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Search results 801 to 900 out of 1337 for Skp1

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Type Details Score
Publication
12504026 | -
First Author: Zheng J
Year: 2002
Journal: Mol Cell
Title: CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex.
Volume: 10
Issue: 6
Pages: 1519-26
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Publication
12504025 | -
First Author: Liu J
Year: 2002
Journal: Mol Cell
Title: NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases.
Volume: 10
Issue: 6
Pages: 1511-8
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Publication
12609982 | -
First Author: Min KW
Year: 2003
Journal: J Biol Chem
Title: TIP120A associates with cullins and modulates ubiquitin ligase activity.
Volume: 278
Issue: 18
Pages: 15905-10
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Publication
16449638 | -
First Author: Lo SC
Year: 2006
Journal: Mol Cell Biol
Title: CAND1-mediated substrate adaptor recycling is required for efficient repression of Nrf2 by Keap1.
Volume: 26
Issue: 4
Pages: 1235-44
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Publication
23453757 | -
First Author: Pierce NW
Year: 2013
Journal: Cell
Title: Cand1 promotes assembly of new SCF complexes through dynamic exchange of F box proteins.
Volume: 153
Issue: 1
Pages: 206-15
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Protein Domain
IPR039852 | CAND1/CAND2
Type: Family
Description: This entry includes cullin-associated NEDD8-dissociated proteins 1 (CAND1 also known as TIP120A) and 2 (CAND2); these proteins have a C-terminal TATA-binding protein interacting (TIP20) domain. CAND1 is required for the assembly of the SCF E3 ubiquitin ligase complex. The SCF ubiquitin E3 ligase consists of SKP1, CUL1 and F-box protein, and it regulates ubiquitin-dependent proteolysis. CAND1 binds to CUL1, preventing it from associating with the other components that form the ligase. Neddylation of CUL1 (or the presence of SKP1 and ATP) dissociates it from CAND1, allowing the ligase complex to form [, , ]. CAND1 also interacts with CUL3, a component of the Cul3-dependent E3 ubiquitin ligase complex []. CAND1 has been proposed to be an F-box protein exchange factor, and as substrates of the ligase complex are degraded by the proteasome and depleted, the ligase complex enters an intermediate, deneddylated state when CAND1 can bind, promoting dissociation of the substrate-recognition subunit and recruitment of a new substrate-recognition subunit []. CAND2 is uncharacterized but is assumed to have similar roles to CAND1.
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Protein Coding Gene
MGI:1923089 | Daw1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1270839 | Cacybp
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1913447 | Cks2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1913765 | Cul7
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1918995 | Cul2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1354743 | Fbxo6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1918426 | Fbxo24
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1922246 | Usp47
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1922967 | Cul5
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1344363 | Arih1
Type: protein_coding_gene
Organism: mouse, laboratory
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Pseudogene
MGI:3710517 | Rbx1-ps
Type: pseudogene
Organism: mouse, laboratory
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Protein
L7N1X6
Organism: Mus musculus/domesticus
Length: 466  
Fragment?: false
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Protein
Q9D417
Organism: Mus musculus/domesticus
Length: 589  
Fragment?: false
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Protein
Q6NXM2
Organism: Mus musculus/domesticus
Length: 531  
Fragment?: false
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Protein
Q99LJ7
Organism: Mus musculus/domesticus
Length: 551  
Fragment?: false
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Protein
Q8K0E1
Organism: Mus musculus/domesticus
Length: 283  
Fragment?: false
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Protein
Q3URF8
Organism: Mus musculus/domesticus
Length: 260  
Fragment?: false
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Protein
Q9QZN3
Organism: Mus musculus/domesticus
Length: 319  
Fragment?: false
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Protein
Q8BK06
Organism: Mus musculus/domesticus
Length: 437  
Fragment?: false
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Protein
Q920G9
Organism: Mus musculus/domesticus
Length: 524  
Fragment?: false
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Protein
Q68FF0
Organism: Mus musculus/domesticus
Length: 718  
Fragment?: false
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Protein
Q7TSZ8
Organism: Mus musculus/domesticus
Length: 514  
Fragment?: false
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Protein
Q9DCM7
Organism: Mus musculus/domesticus
Length: 586  
Fragment?: false
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Protein
F7C9P2
Organism: Mus musculus/domesticus
Length: 466  
Fragment?: false
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Protein
A0A338P6Y5
Organism: Mus musculus/domesticus
Length: 529  
Fragment?: true
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Protein
A0A0U1RNK3
Organism: Mus musculus/domesticus
Length: 93  
Fragment?: true
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Protein
Q497Z0
Organism: Mus musculus/domesticus
Length: 464  
Fragment?: false
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Protein
Q5XG67
Organism: Mus musculus/domesticus
Length: 466  
Fragment?: false
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Protein
Q3UWS5
Organism: Mus musculus/domesticus
Length: 432  
Fragment?: false
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Protein
Q8C2Y5
Organism: Mus musculus/domesticus
Length: 466  
Fragment?: false
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Protein
Q8BI58
Organism: Mus musculus/domesticus
Length: 466  
Fragment?: false
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Protein
B2RTJ2
Organism: Mus musculus/domesticus
Length: 260  
Fragment?: false
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Protein
Q3UPQ4
Organism: Mus musculus/domesticus
Length: 453  
Fragment?: false
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Protein
E9Q3B1
Organism: Mus musculus/domesticus
Length: 517  
Fragment?: false
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Protein
Q3UID6
Organism: Mus musculus/domesticus
Length: 524  
Fragment?: false
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Protein
A0A494B9Q1
Organism: Mus musculus/domesticus
Length: 435  
Fragment?: false
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Protein
D3Z7N9
Organism: Mus musculus/domesticus
Length: 122  
Fragment?: true
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Protein
Q8BP70
Organism: Mus musculus/domesticus
Length: 319  
Fragment?: false
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Protein
O89076
Organism: Mus musculus/domesticus
Length: 137  
Fragment?: true
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Protein
A0A1D5RLF0
Organism: Mus musculus/domesticus
Length: 466  
Fragment?: false
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Protein
A0A494B989
Organism: Mus musculus/domesticus
Length: 385  
Fragment?: false
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Protein
A0A5K1VVR8
Organism: Mus musculus/domesticus
Length: 271  
Fragment?: false
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Protein
B9EHJ2
Organism: Mus musculus/domesticus
Length: 466  
Fragment?: false
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Protein
D3YZH5
Organism: Mus musculus/domesticus
Length: 114  
Fragment?: true
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Protein
A0A338P6N7
Organism: Mus musculus/domesticus
Length: 223  
Fragment?: true
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Protein
Q8BTL0
Organism: Mus musculus/domesticus
Length: 391  
Fragment?: false
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Protein
A0A0G2JET0
Organism: Mus musculus/domesticus
Length: 250  
Fragment?: true
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Protein
Q3UXB1
Organism: Mus musculus/domesticus
Length: 466  
Fragment?: false
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Protein
Q8C2V5
Organism: Mus musculus/domesticus
Length: 385  
Fragment?: false
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Protein
A0A2I3BQ98
Organism: Mus musculus/domesticus
Length: 486  
Fragment?: false
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Protein
Q3U2J9
Organism: Mus musculus/domesticus
Length: 523  
Fragment?: false
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Protein
Q8CD22
Organism: Mus musculus/domesticus
Length: 278  
Fragment?: false
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Protein
Q3UXA1
Organism: Mus musculus/domesticus
Length: 432  
Fragment?: false
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Protein
A0A494B9P6
Organism: Mus musculus/domesticus
Length: 165  
Fragment?: true
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Protein
Q3TS95
Organism: Mus musculus/domesticus
Length: 285  
Fragment?: true
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Protein
M0QWF3
Organism: Mus musculus/domesticus
Length: 713  
Fragment?: false
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Protein
E9Q8A4
Organism: Mus musculus/domesticus
Length: 466  
Fragment?: false
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Protein
E9PXM9
Organism: Mus musculus/domesticus
Length: 466  
Fragment?: false
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Protein
Q571I1
Organism: Mus musculus/domesticus
Length: 229  
Fragment?: true
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Protein
D3Z2R6
Organism: Mus musculus/domesticus
Length: 117  
Fragment?: true
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Protein
Q8BRL1
Organism: Mus musculus/domesticus
Length: 626  
Fragment?: true
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Protein
A2AAX0
Organism: Mus musculus/domesticus
Length: 106  
Fragment?: true
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Protein
E9QJW1
Organism: Mus musculus/domesticus
Length: 640  
Fragment?: false
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Protein
A0A804C8S8
Organism: Mus musculus/domesticus
Length: 222  
Fragment?: false
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Protein
A0A338P6H1
Organism: Mus musculus/domesticus
Length: 136  
Fragment?: true
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Protein
A0A0R4J025
Organism: Mus musculus/domesticus
Length: 531  
Fragment?: false
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Protein
Q5U467
Organism: Mus musculus/domesticus
Length: 468  
Fragment?: false
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Protein
Q8BI38
Organism: Mus musculus/domesticus
Length: 468  
Fragment?: false
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Protein
Q6P3C9
Organism: Mus musculus/domesticus
Length: 270  
Fragment?: false
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Protein
Q66JY5
Organism: Mus musculus/domesticus
Length: 466  
Fragment?: false
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Protein
Q8BI57
Organism: Mus musculus/domesticus
Length: 466  
Fragment?: false
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Protein Coding Gene
MGI:1891829 | Rbx1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1917004 | Fbxo7
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2144023 | Fbxw11
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2146220 | Fbxo4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1351663 | Skp2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2447775 | Fbxo45
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:102551 | Ccnf
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1338871 | Btrc
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1354699 | Fbh1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2446216 | Fbxo2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1349658 | Cul1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1891698 | Pnkp
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:108064 | Siah1a
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
G3X9C2
Organism: Mus musculus/domesticus
Length: 266  
Fragment?: false
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Protein
A0A0A0MQ97
Organism: Mus musculus/domesticus
Length: 291  
Fragment?: false
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Protein
A0A1D5RMD3
Organism: Mus musculus/domesticus
Length: 254  
Fragment?: true
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Protein
F6UI76
Organism: Mus musculus/domesticus
Length: 144  
Fragment?: true
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Protein
Q9CSM7
Organism: Mus musculus/domesticus
Length: 66  
Fragment?: false
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Protein
Q3TEI7
Organism: Mus musculus/domesticus
Length: 156  
Fragment?: false
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Protein
Q8K3B1
Organism: Mus musculus/domesticus
Length: 286  
Fragment?: false
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Protein
Q7TQF2
Organism: Mus musculus/domesticus
Length: 950  
Fragment?: false
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Protein
P97302
Organism: Mus musculus/domesticus
Length: 739  
Fragment?: false
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Protein
P97303
Organism: Mus musculus/domesticus
Length: 839  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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Cambridge CB2 3EH, United Kingdom