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Search results 801 to 900 out of 1344 for T2

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Type Details Score
Allele
Name: adhesion G protein-coupled receptor G3; targeted mutation 1, Zhugang Wang
Allele Type: Targeted
Attribute String: Null/knockout
Genotype
Symbol: Tcrb/Tcrb Tcrd/Tcrd
Background: B6.129P2-Tcrb Tcrd/J
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Igh-J/Igh-J
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Gimap1/Gimap1 Tg(CD2-icre)4Kio/?
Background: involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Grb2/Grb2 Cd79a/Cd79a<+>
Background: involves: BALB/c * BALB/cJ
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Atp11c/?
Background: involves: C57BL/6J
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Igh/Igh
Background: involves: 129 * 129S4/SvJae * C57BL/6
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Cd79a/Cd79a
Background: involves: C57BL/6
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Sppl2a/Sppl2a
Background: involves: C57BL/6
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Sppl2a/Sppl2a
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrl
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Kdelr1/Kdelr1
Background: C57BL/6J-Kdelr1
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Cd19/Cd19<+> Ell2/Ell2
Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Map3k14/Map3k14
Background: B6(Cg)-Map3k14
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Niban3/Niban3
Background: B6.Cg-Niban3
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Card11/Card11
Background: involves: C57BL/6
Zygosity: hm
Has Mutant Allele: true
HT Experiment
Series Id: E-GEOD-66954
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
Publication
First Author: Davey JC
Year: 1995
Journal: J Biol Chem
Title: Cloning of a cDNA for the type II iodothyronine deiodinase.
Volume: 270
Issue: 45
Pages: 26786-9
Protein
Organism: Mus musculus/domesticus
Length: 82  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 107  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 74  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 131  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 61  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 113  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 125  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 208  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 145  
Fragment?: true
Protein Domain
Type: Family
Description: Iodothyronine deiodinase () (DI) []is the vertebrate enzyme responsible for the deiodination ofthe prohormone thyroxine (T4 or 3,5,3',5'-tetraiodothyronine) into the biologically active hormone T3 (3,5,3'-triiodothyronine) and of T3 into the inactive metabolite T2 (3,3'-diiodothyronine). All known DI are proteins of about 250 residues that contain a selenocysteine at their active site. Three types of DI are known, type I is commonly found in the liver and kidney [], type II is essential for providing the brain with the appropriate levels of T3 during the critical period of development, and type III (also known as thyroxine 5-deiodinase) is essential for the regulation of thyroid hormone inactivation during embryological development.
Protein Domain
Type: Active_site
Description: Iodothyronine deiodinase () (DI) []is the vertebrate enzyme responsible for the deiodination ofthe prohormone thyroxine (T4 or 3,5,3',5'-tetraiodothyronine) into the biologically active hormone T3(3,5,3'-triiodothyronine) and of T3 into the inactive metabolite T2 (3,3'-diiodothyronine). All known DI areproteins of about 250 residues that contain a selenocysteine at their active site. Three types of DI areknown, type II is essential for providing the brain with the appropriate levels of T3 during the criticalperiod of development, and type III is essential for the regulation of thyroid hormone inactivation duringembryological development. This signature found in the central part of the enzyme, which contains the active site selenocysteine.
Publication
First Author: Harmelink C
Year: 2013
Journal: Dev Biol
Title: Myocardial Mycn is essential for mouse ventricular wall morphogenesis.
Volume: 373
Issue: 1
Pages: 53-63
Strain
Attribute String: transgenic, targeted mutation, mutant strain, congenic
Strain
Attribute String: congenic, mutant strain, targeted mutation, transgenic
Publication
First Author: Zhang Z
Year: 2019
Journal: Circulation
Title: Kindlin-2 Is Essential for Preserving Integrity of the Developing Heart and Preventing Ventricular Rupture.
Volume: 139
Issue: 12
Pages: 1554-1556
Publication
First Author: Ai S
Year: 2017
Journal: Circ Res
Title: Divergent Requirements for EZH1 in Heart Development Versus Regeneration.
Volume: 121
Issue: 2
Pages: 106-112
Publication
First Author: Sun Q
Year: 2019
Journal: Dev Biol
Title: SEMA6D regulates perinatal cardiomyocyte proliferation and maturation in mice.
Volume: 452
Issue: 1
Pages: 1-7
Genotype
Symbol: Cxadr/Cxadr Tg(Tnnt2-cre)5Blh/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Lims1/Lims1 Lims2/Lims2 Tg(Tnnt2-cre)5Blh/?
Background: involves: 129/Sv * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Tarbp2/Tarbp2 Tg(Tnnt2-cre)5Blh/?
Background: involves: 129 * C57BL/6 * DBA/2J
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Kmt2d/Kmt2d Tg(Tnnt2-cre)5Blh/?
Background: B6.Cg-Kmt2d Tg(Tnnt2-cre)5Blh
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Hspb7/Hspb7 Tg(Tnnt2-cre)5Blh/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Prdm16/Prdm16 Tg(Tnnt2-cre)5Blh/?
Background: involves: 129 * C57BL/6 * C57BL/6J * DBA/2
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Nras/Nras<+> Tg(Tnnt2-cre)5Blh/?
Background: B6.Cg-Nras Tg(Tnnt2-cre)5Blh
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Kmt2d/Kmt2d<+> Tg(Tnnt2-cre)5Blh/?
Background: B6.Cg-Kmt2d Tg(Tnnt2-cre)5Blh
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Med30/Med30 Tg(Tnnt2-cre)5Blh/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Lonp1/Lonp1 Tg(Tnnt2-cre)5Blh/?
Background: involves: C57BL/6 * C57BL/6J * DBA/2
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Mib1/Mib1 Tg(Tnnt2-cre)5Blh/?
Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Jag2/Jag2 Tg(Tnnt2-cre)5Blh/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Fermt2/Fermt2 Tg(Tnnt2-cre)5Blh/?
Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Tg(Tnnt2-cre)5Blh/? Wt1/Wt1
Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Mib1/Mib1<+> Tg(Tnnt2-cre)5Blh/?
Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Dhx36/Dhx36 Tg(Tnnt2-cre)5Blh/?
Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA/2
Zygosity: cn
Has Mutant Allele: true
Publication  
First Author: López-Doménech G
Year: 2012
Journal: Nat Commun
Title: The Eutherian Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro and Trak2.
Volume: 3
Pages: 814
Publication
First Author: Moreno M
Year: 1994
Journal: FEBS Lett
Title: Activation and inactivation of thyroid hormone by type I iodothyronine deiodinase.
Volume: 344
Issue: 2-3
Pages: 143-6
Publication
First Author: Löffler A
Year: 1993
Journal: Eur J Biochem
Title: Amino acid sequence of an intracellular, phosphate-starvation-induced ribonuclease from cultured tomato (Lycopersicon esculentum) cells.
Volume: 214
Issue: 3
Pages: 627-33
Publication
First Author: Meador J 3rd
Year: 1990
Journal: Gene
Title: Cloning and sequencing the gene encoding Escherichia coli ribonuclease I: exact physical mapping using the genome library.
Volume: 95
Issue: 1
Pages: 1-7
Publication
First Author: McClure BA
Year: 1989
Journal: Nature
Title: Style self-incompatibility gene products of Nicotiana alata are ribonucleases.
Volume: 342
Issue: 6252
Pages: 955-7
Publication
First Author: Haring V
Year: 1990
Journal: Science
Title: Self-incompatibility: a self-recognition system in plants.
Volume: 250
Issue: 4983
Pages: 937-41
Protein Domain
Type: Active_site
Description: The fungal ribonucleases T2 from Aspergillus oryzae, M from Aspergillus saitoi and Rh from Rhizopeus niveus are structurally and functionally related 30 Kd glycoproteins []that cleave the 3'-5' internucleotide linkage of RNA via a nucleotide 2',3'-cyclic phosphate intermediates ().A number of other RNAses have been found to be evolutionary related to thesefungal enzymes:Self-incompatibility []in flowering plants is often controlled by a single gene (S-gene) that has several alleles. This gene prevents fertilization by self-pollen or by pollen bearing either of the two S- alleles expressed in the style. The self-incompatibility glycoprotein fromseveral higher plants of the solanaceae family has been shown [, ]to be a ribonuclease.Phosphate-starvation induced RNAses LE and LX from tomato []. These twoenzymes are probably involved in a phosphate-starvation rescue system.Escherichia coli periplasmic RNAse I (EC 3.1.27.6) (gene rna) [].Aeromonas hydrophila periplasmic RNAse.Haemophilus influenzae hypothetical protein HI0526. Two histidines residues have been shown [, ]to be involved in the catalytic mechanism of RNase T2 and Rh. These residues and the region around them are highly conserved. This entry represents the conserved region containing the second His active site. This region also contains a cysteine which is known to be involved in disulfide bond formation.
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Allele
Name: B cell leukemia/lymphoma 3; targeted mutation 1, Ulrich Siebenlist
Allele Type: Targeted
Attribute String: Null/knockout
Allele
Name: AT-rich interaction domain 3A; targeted mutation 1, Philip W Tucker
Allele Type: Targeted
Attribute String: Null/knockout
Allele
Name: spleen tyrosine kinase; targeted mutation 2.1, Friedemann Kiefer
Allele Type: Targeted
Attribute String: Inserted expressed sequence
Genotype
Symbol: Vav1/Vav1 Vav2/Vav2 Vav3/Vav3
Background: involves: 129S1/Sv * 129S2/SvPas * 129S6/SvEvTac * C57BL/6
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Nfkbia/Nfkbia
Background: B6.129-Nfkbia
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Cd19/Cd19<+>
Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Adgrg3/Adgrg3
Background: involves: 129 * C57BL/6
Zygosity: hm
Has Mutant Allele: true
Publication
First Author: Brorson KA
Year: 1989
Journal: J Exp Med
Title: Comparison of exon 5 sequences from 35 class I genes of the BALB/c mouse.
Volume: 170
Issue: 6
Pages: 1837-58
Publication
First Author: Peng Y
Year: 2014
Journal: Cardiovasc Res
Title: Critical roles of miRNA-mediated regulation of TGFβ signalling during mouse cardiogenesis.
Volume: 103
Issue: 2
Pages: 258-67
Publication
First Author: Han L
Year: 2022
Journal: Dev Cell
Title: Changes in nuclear pore numbers control nuclear import and stress response of mouse hearts.
Volume: 57
Issue: 20
Pages: 2397-2411.e9
Publication
First Author: Mu Y
Year: 2020
Journal: PLoS Genet
Title: O-linked β-N-acetylglucosamine transferase plays an essential role in heart development through regulating angiopoietin-1.
Volume: 16
Issue: 4
Pages: e1008730
Strain
Attribute String: mutant stock, transgenic, targeted mutation
Genotype
Symbol: Cxadr/Cxadr Tg(Tnnt2-cre)5Blh/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Bmp4/Bmp4 Tg(Tnnt2-cre)5Blh/?
Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * ICR
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Nipbl/Nipbl<+> Tg(Tnnt2-cre)5Blh/?
Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA/2
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Nipbl/Nipbl<+> Tg(Tnnt2-cre)5Blh/?
Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA/2
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Fkbp1a/Fkbp1a Tg(Tnnt2-cre)5Blh/?
Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Myo18a/Myo18a Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Tnnt2-cre)5Blh/?
Background: involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * C57BL/6N * DBA/2
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Gata4/Gata4 Tg(Tnnt2-cre)5Blh/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Jag1/Jag1 Jag2/Jag2 Tg(Tnnt2-cre)5Blh/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Rest/Rest Tg(Tnnt2-cre)5Blh/?
Background: involves: 129S2/SvPas * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tacr1/Tacr1<+>
Background: involves: 129S6/SvEvTac * C57BL/6NCrl
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Gpr83/Gpr83<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129S6/SvEvTac * C57BL/6NCrl
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Liu Y
Year: 1996
Journal: Glycobiology
Title: Purification, biochemistry and molecular cloning of an insect glycosylasparaginase from Spodoptera frugiperda.
Volume: 6
Issue: 5
Pages: 527-36
Protein Domain
Type: Family
Description: Threonine peptidases are characterised by a threonine nucleophile at the N terminus of the mature enzyme. The threonine peptidases belong to clan PB or are unassigned, clan T-. The type example for this clan is the archaean proteasome beta component of Thermoplasma acidophilum.This group of sequences have a signature that places them in MEROPS peptidase family T2 (clan PB(T)). The glycosylasparaginases () are threonine peptidases. Also in this family is L-asparaginase (), which catalyses the following reaction:L-asparagine + H2O = L-aspartate + NH3Glycosylasparaginase catalyses:N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H(2)O =N-acetyl-beta-glucosaminylamine + L-aspartatecleaving the GlcNAc-Asn bond that links oligosaccharides to asparagine in N-linked glycoproteins. The enzyme is composed of two non-identical alpha/beta subunits joined by strong non-covalent forces and has one glycosylation site located in the alpha subunit []and plays a major role in the degradation of glycoproteins.
Protein Domain
Type: Family
Description: Iodothyronine deiodinase () (DI) []is the vertebrate enzyme responsible for the deiodination ofthe prohormone thyroxine (T4 or 3,5,3',5'-tetraiodothyronine) into the biologically active hormone T3 (3,5,3'-triiodothyronine) and of T3 into the inactive metabolite T2 (3,3'-diiodothyronine). All known DI are proteins of about 250 residues that contain a selenocysteine at their active site. Three types of DI are known, type I is commonly found in the liver and kidney [], type II is essential for providing the brain with the appropriate levels of T3 during the critical period of development, and type III (also known as thyroxine 5-deiodinase) is essential for the regulation of thyroid hormone inactivation during embryological development.This entry represents type I and III Iodothyronine deiodinases.
Protein Domain
Type: Family
Description: These sequences represent 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidases; it is a bifunctional enzyme localized to the periplasm of Gram-negative bacteria. 2',3'-cyclic-nucleotide 2'-phosphodiesters are intermediates formed during the hydrolysis of RNA by the ribonuclease I, which is also found in the periplasm, and other enzymes of the RNAse T2 family. Bacteria are unable to transport 2',3'-cyclic-nucleotides into the cytoplasm. 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidases contains 2 active sites which catalyze the reactions that convert the 2',3'-cyclic-nucleotide into a 3'-nucleotide, which is then converted into nucleic acid and phosphate. Both final products can be transported into the cytoplasm. Thus, it has been suggested that 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidases have a scavenging function. Experimental evidence indicates that a 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase enables Yersinia enterocolitica O:8 to grow on 23-cAMP as a sole source of carbon and energy [].
Publication
First Author: Kumanogoh H
Year: 2008
Journal: Mol Cell Neurosci
Title: Balanced expression of various TrkB receptor isoforms from the Ntrk2 gene locus in the mouse nervous system.
Volume: 39
Issue: 3
Pages: 465-77
Publication
First Author: Lindvall JM
Year: 2006
Journal: Biochem Biophys Res Commun
Title: Distinct gene expression signature in Btk-defective T1 B-cells.
Volume: 346
Issue: 2
Pages: 461-9
Publication
First Author: Dunn JF
Year: 1999
Journal: Muscle Nerve
Title: Quantitative magnetic resonance imaging of the mdx mouse model of Duchenne muscular dystrophy.
Volume: 22
Issue: 10
Pages: 1367-71
Publication
First Author: Matalon R
Year: 2005
Journal: Int J Immunopathol Pharmacol
Title: Abnormal expression of genes associated with development and inflammation in the heart of mouse maternal phenylketonuria offspring.
Volume: 18
Issue: 3
Pages: 557-65
Publication  
First Author: Märklin M
Year: 2020
Journal: Cell Immunol
Title: Genetic loss of NFAT2 (NFATc1) impairs B cell development of B1 and B2 B cells.
Volume: 349
Pages: 104048
Publication
First Author: Everts B
Year: 2012
Journal: J Exp Med
Title: Schistosome-derived omega-1 drives Th2 polarization by suppressing protein synthesis following internalization by the mannose receptor.
Volume: 209
Issue: 10
Pages: 1753-67, S1
Publication
First Author: Gross JA
Year: 2001
Journal: Immunity
Title: TACI-Ig neutralizes molecules critical for B cell development and autoimmune disease. impaired B cell maturation in mice lacking BLyS.
Volume: 15
Issue: 2
Pages: 289-302
Publication
First Author: El Tannir El Tayara N
Year: 2006
Journal: Neurobiol Dis
Title: Age-related evolution of amyloid burden, iron load, and MR relaxation times in a transgenic mouse model of Alzheimer's disease.
Volume: 22
Issue: 1
Pages: 199-208
Publication
First Author: de la Fuente MA
Year: 2006
Journal: Mol Cell Biol
Title: 3BP2 deficiency impairs the response of B cells, but not T cells, to antigen receptor ligation.
Volume: 26
Issue: 14
Pages: 5214-25
Publication
First Author: Bot A
Year: 2001
Journal: J Immunol
Title: Plasmid vaccination with insulin B chain prevents autoimmune diabetes in nonobese diabetic mice.
Volume: 167
Issue: 5
Pages: 2950-5
Publication
First Author: Zhao JJ
Year: 1993
Journal: Genes Dev
Title: The mouse Hox-1.3 gene is functionally equivalent to the Drosophila Sex combs reduced gene.
Volume: 7
Issue: 3
Pages: 343-54
Publication
First Author: Teague BN
Year: 2007
Journal: J Immunol
Title: Cutting edge: Transitional T3 B cells do not give rise to mature B cells, have undergone selection, and are reduced in murine lupus.
Volume: 178
Issue: 12
Pages: 7511-5
Publication      
First Author: Sajuthi SP
Year: 2020
Journal: bioRxiv
Title: Type 2 and interferon inflammation strongly regulate SARS-CoV-2 related gene expression in the airway epithelium.