Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, African clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, African clawed |
|
•
•
•
•
•
|
Publication |
First Author: |
Hsieh JJ |
Year: |
1999 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex. |
Volume: |
96 |
Issue: |
1 |
Pages: |
23-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Raafat A |
Year: |
2017 |
Journal: |
Sci Rep |
Title: |
The ANK repeats of Notch-4/Int3 activate NF-κB canonical pathway in the absence of Rbpj and causes mammary tumorigenesis. |
Volume: |
7 |
Issue: |
1 |
Pages: |
13690 |
|
•
•
•
•
•
|
Publication |
First Author: |
Maita H |
Year: |
2005 |
Journal: |
Exp Cell Res |
Title: |
CIR, a corepressor of CBF1, binds to PAP-1 and effects alternative splicing. |
Volume: |
303 |
Issue: |
2 |
Pages: |
375-87 |
|
•
•
•
•
•
|
Allele |
Name: |
RBPJ interacting and tubulin associated 1; wild type |
Allele Type: |
Not Specified |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Pajerowski AG |
Year: |
2009 |
Journal: |
Immunity |
Title: |
NKAP is a transcriptional repressor of notch signaling and is required for T cell development. |
Volume: |
30 |
Issue: |
5 |
Pages: |
696-707 |
|
•
•
•
•
•
|
Allele |
Name: |
RBPJ interacting and tubulin associated 1; targeted mutation 1a, Wellcome Trust Sanger Institute |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
RBPJ interacting and tubulin associated 1; targeted mutation 1e, Wellcome Trust Sanger Institute |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
RBPJ interacting and tubulin associated 1; targeted mutation 1e, Mouse Biology Program, UC Davis |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
RBPJ interacting and tubulin associated 1; targeted mutation 1a, Mouse Biology Program, UC Davis |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Null/knockout, Reporter |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Allele |
Name: |
recombination signal binding protein for immunoglobulin kappa J region; endonuclease-mediated mutation 2, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE36804 |
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant strain, coisogenic, targeted mutation |
|
•
•
•
•
•
|
Allele |
Name: |
recombination signal binding protein for immunoglobulin kappa J region; targeted mutation 1.1, William T Pu |
Allele Type: |
Targeted |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
Allele |
Name: |
recombination signal binding protein for immunoglobulin kappa J region; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
Publication |
First Author: |
Okuda H |
Year: |
2015 |
Journal: |
PLoS One |
Title: |
A novel transcriptional factor Nkapl is a germ cell-specific suppressor of Notch signaling and is indispensable for spermatogenesis. |
Volume: |
10 |
Issue: |
4 |
Pages: |
e0124293 |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rbpj/Rbpj |
Background: |
involves: 129S4/SvJae * C57BL/6 * SJL * Swiss Webster |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Allele |
Name: |
mesoderm posterior 2; targeted mutation 16.1, Yumiko Saga |
Allele Type: |
Targeted |
Attribute String: |
Dominant negative, Inserted expressed sequence, Null/knockout |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Mesp2/Mesp2 |
Background: |
involves: C57BL/6 * CBA |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
Publication |
First Author: |
Sasaki N |
Year: |
2011 |
Journal: |
Development |
Title: |
The repression of Notch signaling occurs via the destabilization of mastermind-like 1 by Mesp2 and is essential for somitogenesis. |
Volume: |
138 |
Issue: |
1 |
Pages: |
55-64 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
261
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Hazbun TR |
Year: |
2003 |
Journal: |
Mol Cell |
Title: |
Assigning function to yeast proteins by integration of technologies. |
Volume: |
12 |
Issue: |
6 |
Pages: |
1353-65 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This entry represents a 45 residue conserved domain found at the N-terminal end CIR protein (CBF1-interacting co-repressor, also known as corepressor interacting with RBPJ 1). This domain can be found in the fungal CWC25 family members and mammlian LENG1 (leukocyte receptor cluster member 1) protein.CBF1 (centromere-binding factor 1) acts as a transcription factor that causes repression by binding specifically to GTGGGAA motifs in responsive promoters, and it requires CIR as a co-repressor. CIR binds to histone deacetylase and to SAP30 and serves as a linker between CBF1 and the histone deacetylase complex []. CIR also plays a role in alternative splicing []. Budding yeast Cwc25 is a pre-mRNA-splicing factor involved in pre-mRNA splicing []. |
|
•
•
•
•
•
|
Strain |
Attribute String: |
targeted mutation, mutant stock |
|
•
•
•
•
•
|
Allele |
Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 9, Rui Benedito |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Epitope tag, Inserted expressed sequence, Reporter |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE31643 |
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
416
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
206
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
371
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Allele |
Name: |
transgenic transposon concatemer, Rui Benedito |
Allele Type: |
Transgenic |
Attribute String: |
Conditional ready, Epitope tag, Inserted expressed sequence, Reporter, Transposon concatemer |
|
•
•
•
•
•
|
Publication |
First Author: |
Sonoshita M |
Year: |
2011 |
Journal: |
Cancer Cell |
Title: |
Suppression of colon cancer metastasis by Aes through inhibition of Notch signaling. |
Volume: |
19 |
Issue: |
1 |
Pages: |
125-37 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sakai M |
Year: |
2019 |
Journal: |
Immunity |
Title: |
Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity. |
Volume: |
51 |
Issue: |
4 |
Pages: |
655-670.e8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gao J |
Year: |
2009 |
Journal: |
Cell Stem Cell |
Title: |
Hedgehog signaling is dispensable for adult hematopoietic stem cell function. |
Volume: |
4 |
Issue: |
6 |
Pages: |
548-58 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tesone AJ |
Year: |
2016 |
Journal: |
Cell Rep |
Title: |
Satb1 Overexpression Drives Tumor-Promoting Activities in Cancer-Associated Dendritic Cells. |
Volume: |
14 |
Issue: |
7 |
Pages: |
1774-1786 |
|
•
•
•
•
•
|
Publication |
First Author: |
Golson ML |
Year: |
2009 |
Journal: |
Mech Dev |
Title: |
Jagged1 is a competitive inhibitor of Notch signaling in the embryonic pancreas. |
Volume: |
126 |
Issue: |
8-9 |
Pages: |
687-99 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xiao D |
Year: |
2018 |
Journal: |
Nat Commun |
Title: |
Direct reprogramming of fibroblasts into neural stem cells by single non-neural progenitor transcription factor Ptf1a. |
Volume: |
9 |
Issue: |
1 |
Pages: |
2865 |
|
•
•
•
•
•
|
Publication |
First Author: |
López-Arribillaga E |
Year: |
2015 |
Journal: |
Development |
Title: |
Bmi1 regulates murine intestinal stem cell proliferation and self-renewal downstream of Notch. |
Volume: |
142 |
Issue: |
1 |
Pages: |
41-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kitajima K |
Year: |
2013 |
Journal: |
Dev Biol |
Title: |
Wnt signaling regulates left-right axis formation in the node of mouse embryos. |
Volume: |
380 |
Issue: |
2 |
Pages: |
222-32 |
|
•
•
•
•
•
|
Publication |
First Author: |
Duarte S |
Year: |
2018 |
Journal: |
Blood |
Title: |
Canonical Notch signaling is dispensable for adult steady-state and stress myelo-erythropoiesis. |
Volume: |
131 |
Issue: |
15 |
Pages: |
1712-1719 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen ELY |
Year: |
2019 |
Journal: |
Nat Immunol |
Title: |
RBPJ-dependent Notch signaling initiates the T cell program in a subset of thymus-seeding progenitors. |
Volume: |
20 |
Issue: |
11 |
Pages: |
1456-1468 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li Q |
Year: |
2021 |
Journal: |
Stem Cell Reports |
Title: |
RYBP modulates embryonic neurogenesis involving the Notch signaling pathway in a PRC1-independent pattern. |
Volume: |
16 |
Issue: |
12 |
Pages: |
2988-3004 |
|
•
•
•
•
•
|
Publication |
First Author: |
Parmigiani E |
Year: |
2022 |
Journal: |
Cancers (Basel) |
Title: |
Genetic Inactivation of Notch1 Synergizes with Loss of Trp53 to Induce Tumor Formation in the Adult Mouse Forebrain. |
Volume: |
14 |
Issue: |
21 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Guo R |
Year: |
2023 |
Journal: |
Sci Adv |
Title: |
Context-dependent regulation of Notch signaling in glial development and tumorigenesis. |
Volume: |
9 |
Issue: |
45 |
Pages: |
eadi2167 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hiraoka Y |
Year: |
2013 |
Journal: |
Mol Brain |
Title: |
Delta-like 1 regulates Bergmann glial monolayer formation during cerebellar development. |
Volume: |
6 |
|
Pages: |
25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Swarnkar G |
Year: |
2016 |
Journal: |
Sci Rep |
Title: |
Myeloid Deletion of Nemo Causes Osteopetrosis in Mice Owing to Upregulation of Transcriptional Repressors. |
Volume: |
6 |
|
Pages: |
29896 |
|
•
•
•
•
•
|
Publication |
First Author: |
Azimi M |
Year: |
2018 |
Journal: |
Differentiation |
Title: |
Presenilin gene function and Notch signaling feedback regulation in the developing mouse lens. |
Volume: |
102 |
|
Pages: |
40-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Guest RV |
Year: |
2016 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Notch3 drives development and progression of cholangiocarcinoma. |
Volume: |
113 |
Issue: |
43 |
Pages: |
12250-12255 |
|
•
•
•
•
•
|
Publication |
First Author: |
Saravanamuthu SS |
Year: |
2012 |
Journal: |
Dev Biol |
Title: |
Conditional ablation of the Notch2 receptor in the ocular lens. |
Volume: |
362 |
Issue: |
2 |
Pages: |
219-29 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sacilotto N |
Year: |
2013 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Analysis of Dll4 regulation reveals a combinatorial role for Sox and Notch in arterial development. |
Volume: |
110 |
Issue: |
29 |
Pages: |
11893-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bargo S |
Year: |
2010 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Transforming acidic coiled-coil protein-3 (Tacc3) acts as a negative regulator of Notch signaling through binding to CDC10/Ankyrin repeats. |
Volume: |
400 |
Issue: |
4 |
Pages: |
606-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang Y |
Year: |
2016 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Activation of Notch1 inhibits medial edge epithelium apoptosis in all-trans retinoic acid-induced cleft palate in mice. |
Volume: |
477 |
Issue: |
3 |
Pages: |
322-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lu J |
Year: |
2016 |
Journal: |
Sci Rep |
Title: |
Notch Signaling Coordinates Progenitor Cell-Mediated Biliary Regeneration Following Partial Hepatectomy. |
Volume: |
6 |
|
Pages: |
22754 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zaman TS |
Year: |
2017 |
Journal: |
J Immunol |
Title: |
Notch Balances Th17 and Induced Regulatory T Cell Functions in Dendritic Cells by Regulating Aldh1a2 Expression. |
Volume: |
199 |
Issue: |
6 |
Pages: |
1989-1997 |
|
•
•
•
•
•
|
Publication |
First Author: |
Webb LMC |
Year: |
2021 |
Journal: |
Aging Cell |
Title: |
Ageing promotes early T follicular helper cell differentiation by modulating expression of RBPJ. |
Volume: |
20 |
Issue: |
1 |
Pages: |
e13295 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shi M |
Year: |
2021 |
Journal: |
J Pathol |
Title: |
Alcohol drinking inhibits NOTCH-PAX9 signaling in esophageal squamous epithelial cells. |
Volume: |
253 |
Issue: |
4 |
Pages: |
384-395 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen L |
Year: |
2012 |
Journal: |
Stem Cells Dev |
Title: |
The role of notch 1 activation in cardiosphere derived cell differentiation. |
Volume: |
21 |
Issue: |
12 |
Pages: |
2122-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Masui T |
Year: |
2008 |
Journal: |
Mol Cell Biol |
Title: |
Transcriptional autoregulation controls pancreatic Ptf1a expression during development and adulthood. |
Volume: |
28 |
Issue: |
17 |
Pages: |
5458-68 |
|
•
•
•
•
•
|
Publication |
First Author: |
Thiagarajan RD |
Year: |
2011 |
Journal: |
PLoS One |
Title: |
Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways. |
Volume: |
6 |
Issue: |
2 |
Pages: |
e17286 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pontes-Quero S |
Year: |
2017 |
Journal: |
Cell |
Title: |
Dual ifgMosaic: A Versatile Method for Multispectral and Combinatorial Mosaic Gene-Function Analysis. |
Volume: |
170 |
Issue: |
4 |
Pages: |
800-814.e18 |
|
•
•
•
•
•
|
Publication |
First Author: |
University of California, Davis |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by the University of California, Davis |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
International Mouse Strain Resource |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of germline transmission data for alleles from IMSR strain data |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Ko MS |
Year: |
2000 |
Journal: |
Development |
Title: |
Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. |
Volume: |
127 |
Issue: |
8 |
Pages: |
1737-49 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2009 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
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Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
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Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
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Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
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Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
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Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
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Publication |
First Author: |
Huttlin EL |
Year: |
2010 |
Journal: |
Cell |
Title: |
A tissue-specific atlas of mouse protein phosphorylation and expression. |
Volume: |
143 |
Issue: |
7 |
Pages: |
1174-89 |
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