordinating the stress response []. PAK2 also contributes to cancer cell invasion through a mechanism distinct from that of PAK1 []. PAK2 belongs to the group I PAKs.Group I PAKs contain a PBD (p21-binding domain) overlapping with an AID (autoinhibitory domain), a C-terminal catalytic domain, SH3 binding sites and a non-classical SH3 binding site for PIX (PAK-interacting exchange factor). PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac [].
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Publication
10200518 | -
First Author: Bokoch GM
Year: 1998
Journal: Cell Death Differ
Title: Caspase-mediated activation of PAK2 during apoptosis: proteolytic kinase activation as a general mechanism of apoptotic signal transduction?
Volume: 5
Issue: 8
Pages: 637-45
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Publication
11345898 | -
 
First Author: Roig J
Year: 2001
Journal: Vitam Horm
Title: Cytostatic p21 G protein-activated protein kinase gamma-PAK.
Volume: 62
Pages: 167-98
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Publication
23811286 | J:204351
First Author: Liu KH
Year: 2013
Journal: Cancer Lett
Title: P21-activated kinase 1 promotes colorectal cancer survival by up-regulation of hypoxia-inducible factor-1α.
Volume: 340
Issue: 1
Pages: 22-9
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Publication
11950587 | -
First Author: Jaffer ZM
Year: 2002
Journal: Int J Biochem Cell Biol
Title: p21-activated kinases: three more join the Pak.
Volume: 34
Issue: 7
Pages: 713-7
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Publication
15229651 | J:93054
First Author: Alahari SK
Year: 2004
Journal: EMBO J
Title: The integrin-binding protein Nischarin regulates cell migration by inhibiting PAK.
Volume: 23
Issue: 14
Pages: 2777-88
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Publication
22897850 | J:191823
First Author: Kawahara M
Year: 2012
Journal: Cancer Cell
Title: H2.0-like homeobox regulates early hematopoiesis and promotes acute myeloid leukemia.
Volume: 22
Issue: 2
Pages: 194-208
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Publication
28785723 | J:255943
 
First Author: Wang B
Year: 2017
Journal: eNeuro
Title: The Amyloid Precursor Protein Is a Conserved Receptor for Slit to Mediate Axon Guidance.
Volume: 4
Issue: 3
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Publication
20937872 | J:165512
First Author: Guo F
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Coordination of IL-7 receptor and T-cell receptor signaling by cell-division cycle 42 in T-cell homeostasis.
Volume: 107
Issue: 43
Pages: 18505-10
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Publication
28360125 | J:242308
First Author: Majumder P
Year: 2017
Journal: Dis Model Mech
Title: Cellular levels of Grb2 and cytoskeleton stability are correlated in a neurodegenerative scenario.
Volume: 10
Issue: 5
Pages: 655-669
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Publication
12885773 | J:219108
First Author: Oak SA
Year: 2003
Journal: J Biol Chem
Title: Skeletal muscle signaling pathway through the dystrophin glycoprotein complex and Rac1.
Volume: 278
Issue: 41
Pages: 39287-95
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Publication
22404908 | J:187542
 
First Author: Zhou C
Year: 2012
Journal: Mol Cancer
Title: Effect of cancer-associated mutations in the PlexinB1 gene.
Volume: 11
Pages: 11
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Publication
30150766 | J:266320
First Author: Chow HY
Year: 2018
Journal: Nat Commun
Title: Group I Paks are essential for epithelial- mesenchymal transition in an Apc-driven model of colorectal cancer.
Volume: 9
Issue: 1
Pages: 3473
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Publication
38582902 | J:347286
First Author: Zhang P
Year: 2024
Journal: Nat Commun
Title: Gadd45g insufficiency drives the pathogenesis of myeloproliferative neoplasms.
Volume: 15
Issue: 1
Pages: 2989
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Publication
22685302 | J:269564
First Author: Purohit AA
Year: 2012
Journal: J Biol Chem
Title: Down syndrome cell adhesion molecule (DSCAM) associates with uncoordinated-5C (UNC5C) in netrin-1-mediated growth cone collapse.
Volume: 287
Issue: 32
Pages: 27126-38
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Publication
14707132 | J:88954
First Author: Chen W
Year: 2004
Journal: J Biol Chem
Title: Characterization of OSR1, a member of the mammalian Ste20p/germinal center kinase subfamily.
Volume: 279
Issue: 12
Pages: 11129-36
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Publication
20038798 | J:156698
First Author: Sauzeau V
Year: 2010
Journal: J Clin Invest
Title: The Rho/Rac exchange factor Vav2 controls nitric oxide-dependent responses in mouse vascular smooth muscle cells.
Volume: 120
Issue: 1
Pages: 315-30
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Publication
17991871 | J:147519
First Author: Sommerville LJ
Year: 2008
Journal: Arterioscler Thromb Vasc Biol
Title: Increased smooth muscle cell activation and neointima formation in response to injury in AIF-1 transgenic mice.
Volume: 28
Issue: 1
Pages: 47-53
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Publication
29114038 | J:259495
 
First Author: Pyronneau A
Year: 2017
Journal: Sci Signal
Title: Aberrant Rac1-cofilin signaling mediates defects in dendritic spines, synaptic function, and sensory perception in fragile X syndrome.
Volume: 10
Issue: 504
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Publication
28806779 | J:244907
First Author: Crompton M
Year: 2017
Journal: PLoS Genet
Title: A mutation in Nischarin causes otitis media via LIMK1 and NF-κB pathways.
Volume: 13
Issue: 8
Pages: e1006969
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Publication
24352660 | J:313575
First Author: Tian X
Year: 2014
Journal: J Biol Chem
Title: Control of vascular permeability by atrial natriuretic peptide via a GEF-H1-dependent mechanism.
Volume: 289
Issue: 8
Pages: 5168-83
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Publication
36804596 | J:335036
     
First Author: Kunimura K
Year: 2023
Journal: J Allergy Clin Immunol
Title: DOCK2 regulates MRGPRX2/B2-mediated mast cell degranulation and drug-induced anaphylaxis.
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Publication
19890013 | J:154754
First Author: Kim IH
Year: 2009
Journal: J Neurosci
Title: Inositol 1,4,5-trisphosphate 3-kinase a functions as a scaffold for synaptic Rac signaling.
Volume: 29
Issue: 44
Pages: 14039-49
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Publication
18192285 | J:131172
First Author: Pickett EA
Year: 2008
Journal: Development
Title: Disruption of PDGFRalpha-initiated PI3K activation and migration of somite derivatives leads to spina bifida.
Volume: 135
Issue: 3
Pages: 589-98
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Publication
31319858 | J:290602
First Author: Mao R
Year: 2019
Journal: Mol Brain
Title: LIMK1 and LIMK2 regulate cortical development through affecting neural progenitor cell proliferation and migration.
Volume: 12
Issue: 1
Pages: 67
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Publication
19359483 | J:148336
First Author: Zhao Z
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: p21-Activated kinase mediates rapid estradiol-negative feedback actions in the reproductive axis.
Volume: 106
Issue: 17
Pages: 7221-6
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Publication
28765528 | J:263577
First Author: Zhao M
Year: 2017
Journal: Sci Rep
Title: Pdx1-Cre-driven conditional gene depletion suggests PAK4 as dispensable for mouse pancreas development.
Volume: 7
Issue: 1
Pages: 7031
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Publication
24077284 | J:214353
First Author: Cagnet S
Year: 2014
Journal: Oncogene
Title: Signaling events mediated by α3β1 integrin are essential for mammary tumorigenesis.
Volume: 33
Issue: 34
Pages: 4286-95
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Publication
30742951 | J:274324
First Author: Ghatak S
Year: 2019
Journal: Biochim Biophys Acta Gen Subj
Title: Periostin/β1integrin interaction regulates p21-activated kinases in valvular interstitial cell survival and in actin cytoskeleton reorganization.
Volume: 1863
Issue: 5
Pages: 813-829
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Publication
19150879 | J:159782
First Author: Lee MY
Year: 2009
Journal: Arterioscler Thromb Vasc Biol
Title: Mechanisms of vascular smooth muscle NADPH oxidase 1 (Nox1) contribution to injury-induced neointimal formation.
Volume: 29
Issue: 4
Pages: 480-7
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Publication
23423567 | J:208548
First Author: Sylow L
Year: 2013
Journal: Diabetes
Title: Rac1 signaling is required for insulin-stimulated glucose uptake and is dysregulated in insulin-resistant murine and human skeletal muscle.
Volume: 62
Issue: 6
Pages: 1865-75
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Publication
26924049 | J:282481
First Author: Tavasoli M
Year: 2016
Journal: Kidney Int
Title: The chloride intracellular channel 5A stimulates podocyte Rac1, protecting against hypertension-induced glomerular injury.
Volume: 89
Issue: 4
Pages: 833-47
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Publication
14605486 | J:86529
First Author: Leung K
Year: 2003
Journal: Cells Tissues Organs
Title: Targeted expression of activated Rac3 in mammary epithelium leads to defective postlactational involution and benign mammary gland lesions.
Volume: 175
Issue: 2
Pages: 72-83
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Publication
18198211 | J:135001
First Author: Khan AA
Year: 2008
Journal: FASEB J
Title: Regulation of hypoxic neuronal death signaling by neuroglobin.
Volume: 22
Issue: 6
Pages: 1737-47
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Publication
19494130 | J:150659
First Author: Hajdo-Milasinovic A
Year: 2009
Journal: J Cell Sci
Title: Rac3 inhibits adhesion and differentiation of neuronal cells by modifying GIT1 downstream signaling.
Volume: 122
Issue: Pt 12
Pages: 2127-36
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Publication
26369929 | J:226486
First Author: Matveeva EA
Year: 2015
Journal: Biol Open
Title: Vimentin is involved in regulation of mitochondrial motility and membrane potential by Rac1.
Volume: 4
Issue: 10
Pages: 1290-7
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Publication
30860871 | J:295359
First Author: Kiuchi Z
Year: 2019
Journal: FASEB J
Title: GLCCI1 is a novel protector against glucocorticoid-induced apoptosis in T cells.
Volume: 33
Issue: 6
Pages: 7387-7402
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Publication
33812927 | J:343814
 
First Author: Pellegatta M
Year: 2021
Journal: Neurosci Lett
Title: Rac1 and Rac3 have opposite functions in Schwann cells during developmental myelination.
Volume: 753
Pages: 135868
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Publication
29556338 | J:345282
First Author: Pi J
Year: 2018
Journal: Theranostics
Title: Elevated Expression of miR302-367 in Endothelial Cells Inhibits Developmental Angiogenesis via CDC42/CCND1 Mediated Signaling Pathways.
Volume: 8
Issue: 6
Pages: 1511-1526
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Publication
36586552 | J:344484
 
First Author: Katayama KI
Year: 2023
Journal: Exp Neurol
Title: Rac is required for the survival of cortical neurons.
Volume: 361
Pages: 114316
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Publication
16141245 | J:106360
First Author: Gallego MD
Year: 2006
Journal: Int Immunol
Title: WIP and WASP play complementary roles in T cell homing and chemotaxis to SDF-1alpha.
Volume: 18
Issue: 2
Pages: 221-32
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Publication
21085651 | J:166820
First Author: Sosa-García B
Year: 2010
Journal: PLoS One
Title: A role for the retinoblastoma protein as a regulator of mouse osteoblast cell adhesion: implications for osteogenesis and osteosarcoma formation.
Volume: 5
Issue: 11
Pages: e13954
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Publication
34150753 | J:308591
 
First Author: Misra S
Year: 2021
Journal: Front Cell Dev Biol
Title: Periostin/Filamin-A: A Candidate Central Regulatory Axis for Valve Fibrogenesis and Matrix Compaction.
Volume: 9
Pages: 649862
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Publication
16407193 | J:110563
First Author: Vincent P
Year: 2006
Journal: J Biol Chem
Title: Activation of p21-activated kinase 2 and its association with Nef are conserved in murine cells but are not sufficient to induce an AIDS-like disease in CD4C/HIV transgenic mice.
Volume: 281
Issue: 11
Pages: 6940-54
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Publication
17289663 | J:121163
First Author: Wang Z
Year: 2007
Journal: J Biol Chem
Title: Glucose-stimulated Cdc42 signaling is essential for the second phase of insulin secretion.
Volume: 282
Issue: 13
Pages: 9536-46
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Publication
37057180 | J:345398
 
First Author: Lubomirov LT
Year: 2023
Journal: Front Physiol
Title: Dual thick and thin filament linked regulation of stretch- and L-NAME-induced tone in young and senescent murine basilar artery.
Volume: 14
Pages: 1099278
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Protein
Q8CIN4
Organism: Mus musculus/domesticus
Length: 524  
Fragment?: false
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Publication
16919269 | J:112701
First Author: Bailey PJ
Year: 2006
Journal: Exp Cell Res
Title: A global genomic transcriptional code associated with CNS-expressed genes.
Volume: 312
Issue: 16
Pages: 3108-19
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Publication
- | J:237616
     
First Author: MGI and IMPC
Year: 2017
Journal: MGI Direct Data Submission
Title: MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:66660
       
First Author: Mouse Genome Database and National Center for Biotechnology Information Editorial Staff Collaboration
Year: 2001
Title: LocusLink Collaboration
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Publication
- | J:80001
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: FANTOM2 Data Curation in Mouse Genome Informatics
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Publication
- | J:94790
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Mouse Synonym Curation
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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