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Search results 801 to 900 out of 951 for Pax9

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Type Details Score
Publication
20883686 | J:166947
First Author: Fujimori S
Year: 2010
Journal: Dev Biol
Title: Wnt/β-catenin signaling in the dental mesenchyme regulates incisor development by regulating Bmp4.
Volume: 348
Issue: 1
Pages: 97-106
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Publication
34851738 | J:317270
First Author: Bottasso-Arias N
Year: 2022
Journal: Am J Physiol Lung Cell Mol Physiol
Title: BMP4 and Wnt signaling interact to promote mouse tracheal mesenchyme morphogenesis.
Volume: 322
Issue: 2
Pages: L224-L242
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Publication
21465616 | J:171190
First Author: Bensoussan-Trigano V
Year: 2011
Journal: Dev Dyn
Title: Msx1 and Msx2 in limb mesenchyme modulate digit number and identity.
Volume: 240
Issue: 5
Pages: 1190-202
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Publication
11044393 | J:65294
First Author: Dassule HR
Year: 2000
Journal: Development
Title: Sonic hedgehog regulates growth and morphogenesis of the tooth.
Volume: 127
Issue: 22
Pages: 4775-85
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Publication
18634775 | J:139045
First Author: Thomason HA
Year: 2008
Journal: Dev Biol
Title: Facial clefting in Tp63 deficient mice results from altered Bmp4, Fgf8 and Shh signaling.
Volume: 321
Issue: 1
Pages: 273-82
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Publication
18691704 | J:139570
First Author: Capellini TD
Year: 2008
Journal: Dev Biol
Title: Pbx1/Pbx2 govern axial skeletal development by controlling Polycomb and Hox in mesoderm and Pax1/Pax9 in sclerotome.
Volume: 321
Issue: 2
Pages: 500-14
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Publication
20589901 | J:161785
First Author: Gu WX
Year: 2010
Journal: Dev Dyn
Title: Identification of genes controlled by LMX1B in E13.5 mouse limbs.
Volume: 239
Issue: 8
Pages: 2246-55
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Publication
33298461 | J:301249
 
First Author: López-Delgado AC
Year: 2021
Journal: Development
Title: Axial skeleton anterior-posterior patterning is regulated through feedback regulation between Meis transcription factors and retinoic acid.
Volume: 148
Issue: 1
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Publication
14745966 | J:88955
First Author: Schwabe GC
Year: 2004
Journal: Dev Dyn
Title: Ror2 knockout mouse as a model for the developmental pathology of autosomal recessive Robinow syndrome.
Volume: 229
Issue: 2
Pages: 400-10
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Publication
18572160 | J:139188
First Author: Zhao H
Year: 2008
Journal: Dev Biol
Title: TGF-beta type I receptor Alk5 regulates tooth initiation and mandible patterning in a type II receptor-independent manner.
Volume: 320
Issue: 1
Pages: 19-29
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Publication
33328221 | J:313945
 
First Author: Yuan Y
Year: 2020
Journal: Sci Adv
Title: Spatiotemporal cellular movement and fate decisions during first pharyngeal arch morphogenesis.
Volume: 6
Issue: 51
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Publication
27329940 | J:259576
 
First Author: Funato N
Year: 2016
Journal: Sci Rep
Title: Specification of jaw identity by the Hand2 transcription factor.
Volume: 6
Pages: 28405
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Publication
21384471 | J:171052
First Author: Itou J
Year: 2011
Journal: Dev Dyn
Title: HMGB factors are required for posterior digit development through integrating signaling pathway activities.
Volume: 240
Issue: 5
Pages: 1151-62
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Publication
31226309 | J:281425
 
First Author: Nakaniwa M
Year: 2019
Journal: Gene Expr Patterns
Title: Primary cilia in murine palatal rugae development.
Volume: 34
Pages: 119062
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Publication
19783740 | J:153595
First Author: Butterfield NC
Year: 2009
Journal: Development
Title: Patched 1 is a crucial determinant of asymmetry and digit number in the vertebrate limb.
Volume: 136
Issue: 20
Pages: 3515-24
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Publication
34732852 | J:316165
First Author: Nakamura E
Year: 2021
Journal: Commun Biol
Title: Zfhx4 regulates endochondral ossification as the transcriptional platform of Osterix in mice.
Volume: 4
Issue: 1
Pages: 1258
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Publication
25516972 | J:217677
First Author: Snitow ME
Year: 2015
Journal: Development
Title: Ezh2 represses the basal cell lineage during lung endoderm development.
Volume: 142
Issue: 1
Pages: 108-17
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Publication
38345319 | J:346126
 
First Author: Pappas MP
Year: 2024
Journal: Development
Title: Sall4 regulates posterior trunk mesoderm development by promoting mesodermal gene expression and repressing neural genes in the mesoderm.
Volume: 151
Issue: 5
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Publication
34928956 | J:317430
First Author: Sharma D
Year: 2021
Journal: PLoS Genet
Title: HES1 is a novel downstream modifier of the SHH-GLI3 Axis in the development of preaxial polydactyly.
Volume: 17
Issue: 12
Pages: e1009982
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Publication
25773539 | J:236440
First Author: You L
Year: 2015
Journal: J Biol Chem
Title: The chromatin regulator Brpf1 regulates embryo development and cell proliferation.
Volume: 290
Issue: 18
Pages: 11349-64
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Publication
22465667 | J:184012
First Author: Lopez-Rios J
Year: 2012
Journal: Dev Cell
Title: GLI3 constrains digit number by controlling both progenitor proliferation and BMP-dependent exit to chondrogenesis.
Volume: 22
Issue: 4
Pages: 837-48
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Publication
19782673 | J:154916
First Author: Welsh IC
Year: 2009
Journal: Dev Biol
Title: Signaling integration in the rugae growth zone directs sequential SHH signaling center formation during the rostral outgrowth of the palate.
Volume: 336
Issue: 1
Pages: 53-67
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Publication
32866472 | J:297164
First Author: Nie X
Year: 2020
Journal: Dev Biol
Title: mTOR plays a pivotal role in multiple processes of enamel organ development principally through the mTORC1 pathway and in part via regulating cytoskeleton dynamics.
Volume: 467
Issue: 1-2
Pages: 77-87
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Publication
16524929 | J:107400
First Author: Laurikkala J
Year: 2006
Journal: Development
Title: p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation.
Volume: 133
Issue: 8
Pages: 1553-63
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Publication
17951031 | J:127453
First Author: Kettunen P
Year: 2007
Journal: Mech Dev
Title: Fgfr2b mediated epithelial-mesenchymal interactions coordinate tooth morphogenesis and dental trigeminal axon patterning.
Volume: 124
Issue: 11-12
Pages: 868-83
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Publication
29866044 | J:263025
First Author: Zoupa M
Year: 2018
Journal: BMC Genomics
Title: Gene expression profiling in the developing secondary palate in the absence of Tbx1 function.
Volume: 19
Issue: 1
Pages: 429
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Publication
26959361 | J:232412
First Author: Jeon S
Year: 2016
Journal: PLoS Genet
Title: Anteroposterior Limb Skeletal Patterning Requires the Bifunctional Action of SWI/SNF Chromatin Remodeling Complex in Hedgehog Pathway.
Volume: 12
Issue: 3
Pages: e1005915
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Publication
19769959 | J:154920
First Author: Zirzow S
Year: 2009
Journal: Dev Biol
Title: Expression and requirement of T-box transcription factors Tbx2 and Tbx3 during secondary palate development in the mouse.
Volume: 336
Issue: 2
Pages: 145-55
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Publication
31776260 | J:282804
First Author: Kim HT
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: WNT/RYK signaling restricts goblet cell differentiation during lung development and repair.
Volume: 116
Issue: 51
Pages: 25697-25706
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Publication
28570265 | J:356509
 
First Author: Mo Q
Year: 2017
Journal: JCI Insight
Title: Identification and characterization of a supraclavicular brown adipose tissue in mice.
Volume: 2
Issue: 11
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Publication
35831953 | J:327901
 
First Author: Ye Q
Year: 2022
Journal: Development
Title: Understanding the development of oral epithelial organs through single cell transcriptomic analysis.
Volume: 149
Issue: 16
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Publication
39798644 | J:361454
 
First Author: Jasmine
Year: 2025
Journal: Dev Biol
Title: Epithelial and mesenchymal compartments of the developing bladder and urethra display spatially distinct gene expression patterns.
Volume: 520
Pages: 155-170
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Publication
32857879 | J:332131
First Author: Perera SN
Year: 2020
Journal: Glia
Title: Insights into olfactory ensheathing cell development from a laser-microdissection and transcriptome-profiling approach.
Volume: 68
Issue: 12
Pages: 2550-2584
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Publication
11044609 | J:65651
First Author: Neidhardt L
Year: 2000
Journal: Mech Dev
Title: Large-scale screen for genes controlling mammalian embryogenesis, using high-throughput gene expression analysis in mouse embryos.
Volume: 98
Issue: 1-2
Pages: 77-94
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Publication
26238476 | J:226028
First Author: Lewandowski JP
Year: 2015
Journal: Dev Biol
Title: Spatiotemporal regulation of GLI target genes in the mammalian limb bud.
Volume: 406
Issue: 1
Pages: 92-103
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Publication
24146773 | J:209112
First Author: Shimizu H
Year: 2013
Journal: PLoS One
Title: The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo.
Volume: 8
Issue: 10
Pages: e75754
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Publication
22988430 | J:190636
 
First Author: Wiese CB
Year: 2012
Journal: Front Neurosci
Title: A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.
Volume: 6
Pages: 130
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Publication
- | J:15839
       
First Author: International Committee on Standardized Genetic Nomenclature for Mice
Year: 1993
Title: Nomenclature rule change to delete hyphens and parentheses from mouse locus symbols
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Publication
30973865 | J:274872
First Author: Ingham NJ
Year: 2019
Journal: PLoS Biol
Title: Mouse screen reveals multiple new genes underlying mouse and human hearing loss.
Volume: 17
Issue: 4
Pages: e3000194
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Publication
20059953 | J:156017
First Author: Yokoyama S
Year: 2009
Journal: Dev Cell
Title: A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Volume: 17
Issue: 6
Pages: 836-48
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Publication
- | J:94790
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Mouse Synonym Curation
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Publication
15618518 | J:91257
First Author: Gray PA
Year: 2004
Journal: Science
Title: Mouse brain organization revealed through direct genome-scale TF expression analysis.
Volume: 306
Issue: 5705
Pages: 2255-7
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Publication
24952961 | J:215487
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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HT Experiment
GSE63017 | A Developmental Genomic Analysis of Pax1 and Pax9 in Embryonic Intervertebral Disc Development
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
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Publication
29344962 | J:261903
First Author: Fujihara KM
Year: 2018
Journal: J Pathol
Title: Bridging the molecular divide: alcohol-induced downregulation of PAX9 and tumour development.
Volume: 244
Issue: 4
Pages: 386-388
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GXD Expression
GXD Expression
 
Probe: MGI:1334951
Assay Type: RNA in situ
Annotation Date: 2022-08-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1638316
Pattern: Regionally restricted
Stage: TS16
Assay Id: MGI:7327563
Age: embryonic day 10.0
Note: Expressed in domains covered and extended medial and lateral to the Pax9 expression domains in the underlying mesenchyme.
Specimen Label: 2B
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:1334951
Assay Type: RNA in situ
Annotation Date: 2022-08-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1638315
Pattern: Regionally restricted
Stage: TS15
Assay Id: MGI:7327563
Age: embryonic day 9.5
Note: Expressed in domains covered and extended medial and lateral to the Pax9 expression domains in the underlying mesenchyme.
Specimen Label: not shown
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:7327545
Assay Type: RNA in situ
Annotation Date: 2022-08-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1638316
Pattern: Regionally restricted
Stage: TS16
Assay Id: MGI:7327564
Age: embryonic day 10.0
Note: Expressed in ectoderm overlying the distal-medial region of the mandibular arch, between the two Pax9 expression domains, but not in the ectoderm directly over or lateral to them.
Specimen Label: 3A
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:7327545
Assay Type: RNA in situ
Annotation Date: 2022-08-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1638316
Pattern: Regionally restricted
Stage: TS16
Assay Id: MGI:7327564
Age: embryonic day 10.0
Note: Expressed in ectoderm overlying the distal-medial region of the mandibular arch, between the two Pax9 expression domains, but not in the ectoderm directly over or lateral to them.
Specimen Label: 3D
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:1334951
Assay Type: RNA in situ
Annotation Date: 2022-08-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1638317
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:7327563
Age: embryonic day 10.5
Note: Coexpressed with Bmp4 in the ectoderm that overlies the region of weak Pax9 expression between the sites of prospective incisor and molar development.
Specimen Label: 3H
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:1334951
Assay Type: RNA in situ
Annotation Date: 2022-08-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1638317
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:7327563
Age: embryonic day 10.5
Note: Coexpressed with Bmp4 in the ectoderm that overlies the region of weak Pax9 expression between the sites of prospective incisor and molar development.
Specimen Label: 3K
Detected: true
Specimen Num: 4
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Allele
Pax9<em1(cre/ERT2)Ychai> | MGI:5824734
Name: paired box 9; endonuclease-mediated mutation 1, Yang Chai
Allele Type: Endonuclease-mediated
Attribute String: Inducible, Recombinase
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Strain
MGI:5824735 | B6.Cg-Pax9<em1(cre/ERT2)Ychai>/J
Attribute String: mutant strain, endonuclease-mediated mutation
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Allele
Pax9<tm1.1(cre)Sbam> | MGI:6760663
Name: paired box 9; targeted mutation 1.1, Simon Bamforth
Allele Type: Targeted
Attribute String: Null/knockout, Recombinase
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Strain
MGI:7570354 | B6.Cg-Pax9<tm1.1(cre)Sbam>/H
Attribute String: congenic, mutant strain, targeted mutation
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HT Experiment
GSE128087 | Differential gene expression between wild type and Pax9-null pharyngeal arch tissue
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Pax9/Pax9<+>
Background: involves: 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Pax9/Pax9<+>
Background: involves: 129S4/SvJaeSor
Zygosity: cn
Has Mutant Allele: true
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Publication
8786149 | J:33863
First Author: Semenza GL
Year: 1996
Journal: Genomics
Title: Assignment of the hypoxia-inducible factor 1alpha gene to a region of conserved synteny on mouse chromosome 12 and human chromosome 14q.
Volume: 34
Issue: 3
Pages: 437-9
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Publication
14504231 | J:85829
First Author: Santagati F
Year: 2003
Journal: Genetics
Title: Identification of Cis-regulatory elements in the mouse Pax9/Nkx2-9 genomic region: implication for evolutionary conserved synteny.
Volume: 165
Issue: 1
Pages: 235-42
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Publication
24080012 | -
First Author: Takimoto A
Year: 2013
Journal: Exp Cell Res
Title: Pax1 acts as a negative regulator of chondrocyte maturation.
Volume: 319
Issue: 20
Pages: 3128-39
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Protein Domain
IPR033206 | PAX1
Type: Family
Description: PAX1 belongs to the PAX family. PAX1 and PAX9 synergistically act in the proper formation of the vertebral column and play an important role in the formation of the vertebrate axial skeleton, regulating cell proliferation and chondrogenic specification in the sclerotome []. PAX1 also functions as a negative regulator of chondrocyte maturation [].PAX family members are transcription factors characterised by a ~128-amino-acid DNA-binding paired domain that makes sequence specific contacts with DNA []. In mammals, there are nine Pax proteins (PAX1-9). They regulate the morphogenesis of a wide range of organs and are key factors for the development of mammalian sensory organs such as the eye (Pax6, Pax2), nose (Pax6) and ears (Pax2, Pax8) [, ].
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HT Experiment
E-MTAB-42 | Transcription profiling of first molar tooth germ in PPAR-alpha knock-out and wild type mice
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
37249312 | J:359323
First Author: Iwaya C
Year: 2023
Journal: J Dent Res
Title: Autophagy Plays a Crucial Role in Ameloblast Differentiation.
Volume: 102
Issue: 9
Pages: 1047-1057
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Publication
7557441 | J:28816
First Author: Chalepakis G
Year: 1995
Journal: Gene
Title: Identification of DNA recognition sequences for the Pax3 paired domain.
Volume: 162
Issue: 2
Pages: 267-70
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Publication
12752768 | J:103092
First Author: Line SR
Year: 2003
Journal: Evol Dev
Title: Variation of tooth number in mammalian dentition: connecting genetics, development, and evolution.
Volume: 5
Issue: 3
Pages: 295-304
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Publication
16313398 | J:103321
First Author: Hilliard SA
Year: 2005
Journal: J Anat
Title: Regional regulation of palatal growth and patterning along the anterior-posterior axis in mice.
Volume: 207
Issue: 5
Pages: 655-67
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Publication
38910391 | J:352719
   
First Author: Piña JO
Year: 2024
Journal: J Dent Res
Title: Spatial Multi-omics Reveals the Role of the Wnt Modulator, Dkk2, in Palatogenesis'.
Pages: 220345241256600
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Protein Domain
IPR001523 | Paired_dom
Type: Domain
Description: The paired domain is an approximately 126 amino acid DNA-binding domain, which is found in eukaryotic transcription regulatory proteins involved in embryogenesis. The domain was originally described as the 'paired box' in the Drosophila protein paired (prd) [, ]. The paired domain is generally located in the N-terminal part. An octapeptide []and/or a homeodomain can occur C-terminal to the paired domain, as well as a Pro-Ser-Thr-rich C terminus.Paired domain proteins can function as transcription repressors or activators. The paired domain contains three subdomains, which show functional differences in DNA-binding. The crystal structures of prd and Pax proteins show that the DNA-bound paired domain is bipartite, consisting of an N-terminal subdomain (PAI or NTD) and a C-terminal subdomain (RED or CTD), connected by a linker. PAI and RED each form a three-helical fold, with the most C-terminal helices comprising a helix-turn-helix (HTH) motif that binds the DNA major groove. In addition, the PAI subdomain encompasses an N-terminal β-turn andβ-hairpin, also named 'wing', participating in DNA-binding. The linker canbind into the DNA minor groove. Different Pax proteins and their alternativelyspliced isoforms use different (sub)domains for DNA-binding to mediate thespecificity of sequence recognition [, ].Some proteins known to contain a paired domain:Drosophila paired (prd), a segmentation pair-rule class protein.Drosophila gooseberry proximal (gsb-p) and gooseberry distal (gsb-d),segmentation polarity class proteins.Drosophila Pox-meso and Pox-neuro proteins.The Pax proteins:Mammalian protein Pax1, which may play a role in the formation of segmented structures in the embryo. In mouse, mutations in Pax1 produce the undulated phenotype, characterised by vertebral malformations along the entire rostro-caudal axis.Mammalian protein Pax2, a probable transcription factor that may have arole in kidney cell differentiation.Mammalian protein Pax3. Pax3 is expressed during early neurogenesis. In humans, defects in Pax3 are the cause of Waardenburg's syndrome (WS), anautosomal dominant combination of deafness and pigmentary disturbance.Mammalian protein Pax4 pays an important role in the differentiation and development of pancreatic islet beta cells. It binds to a common element in the glucagon, insulin and somatostatin promoters. In humans, it has been related to the rare, familial, clinically and genetically heterogeneous form of diabetes MODY (maturity-onset diabetes of the young).Mammalian protein Pax5, also known as B-cell specific transcription factor(BSAP). Pax5 is involved in the regulation of the CD19 gene. It plays animportant role in B-cell differentiation as well as neural development andspermatogenesis.Mammalian protein Pax6 (oculorhombin). Pax6 is a transcription factor withimportant functions in eye and nasal development. In Man, defects in Pax6are the cause of aniridia type II (AN2), an autosomal dominant disordercharacterised by complete or partial absence of the iris.Mammalian protein Pax7 is involved in the regulation of muscle stem cells proliferation, playing a role in myogenesis and muscle regeneration.Mammalian protein Pax8, required in thyroid development.Mammalian protein Pax9, required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs. In man, defects in Pax9 cause oligodontia.Zebrafish protein Paired box protein Pax-2a, involved in the development of the midbrain/hindbrain boundary organizer and specification of neuronal cell fates.Xenopus laevis protein Paired box protein Pax-3-A, which promotes both hatching gland and neural crest cell fates, two of the cell populations that arise from the neural plate border.
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Protein
P09084
Organism: Mus musculus/domesticus
Length: 446  
Fragment?: false
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Protein
Q548R5
Organism: Mus musculus/domesticus
Length: 361  
Fragment?: false
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Protein
Q8K4Q1
Organism: Mus musculus/domesticus
Length: 212  
Fragment?: true
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Protein
A2ALK0
Organism: Mus musculus/domesticus
Length: 384  
Fragment?: true
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Protein
Q3UZ60
Organism: Mus musculus/domesticus
Length: 361  
Fragment?: false
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Publication
10811620 | -
First Author: Eberhard D
Year: 2000
Journal: EMBO J
Title: Transcriptional repression by Pax5 (BSAP) through interaction with corepressors of the Groucho family.
Volume: 19
Issue: 10
Pages: 2292-303
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Protein
Q9EQ02
Organism: Mus musculus/domesticus
Length: 49  
Fragment?: true
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Protein
Q8VDB6
Organism: Mus musculus/domesticus
Length: 157  
Fragment?: false
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Protein
A2A409
Organism: Mus musculus/domesticus
Length: 139  
Fragment?: true
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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