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Search results 801 to 900 out of 1010 for Stat5a

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Type Details Score
Publication
37550517 | J:340839
First Author: Grockowiak E
Year: 2023
Journal: Nat Cancer
Title: Different niches for stem cells carrying the same oncogenic driver affect pathogenesis and therapy response in myeloproliferative neoplasms.
Volume: 4
Issue: 8
Pages: 1193-1209
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Publication
38658806 | J:349464
First Author: Fortelny N
Year: 2024
Journal: Nat Immunol
Title: JAK-STAT signaling maintains homeostasis in T cells and macrophages.
Volume: 25
Issue: 5
Pages: 847-859
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Publication
28096407 | J:240744
First Author: Ogasawara T
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Development of chronic allergic responses by dampening Bcl6-mediated suppressor activity in memory T helper 2 cells.
Volume: 114
Issue: 5
Pages: E741-E750
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Publication
27748374 | J:241037
First Author: Clarke M
Year: 2017
Journal: Leukemia
Title: Transcriptional regulation of SPROUTY2 by MYB influences myeloid cell proliferation and stem cell properties by enhancing responsiveness to IL-3.
Volume: 31
Issue: 4
Pages: 957-966
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Publication
27131881 | J:235014
First Author: Legrand JM
Year: 2016
Journal: J Invest Dermatol
Title: STAT5 Activation in the Dermal Papilla Is Important for Hair Follicle Growth Phase Induction.
Volume: 136
Issue: 9
Pages: 1781-91
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Publication
18694996 | J:142128
First Author: Kerenyi MA
Year: 2008
Journal: Blood
Title: Stat5 regulates cellular iron uptake of erythroid cells via IRP-2 and TfR-1.
Volume: 112
Issue: 9
Pages: 3878-88
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Publication
15713743 | J:96524
First Author: Bengtsson T
Year: 2005
Journal: J Cell Sci
Title: Loss of alpha10beta1 integrin expression leads to moderate dysfunction of growth plate chondrocytes.
Volume: 118
Issue: Pt 5
Pages: 929-36
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Publication
10781830 | J:62318
First Author: Imada K
Year: 2000
Journal: Mol Immunol
Title: The Jak-STAT pathway.
Volume: 37
Issue: 1-2
Pages: 1-11
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Publication
10200816 | J:53840
First Author: Brown MP
Year: 1999
Journal: Aust N Z J Med
Title: Cytokines, Jaks, Stats, health and disease.
Volume: 29
Issue: 1
Pages: 73-8
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Publication
18499741 | J:138429
First Author: Jin H
Year: 2008
Journal: Mol Endocrinol
Title: JAK2, but not Src family kinases, is required for STAT, ERK, and Akt signaling in response to growth hormone in preadipocytes and hepatoma cells.
Volume: 22
Issue: 8
Pages: 1825-41
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Publication
19734904 | J:152783
First Author: Mandal M
Year: 2009
Journal: Nat Immunol
Title: Ras orchestrates exit from the cell cycle and light-chain recombination during early B cell development.
Volume: 10
Issue: 10
Pages: 1110-7
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Publication
17981124 | J:141453
First Author: Cheng J
Year: 2007
Journal: Cell
Title: SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia.
Volume: 131
Issue: 3
Pages: 584-95
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Publication
26426795 | J:233774
First Author: Mathieu C
Year: 2015
Journal: Eur J Immunol
Title: IL-2 and IL-15 regulate CD8+ memory T-cell differentiation but are dispensable for protective recall responses.
Volume: 45
Issue: 12
Pages: 3324-38
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Publication
28713870 | J:361201
 
First Author: Poholek AC
Year: 2016
Journal: Sci Immunol
Title: IL-10 induces a STAT3-dependent autoregulatory loop in T(H)2 cells that promotes Blimp-1 restriction of cell expansion via antagonism of STAT5 target genes.
Volume: 1
Issue: 5
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Publication
22588720 | J:184505
First Author: Oliver CH
Year: 2012
Journal: Genes Dev
Title: The Stat6-regulated KRAB domain zinc finger protein Zfp157 regulates the balance of lineages in mammary glands and compensates for loss of Gata-3.
Volume: 26
Issue: 10
Pages: 1086-97
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Publication
27578791 | J:237343
First Author: Laresgoiti U
Year: 2016
Journal: Development
Title: Lung epithelial tip progenitors integrate glucocorticoid- and STAT3-mediated signals to control progeny fate.
Volume: 143
Issue: 20
Pages: 3686-3699
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Publication
24749073 | J:309675
First Author: Elias S
Year: 2014
Journal: Stem Cell Reports
Title: Huntingtin regulates mammary stem cell division and differentiation.
Volume: 2
Issue: 4
Pages: 491-506
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Publication
12753872 | J:83831
First Author: Masinde GL
Year: 2003
Journal: Bone
Title: Quantitative trait loci for periosteal circumference (PC): identification of single loci and epistatic effects in F2 MRL/SJL mice.
Volume: 32
Issue: 5
Pages: 554-60
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Publication
17244351 | J:123131
First Author: Yu X
Year: 2007
Journal: Arthritis Res Ther
Title: Combining global genome and transcriptome approaches to identify the candidate genes of small-effect quantitative trait loci in collagen-induced arthritis.
Volume: 9
Issue: 1
Pages: R3
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Publication
36206490 | J:333323
First Author: Chen H
Year: 2023
Journal: Blood
Title: PRL2 phosphatase enhances oncogenic FLT3 signaling via dephosphorylation of the E3 ubiquitin ligase CBL at tyrosine 371.
Volume: 141
Issue: 3
Pages: 244-259
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Publication
29581031 | J:260356
 
First Author: Aiello FB
Year: 2018
Journal: Cell Signal
Title: IL-7-induced phosphorylation of the adaptor Crk-like and other targets.
Volume: 47
Pages: 131-141
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Publication
19666510 | J:151963
First Author: Guo L
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells.
Volume: 106
Issue: 32
Pages: 13463-8
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Publication
11013085 | J:65084
First Author: Pershouse M
Year: 2000
Journal: Genomics
Title: BAC contig from a 3-cM region of mouse chromosome 11 surrounding Brca1.
Volume: 69
Issue: 1
Pages: 139-42
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Publication
8530075 | J:28833
First Author: Copeland NG
Year: 1995
Journal: Genomics
Title: Distribution of the mammalian Stat gene family in mouse chromosomes.
Volume: 29
Issue: 1
Pages: 225-8
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Publication
32428860 | J:336999
First Author: Riedelberger M
Year: 2020
Journal: iScience
Title: Type I Interferons Ameliorate Zinc Intoxication of Candida glabrata by Macrophages and Promote Fungal Immune Evasion.
Volume: 23
Issue: 5
Pages: 101121
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Publication
32075740 | J:349194
First Author: Riedelberger M
Year: 2020
Journal: Cell Host Microbe
Title: Type I Interferon Response Dysregulates Host Iron Homeostasis and Enhances Candida glabrata Infection.
Volume: 27
Issue: 3
Pages: 454-466.e8
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Publication
21041952 | J:171873
First Author: Chen PC
Year: 2010
Journal: J Clin Invest
Title: Activation of multiple signaling pathways causes developmental defects in mice with a Noonan syndrome–associated Sos1 mutation.
Volume: 120
Issue: 12
Pages: 4353-65
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Publication
34564702 | J:312485
First Author: Zhang Q
Year: 2021
Journal: Cell Death Dis
Title: Satb2 regulates the development of dopaminergic neurons in the arcuate nucleus by Dlx1.
Volume: 12
Issue: 10
Pages: 879
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Publication
28067668 | J:239830
First Author: Hirai M
Year: 2017
Journal: J Clin Invest
Title: Adaptor proteins NUMB and NUMBL promote cell cycle withdrawal by targeting ERBB2 for degradation.
Volume: 127
Issue: 2
Pages: 569-582
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Publication
31806625 | J:284574
First Author: Moon JH
Year: 2020
Journal: Diabetes
Title: Serotonin Regulates Adult β-Cell Mass by Stimulating Perinatal β-Cell Proliferation.
Volume: 69
Issue: 2
Pages: 205-214
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Publication
30081710 | J:306954
First Author: Zecchini S
Year: 2019
Journal: Autophagy
Title: Autophagy controls neonatal myogenesis by regulating the GH-IGF1 system through a NFE2L2- and DDIT3-mediated mechanism.
Volume: 15
Issue: 1
Pages: 58-77
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Publication
14522949 | J:85994
First Author: Aszodi A
Year: 2003
Journal: Genes Dev
Title: Beta1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis.
Volume: 17
Issue: 19
Pages: 2465-79
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Publication
21525287 | J:171421
First Author: VanDunk C
Year: 2011
Journal: J Neurosci
Title: Development, maturation, and necessity of transcription factors in the mouse suprachiasmatic nucleus.
Volume: 31
Issue: 17
Pages: 6457-67
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Publication
37813816 | J:358134
First Author: Soma S
Year: 2024
Journal: Stem Cells
Title: O-Linked N-Acetylglucosamine Transferase Ensures Survival of Mouse Fetal Liver Hematopoietic Progenitors Partly by Regulating Bcl-xL and Oxidative Phosphorylation.
Volume: 42
Issue: 1
Pages: 55-63
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Publication
26764350 | J:232444
First Author: Li S
Year: 2016
Journal: Biol Reprod
Title: Ggnbp2 Is Essential for Pregnancy Success via Regulation of Mouse Trophoblast Stem Cell Proliferation and Differentiation.
Volume: 94
Issue: 2
Pages: 41
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
21731673 | J:174767
First Author: Tang F
Year: 2011
Journal: PLoS One
Title: Deterministic and stochastic allele specific gene expression in single mouse blastomeres.
Volume: 6
Issue: 6
Pages: e21208
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Publication
- | J:46439
     
First Author: Freeman TC
Year: 1998
Journal: MGI Direct Data Submission
Title: Expression Mapping of Mouse Genes
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Publication
22988430 | J:190636
 
First Author: Wiese CB
Year: 2012
Journal: Front Neurosci
Title: A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.
Volume: 6
Pages: 130
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Publication
20412781 | J:140465
First Author: Guo G
Year: 2010
Journal: Dev Cell
Title: Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.
Volume: 18
Issue: 4
Pages: 675-85
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Publication
20059953 | J:156017
First Author: Yokoyama S
Year: 2009
Journal: Dev Cell
Title: A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Volume: 17
Issue: 6
Pages: 836-48
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Publication
15618518 | J:91257
First Author: Gray PA
Year: 2004
Journal: Science
Title: Mouse brain organization revealed through direct genome-scale TF expression analysis.
Volume: 306
Issue: 5705
Pages: 2255-7
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Publication
24952961 | J:215487
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
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Publication
14681479 | J:122989
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
11133982 | J:113883
First Author: Gowri PM
Year: 2001
Journal: J Biol Chem
Title: Conversion of threonine 757 to valine enhances Stat5a transactivation potential.
Volume: 276
Issue: 13
Pages: 10485-91
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Publication
31123029 | J:358408
First Author: Maurer B
Year: 2020
Journal: Haematologica
Title: High activation of STAT5A drives peripheral T-cell lymphoma and leukemia.
Volume: 105
Issue: 2
Pages: 435-447
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HT Experiment
E-GEOD-17723 | Development of mammary luminal progenitor cells is controlled by the transcription factor STAT5A
Series Id: GSE17723
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
9689910 | J:48462
First Author: Schröder P
Year: 1998
Journal: Biochim Biophys Acta
Title: Cloning and sequencing of the bovine STAT5A cDNA reveals significant sequence divergence with ovine.
Volume: 1398
Issue: 2
Pages: 99-105
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Publication
18347089 | J:138503
First Author: Hennighausen L
Year: 2008
Journal: Genes Dev
Title: Interpretation of cytokine signaling through the transcription factors STAT5A and STAT5B.
Volume: 22
Issue: 6
Pages: 711-21
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Publication
27018255 | J:259640
First Author: Tsuruyama T
Year: 2016
Journal: J Cell Biochem
Title: STAT5A Modulates Chemokine Receptor CCR6 Expression and Enhances Pre-B Cell Growth in a CCL20-Dependent Manner.
Volume: 117
Issue: 11
Pages: 2630-42
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Publication
16192273 | -
First Author: Neculai D
Year: 2005
Journal: J Biol Chem
Title: Structure of the unphosphorylated STAT5a dimer.
Volume: 280
Issue: 49
Pages: 40782-7
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Publication
9742102 | J:50035
First Author: Verdier F
Year: 1998
Journal: Mol Cell Biol
Title: A sequence of the CIS gene promoter interacts preferentially with two associated STAT5A dimers: a distinct biochemical difference between STAT5A and STAT5B.
Volume: 18
Issue: 10
Pages: 5852-60
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Interaction Experiment
Chen Y (2006)
Description: Proteasome-dependent down-regulation of activated Stat5A in the nucleus.
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Interaction Experiment
Wang Y (2004)
Description: ERalpha and STAT5a cross-talk: interaction through C-terminal portions of the proteins decreases STAT5a phosphorylation, nuclear translocation and DNA-binding.
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Interaction Experiment
Chan CB (2010)
Description: PIKE-A is required for prolactin-mediated STAT5a activation in mammary gland development.
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Publication
15863494 | -
First Author: Clark DE
Year: 2005
Journal: J Biol Chem
Title: ERBB4/HER4 potentiates STAT5A transcriptional activity by regulating novel STAT5A serine phosphorylation events.
Volume: 280
Issue: 25
Pages: 24175-80
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Allele
Stat5a<em1Smoc> | MGI:7292611
Name: signal transducer and activator of transcription 5A; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Publication
9528750 | -
First Author: Cella N
Year: 1998
Journal: Mol Cell Biol
Title: Characterization of Stat5a and Stat5b homodimers and heterodimers and their association with the glucocortiocoid receptor in mammary cells.
Volume: 18
Issue: 4
Pages: 1783-92
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Publication
15304355 | -
First Author: Wang Y
Year: 2004
Journal: FEBS Lett
Title: ERalpha and STAT5a cross-talk: interaction through C-terminal portions of the proteins decreases STAT5a phosphorylation, nuclear translocation and DNA-binding.
Volume: 572
Issue: 1-3
Pages: 238-44
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Strain
MGI:6355225 | C57BL/6JSmoc-Stat5a<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Allele
Tg(BLG-STAT5A)6Itb | MGI:2447716
Name: transgene insertion 6, Itamar Barash
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Genotype
Genotype
Symbol: Tg(BLG-STAT5A)6Itb/?
Background: involves: FVB/N
Zygosity: ot
Has Mutant Allele: true
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Allele
Tg(BLG-STAT5A)15Itb | MGI:2447712
Name: transgene insertion 15, Itamar Barash
Allele Type: Transgenic
Attribute String: Constitutively active, Inserted expressed sequence
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Allele
Stat5b<tm2Jni> | MGI:3577898
Name: signal transducer and activator of transcription 5B; targeted mutation 2, James N Ihle
Allele Type: Targeted
Attribute String: Null/knockout
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Publication
18811984 | J:143092
 
First Author: Eilon T
Year: 2008
Journal: BMC Cancer
Title: Different gene-expression profiles for the poorly differentiated carcinoma and the highly differentiated papillary adenocarcinoma in mammary glands support distinct metabolic pathways.
Volume: 8
Pages: 270
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Publication
19450255 | J:149668
 
First Author: Eilon T
Year: 2009
Journal: BMC Genomics
Title: Distinct gene-expression profiles characterize mammary tumors developed in transgenic mice expressing constitutively active and C-terminally truncated variants of STAT5.
Volume: 10
Pages: 231
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Genotype
Genotype
Symbol: Tg(BLG-STAT5A)15Itb/?
Background: involves: FVB/N
Zygosity: ot
Has Mutant Allele: true
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Publication
21276004 | -
 
First Author: Heltemes-Harris LM
Year: 2011
Journal: Ann N Y Acad Sci
Title: The role of STAT5 in the development, function, and transformation of B and T lymphocytes.
Volume: 1217
Pages: 18-31
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Protein Domain
IPR035886 | STAT5b_SH2
Type: Domain
Description: This entry represents the SH2 domain of STAT5b.STAT5 is a member of the STAT family of transcription factors. Two highly related proteins, STAT5a and STAT5b are encoded by separate genes, but are 90% identical at the amino acid level. Both STAT5a and STAT5b are ubiquitously expressed and functionally interchangeable. They regulate B and T cell development [, ].STAT proteins have a dual function: signal transduction and activation of transcription. When cytokines are bound to cell surface receptors, the associated Janus kinases (JAKs) are activated, leading to tyrosine phosphorylation of the given STAT proteins []. Phosphorylated STATs form dimers, translocate to the nucleus, and bind specific response elements to activate transcription of target genes []. STAT proteins contain an N-terminal domain (NTD), a coiled-coil domain (CCD), a DNA-binding domain (DBD), an α-helical linker domain (LD), an SH2 domain, and a transactivation domain (TAD). The SH2 domain is necessary for receptor association and tyrosine phosphodimer formation. There are seven mammalian STAT family members which have been identified: STAT1, STAT2, STAT3, STAT4, STAT5 (STAT5A and STAT5B), and STAT6 [].
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Protein Domain
IPR035858 | STAT5a/5b
Type: Family
Description: STAT5 is a member of the STAT family of transcription factors. Two highly related proteins, STAT5a and STAT5b are encoded by separate genes, but are 90% identical at the amino acid level. Both STAT5a and STAT5b are ubiquitously expressed and functionally interchangeable. They regulate B and T cell development [, ].STAT proteins have a dual function: signal transduction and activation of transcription. When cytokines are bound to cell surface receptors, the associated Janus kinases (JAKs) are activated, leading to tyrosine phosphorylation of the given STAT proteins []. Phosphorylated STATs form dimers, translocate to the nucleus, and bind specific response elements to activate transcription of target genes []. STAT proteins contain an N-terminal domain (NTD), a coiled-coil domain (CCD), a DNA-binding domain (DBD), an α-helical linker domain (LD), an SH2 domain, and a transactivation domain (TAD). The SH2 domain is necessary for receptor association and tyrosine phosphodimer formation. There are seven mammalian STAT family members which have been identified: STAT1, STAT2, STAT3, STAT4, STAT5 (STAT5A and STAT5B), and STAT6 [].
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Publication
14662332 | J:115667
First Author: Snow JW
Year: 2003
Journal: Exp Hematol
Title: Transgenic bcl-2 is not sufficient to rescue all hematolymphoid defects in STAT5A/5B-deficient mice.
Volume: 31
Issue: 12
Pages: 1253-8
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Genotype
Genotype
Symbol: Stat5a/Stat5a Stat5b/Stat5b
Background: either: (involves: 129P2/OlaHsd) or (involves: 129X1/SvJ)
Zygosity: cx
Has Mutant Allele: true
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