Type |
Details |
Score |
Allele |
Name: |
adhesion G protein-coupled receptor G3; targeted mutation 1, Zhugang Wang |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tcrb/Tcrb Tcrd/Tcrd |
Background: |
B6.129P2-Tcrb Tcrd/J |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Igh-J/Igh-J |
Background: |
Not Specified |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gimap1/Gimap1 Tg(CD2-icre)4Kio/? |
Background: |
involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Grb2/Grb2 Cd79a/Cd79a<+> |
Background: |
involves: BALB/c * BALB/cJ |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Atp11c/? |
Background: |
involves: C57BL/6J |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Igh/Igh |
Background: |
involves: 129 * 129S4/SvJae * C57BL/6 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Cd79a/Cd79a |
Background: |
involves: C57BL/6 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Sppl2a/Sppl2a |
Background: |
involves: C57BL/6 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Sppl2a/Sppl2a |
Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrl |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Kdelr1/Kdelr1 |
Background: |
C57BL/6J-Kdelr1 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Cd19/Cd19<+> Ell2/Ell2 |
Background: |
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Map3k14/Map3k14 |
Background: |
B6(Cg)-Map3k14 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Niban3/Niban3 |
Background: |
B6.Cg-Niban3 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Card11/Card11 |
Background: |
involves: C57BL/6 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
E-GEOD-66954 |
Experiment Type: |
RNA-Seq |
Study Type: |
Baseline |
Source: |
GEO |
|
•
•
•
•
•
|
Publication |
First Author: |
Davey JC |
Year: |
1995 |
Journal: |
J Biol Chem |
Title: |
Cloning of a cDNA for the type II iodothyronine deiodinase. |
Volume: |
270 |
Issue: |
45 |
Pages: |
26786-9 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
82
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
107
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
74
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
131
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
61
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
113
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
125
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
208
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
145
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Iodothyronine deiodinase () (DI) []is the vertebrate enzyme responsible for the deiodination ofthe prohormone thyroxine (T4 or 3,5,3',5'-tetraiodothyronine) into the biologically active hormone T3 (3,5,3'-triiodothyronine) and of T3 into the inactive metabolite T2 (3,3'-diiodothyronine). All known DI are proteins of about 250 residues that contain a selenocysteine at their active site. Three types of DI are known, type I is commonly found in the liver and kidney [], type II is essential for providing the brain with the appropriate levels of T3 during the critical period of development, and type III (also known as thyroxine 5-deiodinase) is essential for the regulation of thyroid hormone inactivation during embryological development. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Active_site |
Description: |
Iodothyronine deiodinase () (DI) []is the vertebrate enzyme responsible for the deiodination ofthe prohormone thyroxine (T4 or 3,5,3',5'-tetraiodothyronine) into the biologically active hormone T3(3,5,3'-triiodothyronine) and of T3 into the inactive metabolite T2 (3,3'-diiodothyronine). All known DI areproteins of about 250 residues that contain a selenocysteine at their active site. Three types of DI areknown, type II is essential for providing the brain with the appropriate levels of T3 during the criticalperiod of development, and type III is essential for the regulation of thyroid hormone inactivation duringembryological development. This signature found in the central part of the enzyme, which contains the active site selenocysteine. |
|
•
•
•
•
•
|
Publication |
First Author: |
Harmelink C |
Year: |
2013 |
Journal: |
Dev Biol |
Title: |
Myocardial Mycn is essential for mouse ventricular wall morphogenesis. |
Volume: |
373 |
Issue: |
1 |
Pages: |
53-63 |
|
•
•
•
•
•
|
Strain |
Attribute String: |
transgenic, targeted mutation, mutant strain, congenic |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, mutant strain, targeted mutation, transgenic |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang Z |
Year: |
2019 |
Journal: |
Circulation |
Title: |
Kindlin-2 Is Essential for Preserving Integrity of the Developing Heart and Preventing Ventricular Rupture. |
Volume: |
139 |
Issue: |
12 |
Pages: |
1554-1556 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ai S |
Year: |
2017 |
Journal: |
Circ Res |
Title: |
Divergent Requirements for EZH1 in Heart Development Versus Regeneration. |
Volume: |
121 |
Issue: |
2 |
Pages: |
106-112 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sun Q |
Year: |
2019 |
Journal: |
Dev Biol |
Title: |
SEMA6D regulates perinatal cardiomyocyte proliferation and maturation in mice. |
Volume: |
452 |
Issue: |
1 |
Pages: |
1-7 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Cxadr/Cxadr Tg(Tnnt2-cre)5Blh/? |
Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Lims1/Lims1 Lims2/Lims2 Tg(Tnnt2-cre)5Blh/? |
Background: |
involves: 129/Sv * C57BL/6 * DBA/2 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tarbp2/Tarbp2 Tg(Tnnt2-cre)5Blh/? |
Background: |
involves: 129 * C57BL/6 * DBA/2J |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Kmt2d/Kmt2d Tg(Tnnt2-cre)5Blh/? |
Background: |
B6.Cg-Kmt2d Tg(Tnnt2-cre)5Blh |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Hspb7/Hspb7 Tg(Tnnt2-cre)5Blh/? |
Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Prdm16/Prdm16 Tg(Tnnt2-cre)5Blh/? |
Background: |
involves: 129 * C57BL/6 * C57BL/6J * DBA/2 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Nras/Nras<+> Tg(Tnnt2-cre)5Blh/? |
Background: |
B6.Cg-Nras Tg(Tnnt2-cre)5Blh |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Kmt2d/Kmt2d<+> Tg(Tnnt2-cre)5Blh/? |
Background: |
B6.Cg-Kmt2d Tg(Tnnt2-cre)5Blh |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Med30/Med30 Tg(Tnnt2-cre)5Blh/? |
Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Lonp1/Lonp1 Tg(Tnnt2-cre)5Blh/? |
Background: |
involves: C57BL/6 * C57BL/6J * DBA/2 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Mib1/Mib1 Tg(Tnnt2-cre)5Blh/? |
Background: |
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Jag2/Jag2 Tg(Tnnt2-cre)5Blh/? |
Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Fermt2/Fermt2 Tg(Tnnt2-cre)5Blh/? |
Background: |
involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 * DBA/2 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(Tnnt2-cre)5Blh/? Wt1/Wt1 |
Background: |
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Mib1/Mib1<+> Tg(Tnnt2-cre)5Blh/? |
Background: |
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Dhx36/Dhx36 Tg(Tnnt2-cre)5Blh/? |
Background: |
involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA/2 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
López-Doménech G |
Year: |
2012 |
Journal: |
Nat Commun |
Title: |
The Eutherian Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro and Trak2. |
Volume: |
3 |
|
Pages: |
814 |
|
•
•
•
•
•
|
Publication |
First Author: |
Moreno M |
Year: |
1994 |
Journal: |
FEBS Lett |
Title: |
Activation and inactivation of thyroid hormone by type I iodothyronine deiodinase. |
Volume: |
344 |
Issue: |
2-3 |
Pages: |
143-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Löffler A |
Year: |
1993 |
Journal: |
Eur J Biochem |
Title: |
Amino acid sequence of an intracellular, phosphate-starvation-induced ribonuclease from cultured tomato (Lycopersicon esculentum) cells. |
Volume: |
214 |
Issue: |
3 |
Pages: |
627-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Meador J 3rd |
Year: |
1990 |
Journal: |
Gene |
Title: |
Cloning and sequencing the gene encoding Escherichia coli ribonuclease I: exact physical mapping using the genome library. |
Volume: |
95 |
Issue: |
1 |
Pages: |
1-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
McClure BA |
Year: |
1989 |
Journal: |
Nature |
Title: |
Style self-incompatibility gene products of Nicotiana alata are ribonucleases. |
Volume: |
342 |
Issue: |
6252 |
Pages: |
955-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Haring V |
Year: |
1990 |
Journal: |
Science |
Title: |
Self-incompatibility: a self-recognition system in plants. |
Volume: |
250 |
Issue: |
4983 |
Pages: |
937-41 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Active_site |
Description: |
The fungal ribonucleases T2 from Aspergillus oryzae, M from Aspergillus saitoi and Rh from Rhizopeus niveus are structurally and functionally related 30 Kd glycoproteins []that cleave the 3'-5' internucleotide linkage of RNA via a nucleotide 2',3'-cyclic phosphate intermediates ().A number of other RNAses have been found to be evolutionary related to thesefungal enzymes:Self-incompatibility []in flowering plants is often controlled by a single gene (S-gene) that has several alleles. This gene prevents fertilization by self-pollen or by pollen bearing either of the two S- alleles expressed in the style. The self-incompatibility glycoprotein fromseveral higher plants of the solanaceae family has been shown [, ]to be a ribonuclease.Phosphate-starvation induced RNAses LE and LX from tomato []. These twoenzymes are probably involved in a phosphate-starvation rescue system.Escherichia coli periplasmic RNAse I (EC 3.1.27.6) (gene rna) [].Aeromonas hydrophila periplasmic RNAse.Haemophilus influenzae hypothetical protein HI0526. Two histidines residues have been shown [, ]to be involved in the catalytic mechanism of RNase T2 and Rh. These residues and the region around them are highly conserved. This entry represents the conserved region containing the second His active site. This region also contains a cysteine which is known to be involved in disulfide bond formation. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Allele |
Name: |
B cell leukemia/lymphoma 3; targeted mutation 1, Ulrich Siebenlist |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
AT-rich interaction domain 3A; targeted mutation 1, Philip W Tucker |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
spleen tyrosine kinase; targeted mutation 2.1, Friedemann Kiefer |
Allele Type: |
Targeted |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Vav1/Vav1 Vav2/Vav2 Vav3/Vav3 |
Background: |
involves: 129S1/Sv * 129S2/SvPas * 129S6/SvEvTac * C57BL/6 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Nfkbia/Nfkbia |
Background: |
B6.129-Nfkbia |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Cd19/Cd19<+> |
Background: |
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Adgrg3/Adgrg3 |
Background: |
involves: 129 * C57BL/6 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Brorson KA |
Year: |
1989 |
Journal: |
J Exp Med |
Title: |
Comparison of exon 5 sequences from 35 class I genes of the BALB/c mouse. |
Volume: |
170 |
Issue: |
6 |
Pages: |
1837-58 |
|
•
•
•
•
•
|
Publication |
First Author: |
Peng Y |
Year: |
2014 |
Journal: |
Cardiovasc Res |
Title: |
Critical roles of miRNA-mediated regulation of TGFβ signalling during mouse cardiogenesis. |
Volume: |
103 |
Issue: |
2 |
Pages: |
258-67 |
|
•
•
•
•
•
|
Publication |
First Author: |
Han L |
Year: |
2022 |
Journal: |
Dev Cell |
Title: |
Changes in nuclear pore numbers control nuclear import and stress response of mouse hearts. |
Volume: |
57 |
Issue: |
20 |
Pages: |
2397-2411.e9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mu Y |
Year: |
2020 |
Journal: |
PLoS Genet |
Title: |
O-linked β-N-acetylglucosamine transferase plays an essential role in heart development through regulating angiopoietin-1. |
Volume: |
16 |
Issue: |
4 |
Pages: |
e1008730 |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, transgenic, targeted mutation |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Cxadr/Cxadr Tg(Tnnt2-cre)5Blh/? |
Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Bmp4/Bmp4 Tg(Tnnt2-cre)5Blh/? |
Background: |
involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * ICR |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Nipbl/Nipbl<+> Tg(Tnnt2-cre)5Blh/? |
Background: |
involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA/2 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Nipbl/Nipbl<+> Tg(Tnnt2-cre)5Blh/? |
Background: |
involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA/2 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Fkbp1a/Fkbp1a Tg(Tnnt2-cre)5Blh/? |
Background: |
involves: 129S7/SvEvBrd * C57BL/6 * DBA/2 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Myo18a/Myo18a Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Tnnt2-cre)5Blh/? |
Background: |
involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * C57BL/6N * DBA/2 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gata4/Gata4 Tg(Tnnt2-cre)5Blh/? |
Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Jag1/Jag1 Jag2/Jag2 Tg(Tnnt2-cre)5Blh/? |
Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA |
Zygosity: |
cn |
Has Mutant Allele: |
true |
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Genotype |
Symbol: |
Rest/Rest Tg(Tnnt2-cre)5Blh/? |
Background: |
involves: 129S2/SvPas * C57BL/6 * DBA/2 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
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Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tacr1/Tacr1<+> |
Background: |
involves: 129S6/SvEvTac * C57BL/6NCrl |
Zygosity: |
cn |
Has Mutant Allele: |
true |
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Genotype |
Symbol: |
Gpr83/Gpr83<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> |
Background: |
involves: 129S6/SvEvTac * C57BL/6NCrl |
Zygosity: |
cn |
Has Mutant Allele: |
true |
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Publication |
First Author: |
Liu Y |
Year: |
1996 |
Journal: |
Glycobiology |
Title: |
Purification, biochemistry and molecular cloning of an insect glycosylasparaginase from Spodoptera frugiperda. |
Volume: |
6 |
Issue: |
5 |
Pages: |
527-36 |
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Protein Domain |
Type: |
Family |
Description: |
Threonine peptidases are characterised by a threonine nucleophile at the N terminus of the mature enzyme. The threonine peptidases belong to clan PB or are unassigned, clan T-. The type example for this clan is the archaean proteasome beta component of Thermoplasma acidophilum.This group of sequences have a signature that places them in MEROPS peptidase family T2 (clan PB(T)). The glycosylasparaginases () are threonine peptidases. Also in this family is L-asparaginase (), which catalyses the following reaction:L-asparagine + H2O = L-aspartate + NH3Glycosylasparaginase catalyses:N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H(2)O =N-acetyl-beta-glucosaminylamine + L-aspartatecleaving the GlcNAc-Asn bond that links oligosaccharides to asparagine in N-linked glycoproteins. The enzyme is composed of two non-identical alpha/beta subunits joined by strong non-covalent forces and has one glycosylation site located in the alpha subunit []and plays a major role in the degradation of glycoproteins. |
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Protein Domain |
Type: |
Family |
Description: |
Iodothyronine deiodinase () (DI) []is the vertebrate enzyme responsible for the deiodination ofthe prohormone thyroxine (T4 or 3,5,3',5'-tetraiodothyronine) into the biologically active hormone T3 (3,5,3'-triiodothyronine) and of T3 into the inactive metabolite T2 (3,3'-diiodothyronine). All known DI are proteins of about 250 residues that contain a selenocysteine at their active site. Three types of DI are known, type I is commonly found in the liver and kidney [], type II is essential for providing the brain with the appropriate levels of T3 during the critical period of development, and type III (also known as thyroxine 5-deiodinase) is essential for the regulation of thyroid hormone inactivation during embryological development.This entry represents type I and III Iodothyronine deiodinases. |
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Protein Domain |
Type: |
Family |
Description: |
These sequences represent 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidases; it is a bifunctional enzyme localized to the periplasm of Gram-negative bacteria. 2',3'-cyclic-nucleotide 2'-phosphodiesters are intermediates formed during the hydrolysis of RNA by the ribonuclease I, which is also found in the periplasm, and other enzymes of the RNAse T2 family. Bacteria are unable to transport 2',3'-cyclic-nucleotides into the cytoplasm. 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidases contains 2 active sites which catalyze the reactions that convert the 2',3'-cyclic-nucleotide into a 3'-nucleotide, which is then converted into nucleic acid and phosphate. Both final products can be transported into the cytoplasm. Thus, it has been suggested that 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidases have a scavenging function. Experimental evidence indicates that a 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase enables Yersinia enterocolitica O:8 to grow on 23-cAMP as a sole source of carbon and energy []. |
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Publication |
First Author: |
Kumanogoh H |
Year: |
2008 |
Journal: |
Mol Cell Neurosci |
Title: |
Balanced expression of various TrkB receptor isoforms from the Ntrk2 gene locus in the mouse nervous system. |
Volume: |
39 |
Issue: |
3 |
Pages: |
465-77 |
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Publication |
First Author: |
Lindvall JM |
Year: |
2006 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Distinct gene expression signature in Btk-defective T1 B-cells. |
Volume: |
346 |
Issue: |
2 |
Pages: |
461-9 |
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Publication |
First Author: |
Dunn JF |
Year: |
1999 |
Journal: |
Muscle Nerve |
Title: |
Quantitative magnetic resonance imaging of the mdx mouse model of Duchenne muscular dystrophy. |
Volume: |
22 |
Issue: |
10 |
Pages: |
1367-71 |
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Publication |
First Author: |
Matalon R |
Year: |
2005 |
Journal: |
Int J Immunopathol Pharmacol |
Title: |
Abnormal expression of genes associated with development and inflammation in the heart of mouse maternal phenylketonuria offspring. |
Volume: |
18 |
Issue: |
3 |
Pages: |
557-65 |
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Publication |
First Author: |
Märklin M |
Year: |
2020 |
Journal: |
Cell Immunol |
Title: |
Genetic loss of NFAT2 (NFATc1) impairs B cell development of B1 and B2 B cells. |
Volume: |
349 |
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Pages: |
104048 |
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Publication |
First Author: |
Everts B |
Year: |
2012 |
Journal: |
J Exp Med |
Title: |
Schistosome-derived omega-1 drives Th2 polarization by suppressing protein synthesis following internalization by the mannose receptor. |
Volume: |
209 |
Issue: |
10 |
Pages: |
1753-67, S1 |
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Publication |
First Author: |
Gross JA |
Year: |
2001 |
Journal: |
Immunity |
Title: |
TACI-Ig neutralizes molecules critical for B cell development and autoimmune disease. impaired B cell maturation in mice lacking BLyS. |
Volume: |
15 |
Issue: |
2 |
Pages: |
289-302 |
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Publication |
First Author: |
El Tannir El Tayara N |
Year: |
2006 |
Journal: |
Neurobiol Dis |
Title: |
Age-related evolution of amyloid burden, iron load, and MR relaxation times in a transgenic mouse model of Alzheimer's disease. |
Volume: |
22 |
Issue: |
1 |
Pages: |
199-208 |
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Publication |
First Author: |
de la Fuente MA |
Year: |
2006 |
Journal: |
Mol Cell Biol |
Title: |
3BP2 deficiency impairs the response of B cells, but not T cells, to antigen receptor ligation. |
Volume: |
26 |
Issue: |
14 |
Pages: |
5214-25 |
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Publication |
First Author: |
Bot A |
Year: |
2001 |
Journal: |
J Immunol |
Title: |
Plasmid vaccination with insulin B chain prevents autoimmune diabetes in nonobese diabetic mice. |
Volume: |
167 |
Issue: |
5 |
Pages: |
2950-5 |
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Publication |
First Author: |
Zhao JJ |
Year: |
1993 |
Journal: |
Genes Dev |
Title: |
The mouse Hox-1.3 gene is functionally equivalent to the Drosophila Sex combs reduced gene. |
Volume: |
7 |
Issue: |
3 |
Pages: |
343-54 |
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Publication |
First Author: |
Teague BN |
Year: |
2007 |
Journal: |
J Immunol |
Title: |
Cutting edge: Transitional T3 B cells do not give rise to mature B cells, have undergone selection, and are reduced in murine lupus. |
Volume: |
178 |
Issue: |
12 |
Pages: |
7511-5 |
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Publication |
First Author: |
Sajuthi SP |
Year: |
2020 |
Journal: |
bioRxiv |
Title: |
Type 2 and interferon inflammation strongly regulate SARS-CoV-2 related gene expression in the airway epithelium. |
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