Type |
Details |
Score |
Genotype |
Symbol: |
Gja1/Gja1 Tg(S100b-cre)20Ito/? |
Background: |
involves: 129P2/OlaHsd * C57BL/6 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(CAG-cat,-lacZ)11Miya/? Tg(S100b-cre)20Ito/? |
Background: |
involves: C57BL/6 * DBA/2 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Schiffner S |
Year: |
2014 |
Journal: |
Exp Eye Res |
Title: |
Tg(Grm1) transgenic mice: a murine model that mimics spontaneous uveal melanoma in humans? |
Volume: |
127 |
|
Pages: |
59-68 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huang X |
Year: |
2023 |
Journal: |
Nat Commun |
Title: |
Transcriptional repression of beige fat innervation via a YAP/TAZ-S100B axis. |
Volume: |
14 |
Issue: |
1 |
Pages: |
7102 |
|
•
•
•
•
•
|
Publication |
First Author: |
Emberley ED |
Year: |
2004 |
Journal: |
Biochem Cell Biol |
Title: |
S100 proteins and their influence on pro-survival pathways in cancer. |
Volume: |
82 |
Issue: |
4 |
Pages: |
508-15 |
|
•
•
•
•
•
|
Publication |
First Author: |
Choi KC |
Year: |
2005 |
Journal: |
Reprod Biol Endocrinol |
Title: |
Biology and physiology of Calbindin-D9k in female reproductive tissues: involvement of steroids and endocrine disruptors. |
Volume: |
3 |
|
Pages: |
66 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bronner F |
Year: |
2003 |
Journal: |
J Cell Biochem |
Title: |
Mechanisms of intestinal calcium absorption. |
Volume: |
88 |
Issue: |
2 |
Pages: |
387-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mikhaylova M |
Year: |
2009 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Calneurons provide a calcium threshold for trans-Golgi network to plasma membrane trafficking. |
Volume: |
106 |
Issue: |
22 |
Pages: |
9093-8 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Conserved_site |
Description: |
The calcium-binding domain found in S100, CaBP7/8 and similar proteins mainly from animals. It is a subfamily of the EF-hand calcium-binding domain []. S100s are small dimeric acidic calcium and zinc-binding proteins abundant in the brain, with S100B playing an important role in modulating the proliferation and differentiation of neurons and glia cells []. S100 proteins have two different types of calcium-binding sites: a low affinity one with a special structure, and a 'normal' EF-hand type high-affinity site.Protein S100-G from humans (formerly known as Calbindin-D9k) also belong to this family of proteins, but it does not form dimers. CaBP-9k is a cytosolic protein expressed in a variety of tissues. Although its precise function is unknown, it appears to be under the control of the steroid hormones oestrogen and progesterone in the female reproductive system []. In the intestine, this protein may be involved in calcium absorption by mediating intracellular diffusion [].Calcium-binding protein 8 from Rattus norvegicus (Rat) regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity. It may play a role in the physiology of neurons and is potentially important in memory and learning []. A number of these proteins are known to bind calcium while others are not. This entry represents the region of the EF-hand high affinity site but makes no assumptions on the calcium-binding properties of this site. |
|
•
•
•
•
•
|
Publication |
First Author: |
Chow KH |
Year: |
2017 |
Journal: |
Cancer Res |
Title: |
S100A4 Is a Biomarker and Regulator of Glioma Stem Cells That Is Critical for Mesenchymal Transition in Glioblastoma. |
Volume: |
77 |
Issue: |
19 |
Pages: |
5360-5373 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tanaka M |
Year: |
2008 |
Journal: |
Front Behav Neurosci |
Title: |
Lack of Connexin43-mediated bergmann glial gap junctional coupling does not affect cerebellar long-term depression, motor coordination, or eyeblink conditioning. |
Volume: |
2 |
|
Pages: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Friend WC |
Year: |
1992 |
Journal: |
J Neurosci |
Title: |
Cell-specific expression of high levels of human S100 beta in transgenic mouse brain is dependent on gene dosage. |
Volume: |
12 |
Issue: |
11 |
Pages: |
4337-46 |
|
•
•
•
•
•
|
Publication |
First Author: |
Han SB |
Year: |
2017 |
Journal: |
J Neurosci |
Title: |
Postinjury Induction of Activated ErbB2 Selectively Hyperactivates Denervated Schwann Cells and Promotes Robust Dorsal Root Axon Regeneration. |
Volume: |
37 |
Issue: |
45 |
Pages: |
10955-10970 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hayworth CR |
Year: |
2006 |
Journal: |
J Neurosci |
Title: |
Induction of neuregulin signaling in mouse schwann cells in vivo mimics responses to denervation. |
Volume: |
26 |
Issue: |
25 |
Pages: |
6873-84 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gao X |
Year: |
2008 |
Journal: |
Am J Physiol Heart Circ Physiol |
Title: |
AGE/RAGE produces endothelial dysfunction in coronary arterioles in type 2 diabetic mice. |
Volume: |
295 |
Issue: |
2 |
Pages: |
H491-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Meng L |
Year: |
2010 |
Journal: |
Am J Physiol Heart Circ Physiol |
Title: |
Diabetic conditions promote binding of monocytes to vascular smooth muscle cells and their subsequent differentiation. |
Volume: |
298 |
Issue: |
3 |
Pages: |
H736-45 |
|
•
•
•
•
•
|
Publication |
First Author: |
Petzold A |
Year: |
2005 |
Journal: |
J Neurochem |
Title: |
Amniotic fluid brain-specific proteins are biomarkers for spinal cord injury in experimental myelomeningocele. |
Volume: |
95 |
Issue: |
2 |
Pages: |
594-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Teramoto H |
Year: |
2023 |
Journal: |
Cells |
Title: |
Calcineurin B1 Deficiency Reduces Proliferation, Increases Apoptosis, and Alters Secretion in Enteric Glial Cells of Mouse Small Intestine in Culture. |
Volume: |
12 |
Issue: |
14 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marchese E |
Year: |
2017 |
Journal: |
Neurochem Res |
Title: |
Post-natal Deletion of Neuronal cAMP Responsive-Element Binding (CREB)-1 Promotes Pro-inflammatory Changes in the Mouse Hippocampus. |
Volume: |
42 |
Issue: |
8 |
Pages: |
2230-2245 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nowicka N |
Year: |
2022 |
Journal: |
Int J Mol Sci |
Title: |
The Involvement of RAGE and Its Ligands during Progression of ALS in SOD1 G93A Transgenic Mice. |
Volume: |
23 |
Issue: |
4 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hearst SM |
Year: |
2010 |
Journal: |
J Neurochem |
Title: |
Dopamine D2 receptor signaling modulates mutant ataxin-1 S776 phosphorylation and aggregation. |
Volume: |
114 |
Issue: |
3 |
Pages: |
706-16 |
|
•
•
•
•
•
|
Publication |
First Author: |
Belkind-Gerson J |
Year: |
2017 |
Journal: |
Sci Rep |
Title: |
Colitis promotes neuronal differentiation of Sox2+ and PLP1+ enteric cells. |
Volume: |
7 |
Issue: |
1 |
Pages: |
2525 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen M |
Year: |
2014 |
Journal: |
PLoS One |
Title: |
RAGE regulates immune cell infiltration and angiogenesis in choroidal neovascularization. |
Volume: |
9 |
Issue: |
2 |
Pages: |
e89548 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yeh CW |
Year: |
2015 |
Journal: |
Neurobiol Aging |
Title: |
Impaired cognition and cerebral glucose regulation are associated with astrocyte activation in the parenchyma of metabolically stressed APPswe/PS1dE9 mice. |
Volume: |
36 |
Issue: |
11 |
Pages: |
2984-2994 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu M |
Year: |
2023 |
Journal: |
J Comp Neurol |
Title: |
The effects of voluntary running exercise on the astrocytes of the medial prefrontal cortex in APP/PS1 mice. |
Volume: |
531 |
Issue: |
11 |
Pages: |
1147-1162 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hayashi A |
Year: |
2008 |
Journal: |
Exp Neurol |
Title: |
Treatment modality affects allograft-derived Schwann cell phenotype and myelinating capacity. |
Volume: |
212 |
Issue: |
2 |
Pages: |
324-36 |
|
•
•
•
•
•
|
Publication |
First Author: |
Créau N |
Year: |
2016 |
Journal: |
Brain Res |
Title: |
Specific age-related molecular alterations in the cerebellum of Down syndrome mouse models. |
Volume: |
1646 |
|
Pages: |
342-353 |
|
•
•
•
•
•
|
Publication |
First Author: |
Motoyoshi S |
Year: |
2014 |
Journal: |
Biochem J |
Title: |
cAMP ameliorates inflammation by modulation of macrophage receptor for advanced glycation end-products. |
Volume: |
463 |
Issue: |
1 |
Pages: |
75-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rubio T |
Year: |
2023 |
Journal: |
Neurobiol Dis |
Title: |
TNF and IL6/Jak2 signaling pathways are the main contributors of the glia-derived neuroinflammation present in Lafora disease, a fatal form of progressive myoclonus epilepsy. |
Volume: |
176 |
|
Pages: |
105964 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kazlauckas V |
Year: |
2011 |
Journal: |
Behav Brain Res |
Title: |
Distinctive effects of unpredictable subchronic stress on memory, serum corticosterone and hippocampal BDNF levels in high and low exploratory mice. |
Volume: |
218 |
Issue: |
1 |
Pages: |
80-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Singh VB |
Year: |
2017 |
Journal: |
Sci Rep |
Title: |
Sonic Hedgehog mimetic prevents leukocyte infiltration into the CNS during acute HIV infection. |
Volume: |
7 |
Issue: |
1 |
Pages: |
9578 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gomez-Lopez N |
Year: |
2019 |
Journal: |
Biol Reprod |
Title: |
Inhibition of the NLRP3 inflammasome can prevent sterile intra-amniotic inflammation, preterm labor/birth, and adverse neonatal outcomes†. |
Volume: |
100 |
Issue: |
5 |
Pages: |
1306-1318 |
|
•
•
•
•
•
|
Publication |
First Author: |
Daneshvar N |
Year: |
2020 |
Journal: |
Am J Physiol Cell Physiol |
Title: |
Premature satellite cell activation before injury accelerates myogenesis and disrupts neuromuscular junction maturation in regenerating muscle. |
Volume: |
319 |
Issue: |
1 |
Pages: |
C116-C128 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
113
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
113
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
104
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
63
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
92
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
104
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
72
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Tanaka M |
Year: |
2008 |
Journal: |
Front Neurosci |
Title: |
Connexin43 and bergmann glial gap junctions in cerebellar function. |
Volume: |
2 |
Issue: |
2 |
Pages: |
225-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim YY |
Year: |
2020 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Hearing loss through apoptosis of the spiral ganglion neurons in apolipoprotein E knockout mice fed with a western diet. |
Volume: |
523 |
Issue: |
3 |
Pages: |
692-698 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huang SH |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
Circulating brain microvascular endothelial cells (cBMECs) as potential biomarkers of the blood-brain barrier disorders caused by microbial and non-microbial factors. |
Volume: |
8 |
Issue: |
4 |
Pages: |
e62164 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gomes C |
Year: |
2019 |
Journal: |
Mol Neurobiol |
Title: |
Cortical Neurotoxic Astrocytes with Early ALS Pathology and miR-146a Deficit Replicate Gliosis Markers of Symptomatic SOD1G93A Mouse Model. |
Volume: |
56 |
Issue: |
3 |
Pages: |
2137-2158 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cunha C |
Year: |
2018 |
Journal: |
Mol Neurobiol |
Title: |
Downregulated Glia Interplay and Increased miRNA-155 as Promising Markers to Track ALS at an Early Stage. |
Volume: |
55 |
Issue: |
5 |
Pages: |
4207-4224 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nowicka N |
Year: |
2024 |
Journal: |
PLoS One |
Title: |
Novel insights into RAGE signaling pathways during the progression of amyotrophic lateral sclerosis in RAGE-deficient SOD1 G93A mice. |
Volume: |
19 |
Issue: |
3 |
Pages: |
e0299567 |
|
•
•
•
•
•
|
Publication |
First Author: |
Brown TG |
Year: |
2023 |
Journal: |
Front Cell Neurosci |
Title: |
Striatal spatial heterogeneity, clustering, and white matter association of GFAP(+) astrocytes in a mouse model of Huntington's disease. |
Volume: |
17 |
|
Pages: |
1094503 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ahmed MM |
Year: |
2013 |
Journal: |
Hum Mol Genet |
Title: |
Protein profiles in Tc1 mice implicate novel pathway perturbations in the Down syndrome brain. |
Volume: |
22 |
Issue: |
9 |
Pages: |
1709-24 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
92
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
92
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
98
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
64
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
98
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
117
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
160
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Nakazato R |
Year: |
2017 |
Journal: |
J Neurosci |
Title: |
Disruption of Bmal1 Impairs Blood-Brain Barrier Integrity via Pericyte Dysfunction. |
Volume: |
37 |
Issue: |
42 |
Pages: |
10052-10062 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kraus C |
Year: |
2009 |
Journal: |
J Mol Cell Cardiol |
Title: |
S100A1 in cardiovascular health and disease: closing the gap between basic science and clinical therapy. |
Volume: |
47 |
Issue: |
4 |
Pages: |
445-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Belmokhtar K |
Year: |
2016 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Signaling of Serum Amyloid A Through Receptor for Advanced Glycation End Products as a Possible Mechanism for Uremia-Related Atherosclerosis. |
Volume: |
36 |
Issue: |
5 |
Pages: |
800-9 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
94
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
97
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
89
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
101
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
98
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
89
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
99
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
94
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
79
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
101
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
94
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
97
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
147
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
97
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Fourgeaud L |
Year: |
2016 |
Journal: |
Nature |
Title: |
TAM receptors regulate multiple features of microglial physiology. |
Volume: |
532 |
Issue: |
7598 |
Pages: |
240-244 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2362
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2496
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1118
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
93
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
79
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
101
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
89
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
101
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
79
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
89
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2336
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
872
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
93
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
357
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
554
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
261
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
3411
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1920
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
148
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
3234
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
80
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
357
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
261
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
215
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
108
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
124
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
638
 |
Fragment?: |
false |
|
•
•
•
•
•
|