| Type |
Details |
Score |
| Publication |
| First Author: |
The Gene Ontology Consortium |
| Year: |
2010 |
|
| Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Diez-Roux G |
| Year: |
2011 |
| Journal: |
PLoS Biol |
| Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
| Volume: |
9 |
| Issue: |
1 |
| Pages: |
e1000582 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
|
| Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
MGI Genome Annotation Group and UniGene Staff |
| Year: |
2015 |
| Journal: |
Database Download |
| Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
| Year: |
2010 |
|
| Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
| Year: |
2000 |
| Journal: |
Database Release |
| Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Allen Institute for Brain Science |
| Year: |
2004 |
| Journal: |
Allen Institute |
| Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Group |
| Year: |
2003 |
| Journal: |
Database Procedure |
| Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bairoch A |
| Year: |
1999 |
| Journal: |
Database Release |
| Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics |
| Year: |
2010 |
| Journal: |
Database Release |
| Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Laszczyk AM |
| Year: |
2020 |
| Journal: |
J Am Soc Nephrol |
| Title: |
Pax2 and Pax8 Proteins Regulate Urea Transporters and Aquaporins to Control Urine Concentration in the Adult Kidney. |
| Volume: |
31 |
| Issue: |
6 |
| Pages: |
1212-1225 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Drews C |
| Year: |
2011 |
| Journal: |
BMC Dev Biol |
| Title: |
The nephrogenic potential of the transcription factors osr1, osr2, hnf1b, lhx1 and pax8 assessed in Xenopus animal caps. |
| Volume: |
11 |
|
| Pages: |
5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Meeus L |
| Year: |
2004 |
| Journal: |
J Clin Endocrinol Metab |
| Title: |
Characterization of a novel loss of function mutation of PAX8 in a familial case of congenital hypothyroidism with in-place, normal-sized thyroid. |
| Volume: |
89 |
| Issue: |
9 |
| Pages: |
4285-91 |
|
•
•
•
•
•
|
| DO Term |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3577967 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2021-04-05 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:2909822 |
| Pattern: |
Not Specified |
| Stage: |
TS22 |
| Assay Id: |
MGI:6514880 |
| Age: |
embryonic day 14.5 |
| Image: |
8A left |
| Note: |
Amh-positive cells were found co-expressing Pax8 at the mesonephric border of the testis at E14.5. These cells were also found to express Sox9. |
| Specimen Label: |
8A left |
| Detected: |
true |
| Specimen Num: |
21 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6382565 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2021-04-06 |
| Strength: |
Present |
| Sex: |
Female |
| Emaps: |
EMAPS:2892921 |
| Pattern: |
Regionally restricted |
| Stage: |
TS21 |
| Assay Id: |
MGI:6515597 |
| Age: |
embryonic day 13.5 |
| Image: |
9C lower |
| Note: |
Foxl2-positive cells that co-expressed Sox9 and Pax8 were found in the part of the rete ovarii adjacent to the gonad tissue. |
| Specimen Label: |
9C lower |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3577967 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2021-04-05 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1868524 |
| Pattern: |
Not Specified |
| Stage: |
TS24 |
| Assay Id: |
MGI:6514880 |
| Age: |
embryonic day 16.5 |
| Image: |
8C left |
| Note: |
Amh-positive cells were found co-expressing Pax8 at the border between testis cords and the rete testis at E16.5. These cells were also found to express Sox9. |
| Specimen Label: |
8C left |
| Detected: |
true |
| Specimen Num: |
25 |
|
•
•
•
•
•
|
| Allele |
| Name: |
paired box 8; endonuclease-mediated mutation 2, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
| Allele |
| Name: |
paired box 8; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Recombinase |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
This entry represents the PDZK1-interacting protein 1 (PDZK1IP1) family. Members include PDZK1IP1 and proximal tubules-expressed gene protein (also known as PDZK1-interacting protein 1-like andMAP17).The function of PDZK1IP1 is unknown. However, it has been found diffusely expressed in various carcinomas originating from kidney, colon, lung and breast in humans [].Proximal tubules-expressed gene protein, meanwhile, has been shown to be essential for pronephric tubule development, acting upstream of pax8 and lhx1/lim1 and downstream of retinoic acid signaling to induce pronephric mesoderm to form pronephric tubule-specific cells []. |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 1, Ronald J Koenig |
| Allele Type: |
Transgenic |
| Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
| Allele |
| Name: |
paired box 3; targeted mutation 6, Margaret E Buckingham |
| Allele Type: |
Targeted |
| Attribute String: |
Inserted expressed sequence, Null/knockout, Reporter |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Traykova-Brauch M |
| Year: |
2008 |
| Journal: |
Nat Med |
| Title: |
An efficient and versatile system for acute and chronic modulation of renal tubular function in transgenic mice. |
| Volume: |
14 |
| Issue: |
9 |
| Pages: |
979-84 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Faresse N |
| Year: |
2012 |
| Journal: |
Am J Physiol Renal Physiol |
| Title: |
Inducible kidney-specific Sgk1 knockout mice show a salt-losing phenotype. |
| Volume: |
302 |
| Issue: |
8 |
| Pages: |
F977-85 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang S |
| Year: |
2019 |
| Journal: |
Nat Commun |
| Title: |
Both fallopian tube and ovarian surface epithelium are cells-of-origin for high-grade serous ovarian carcinoma. |
| Volume: |
10 |
| Issue: |
1 |
| Pages: |
5367 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
114
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
108
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
181
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kocher O |
| Year: |
1998 |
| Journal: |
Lab Invest |
| Title: |
Identification and partial characterization of PDZK1: a novel protein containing PDZ interaction domains. |
| Volume: |
78 |
| Issue: |
1 |
| Pages: |
117-25 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lee SJ |
| Year: |
2010 |
| Journal: |
Mech Dev |
| Title: |
XPteg (Xenopus proximal tubules-expressed gene) is essential for pronephric mesoderm specification and tubulogenesis. |
| Volume: |
127 |
| Issue: |
1-2 |
| Pages: |
49-61 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Espana-Agusti J |
| Year: |
2016 |
| Journal: |
PLoS One |
| Title: |
Generation and Characterisation of a Pax8-CreERT2 Transgenic Line and a Slc22a6-CreERT2 Knock-In Line for Inducible and Specific Genetic Manipulation of Renal Tubular Epithelial Cells. |
| Volume: |
11 |
| Issue: |
2 |
| Pages: |
e0148055 |
|
•
•
•
•
•
|
| Allele |
| Name: |
paired box 8; targeted mutation 1.1, Meinrad Busslinger |
| Allele Type: |
Targeted |
| Attribute String: |
Recombinase |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
targeted mutation, mutant strain, congenic |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 1, Robert Koesters |
| Allele Type: |
Transgenic |
| Attribute String: |
Transactivator |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant stock, transgenic |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
congenic, transgenic |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
transgenic, mutant strain, congenic |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Singh S |
| Year: |
2016 |
| Journal: |
PLoS One |
| Title: |
Tubular Overexpression of Angiopoietin-1 Attenuates Renal Fibrosis. |
| Volume: |
11 |
| Issue: |
7 |
| Pages: |
e0158908 |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion C, Athena Matakidou |
| Allele Type: |
Transgenic |
| Attribute String: |
Inducible, Recombinase |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Pax3/Pax3<+> |
| Background: |
involves: 129S2/SvPas |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Pax3/Pax3 |
| Background: |
involves: 129S2/SvPas |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Pax8/Pax8 |
| Background: |
involves: 129P2/OlaHsd * C57BL/6 * SJL |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
congenic, mutant strain, targeted mutation, transgenic |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Miguel V |
| Year: |
2023 |
| Journal: |
Redox Biol |
| Title: |
Enhanced fatty acid oxidation through metformin and baicalin as therapy for COVID-19 and associated inflammatory states in lung and kidney. |
| Volume: |
68 |
|
| Pages: |
102957 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Miguel V |
| Year: |
2021 |
| Journal: |
J Clin Invest |
| Title: |
Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis. |
| Volume: |
131 |
| Issue: |
5 |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 1, Andrew P McMahon |
| Allele Type: |
Transgenic |
| Attribute String: |
Reporter |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, transgenic |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Ugcg/Ugcg Pax8/Pax8<+> |
| Background: |
involves: 129P2/OlaHsd * C57BL/6 |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Pax8/Pax8<+> Plxnb2/Plxnb2 |
| Background: |
involves: 129P2/OlaHsd * C57BL/6 |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Hnrnpf/Hnrnpf Pax8/Pax8<+> |
| Background: |
involves: 129P2/OlaHsd * C57BL/6 |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Glis3/Glis3 Pax8/Pax8<+> |
| Background: |
involves: 129P2/OlaHsd * C57BL/6J |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Stuart ET |
| Year: |
1995 |
| Journal: |
EMBO J |
| Title: |
Loss of p53 function through PAX-mediated transcriptional repression. |
| Volume: |
14 |
| Issue: |
22 |
| Pages: |
5638-45 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lòpez-Corrales NL |
| Year: |
1999 |
| Journal: |
Cytogenet Cell Genet |
| Title: |
Physical mapping of the bovine, caprine and ovine homologues of the paired box gene PAX8. |
| Volume: |
84 |
| Issue: |
3-4 |
| Pages: |
179-81 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sinha S |
| Year: |
2020 |
| Journal: |
FASEB J |
| Title: |
Glycogen synthase kinase-3β inhibits tubular regeneration in acute kidney injury by a FoxM1-dependent mechanism. |
| Volume: |
34 |
| Issue: |
10 |
| Pages: |
13597-13608 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yakulov TA |
| Year: |
2018 |
| Journal: |
Nat Commun |
| Title: |
CXCL12 and MYC control energy metabolism to support adaptive responses after kidney injury. |
| Volume: |
9 |
| Issue: |
1 |
| Pages: |
3660 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yuan Q |
| Year: |
2021 |
| Journal: |
Cell Death Dis |
| Title: |
CPT1α maintains phenotype of tubules via mitochondrial respiration during kidney injury and repair. |
| Volume: |
12 |
| Issue: |
8 |
| Pages: |
792 |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
congenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Friedrich S |
| Year: |
2021 |
| Journal: |
Sci Rep |
| Title: |
Identification of pathological transcription in autosomal dominant polycystic kidney disease epithelia. |
| Volume: |
11 |
| Issue: |
1 |
| Pages: |
15139 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kang HM |
| Year: |
2015 |
| Journal: |
Nat Med |
| Title: |
Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development. |
| Volume: |
21 |
| Issue: |
1 |
| Pages: |
37-46 |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
transgenic, mutant stock |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Tg(Pax8-rtTA2S*M2)1Koes/? Tg(tetO-MYC)36aBop/? |
| Background: |
involves: C57BL/6 * DBA * FVB/N |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Dkk1/Dkk1 Pax8/Pax8<+> |
| Background: |
involves: 129P2/OlaHsd * C57BL/6 * SJL |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Tg(CAG-EGFP,-PAX8/PPARG)1Rkoe/? Tg(TPO-cre)1Shk/? |
| Background: |
involves: FVB/NCr * FVB/NJ |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Pax8/Pax8 |
| Background: |
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Gal3st1/Gal3st1 Pax8/Pax8<+> |
| Background: |
involves: 129P2/OlaHsd * C57BL/6 |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Pax8/Pax8 |
| Background: |
B6.129(Cg)-Pax8 Pax8 |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Pax8/Pax8<+> Plxnb1/Plxnb1 Plxnb2/Plxnb2 |
| Background: |
involves: 129P2/OlaHsd * C57BL/6 |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Pax8/Pax8<+> Pbrm1/Pbrm1 |
| Background: |
involves: 129P2/OlaHsd * C57BL/6J |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nizar JM |
| Year: |
2018 |
| Journal: |
JCI Insight |
| Title: |
Renal tubule insulin receptor modestly promotes elevated blood pressure and markedly stimulates glucose reabsorption. |
| Volume: |
3 |
| Issue: |
16 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Terker AS |
| Year: |
2016 |
| Journal: |
J Am Soc Nephrol |
| Title: |
Direct and Indirect Mineralocorticoid Effects Determine Distal Salt Transport. |
| Volume: |
27 |
| Issue: |
8 |
| Pages: |
2436-45 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Haykir B |
| Year: |
2024 |
| Journal: |
J Am Soc Nephrol |
| Title: |
The Ip6k1 and Ip6k2 Kinases Are Critical for Normal Renal Tubular Function. |
| Volume: |
35 |
| Issue: |
4 |
| Pages: |
441-455 |
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•
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| Publication |
| First Author: |
Hu C |
| Year: |
2022 |
| Journal: |
Am J Physiol Renal Physiol |
| Title: |
Multiomic identification of factors associated with progression to cystic kidney disease in mice with nephron Ift88 disruption. |
| Volume: |
322 |
| Issue: |
2 |
| Pages: |
F175-F192 |
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•
•
•
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| Publication |
| First Author: |
Trepiccione F |
| Year: |
2016 |
| Journal: |
J Am Soc Nephrol |
| Title: |
Renal Atp6ap2/(Pro)renin Receptor Is Required for Normal Vacuolar H+-ATPase Function but Not for the Renin-Angiotensin System. |
| Volume: |
27 |
| Issue: |
11 |
| Pages: |
3320-3330 |
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•
•
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•
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| Publication |
| First Author: |
Hu C |
| Year: |
2021 |
| Journal: |
J Am Soc Nephrol |
| Title: |
Sex-Dependent Effects of Nephron Ift88 Disruption on BP, Renal Function, and Cystogenesis. |
| Volume: |
32 |
| Issue: |
9 |
| Pages: |
2210-2222 |
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•
•
•
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| Publication |
| First Author: |
Figueiredo M |
| Year: |
2021 |
| Journal: |
Pflugers Arch |
| Title: |
The (pro)renin receptor (ATP6ap2) facilitates receptor-mediated endocytosis and lysosomal function in the renal proximal tubule. |
| Volume: |
473 |
| Issue: |
8 |
| Pages: |
1229-1246 |
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•
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| Publication |
| First Author: |
Hu C |
| Year: |
2022 |
| Journal: |
Physiol Rep |
| Title: |
Profiling renal sodium transporters in mice with nephron Ift88 disruption: Association with sex, cysts, and blood pressure. |
| Volume: |
10 |
| Issue: |
5 |
| Pages: |
e15206 |
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| First Author: |
Saritas T |
| Year: |
2019 |
| Journal: |
Sci Rep |
| Title: |
Disruption of CUL3-mediated ubiquitination causes proximal tubule injury and kidney fibrosis. |
| Volume: |
9 |
| Issue: |
1 |
| Pages: |
4596 |
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•
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| First Author: |
Grahammer F |
| Year: |
2014 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress. |
| Volume: |
111 |
| Issue: |
27 |
| Pages: |
E2817-26 |
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| Publication |
| First Author: |
Yanda MK |
| Year: |
2018 |
| Journal: |
J Biol Chem |
| Title: |
A potential strategy for reducing cysts in autosomal dominant polycystic kidney disease with a CFTR corrector. |
| Volume: |
293 |
| Issue: |
29 |
| Pages: |
11513-11526 |
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| First Author: |
Yanda MK |
| Year: |
2017 |
| Journal: |
J Biol Chem |
| Title: |
Histone deacetylase 6 inhibition reduces cysts by decreasing cAMP and Ca2+ in knock-out mouse models of polycystic kidney disease. |
| Volume: |
292 |
| Issue: |
43 |
| Pages: |
17897-17908 |
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| First Author: |
Yanda MK |
| Year: |
2019 |
| Journal: |
J Biol Chem |
| Title: |
Pharmacological reversal of renal cysts from secretion to absorption suggests a potential therapeutic strategy for managing autosomal dominant polycystic kidney disease. |
| Volume: |
294 |
| Issue: |
45 |
| Pages: |
17090-17104 |
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| First Author: |
Yanda MK |
| Year: |
2017 |
| Journal: |
Am J Physiol Renal Physiol |
| Title: |
An inhibitor of histone deacetylase 6 activity, ACY-1215, reduces cAMP and cyst growth in polycystic kidney disease. |
| Volume: |
313 |
| Issue: |
4 |
| Pages: |
F997-F1004 |
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| First Author: |
Liu X |
| Year: |
2018 |
| Journal: |
Elife |
| Title: |
Polycystin-2 is an essential ion channel subunit in the primary cilium of the renal collecting duct epithelium. |
| Volume: |
7 |
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| First Author: |
Tran MT |
| Year: |
2016 |
| Journal: |
Nature |
| Title: |
PGC1α drives NAD biosynthesis linking oxidative metabolism to renal protection. |
| Volume: |
531 |
| Issue: |
7595 |
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528-32 |
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| First Author: |
Hakroush S |
| Year: |
2009 |
| Journal: |
Am J Pathol |
| Title: |
Effects of increased renal tubular vascular endothelial growth factor (VEGF) on fibrosis, cyst formation, and glomerular disease. |
| Volume: |
175 |
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5 |
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1883-95 |
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| First Author: |
Ryu DR |
| Year: |
2019 |
| Journal: |
Aging Cell |
| Title: |
Sirt1-hypoxia-inducible factor-1α interaction is a key mediator of tubulointerstitial damage in the aged kidney. |
| Volume: |
18 |
| Issue: |
2 |
| Pages: |
e12904 |
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| First Author: |
Lan R |
| Year: |
2012 |
| Journal: |
Am J Physiol Renal Physiol |
| Title: |
PTEN loss defines a TGF-β-induced tubule phenotype of failed differentiation and JNK signaling during renal fibrosis. |
| Volume: |
302 |
| Issue: |
9 |
| Pages: |
F1210-23 |
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•
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| Publication |
| First Author: |
Han SH |
| Year: |
2017 |
| Journal: |
J Am Soc Nephrol |
| Title: |
PGC-1α Protects from Notch-Induced Kidney Fibrosis Development. |
| Volume: |
28 |
| Issue: |
11 |
| Pages: |
3312-3322 |
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•
•
•
•
•
|
| Genotype |
| Symbol: |
Tg(Pax8-rtTA2S*M2)1Koes/? Tg(tetO-TGFB1*C223S*C225S)1Glk/? |
| Background: |
involves: C57BL/6 * DBA |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Gal3st1/Gal3st1 Ugcg/Ugcg Pax8/Pax8<+> |
| Background: |
involves: 129P2/OlaHsd * C57BL/6 |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Dicer1/Dicer1 Pax8/Pax8<+> |
| Background: |
involves: 129P2/OlaHsd * 129S7/SvEvBrd |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Cdc42/Cdc42 Tg(Pax8-rtTA2S*M2)1Koes/? Tg(tetO-cre)LC1Bjd/? |
| Background: |
involves: BALB/c * C57BL/6 * DBA |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|