Type |
Details |
Score |
Publication |
First Author: |
Riedelberger M |
Year: |
2020 |
Journal: |
iScience |
Title: |
Type I Interferons Ameliorate Zinc Intoxication of Candida glabrata by Macrophages and Promote Fungal Immune Evasion. |
Volume: |
23 |
Issue: |
5 |
Pages: |
101121 |
|
•
•
•
•
•
|
Publication |
First Author: |
Riedelberger M |
Year: |
2020 |
Journal: |
Cell Host Microbe |
Title: |
Type I Interferon Response Dysregulates Host Iron Homeostasis and Enhances Candida glabrata Infection. |
Volume: |
27 |
Issue: |
3 |
Pages: |
454-466.e8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang D |
Year: |
2020 |
Journal: |
Adv Sci (Weinh) |
Title: |
Deficiency of STING Signaling in Embryonic Cerebral Cortex Leads to Neurogenic Abnormalities and Autistic-Like Behaviors. |
Volume: |
7 |
Issue: |
23 |
Pages: |
2002117 |
|
•
•
•
•
•
|
Publication |
First Author: |
Motomura Y |
Year: |
2011 |
Journal: |
Nat Immunol |
Title: |
The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells. |
Volume: |
12 |
Issue: |
5 |
Pages: |
450-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li S |
Year: |
2012 |
Journal: |
Development |
Title: |
Foxp1/4 control epithelial cell fate during lung development and regeneration through regulation of anterior gradient 2. |
Volume: |
139 |
Issue: |
14 |
Pages: |
2500-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
GO Annotation working group |
Year: |
2023 |
|
Title: |
Manual annotations that require more than one source of functional data to support the assignment of the associated GO term |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Lei Z |
Year: |
2022 |
Journal: |
Front Immunol |
Title: |
EpCAM Is Essential to Maintaining the Immune Homeostasis of Intestines via Keeping the Expression of pIgR in the Intestinal Epithelium of Mice. |
Volume: |
13 |
|
Pages: |
843378 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li S |
Year: |
2016 |
Journal: |
Biol Reprod |
Title: |
Ggnbp2 Is Essential for Pregnancy Success via Regulation of Mouse Trophoblast Stem Cell Proliferation and Differentiation. |
Volume: |
94 |
Issue: |
2 |
Pages: |
41 |
|
•
•
•
•
•
|
Publication |
First Author: |
MouseBookTM |
Year: |
2005 |
Journal: |
Unpublished |
Title: |
Information obtained from MouseBookTM, Medical Research Council Mammalian Genetics Unit, Harwell, UK. |
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|
|
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•
•
•
•
•
|
Publication |
First Author: |
Taher L |
Year: |
2011 |
Journal: |
PLoS One |
Title: |
Global gene expression analysis of murine limb development. |
Volume: |
6 |
Issue: |
12 |
Pages: |
e28358 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li J |
Year: |
2018 |
Journal: |
Database (Oxford) |
Title: |
CITGeneDB: a comprehensive database of human and mouse genes enhancing or suppressing cold-induced thermogenesis validated by perturbation experiments in mice. |
Volume: |
2018 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Tang F |
Year: |
2011 |
Journal: |
PLoS One |
Title: |
Deterministic and stochastic allele specific gene expression in single mouse blastomeres. |
Volume: |
6 |
Issue: |
6 |
Pages: |
e21208 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gray PA |
Year: |
2004 |
Journal: |
Science |
Title: |
Mouse brain organization revealed through direct genome-scale TF expression analysis. |
Volume: |
306 |
Issue: |
5705 |
Pages: |
2255-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
GUDMAP Consortium |
Year: |
2004 |
Journal: |
www.gudmap.org |
Title: |
GUDMAP: the GenitoUrinary Development Molecular Anatomy Project |
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Shanghai Model Organisms Center |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen GM |
Year: |
2008 |
Journal: |
Genome Res |
Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
Volume: |
18 |
Issue: |
10 |
Pages: |
1670-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2014 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
|
Title: |
Cyagen Biosciences Website. |
|
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|
|
•
•
•
•
•
|
Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
|
Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
Publication |
First Author: |
Lu B |
Year: |
1997 |
Journal: |
J Immunol |
Title: |
Identification of a STAT6 domain required for IL-4-induced activation of transcription. |
Volume: |
159 |
Issue: |
3 |
Pages: |
1255-64 |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
Grail controls Th2 cell development by targeting STAT6 for degradation. |
|
•
•
•
•
•
|
Publication |
First Author: |
Ohmori Y |
Year: |
1998 |
Journal: |
J Biol Chem |
Title: |
STAT6 is required for the anti-inflammatory activity of interleukin-4 in mouse peritoneal macrophages. |
Volume: |
273 |
Issue: |
44 |
Pages: |
29202-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang X |
Year: |
2017 |
Journal: |
Sci Rep |
Title: |
Lyn regulates mucus secretion and MUC5AC via the STAT6 signaling pathway during allergic airway inflammation. |
Volume: |
7 |
|
Pages: |
42675 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xiong X |
Year: |
2022 |
Journal: |
Int J Mol Sci |
Title: |
Intestinal Epithelial STAT6 Activation Rescues the Defective Anti-Helminth Responses Caused by Ogt Deletion. |
Volume: |
23 |
Issue: |
19 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hamid MA |
Year: |
2018 |
Journal: |
Eur J Immunol |
Title: |
Unexpected involvement of IL-13 signalling via a STAT6 independent mechanism during murine IgG2a development following viral vaccination. |
Volume: |
48 |
Issue: |
7 |
Pages: |
1153-1163 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yu CR |
Year: |
2004 |
Journal: |
J Immunol |
Title: |
Cell proliferation and STAT6 pathways are negatively regulated in T cells by STAT1 and suppressors of cytokine signaling. |
Volume: |
173 |
Issue: |
2 |
Pages: |
737-46 |
|
•
•
•
•
•
|
Publication |
First Author: |
Seki Y |
Year: |
2002 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation. |
Volume: |
99 |
Issue: |
20 |
Pages: |
13003-8 |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
Selective potentiation of Stat-dependent gene expression by collaborator of Stat6 (CoaSt6), a transcriptional cofactor. |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
IFN-gamma suppresses STAT6 phosphorylation by inhibiting its recruitment to the IL-4 receptor. |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee CE |
Year: |
2001 |
Journal: |
Mol Cells |
Title: |
Interleukin-4 induces two distinct GAS-binding complexes containing STAT6: evidence for DNA binding of STAT6 monomer. |
Volume: |
11 |
Issue: |
1 |
Pages: |
28-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bao L |
Year: |
2014 |
Journal: |
Immunology |
Title: |
Interleukin-4 up-regulation of epidermal interleukin-19 expression in keratinocytes involves the binding of signal transducer and activator of transcription 6 (Stat6) to the imperfect Stat6 sites. |
Volume: |
143 |
Issue: |
4 |
Pages: |
601-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mora AL |
Year: |
2003 |
Journal: |
J Immunol |
Title: |
New programming of IL-4 receptor signal transduction in activated T cells: Stat6 induction and Th2 differentiation mediated by IL-4Ralpha lacking cytoplasmic tyrosines. |
Volume: |
171 |
Issue: |
4 |
Pages: |
1891-900 |
|
•
•
•
•
•
|
Publication |
First Author: |
Berton MT |
Year: |
2004 |
Journal: |
Int Immunol |
Title: |
NF-kappaB elements associated with the Stat6 site in the germline gamma1 immunoglobulin promoter are not necessary for the transcriptional response to CD40 ligand. |
Volume: |
16 |
Issue: |
12 |
Pages: |
1741-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yang L |
Year: |
2022 |
Journal: |
Front Cell Dev Biol |
Title: |
SEC5 is involved in M2 polarization of macrophages via the STAT6 pathway, and its dysfunction in decidual macrophages is associated with recurrent spontaneous abortion. |
Volume: |
10 |
|
Pages: |
891748 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nappo G |
Year: |
2017 |
Journal: |
Oncogenesis |
Title: |
The immunosuppressive cytokine interleukin-4 increases the clonogenic potential of prostate stem-like cells by activation of STAT6 signalling. |
Volume: |
6 |
Issue: |
5 |
Pages: |
e342 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dunnick WA |
Year: |
2004 |
Journal: |
J Immunol |
Title: |
Germline transcription and switch recombination of a transgene containing the entire H chain constant region locus: effect of a mutation in a STAT6 binding site in the gamma 1 promoter. |
Volume: |
173 |
Issue: |
9 |
Pages: |
5531-9 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1817
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Daniel B |
Year: |
2020 |
Journal: |
Genes Dev |
Title: |
The transcription factor EGR2 is the molecular linchpin connecting STAT6 activation to the late, stable epigenomic program of alternative macrophage polarization. |
Volume: |
34 |
Issue: |
21-22 |
Pages: |
1474-1492 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1228
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Niu Y |
Year: |
2003 |
Journal: |
FEBS Lett |
Title: |
MIP-T3 associates with IL-13Ralpha1 and suppresses STAT6 activation in response to IL-13 stimulation. |
Volume: |
550 |
Issue: |
1-3 |
Pages: |
139-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Litterst CM |
Year: |
2002 |
Journal: |
J Biol Chem |
Title: |
An LXXLL motif in the transactivation domain of STAT6 mediates recruitment of NCoA-1/SRC-1. |
Volume: |
277 |
Issue: |
39 |
Pages: |
36052-60 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Razeto A |
Year: |
2004 |
Journal: |
J Mol Biol |
Title: |
Structure of the NCoA-1/SRC-1 PAS-B domain bound to the LXXLL motif of the STAT6 transactivation domain. |
Volume: |
336 |
Issue: |
2 |
Pages: |
319-29 |
|
•
•
•
•
•
|
Publication |
First Author: |
Begitt A |
Year: |
2018 |
Journal: |
Nat Commun |
Title: |
On the role of STAT1 and STAT6 ADP-ribosylation in the regulation of macrophage activation. |
Volume: |
9 |
Issue: |
1 |
Pages: |
2144 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gray MJ |
Year: |
2005 |
Journal: |
Gene |
Title: |
Induction of arginase I transcription by IL-4 requires a composite DNA response element for STAT6 and C/EBPbeta. |
Volume: |
353 |
Issue: |
1 |
Pages: |
98-106 |
|
•
•
•
•
•
|
Publication |
First Author: |
Arimura A |
Year: |
2004 |
Journal: |
J Biol Chem |
Title: |
The transcriptional co-activator p/CIP (NCoA-3) is up-regulated by STAT6 and serves as a positive regulator of transcriptional activation by STAT6. |
Volume: |
279 |
Issue: |
30 |
Pages: |
31105-12 |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 1, David J Erle |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
Allele |
Name: |
signal transducer and activator of transcription 6; targeted mutation 1, David Voehringer |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Constitutively active, Epitope tag, Inserted expressed sequence |
|
•
•
•
•
•
|
GO Term |
|
•
•
•
•
•
|
GO Term |
|
•
•
•
•
•
|
Publication |
First Author: |
Sehra S |
Year: |
2008 |
Journal: |
J Immunol |
Title: |
IL-4 is a critical determinant in the generation of allergic inflammation initiated by a constitutively active Stat6. |
Volume: |
180 |
Issue: |
5 |
Pages: |
3551-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sehra S |
Year: |
2010 |
Journal: |
J Immunol |
Title: |
IL-4 regulates skin homeostasis and the predisposition toward allergic skin inflammation. |
Volume: |
184 |
Issue: |
6 |
Pages: |
3186-90 |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 78, Mark H Kaplan |
Allele Type: |
Transgenic |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Publication |
First Author: |
Krishnamurthy P |
Year: |
2017 |
Journal: |
Immunology |
Title: |
Poly-ADP ribose polymerase-14 limits severity of allergic skin disease. |
Volume: |
152 |
Issue: |
3 |
Pages: |
451-461 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
295
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This family represents the C terminus of mammalian STAT6 (signal transducer and activator of transcription 6). It contains an LXXLL motif which binds to NCOA1 (Nuclear receptor coactivator 1) []. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
STAT6 mediate signals from the IL-4 receptor. Unlike the other STAT proteins which bind an IFNgamma Activating Sequence (GAS), STAT6 stands out as having a unique binding site preference. This site consists of a palindromic sequence separated by a 3 bp spacer (TTCNNNG-AA)(N3 site). STAT6 is able to bind the GAS site but only at a low affinity upon IL-4-induced activation []. There is speculation that the inappropriate activation of STAT6 is involved in uncontrolled cell growth in an oncogenic state []. IL-4 signaling via STAT6 initially occurs unopposed, but is then dampened by a negative feedback mechanism through the IL-4/Stat6 dependent induction of SOCS1 expression. The IL-4 dependent aspect of Th2 differentiation requires the activation of STAT6. IL-4 signaling and STAT6 appear to play an important role in the immune response. It was shown that large scale chromatin remodeling of the IL-4 gene occurs as cells differentiate into Th2 effectors is STAT6 dependent []. This entry represents the SH2 domain of STAT6.STAT proteins have a dual function: signal transduction and activation of transcription. When cytokines are bound to cell surface receptors, the associated Janus kinases (JAKs) are activated, leading to tyrosine phosphorylation of the given STAT proteins []. Phosphorylated STATs form dimers, translocate to the nucleus, and bind specific response elements to activate transcription of target genes []. STAT proteins contain an N-terminal domain (NTD), a coiled-coil domain (CCD), a DNA-binding domain (DBD), an α-helical linker domain (LD), an SH2 domain, and a transactivation domain (TAD). The SH2 domain is necessary for receptor association and tyrosine phosphodimer formation. There are seven mammalian STAT family members which have been identified: STAT1, STAT2, STAT3, STAT4, STAT5 (STAT5A and STAT5B), and STAT6 []. |
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Publication |
First Author: |
Stritesky GL |
Year: |
2011 |
Journal: |
Immunity |
Title: |
The transcription factor STAT3 is required for T helper 2 cell development. |
Volume: |
34 |
Issue: |
1 |
Pages: |
39-49 |
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Allele |
Name: |
signal transducer and activator of transcription 6; targeted mutation 1, James N Ihle |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
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Publication |
First Author: |
Catunda RQ |
Year: |
2023 |
Journal: |
Int Dent J |
Title: |
Loricrin and Cytokeratin Disorganisation in Severe Forms of Periodontitis. |
Volume: |
73 |
Issue: |
6 |
Pages: |
862-872 |
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Genotype |
Symbol: |
Tg(CD2-Stat6*V625A*T626A)78Mhk/? |
Background: |
involves: C3H * C57BL/6 |
Zygosity: |
ot |
Has Mutant Allele: |
true |
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Publication |
First Author: |
Khan IM |
Year: |
2021 |
Journal: |
Immunohorizons |
Title: |
Selectin Dependence of Allergic Skin Inflammation Is Diminished by Maternal Atopy. |
Volume: |
5 |
Issue: |
8 |
Pages: |
703-710 |
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Genotype |
Symbol: |
Stat6/Stat6 |
Background: |
involves: 129S/SvEv * C57BL/6 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
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Genotype |
Symbol: |
Stat6/Stat6 |
Background: |
involves: 129S/SvEv |
Zygosity: |
hm |
Has Mutant Allele: |
true |
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Genotype |
Symbol: |
Il4/Il4 Tg(CD2-Stat6*V625A*T626A)78Mhk/? |
Background: |
involves: 129P2/OlaHsd * C3H * C57BL/6 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
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Genotype |
Symbol: |
Hr /Hr Tg(CD2-Stat6*V625A*T626A)78Mhk/? |
Background: |
involves: C3H * SKH1 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
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Publication |
First Author: |
DaSilva-Arnold SC |
Year: |
2018 |
Journal: |
Arch Dermatol Res |
Title: |
Phenotyping acute and chronic atopic dermatitis-like lesions in Stat6VT mice identifies a role for IL-33 in disease pathogenesis. |
Volume: |
310 |
Issue: |
3 |
Pages: |
197-207 |
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Genotype |
Symbol: |
Stat4/Stat4 Stat6/Stat6 |
Background: |
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
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Protein Domain |
Type: |
Family |
Description: |
TRAF3-interacting protein 1 (TRAF3IP1) recruits TRAF3 (tumour necrosis factor receptor-associated factor 3) and DISC1 (Disrupted-In-Schizophrenia 1) to the microtubules and is conserved from worms to humans []. The N-terminal region is the microtubule binding domain and is well-conserved; the C-terminal 100 residues, also well-conserved, constitute the coiled-coil region which binds to TRAF3. The central region of the protein is rich in lysine and glutamic acid and carries KKE motifs which may also be necessary for tubulin-binding, but this region is the least well-conserved []. In humans, it plays an inhibitory role on IL13 signaling by binding to IL13RA1. It is involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding [, ]. |
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HT Experiment |
Series Id: |
E-GEOD-64403 |
Experiment Type: |
RNA-Seq |
Study Type: |
Baseline |
Source: |
GEO |
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Publication |
First Author: |
Levy DE |
Year: |
2002 |
Journal: |
Nat Rev Mol Cell Biol |
Title: |
Stats: transcriptional control and biological impact. |
Volume: |
3 |
Issue: |
9 |
Pages: |
651-62 |
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Publication |
First Author: |
Shuai K |
Year: |
2003 |
Journal: |
Nat Rev Immunol |
Title: |
Regulation of JAK-STAT signalling in the immune system. |
Volume: |
3 |
Issue: |
11 |
Pages: |
900-11 |
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Publication |
First Author: |
Takakuma K |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
Novel multiplexed assay for identifying SH2 domain antagonists of STAT family proteins. |
Volume: |
8 |
Issue: |
8 |
Pages: |
e71646 |
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GO Term |
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Genotype |
Symbol: |
Stat6/Stat6 Tg(Scgb1a1-Il13)2Eli/? Tg(Scgb1a1-STAT6)1Erle/? |
Background: |
involves: 129S2/SvPas * C57BL/6 * CBA * FVB |
Zygosity: |
cx |
Has Mutant Allele: |
true |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
625
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Fragment?: |
false |
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