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Search results 801 to 900 out of 3238 for Psen1

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Type Details Score
Publication
First Author: Hamilton A
Year: 2016
Journal: Cell Rep
Title: Chronic Pharmacological mGluR5 Inhibition Prevents Cognitive Impairment and Reduces Pathogenesis in an Alzheimer Disease Mouse Model.
Volume: 15
Issue: 9
Pages: 1859-65
Publication  
First Author: Zhao J
Year: 2020
Journal: Front Immunol
Title: Administration of Amyloid Precursor Protein Gene Deleted Mouse ESC-Derived Thymic Epithelial Progenitors Attenuates Alzheimer's Pathology.
Volume: 11
Pages: 1781
Publication
First Author: Kuwabara Y
Year: 2014
Journal: J Neurochem
Title: Impairments of long-term depression induction and motor coordination precede Aβ accumulation in the cerebellum of APPswe/PS1dE9 double transgenic mice.
Volume: 130
Issue: 3
Pages: 432-43
Publication
First Author: Fang EF
Year: 2019
Journal: Nat Neurosci
Title: Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease.
Volume: 22
Issue: 3
Pages: 401-412
Publication      
First Author: Kong Y
Year: 2024
Journal: Mol Neurobiol
Title: Relationship Between Reactive Astrocytes, by [(18)F]SMBT-1 Imaging, with Amyloid-Beta, Tau, Glucose Metabolism, and TSPO in Mouse Models of Alzheimer's Disease.
Publication
First Author: Mizuguchi R
Year: 2006
Journal: Nat Neurosci
Title: Ascl1 and Gsh1/2 control inhibitory and excitatory cell fate in spinal sensory interneurons.
Volume: 9
Issue: 6
Pages: 770-8
Publication
First Author: Chen F
Year: 2003
Journal: J Biol Chem
Title: Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain.
Volume: 278
Issue: 22
Pages: 19974-9
Publication
First Author: Gwon Y
Year: 2018
Journal: J Neurosci
Title: TOM1 Regulates Neuronal Accumulation of Amyloid-β Oligomers by FcγRIIb2 Variant in Alzheimer's Disease.
Volume: 38
Issue: 42
Pages: 9001-9018
Publication
First Author: Uribe-Arias A
Year: 2016
Journal: J Neurochem
Title: p120-catenin is necessary for neuroprotection induced by CDK5 silencing in models of Alzheimer's disease.
Volume: 138
Issue: 4
Pages: 624-39
Publication
First Author: Justice NJ
Year: 2015
Journal: J Neurosci
Title: Posttraumatic stress disorder-like induction elevates β-amyloid levels, which directly activates corticotropin-releasing factor neurons to exacerbate stress responses.
Volume: 35
Issue: 6
Pages: 2612-23
Publication  
First Author: Bécot A
Year: 2020
Journal: Cells
Title: The Transcription Factor EB Reduces the Intraneuronal Accumulation of the Beta-Secretase-Derived APP Fragment C99 in Cellular and Mouse Alzheimer’s Disease Models.
Volume: 9
Issue: 5
Publication
First Author: Liu Y
Year: 2010
Journal: Mol Cell Neurosci
Title: Circulating neprilysin clears brain amyloid.
Volume: 45
Issue: 2
Pages: 101-7
Publication  
First Author: Wu M
Year: 2018
Journal: Neurosci Lett
Title: Abnormal circadian locomotor rhythms and Per gene expression in six-month-old triple transgenic mice model of Alzheimer's disease.
Volume: 676
Pages: 13-18
Publication  
First Author: Manuel I
Year: 2016
Journal: Neuroscience
Title: Activity of muscarinic, galanin and cannabinoid receptors in the prodromal and advanced stages in the triple transgenic mice model of Alzheimer's disease.
Volume: 329
Pages: 284-93
Publication
First Author: Caccamo A
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: CBP gene transfer increases BDNF levels and ameliorates learning and memory deficits in a mouse model of Alzheimer's disease.
Volume: 107
Issue: 52
Pages: 22687-92
Publication
First Author: Chu J
Year: 2013
Journal: PLoS One
Title: Zileuton improves memory deficits, amyloid and tau pathology in a mouse model of Alzheimer's disease with plaques and tangles.
Volume: 8
Issue: 8
Pages: e70991
Publication
First Author: Khandelwal PJ
Year: 2011
Journal: Hum Mol Genet
Title: Parkin mediates beclin-dependent autophagic clearance of defective mitochondria and ubiquitinated Abeta in AD models.
Volume: 20
Issue: 11
Pages: 2091-102
Publication
First Author: Cissé M
Year: 2017
Journal: Mol Psychiatry
Title: The transcription factor XBP1s restores hippocampal synaptic plasticity and memory by control of the Kalirin-7 pathway in Alzheimer model.
Volume: 22
Issue: 11
Pages: 1562-1575
Publication
First Author: Romberg C
Year: 2011
Journal: J Neurosci
Title: Impaired attention in the 3xTgAD mouse model of Alzheimer's disease: rescue by donepezil (Aricept).
Volume: 31
Issue: 9
Pages: 3500-7
Publication
First Author: Joseph DJ
Year: 2019
Journal: PLoS One
Title: Isoflurane mediated neuropathological and cognitive impairments in the triple transgenic Alzheimer's mouse model are associated with hippocampal synaptic deficits in an age-dependent manner.
Volume: 14
Issue: 10
Pages: e0223509
Publication
First Author: Cai HY
Year: 2018
Journal: Biochem Biophys Res Commun
Title: Lixisenatide reduces amyloid plaques, neurofibrillary tangles and neuroinflammation in an APP/PS1/tau mouse model of Alzheimer's disease.
Volume: 495
Issue: 1
Pages: 1034-1040
Publication  
First Author: Wu Z
Year: 2020
Journal: Prog Neurobiol
Title: Traumatic brain injury triggers APP and Tau cleavage by delta-secretase, mediating Alzheimer's disease pathology.
Volume: 185
Pages: 101730
Publication  
First Author: Giovinazzo D
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Hydrogen sulfide is neuroprotective in Alzheimer's disease by sulfhydrating GSK3β and inhibiting Tau hyperphosphorylation.
Volume: 118
Issue: 4
Publication
First Author: Wang H
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Spatiotemporal activation of the C/EBPβ/δ-secretase axis regulates the pathogenesis of Alzheimer's disease.
Volume: 115
Issue: 52
Pages: E12427-E12434
Publication
First Author: Liu D
Year: 2017
Journal: Mol Ther
Title: Targeting the HDAC2/HNF-4A/miR-101b/AMPK Pathway Rescues Tauopathy and Dendritic Abnormalities in Alzheimer's Disease.
Volume: 25
Issue: 3
Pages: 752-764
Publication
First Author: Caccamo A
Year: 2011
Journal: J Biol Chem
Title: Naturally secreted amyloid-beta increases mammalian target of rapamycin (mTOR) activity via a PRAS40-mediated mechanism.
Volume: 286
Issue: 11
Pages: 8924-32
Publication
First Author: Knuesel I
Year: 2009
Journal: Neurobiol Aging
Title: Age-related accumulation of Reelin in amyloid-like deposits.
Volume: 30
Issue: 5
Pages: 697-716
Publication
First Author: Jang S
Year: 2018
Journal: Biochem Biophys Res Commun
Title: Particulate matter increases beta-amyloid and activated glial cells in hippocampal tissues of transgenic Alzheimer's mouse: Involvement of PARP-1.
Volume: 500
Issue: 2
Pages: 333-338
Publication
First Author: Bittner T
Year: 2010
Journal: PLoS One
Title: Multiple events lead to dendritic spine loss in triple transgenic Alzheimer's disease mice.
Volume: 5
Issue: 11
Pages: e15477
Publication
First Author: Shibuya Y
Year: 2014
Journal: J Neurosci
Title: Inhibiting ACAT1/SOAT1 in microglia stimulates autophagy-mediated lysosomal proteolysis and increases Aβ1-42 clearance.
Volume: 34
Issue: 43
Pages: 14484-501
Publication
First Author: Xiang J
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Delta-secretase-cleaved Tau antagonizes TrkB neurotrophic signalings, mediating Alzheimer's disease pathologies.
Volume: 116
Issue: 18
Pages: 9094-9102
Publication
First Author: Jong Huat T
Year: 2024
Journal: Sci Rep
Title: The impact of astrocytic NF-κB on healthy and Alzheimer's disease brains.
Volume: 14
Issue: 1
Pages: 14305
Publication
First Author: Caberlotto L
Year: 2019
Journal: Sci Rep
Title: Cross-disease analysis of Alzheimer's disease and type-2 Diabetes highlights the role of autophagy in the pathophysiology of two highly comorbid diseases.
Volume: 9
Issue: 1
Pages: 3965
Publication  
First Author: Wang J
Year: 2024
Journal: Brain Behav Immun
Title: A TrkB cleavage fragment in hippocampus promotes Depressive-Like behavior in mice.
Volume: 119
Pages: 56-83
Publication
First Author: Sun S
Year: 2014
Journal: Neuron
Title: Reduced synaptic STIM2 expression and impaired store-operated calcium entry cause destabilization of mature spines in mutant presenilin mice.
Volume: 82
Issue: 1
Pages: 79-93
Publication
First Author: Hegedüs P
Year: 2021
Journal: STAR Protoc
Title: Training protocol for probabilistic Pavlovian conditioning in mice using an open-source head-fixed setup.
Volume: 2
Issue: 3
Pages: 100795
Publication  
First Author: Wang Y
Year: 2023
Journal: Front Aging Neurosci
Title: A tau fragment links depressive-like behaviors and cognitive declines in Alzheimer's disease mouse models through attenuating mitochondrial function.
Volume: 15
Pages: 1293164
Publication
First Author: Wang W
Year: 2021
Journal: Theranostics
Title: A novel small-molecule PROTAC selectively promotes tau clearance to improve cognitive functions in Alzheimer-like models.
Volume: 11
Issue: 11
Pages: 5279-5295
Publication
First Author: Comerota MM
Year: 2019
Journal: Mol Neurobiol
Title: Near Infrared Light Treatment Reduces Synaptic Levels of Toxic Tau Oligomers in Two Transgenic Mouse Models of Human Tauopathies.
Volume: 56
Issue: 5
Pages: 3341-3355
Publication
First Author: Bevan RJ
Year: 2020
Journal: Acta Neuropathol Commun
Title: Retinal ganglion cell degeneration correlates with hippocampal spine loss in experimental Alzheimer's disease.
Volume: 8
Issue: 1
Pages: 216
Publication
First Author: Fuhrmann M
Year: 2010
Journal: Nat Neurosci
Title: Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease.
Volume: 13
Issue: 4
Pages: 411-3
Publication
First Author: Tapella L
Year: 2024
Journal: Glia
Title: Genetic deletion of astrocytic calcineurin B1 prevents cognitive impairment and neuropathology development in acute and chronic mouse models of Alzheimer's disease.
Volume: 72
Issue: 5
Pages: 899-915
Publication
First Author: Jadiya P
Year: 2019
Journal: Nat Commun
Title: Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer's disease.
Volume: 10
Issue: 1
Pages: 3885
Publication  
First Author: Lardenoije R
Year: 2018
Journal: Mol Cell Neurosci
Title: Age-related epigenetic changes in hippocampal subregions of four animal models of Alzheimer's disease.
Volume: 86
Pages: 1-15
Publication
First Author: Jan A
Year: 2017
Journal: Acta Neuropathol
Title: eEF2K inhibition blocks Aβ42 neurotoxicity by promoting an NRF2 antioxidant response.
Volume: 133
Issue: 1
Pages: 101-119
Publication
First Author: Dudeffant C
Year: 2017
Journal: Sci Rep
Title: Contrast-enhanced MR microscopy of amyloid plaques in five mouse models of amyloidosis and in human Alzheimer's disease brains.
Volume: 7
Issue: 1
Pages: 4955
Publication
First Author: Tadeu AM
Year: 2013
Journal: Development
Title: Notch signaling represses p63 expression in the developing surface ectoderm.
Volume: 140
Issue: 18
Pages: 3777-86
Publication
First Author: Castello NA
Year: 2012
Journal: PLoS One
Title: Genetic knockdown of brain-derived neurotrophic factor in 3xTg-AD mice does not alter Aβ or tau pathology.
Volume: 7
Issue: 8
Pages: e39566
Publication
First Author: Wines-Samuelson M
Year: 2005
Journal: Dev Biol
Title: Role of presenilin-1 in cortical lamination and survival of Cajal-Retzius neurons.
Volume: 277
Issue: 2
Pages: 332-46
Publication
First Author: Kam MK
Year: 2020
Journal: Biochem J
Title: Amyloid-beta oligomers induce Parkin-mediated mitophagy by reducing Miro1.
Volume: 477
Issue: 23
Pages: 4581-4597
Publication
First Author: Posada-Duque RA
Year: 2015
Journal: J Neurochem
Title: p35 and Rac1 underlie the neuroprotection and cognitive improvement induced by CDK5 silencing.
Volume: 134
Issue: 2
Pages: 354-70
Publication
First Author: Benoit ME
Year: 2013
Journal: J Biol Chem
Title: C1q-induced LRP1B and GPR6 proteins expressed early in Alzheimer disease mouse models, are essential for the C1q-mediated protection against amyloid-β neurotoxicity.
Volume: 288
Issue: 1
Pages: 654-65
Publication
First Author: Branca C
Year: 2017
Journal: Aging Cell
Title: Dyrk1 inhibition improves Alzheimer's disease-like pathology.
Volume: 16
Issue: 5
Pages: 1146-1154
Publication
First Author: Montgomery SL
Year: 2011
Journal: Am J Pathol
Title: Ablation of TNF-RI/RII expression in Alzheimer's disease mice leads to an unexpected enhancement of pathology: implications for chronic pan-TNF-α suppressive therapeutic strategies in the brain.
Volume: 179
Issue: 4
Pages: 2053-70
Publication
First Author: Um JW
Year: 2013
Journal: Neuron
Title: Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein.
Volume: 79
Issue: 5
Pages: 887-902
Publication
First Author: Bryleva EY
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD.
Volume: 107
Issue: 7
Pages: 3081-6
Publication    
First Author: Deyts C
Year: 2016
Journal: Elife
Title: Loss of presenilin function is associated with a selective gain of APP function.
Volume: 5
Publication
First Author: Pera M
Year: 2017
Journal: EMBO J
Title: Increased localization of APP-C99 in mitochondria-associated ER membranes causes mitochondrial dysfunction in Alzheimer disease.
Volume: 36
Issue: 22
Pages: 3356-3371
Publication
First Author: Li H
Year: 2018
Journal: Biochem Biophys Res Commun
Title: FTO is involved in Alzheimer's disease by targeting TSC1-mTOR-Tau signaling.
Volume: 498
Issue: 1
Pages: 234-239
Publication
First Author: Li H
Year: 2010
Journal: J Biol Chem
Title: Genetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesis.
Volume: 285
Issue: 40
Pages: 30598-605
Publication
First Author: Baglietto-Vargas D
Year: 2021
Journal: Nat Commun
Title: Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer's disease-like pathology.
Volume: 12
Issue: 1
Pages: 2421
Publication
First Author: Chen J
Year: 2023
Journal: Cell Mol Life Sci
Title: APP mediates tau uptake and its overexpression leads to the exacerbated tau pathology.
Volume: 80
Issue: 5
Pages: 123
Publication
First Author: Zhao Y
Year: 2017
Journal: Neuron
Title: Amyloid Beta Peptides Block New Synapse Assembly by Nogo Receptor-Mediated Inhibition of T-Type Calcium Channels.
Volume: 96
Issue: 2
Pages: 355-372.e6
Publication  
First Author: Hirata-Fukae C
Year: 2008
Journal: Brain Res
Title: Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model.
Volume: 1216
Pages: 92-103
Publication
First Author: Peng S
Year: 2009
Journal: J Neurosci
Title: Decreased brain-derived neurotrophic factor depends on amyloid aggregation state in transgenic mouse models of Alzheimer's disease.
Volume: 29
Issue: 29
Pages: 9321-9
Publication
First Author: Kamphuis W
Year: 2012
Journal: PLoS One
Title: GFAP isoforms in adult mouse brain with a focus on neurogenic astrocytes and reactive astrogliosis in mouse models of Alzheimer disease.
Volume: 7
Issue: 8
Pages: e42823
Publication  
First Author: Zhou Q
Year: 2022
Journal: EBioMedicine
Title: Human tau accumulation promotes glycogen synthase kinase-3β acetylation and thus upregulates the kinase: A vicious cycle in Alzheimer neurodegeneration.
Volume: 78
Pages: 103970
Publication
First Author: Hashimoto S
Year: 2018
Journal: J Biol Chem
Title: Endoplasmic reticulum stress responses in mouse models of Alzheimer's disease: Overexpression paradigm versus knockin paradigm.
Volume: 293
Issue: 9
Pages: 3118-3125
Publication
First Author: Ceglia I
Year: 2015
Journal: Nat Med
Title: APP intracellular domain-WAVE1 pathway reduces amyloid-β production.
Volume: 21
Issue: 9
Pages: 1054-9
Publication
First Author: Sorrentino V
Year: 2017
Journal: Nature
Title: Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity.
Volume: 552
Issue: 7684
Pages: 187-193
Publication
First Author: Kumar S
Year: 2020
Journal: Acta Neuropathol Commun
Title: Phosphorylated Aβ peptides in human Down syndrome brain and different Alzheimer's-like mouse models.
Volume: 8
Issue: 1
Pages: 118
Publication
First Author: Zhang ZH
Year: 2017
Journal: J Neurosci
Title: Selenomethionine Mitigates Cognitive Decline by Targeting Both Tau Hyperphosphorylation and Autophagic Clearance in an Alzheimer's Disease Mouse Model.
Volume: 37
Issue: 9
Pages: 2449-2462
Publication    
First Author: Kam TI
Year: 2016
Journal: Elife
Title: FcγRIIb-SHIP2 axis links Aβ to tau pathology by disrupting phosphoinositide metabolism in Alzheimer's disease model.
Volume: 5
Publication
First Author: Kang SS
Year: 2020
Journal: J Clin Invest
Title: Norepinephrine metabolite DOPEGAL activates AEP and pathological Tau aggregation in locus coeruleus.
Volume: 130
Issue: 1
Pages: 422-437
Publication
First Author: Xiong J
Year: 2022
Journal: Nature
Title: FSH blockade improves cognition in mice with Alzheimer's disease.
Volume: 603
Issue: 7901
Pages: 470-476
Publication
First Author: Zhou LT
Year: 2023
Journal: Sci Adv
Title: Tau pathology epigenetically remodels the neuron-glial cross-talk in Alzheimer's disease.
Volume: 9
Issue: 16
Pages: eabq7105
Publication
First Author: Jiang H
Year: 2020
Journal: Sci Rep
Title: Live Neuron High-Content Screening Reveals Synaptotoxic Activity in Alzheimer Mouse Model Homogenates.
Volume: 10
Issue: 1
Pages: 3412
Publication  
First Author: Chen G
Year: 2021
Journal: Sci Adv
Title: Netrin-1 receptor UNC5C cleavage by active δ-secretase enhances neurodegeneration, promoting Alzheimer's disease pathologies.
Volume: 7
Issue: 16
Publication  
First Author: Shen X
Year: 2016
Journal: eNeuro
Title: Neurons in Vulnerable Regions of the Alzheimer's Disease Brain Display Reduced ATM Signaling.
Volume: 3
Issue: 1
Publication
First Author: Ishii M
Year: 2015
Journal: Cell Metab
Title: Metabolic and Non-Cognitive Manifestations of Alzheimer's Disease: The Hypothalamus as Both Culprit and Target of Pathology.
Volume: 22
Issue: 5
Pages: 761-76
Publication
First Author: Genethliou N
Year: 2009
Journal: Biochem Biophys Res Commun
Title: SOX1 links the function of neural patterning and Notch signalling in the ventral spinal cord during the neuron-glial fate switch.
Volume: 390
Issue: 4
Pages: 1114-20
Publication
First Author: Yang X
Year: 2004
Journal: Dev Biol
Title: Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway.
Volume: 269
Issue: 1
Pages: 81-94
Publication  
First Author: Sartoretti MM
Year: 2022
Journal: Development
Title: Dbx1 controls the development of astrocytes of the intermediate spinal cord by modulating Notch signaling.
Volume: 149
Issue: 15
Publication
First Author: Lacomme M
Year: 2022
Journal: Sci Adv
Title: Numb regulates Tau levels and prevents neurodegeneration in tauopathy mouse models.
Volume: 8
Issue: 42
Pages: eabm4295
Publication
First Author: Boyle SC
Year: 2014
Journal: Development
Title: Notch signaling is required for the formation of mesangial cells from a stromal mesenchyme precursor during kidney development.
Volume: 141
Issue: 2
Pages: 346-54
Publication
First Author: Chow HM
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: CDK5 activator protein p25 preferentially binds and activates GSK3β.
Volume: 111
Issue: 45
Pages: E4887-95
Publication
First Author: Benzow K
Year: 2024
Journal: Alzheimers Dement
Title: Gene replacement-Alzheimer's disease (GR-AD): Modeling the genetics of human dementias in mice.
Volume: 20
Issue: 4
Pages: 3080-3087
Publication
First Author: Frake RA
Year: 2015
Journal: J Clin Invest
Title: Autophagy and neurodegeneration.
Volume: 125
Issue: 1
Pages: 65-74
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory