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Search results 801 to 900 out of 1177 for Stat6

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Type Details Score
Publication
First Author: Riedelberger M
Year: 2020
Journal: iScience
Title: Type I Interferons Ameliorate Zinc Intoxication of Candida glabrata by Macrophages and Promote Fungal Immune Evasion.
Volume: 23
Issue: 5
Pages: 101121
Publication
First Author: Riedelberger M
Year: 2020
Journal: Cell Host Microbe
Title: Type I Interferon Response Dysregulates Host Iron Homeostasis and Enhances Candida glabrata Infection.
Volume: 27
Issue: 3
Pages: 454-466.e8
Publication
First Author: Zhang D
Year: 2020
Journal: Adv Sci (Weinh)
Title: Deficiency of STING Signaling in Embryonic Cerebral Cortex Leads to Neurogenic Abnormalities and Autistic-Like Behaviors.
Volume: 7
Issue: 23
Pages: 2002117
Publication
First Author: Motomura Y
Year: 2011
Journal: Nat Immunol
Title: The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells.
Volume: 12
Issue: 5
Pages: 450-9
Publication
First Author: Li S
Year: 2012
Journal: Development
Title: Foxp1/4 control epithelial cell fate during lung development and regeneration through regulation of anterior gradient 2.
Volume: 139
Issue: 14
Pages: 2500-9
Publication        
First Author: GO Annotation working group
Year: 2023
Title: Manual annotations that require more than one source of functional data to support the assignment of the associated GO term
Publication  
First Author: Lei Z
Year: 2022
Journal: Front Immunol
Title: EpCAM Is Essential to Maintaining the Immune Homeostasis of Intestines via Keeping the Expression of pIgR in the Intestinal Epithelium of Mice.
Volume: 13
Pages: 843378
Publication
First Author: Li S
Year: 2016
Journal: Biol Reprod
Title: Ggnbp2 Is Essential for Pregnancy Success via Regulation of Mouse Trophoblast Stem Cell Proliferation and Differentiation.
Volume: 94
Issue: 2
Pages: 41
Publication      
First Author: MouseBookTM
Year: 2005
Journal: Unpublished
Title: Information obtained from MouseBookTM, Medical Research Council Mammalian Genetics Unit, Harwell, UK.
Publication
First Author: Taher L
Year: 2011
Journal: PLoS One
Title: Global gene expression analysis of murine limb development.
Volume: 6
Issue: 12
Pages: e28358
Publication    
First Author: Li J
Year: 2018
Journal: Database (Oxford)
Title: CITGeneDB: a comprehensive database of human and mouse genes enhancing or suppressing cold-induced thermogenesis validated by perturbation experiments in mice.
Volume: 2018
Publication
First Author: Tang F
Year: 2011
Journal: PLoS One
Title: Deterministic and stochastic allele specific gene expression in single mouse blastomeres.
Volume: 6
Issue: 6
Pages: e21208
Publication
First Author: Gray PA
Year: 2004
Journal: Science
Title: Mouse brain organization revealed through direct genome-scale TF expression analysis.
Volume: 306
Issue: 5705
Pages: 2255-7
Publication      
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
Publication      
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication        
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication        
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
Publication
First Author: Lu B
Year: 1997
Journal: J Immunol
Title: Identification of a STAT6 domain required for IL-4-induced activation of transcription.
Volume: 159
Issue: 3
Pages: 1255-64
Interaction Experiment
Description: Grail controls Th2 cell development by targeting STAT6 for degradation.
Publication
First Author: Ohmori Y
Year: 1998
Journal: J Biol Chem
Title: STAT6 is required for the anti-inflammatory activity of interleukin-4 in mouse peritoneal macrophages.
Volume: 273
Issue: 44
Pages: 29202-9
Publication  
First Author: Wang X
Year: 2017
Journal: Sci Rep
Title: Lyn regulates mucus secretion and MUC5AC via the STAT6 signaling pathway during allergic airway inflammation.
Volume: 7
Pages: 42675
Publication  
First Author: Xiong X
Year: 2022
Journal: Int J Mol Sci
Title: Intestinal Epithelial STAT6 Activation Rescues the Defective Anti-Helminth Responses Caused by Ogt Deletion.
Volume: 23
Issue: 19
Publication
First Author: Hamid MA
Year: 2018
Journal: Eur J Immunol
Title: Unexpected involvement of IL-13 signalling via a STAT6 independent mechanism during murine IgG2a development following viral vaccination.
Volume: 48
Issue: 7
Pages: 1153-1163
Publication
First Author: Yu CR
Year: 2004
Journal: J Immunol
Title: Cell proliferation and STAT6 pathways are negatively regulated in T cells by STAT1 and suppressors of cytokine signaling.
Volume: 173
Issue: 2
Pages: 737-46
Publication
First Author: Seki Y
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation.
Volume: 99
Issue: 20
Pages: 13003-8
Interaction Experiment
Description: Selective potentiation of Stat-dependent gene expression by collaborator of Stat6 (CoaSt6), a transcriptional cofactor.
Interaction Experiment
Description: IFN-gamma suppresses STAT6 phosphorylation by inhibiting its recruitment to the IL-4 receptor.
Publication
First Author: Lee CE
Year: 2001
Journal: Mol Cells
Title: Interleukin-4 induces two distinct GAS-binding complexes containing STAT6: evidence for DNA binding of STAT6 monomer.
Volume: 11
Issue: 1
Pages: 28-34
Publication
First Author: Bao L
Year: 2014
Journal: Immunology
Title: Interleukin-4 up-regulation of epidermal interleukin-19 expression in keratinocytes involves the binding of signal transducer and activator of transcription 6 (Stat6) to the imperfect Stat6 sites.
Volume: 143
Issue: 4
Pages: 601-8
Publication
First Author: Mora AL
Year: 2003
Journal: J Immunol
Title: New programming of IL-4 receptor signal transduction in activated T cells: Stat6 induction and Th2 differentiation mediated by IL-4Ralpha lacking cytoplasmic tyrosines.
Volume: 171
Issue: 4
Pages: 1891-900
Publication
First Author: Berton MT
Year: 2004
Journal: Int Immunol
Title: NF-kappaB elements associated with the Stat6 site in the germline gamma1 immunoglobulin promoter are not necessary for the transcriptional response to CD40 ligand.
Volume: 16
Issue: 12
Pages: 1741-9
Publication  
First Author: Yang L
Year: 2022
Journal: Front Cell Dev Biol
Title: SEC5 is involved in M2 polarization of macrophages via the STAT6 pathway, and its dysfunction in decidual macrophages is associated with recurrent spontaneous abortion.
Volume: 10
Pages: 891748
Publication
First Author: Nappo G
Year: 2017
Journal: Oncogenesis
Title: The immunosuppressive cytokine interleukin-4 increases the clonogenic potential of prostate stem-like cells by activation of STAT6 signalling.
Volume: 6
Issue: 5
Pages: e342
Publication
First Author: Dunnick WA
Year: 2004
Journal: J Immunol
Title: Germline transcription and switch recombination of a transgene containing the entire H chain constant region locus: effect of a mutation in a STAT6 binding site in the gamma 1 promoter.
Volume: 173
Issue: 9
Pages: 5531-9
Protein
Organism: Mus musculus/domesticus
Length: 1817  
Fragment?: false
Publication
First Author: Daniel B
Year: 2020
Journal: Genes Dev
Title: The transcription factor EGR2 is the molecular linchpin connecting STAT6 activation to the late, stable epigenomic program of alternative macrophage polarization.
Volume: 34
Issue: 21-22
Pages: 1474-1492
Protein
Organism: Mus musculus/domesticus
Length: 1228  
Fragment?: false
Publication
First Author: Niu Y
Year: 2003
Journal: FEBS Lett
Title: MIP-T3 associates with IL-13Ralpha1 and suppresses STAT6 activation in response to IL-13 stimulation.
Volume: 550
Issue: 1-3
Pages: 139-43
Publication
First Author: Litterst CM
Year: 2002
Journal: J Biol Chem
Title: An LXXLL motif in the transactivation domain of STAT6 mediates recruitment of NCoA-1/SRC-1.
Volume: 277
Issue: 39
Pages: 36052-60
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Razeto A
Year: 2004
Journal: J Mol Biol
Title: Structure of the NCoA-1/SRC-1 PAS-B domain bound to the LXXLL motif of the STAT6 transactivation domain.
Volume: 336
Issue: 2
Pages: 319-29
Publication
First Author: Begitt A
Year: 2018
Journal: Nat Commun
Title: On the role of STAT1 and STAT6 ADP-ribosylation in the regulation of macrophage activation.
Volume: 9
Issue: 1
Pages: 2144
Publication
First Author: Gray MJ
Year: 2005
Journal: Gene
Title: Induction of arginase I transcription by IL-4 requires a composite DNA response element for STAT6 and C/EBPbeta.
Volume: 353
Issue: 1
Pages: 98-106
Publication
First Author: Arimura A
Year: 2004
Journal: J Biol Chem
Title: The transcriptional co-activator p/CIP (NCoA-3) is up-regulated by STAT6 and serves as a positive regulator of transcriptional activation by STAT6.
Volume: 279
Issue: 30
Pages: 31105-12
Allele
Name: transgene insertion 1, David J Erle
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Allele
Name: signal transducer and activator of transcription 6; targeted mutation 1, David Voehringer
Allele Type: Targeted
Attribute String: Conditional ready, Constitutively active, Epitope tag, Inserted expressed sequence
GO Term
GO Term
Publication
First Author: Sehra S
Year: 2008
Journal: J Immunol
Title: IL-4 is a critical determinant in the generation of allergic inflammation initiated by a constitutively active Stat6.
Volume: 180
Issue: 5
Pages: 3551-9
Publication
First Author: Sehra S
Year: 2010
Journal: J Immunol
Title: IL-4 regulates skin homeostasis and the predisposition toward allergic skin inflammation.
Volume: 184
Issue: 6
Pages: 3186-90
Allele
Name: transgene insertion 78, Mark H Kaplan
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
Strain
Attribute String: congenic, mutant strain, targeted mutation
Publication
First Author: Krishnamurthy P
Year: 2017
Journal: Immunology
Title: Poly-ADP ribose polymerase-14 limits severity of allergic skin disease.
Volume: 152
Issue: 3
Pages: 451-461
Protein
Organism: Mus musculus/domesticus
Length: 295  
Fragment?: false
Protein Domain
Type: Domain
Description: This family represents the C terminus of mammalian STAT6 (signal transducer and activator of transcription 6). It contains an LXXLL motif which binds to NCOA1 (Nuclear receptor coactivator 1) [].
Protein Domain
Type: Domain
Description: STAT6 mediate signals from the IL-4 receptor. Unlike the other STAT proteins which bind an IFNgamma Activating Sequence (GAS), STAT6 stands out as having a unique binding site preference. This site consists of a palindromic sequence separated by a 3 bp spacer (TTCNNNG-AA)(N3 site). STAT6 is able to bind the GAS site but only at a low affinity upon IL-4-induced activation []. There is speculation that the inappropriate activation of STAT6 is involved in uncontrolled cell growth in an oncogenic state []. IL-4 signaling via STAT6 initially occurs unopposed, but is then dampened by a negative feedback mechanism through the IL-4/Stat6 dependent induction of SOCS1 expression. The IL-4 dependent aspect of Th2 differentiation requires the activation of STAT6. IL-4 signaling and STAT6 appear to play an important role in the immune response. It was shown that large scale chromatin remodeling of the IL-4 gene occurs as cells differentiate into Th2 effectors is STAT6 dependent []. This entry represents the SH2 domain of STAT6.STAT proteins have a dual function: signal transduction and activation of transcription. When cytokines are bound to cell surface receptors, the associated Janus kinases (JAKs) are activated, leading to tyrosine phosphorylation of the given STAT proteins []. Phosphorylated STATs form dimers, translocate to the nucleus, and bind specific response elements to activate transcription of target genes []. STAT proteins contain an N-terminal domain (NTD), a coiled-coil domain (CCD), a DNA-binding domain (DBD), an α-helical linker domain (LD), an SH2 domain, and a transactivation domain (TAD). The SH2 domain is necessary for receptor association and tyrosine phosphodimer formation. There are seven mammalian STAT family members which have been identified: STAT1, STAT2, STAT3, STAT4, STAT5 (STAT5A and STAT5B), and STAT6 [].
Publication
First Author: Stritesky GL
Year: 2011
Journal: Immunity
Title: The transcription factor STAT3 is required for T helper 2 cell development.
Volume: 34
Issue: 1
Pages: 39-49
Allele
Name: signal transducer and activator of transcription 6; targeted mutation 1, James N Ihle
Allele Type: Targeted
Attribute String: Null/knockout
Publication
First Author: Catunda RQ
Year: 2023
Journal: Int Dent J
Title: Loricrin and Cytokeratin Disorganisation in Severe Forms of Periodontitis.
Volume: 73
Issue: 6
Pages: 862-872
Genotype
Symbol: Tg(CD2-Stat6*V625A*T626A)78Mhk/?
Background: involves: C3H * C57BL/6
Zygosity: ot
Has Mutant Allele: true
Publication
First Author: Khan IM
Year: 2021
Journal: Immunohorizons
Title: Selectin Dependence of Allergic Skin Inflammation Is Diminished by Maternal Atopy.
Volume: 5
Issue: 8
Pages: 703-710
Genotype
Symbol: Stat6/Stat6
Background: involves: 129S/SvEv * C57BL/6
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Stat6/Stat6
Background: involves: 129S/SvEv
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Il4/Il4 Tg(CD2-Stat6*V625A*T626A)78Mhk/?
Background: involves: 129P2/OlaHsd * C3H * C57BL/6
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Hr
/Hr
Tg(CD2-Stat6*V625A*T626A)78Mhk/?
Background: involves: C3H * SKH1
Zygosity: cx
Has Mutant Allele: true
Publication
First Author: DaSilva-Arnold SC
Year: 2018
Journal: Arch Dermatol Res
Title: Phenotyping acute and chronic atopic dermatitis-like lesions in Stat6VT mice identifies a role for IL-33 in disease pathogenesis.
Volume: 310
Issue: 3
Pages: 197-207
Genotype
Symbol: Stat4/Stat4 Stat6/Stat6
Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6
Zygosity: cx
Has Mutant Allele: true
Protein Domain
Type: Family
Description: TRAF3-interacting protein 1 (TRAF3IP1) recruits TRAF3 (tumour necrosis factor receptor-associated factor 3) and DISC1 (Disrupted-In-Schizophrenia 1) to the microtubules and is conserved from worms to humans []. The N-terminal region is the microtubule binding domain and is well-conserved; the C-terminal 100 residues, also well-conserved, constitute the coiled-coil region which binds to TRAF3. The central region of the protein is rich in lysine and glutamic acid and carries KKE motifs which may also be necessary for tubulin-binding, but this region is the least well-conserved []. In humans, it plays an inhibitory role on IL13 signaling by binding to IL13RA1. It is involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding [, ].
HT Experiment
Series Id: E-GEOD-64403
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
Publication
First Author: Levy DE
Year: 2002
Journal: Nat Rev Mol Cell Biol
Title: Stats: transcriptional control and biological impact.
Volume: 3
Issue: 9
Pages: 651-62
Publication
First Author: Shuai K
Year: 2003
Journal: Nat Rev Immunol
Title: Regulation of JAK-STAT signalling in the immune system.
Volume: 3
Issue: 11
Pages: 900-11
Publication
First Author: Takakuma K
Year: 2013
Journal: PLoS One
Title: Novel multiplexed assay for identifying SH2 domain antagonists of STAT family proteins.
Volume: 8
Issue: 8
Pages: e71646
GO Term
Genotype
Symbol: Stat6/Stat6 Tg(Scgb1a1-Il13)2Eli/? Tg(Scgb1a1-STAT6)1Erle/?
Background: involves: 129S2/SvPas * C57BL/6 * CBA * FVB
Zygosity: cx
Has Mutant Allele: true
Protein
Organism: Mus musculus/domesticus
Length: 625  
Fragment?: false