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Search results 801 to 900 out of 1005 for Ripk1

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Hits by Strain

Type Details Score
Allele
Cradd<Gt(OST389052)Lex> | MGI:4302600
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap OST389052, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Cradd<Gt(OST392493)Lex> | MGI:4303945
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap OST392493, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Cradd<Gt(OST426914)Lex> | MGI:4313373
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap OST426914, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Cradd<Gt(OST430707)Lex> | MGI:4314542
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap OST430707, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Cradd<Gt(OST435030)Lex> | MGI:4316216
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap OST435030, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Cradd<Gt(OST436316)Lex> | MGI:4316597
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap OST436316, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Cradd<Gt(OST436748)Lex> | MGI:4316729
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap OST436748, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Cradd<Gt(OST443108)Lex> | MGI:4319158
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap OST443108, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Cradd<Gt(OST463321)Lex> | MGI:4325534
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap OST463321, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Cradd<Gt(S13-2B1)Sor> | MGI:4974140
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap S13-2B1, Philippe Soriano
Allele Type: Gene trapped
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Publication
23815625 | J:202711
First Author: Jean YY
Year: 2013
Journal: Biochem J
Title: Caspase-2 is essential for c-Jun transcriptional activation and Bim induction in neuron death.
Volume: 455
Issue: 1
Pages: 15-25
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Strain
MGI:6439407 | B6;129S5-Cradd<Gt(OST55)Lex>/Tac
Attribute String: mutant stock, gene trap
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Allele
Cradd<tm1Mak> | MGI:3604302
Name: CASP2 and RIPK1 domain containing adaptor with death domain; targeted mutation 1, Tak W Mak
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Cradd<Gt(D085A10)Wrst> | MGI:3890143
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap D085A10, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Cradd<Gt(D174G10)Wrst> | MGI:3892925
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap D174G10, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Cradd<Gt(E003G02)Wrst> | MGI:3893452
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap E003G02, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Cradd<Gt(E046D03)Wrst> | MGI:3894349
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap E046D03, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Cradd<Gt(E050C10)Wrst> | MGI:3894469
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap E050C10, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Cradd<Gt(E202D06)Wrst> | MGI:3918347
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap E202D06, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Cradd<Gt(E231H08)Wrst> | MGI:3919522
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap E231H08, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Cradd<Gt(E258G01)Wrst> | MGI:3920696
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap E258G01, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Cradd<Gt(E268D01)Wrst> | MGI:3921144
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap E268D01, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Cradd<Gt(IST10904E1)Tigm> | MGI:3975595
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap IST10904E1, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Cradd<Gt(IST13050D1)Tigm> | MGI:4112190
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap IST13050D1, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Cradd<Gt(W079E06)Wrst> | MGI:4122870
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap W079E06, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Cradd<Gt(XR0783)Wtsi> | MGI:4338264
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap XR0783, Wellcome Trust Sanger Institute
Allele Type: Gene trapped
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Allele
Cradd<Gt(EUCE0246h06)Hmgu> | MGI:4368472
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap EUCE0246h06, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Cradd<Gt(EUCE0263c12)Hmgu> | MGI:4370410
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap EUCE0263c12, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Cradd<Gt(EUCE00172g03)Hmgu> | MGI:4387719
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap EUCE00172g03, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Cradd<Gt(EUCE0255g08)Hmgu> | MGI:4395235
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap EUCE0255g08, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Cradd<Gt(EUCE0250e10)Hmgu> | MGI:4395483
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap EUCE0250e10, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Cradd<Gt(b3p2a7)Rul> | MGI:4832097
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap b3p2a7, H Earl Ruley
Allele Type: Gene trapped
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Allele
Cradd<Gt(C25)Rul> | MGI:4832392
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap C25, H Earl Ruley
Allele Type: Gene trapped
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Allele
Cradd<Gt(b3p3g6)Rul> | MGI:4832211
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap b3p3g6, H Earl Ruley
Allele Type: Gene trapped
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Allele
Cradd<Gt(b5p5d8)Rul> | MGI:4833027
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap b5p5d8, H Earl Ruley
Allele Type: Gene trapped
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Allele
Cradd<Gt(EUCJ0058c03)Hmgu> | MGI:4872664
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap EUCJ0058c03, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Cradd<Gt(499B12)Cmhd> | MGI:4954577
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap 499B12, Centre for Modeling Human Disease
Allele Type: Gene trapped
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Allele
Cradd<Gt(500H12)Cmhd> | MGI:4954592
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap 500H12, Centre for Modeling Human Disease
Allele Type: Gene trapped
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Allele
Cradd<Gt(98D5)Cmhd> | MGI:4958242
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap 98D5, Centre for Modeling Human Disease
Allele Type: Gene trapped
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Allele
Cradd<Gt(512.1E1)Cmhd> | MGI:4958426
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap 512.1E1, Centre for Modeling Human Disease
Allele Type: Gene trapped
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Allele
Cradd<Gt(398A7)Cmhd> | MGI:4963280
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap 398A7, Centre for Modeling Human Disease
Allele Type: Gene trapped
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Allele
Cradd<Gt(365G12)Cmhd> | MGI:4964800
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap 365G12, Centre for Modeling Human Disease
Allele Type: Gene trapped
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Allele
Cradd<Gt(359C1)Cmhd> | MGI:4965918
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap 359C1, Centre for Modeling Human Disease
Allele Type: Gene trapped
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Allele
Cradd<Gt(358C1)Cmhd> | MGI:4966001
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap 358C1, Centre for Modeling Human Disease
Allele Type: Gene trapped
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Allele
Cradd<Gt(77G9)Cmhd> | MGI:4973086
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap 77G9, Centre for Modeling Human Disease
Allele Type: Gene trapped
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Allele
Cradd<Gt(IST13145B5)Tigm> | MGI:5152931
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap IST13145B5, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Cradd<Gt(IST13146B4)Tigm> | MGI:5152988
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap IST13146B4, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Cradd<Gt(IST13263E3)Tigm> | MGI:5158685
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap IST13263E3, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Cradd<Gt(IST13305F1)Tigm> | MGI:5162455
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap IST13305F1, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Cradd<Gt(IST13889E2)Tigm> | MGI:5194799
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap IST13889E2, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Cradd<Gt(IST14104D11)Tigm> | MGI:5209570
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap IST14104D11, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Cradd<Gt(IST14467C9)Tigm> | MGI:5232621
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap IST14467C9, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Cradd<Gt(IST14681A1)Tigm> | MGI:5251443
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap IST14681A1, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Cradd<Gt(IST14762C7)Tigm> | MGI:5257079
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap IST14762C7, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Cradd<Gt(IST14741F5)Tigm> | MGI:5258198
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap IST14741F5, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Cradd<Gt(IST14775H12)Tigm> | MGI:5258647
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap IST14775H12, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Cradd<Gt(IST14926H6)Tigm> | MGI:5268857
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap IST14926H6, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Cradd<Gt(IST14926H8)Tigm> | MGI:5268858
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap IST14926H8, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Cradd<Gt(IST15072B6)Tigm> | MGI:5278920
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap IST15072B6, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Cradd<Gt(IST15053H2)Tigm> | MGI:5280893
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap IST15053H2, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Cradd<Gt(IST15078G6)Tigm> | MGI:5281179
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap IST15078G6, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Cradd<Gt(IST15096C10)Tigm> | MGI:5283293
 
Name: CASP2 and RIPK1 domain containing adaptor with death domain; gene trap IST15096C10, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Cradd<tm1(KOMP)Mbp> | MGI:5287724
Name: CASP2 and RIPK1 domain containing adaptor with death domain; targeted mutation 1, Mouse Biology Program, UC Davis
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Cradd<tm1a(EUCOMM)Hmgu> | MGI:5472630
Name: CASP2 and RIPK1 domain containing adaptor with death domain; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Allele
Cradd<tm1e(EUCOMM)Hmgu> | MGI:5497286
Name: CASP2 and RIPK1 domain containing adaptor with death domain; targeted mutation 1e, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Genotype
Genotype
Symbol: Cradd/Cradd
Background: involves: 129P2/OlaHsd * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cradd/Cradd
Background: involves: 129 * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Publication
15073321 | J:320335
First Author: Tinel A
Year: 2004
Journal: Science
Title: The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress.
Volume: 304
Issue: 5672
Pages: 843-6
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DO Term
DOID:0111952 | immunodeficiency 57
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HT Experiment
GSE116613 | TBK1 suppresses RIPK1-driven apoptosis and inflammation during development and in aging
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
28432080 | J:246097
First Author: Ando K
Year: 2017
Journal: J Cell Biol
Title: NPM1 directs PIDDosome-dependent caspase-2 activation in the nucleolus.
Volume: 216
Issue: 6
Pages: 1795-1810
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GO Term
GO:0097342 | ripoptosome
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Genotype
Genotype
Symbol: Cradd/Cradd<+>
Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ripk1/Ripk1 Senp1/Senp1
Background: involves: 129P2/OlaHsd * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Allele
Socs2<hg> | MGI:1856899
 
Name: suppressor of cytokine signaling 2; high growth
Allele Type: Spontaneous
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Publication
9325297 | -
First Author: Stennicke HR
Year: 1997
Journal: J Biol Chem
Title: Biochemical characteristics of caspases-3, -6, -7, and -8.
Volume: 272
Issue: 41
Pages: 25719-23
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Publication
12110583 | -
First Author: Chang DW
Year: 2002
Journal: EMBO J
Title: c-FLIP(L) is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis.
Volume: 21
Issue: 14
Pages: 3704-14
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Publication
15209560 | -
First Author: Boatright KM
Year: 2004
Journal: Biochem J
Title: Activation of caspases-8 and -10 by FLIP(L).
Volume: 382
Issue: Pt 2
Pages: 651-7
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Publication
21235526 | -
First Author: Pop C
Year: 2011
Journal: Biochem J
Title: FLIP(L) induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity.
Volume: 433
Issue: 3
Pages: 447-457
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Publication
9721089 | -
First Author: Ashkenazi A
Year: 1998
Journal: Science
Title: Death receptors: signaling and modulation.
Volume: 281
Issue: 5381
Pages: 1305-8
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Protein Domain
IPR033170 | Caspase-8
Type: Family
Description: Caspase-8 (MEROPS identifier C14.009) is a cytoplasmic cysteine endopeptidase with a preference for aspartyl bonds, acing at neutral pH []. It is active as a homodimer or as a heterodimer in association with the long isoform of FLICE, and proteolytic processing of the caspase-8 precursor is required for stabilisation of the dimer [, , ]. It is one of the activator caspases. Caspase-8 has a strict requirement for Asp in P1, a preference for Glu in P3 and small residues in P1' []. The caspase-8 proenzyme has two N-terminal death effector domains which are removed upon activation along with a linker region between the large and small subunits of the C-terminal catalytic domain. The death inducing signalling complex, composed of a transmembrane death receptor and the adapter protein FADD assembles at the cell membrane following binding of a death ligand. Procaspase-8 is recruited to this complex, and becomes active by dimerisation. Active caspase-8 can then activate the executioner caspases -3 and -7 [].Caspase-8 cleaves RIPK1, which is crucial to inhibit RIPK1 kinase activity, limiting TNF-induced apoptosis, necroptosis and inflammatory response. In humans, non-cleavable RIPK1 leads to autoinflammatory disease characterized by hypersensitivity to apoptosis and necroptosis and increased inflammatory response [, ].
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Publication
15741512 | J:97506
First Author: Osipovich AB
Year: 2005
Journal: Genome Res
Title: Post-entrapment genome engineering: first exon size does not affect the expression of fusion transcripts generated by gene entrapment.
Volume: 15
Issue: 3
Pages: 428-35
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Publication
25459879 | J:219499
First Author: Weinlich R
Year: 2014
Journal: Mol Cell
Title: The two faces of receptor interacting protein kinase-1.
Volume: 56
Issue: 4
Pages: 469-80
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Publication
19336533 | J:148540
First Author: Farber CR
Year: 2009
Journal: Physiol Genomics
Title: Genetic dissection of a major mouse obesity QTL (Carfhg2): integration of gene expression and causality modeling.
Volume: 37
Issue: 3
Pages: 294-302
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Publication
11401434 | J:68342
First Author: Horvat S
Year: 2001
Journal: Genomics
Title: Lack of Socs2 expression causes the high-growth phenotype in mice.
Volume: 72
Issue: 2
Pages: 209-12
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Strain
MGI:5651641 | involves: C57BL/6J-Socs2<hg> * CAST/EiJ
Attribute String: mutant strain
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Strain
MGI:6194953 | HG.CAST-(D17Mit196-D17Mit190)
Attribute String: mutant strain, QTL, spontaneous mutation, congenic, deletion
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Strain
MGI:2160834 | B6.Cg-Socs2<hg>
Attribute String: mutant strain
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Strain
MGI:6194949 | HG.CAST-(D2Mit329-D2Mit457)
Attribute String: congenic, deletion, mutant strain, QTL, spontaneous mutation
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Strain
MGI:3849572 | HG/Jfmuc
Attribute String: congenic, spontaneous mutation
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Strain
MGI:5651678 | involves: CAST/EiJ * C57BL/6J-Socs2<hg>
Attribute String: spontaneous mutation
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Publication
5664389 | J:220665
First Author: Bradford GE
Year: 1968
Journal: Genetics
Title: Selection for litter size in mice in the presence and absence of gonadotropin treatment.
Volume: 58
Issue: 2
Pages: 283-95
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Publication
11015596 | J:65388
First Author: Corva PM
Year: 2000
Journal: Physiol Genomics
Title: Diet effects on weight gain and body composition in high growth (hg/hg) mice.
Volume: 3
Issue: 1
Pages: 17-23
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Publication
5168371 | J:220666
First Author: Bradford GE
Year: 1971
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First Author: Dilts RB
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First Author: Summers PJ
Year: 1994
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First Author: Medrano JF
Year: 1991
Journal: Genet Res
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Title: Infertility in a line of mice with the high growth mutation is due to luteal insufficiency resulting from disruption at the hypothalamic-pituitary axis.
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First Author: Cargill SL
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Journal: Growth Dev Aging
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