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Search results 801 to 900 out of 918 for Traf6

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Hits by Strain

Type Details Score
Publication
29566008 | J:265765
First Author: Johnson M
Year: 2018
Journal: PLoS One
Title: Genomic and transcriptomic comparison of allergen and silver nanoparticle-induced mast cell degranulation reveals novel non-immunoglobulin E mediated mechanisms.
Volume: 13
Issue: 3
Pages: e0193499
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Publication
32171293 | J:299872
First Author: Wang L
Year: 2020
Journal: J Neuroinflammation
Title: Pellino1 regulates neuropathic pain as well as microglial activation through the regulation of MAPK/NF-κB signaling in the spinal cord.
Volume: 17
Issue: 1
Pages: 83
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Protein
A0A0A6YXC4
Organism: Mus musculus/domesticus
Length: 138  
Fragment?: true
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Publication
10518213 | J:57751
First Author: Ye H
Year: 1999
Journal: Mol Cell
Title: The structural basis for the recognition of diverse receptor sequences by TRAF2.
Volume: 4
Issue: 3
Pages: 321-30
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Publication
28422092 | -
 
First Author: Huang N
Year: 2017
Journal: Nat Commun
Title: Hierarchical assembly of centriole subdistal appendages via centrosome binding proteins CCDC120 and CCDC68.
Volume: 8
Pages: 15057
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Protein
A2AEV7
Organism: Mus musculus/domesticus
Length: 629  
Fragment?: false
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Protein
Q7TN12
Organism: Mus musculus/domesticus
Length: 663  
Fragment?: false
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Protein
P70347
Organism: Mus musculus/domesticus
Length: 448  
Fragment?: false
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Protein
Q8C2D3
Organism: Mus musculus/domesticus
Length: 413  
Fragment?: false
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Protein
F6U5N5
Organism: Mus musculus/domesticus
Length: 97  
Fragment?: true
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Protein
D3YZT8
Organism: Mus musculus/domesticus
Length: 200  
Fragment?: true
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Protein
A0A0A6YWD6
Organism: Mus musculus/domesticus
Length: 78  
Fragment?: true
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Protein
Q9CXV4
Organism: Mus musculus/domesticus
Length: 331  
Fragment?: false
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Protein
Q3UGW0
Organism: Mus musculus/domesticus
Length: 414  
Fragment?: false
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Protein
G3X9Z8
Organism: Mus musculus/domesticus
Length: 677  
Fragment?: false
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Protein
Q3TNB4
Organism: Mus musculus/domesticus
Length: 413  
Fragment?: false
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Protein
A2AR76
Organism: Mus musculus/domesticus
Length: 447  
Fragment?: false
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Protein
D3YZL7
Organism: Mus musculus/domesticus
Length: 212  
Fragment?: true
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Protein
Q8R383
Organism: Mus musculus/domesticus
Length: 413  
Fragment?: false
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Protein Domain
IPR000058 | Znf_AN1
Type: Domain
Description: Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. Some of these domains bind zinc, but many do not; instead binding other metals such as iron, or no metal at all. For example, some family members form salt bridges to stabilise the finger-like folds. They were first identified as a DNA-binding motif in transcription factor TFIIIA from Xenopus laevis (African clawed frog), however they are now recognised to bind DNA, RNA, protein and/or lipid substrates [, , , , ]. Their binding properties depend on the amino acid sequence of the finger domains and of the linker between fingers, as well as on the higher-order structures and the number of fingers. Znf domains are often found in clusters, where fingers can have different binding specificities. There are many superfamilies of Znf motifs, varying in both sequence and structure. They display considerable versatility in binding modes, even between members of the same class (e.g. some bind DNA, others protein), suggesting that Znf motifs are stable scaffolds that have evolved specialised functions. For example, Znf-containing proteins function in gene transcription, translation, mRNA trafficking, cytoskeleton organisation, epithelial development, cell adhesion, protein folding, chromatin remodelling and zinc sensing, to name but a few []. Zinc-binding motifs are stable structures, and they rarely undergo conformational changes upon binding their target. This entry represents the AN1-type zinc finger domain, which has a dimetal (zinc)-bound alpha/beta fold. This domain was first identified as a zinc finger at the C terminus of AN1 , a ubiquitin-likeprotein in Xenopus laevis []. The AN1-type zinc finger contains six conserved cysteines and two histidines that could potentially coordinate 2 zinc atoms.Certain stress-associated proteins (SAP) contain AN1 domain, often in combination with A20 zinc finger domains (SAP8) or C2H2 domains (SAP16) []. For example, the human protein Znf216 has an A20 zinc-finger at the N terminus and an AN1 zinc-finger at the C terminus, acting to negatively regulate the NFkappaB activation pathway and to interact with components of the immune response like RIP, IKKgamma and TRAF6. The interact of Znf216 with IKK-gamma and RIP is mediated by the A20 zinc-finger domain, while its interaction with TRAF6 is mediated by the AN1 zinc-finger domain; therefore, both zinc-finger domains are involved in regulating the immune response []. The AN1 zinc finger domain is also found in proteins containing a ubiquitin-like domain, which are involved in the ubiquitination pathway []. Proteins containing an AN1-type zinc finger include:Ascidian posterior end mark 6 (pem-6) protein [].Human AWP1 protein (associated with PRK1), which is expressed during early embryogenesis [].Human immunoglobulin mu binding protein 2 (SMUBP-2), mutations in which cause muscular atrophy with respiratory distress type 1 [].
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Protein Domain
IPR035896 | AN1-like_Znf
Type: Homologous_superfamily
Description: Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. Some of these domains bind zinc, but many do not; instead binding other metals such as iron, or no metal at all. For example, some family members form salt bridges to stabilise the finger-like folds. They were first identified as a DNA-binding motif in transcription factor TFIIIA from Xenopus laevis (African clawed frog), however they are now recognised to bind DNA, RNA, protein and/or lipid substrates [, , , , ]. Their binding properties depend on the amino acid sequence of the finger domains and of the linker between fingers, as well as on the higher-order structures and the number of fingers. Znf domains are often found in clusters, where fingers can have different binding specificities. There are many superfamilies of Znf motifs, varying in both sequence and structure. They display considerable versatility in binding modes, even between members of the same class (e.g. some bind DNA, others protein), suggesting that Znf motifs are stable scaffolds that have evolved specialised functions. For example, Znf-containing proteins function in gene transcription, translation, mRNA trafficking, cytoskeleton organisation, epithelial development, cell adhesion, protein folding, chromatin remodelling and zinc sensing, to name but a few []. Zinc-binding motifs are stable structures, and they rarely undergo conformational changes upon binding their target. This entry represents the AN1-type zinc finger domain, which has a dimetal (zinc)-bound alpha/beta fold. This domain was first identified as a zinc finger at the C terminus of AN1 , a ubiquitin-likeprotein in Xenopus laevis []. The AN1-type zinc finger contains six conserved cysteines and two histidines that could potentially coordinate 2 zinc atoms.Certain stress-associated proteins (SAP) contain AN1 domain, often in combination with A20 zinc finger domains (SAP8) or C2H2 domains (SAP16) []. For example, the human protein Znf216 has an A20 zinc-finger at the N terminus and an AN1 zinc-finger at the C terminus, acting to negatively regulate the NFkappaB activation pathway and to interact with components of the immune response like RIP, IKKgamma and TRAF6. The interact of Znf216 with IKK-gamma and RIP is mediated by the A20 zinc-finger domain, while its interaction with TRAF6 is mediated by the AN1 zinc-finger domain; therefore, both zinc-finger domains are involved in regulating the immune response []. The AN1 zinc finger domain is also found in proteins containing a ubiquitin-like domain, which are involved in the ubiquitination pathway []. Proteins containing an AN1-type zinc finger include:Ascidian posterior end mark 6 (pem-6) protein [].Human AWP1 protein (associated with PRK1), which is expressed during early embryogenesis [].Human immunoglobulin mu binding protein 2 (SMUBP-2), mutations in which cause muscular atrophy with respiratory distress type 1 [].
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Protein Coding Gene
MGI:103575 | Skp1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1349658 | Cul1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1321161 | Ppp2cb
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1920949 | Ppp2r1b
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1338074 | Ikbkg
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q7TNP2
Organism: Mus musculus/domesticus
Length: 601  
Fragment?: false
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Protein
Q9WTX6
Organism: Mus musculus/domesticus
Length: 776  
Fragment?: false
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Protein
O88522
Organism: Mus musculus/domesticus
Length: 412  
Fragment?: false
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Protein
P62715
Organism: Mus musculus/domesticus
Length: 309  
Fragment?: false
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Protein
Q9WTX5
Organism: Mus musculus/domesticus
Length: 163  
Fragment?: false
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Publication
11054541 | J:65465
First Author: Duan W
Year: 2000
Journal: Gene
Title: Cloning and characterization of AWP1, a novel protein that associates with serine/threonine kinase PRK1 in vivo.
Volume: 256
Issue: 1-2
Pages: 113-21
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Publication
14754897 | -
First Author: Huang J
Year: 2004
Journal: J Biol Chem
Title: ZNF216 Is an A20-like and IkappaB kinase gamma-interacting inhibitor of NFkappaB activation.
Volume: 279
Issue: 16
Pages: 16847-53
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Protein
Q8BFR6
Organism: Mus musculus/domesticus
Length: 268  
Fragment?: false
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Protein
Q9JII7
Organism: Mus musculus/domesticus
Length: 171  
Fragment?: false
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Protein
Q61382
Organism: Mus musculus/domesticus
Length: 470  
Fragment?: false
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Protein
D3YUL0
Organism: Mus musculus/domesticus
Length: 89  
Fragment?: true
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Protein
D3Z7G5
Organism: Mus musculus/domesticus
Length: 207  
Fragment?: false
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Protein
F7CFT1
Organism: Mus musculus/domesticus
Length: 247  
Fragment?: true
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Protein
B1ASY9
Organism: Mus musculus/domesticus
Length: 716  
Fragment?: false
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Publication
8390387 | -
First Author: Linnen JM
Year: 1993
Journal: Gene
Title: Two related localized mRNAs from Xenopus laevis encode ubiquitin-like fusion proteins.
Volume: 128
Issue: 2
Pages: 181-8
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Publication
9441682 | -
First Author: Satou Y
Year: 1997
Journal: Dev Biol
Title: Posterior end mark 2 (pem-2), pem-4, pem-5, and pem-6: maternal genes with localized mRNA in the ascidian embryo.
Volume: 192
Issue: 2
Pages: 467-81
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Publication
17033811 | -
First Author: Vij S
Year: 2006
Journal: Mol Genet Genomics
Title: Genome-wide analysis of the stress associated protein (SAP) gene family containing A20/AN1 zinc-finger(s) in rice and their phylogenetic relationship with Arabidopsis.
Volume: 276
Issue: 6
Pages: 565-75
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Publication
30949903 | J:295897
First Author: Yang M
Year: 2019
Journal: Dig Dis Sci
Title: Effects and Mechanism of Constitutive TL1A Expression on Intestinal Mucosal Barrier in DSS-Induced Colitis.
Volume: 64
Issue: 7
Pages: 1844-1856
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Publication
16234979 | J:128134
First Author: Kanazawa K
Year: 2005
Journal: J Bone Miner Res
Title: Self-assembled RANK induces osteoclastogenesis ligand-independently.
Volume: 20
Issue: 11
Pages: 2053-60
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Publication
34488443 | J:313044
First Author: Wang L
Year: 2021
Journal: mBio
Title: The Ubiquitin Sensor and Adaptor Protein p62 Mediates Signal Transduction of a Viral Oncogenic Pathway.
Volume: 12
Issue: 5
Pages: e0109721
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Publication
37988467 | J:359664
First Author: Schmidt H
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: Unrestrained cleavage of Roquin-1 by MALT1 induces spontaneous T cell activation and the development of autoimmunity.
Volume: 120
Issue: 48
Pages: e2309205120
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Protein
Q8JZM6
Organism: Mus musculus/domesticus
Length: 147  
Fragment?: false
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Protein
Q8K2V1
Organism: Mus musculus/domesticus
Length: 951  
Fragment?: false
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Protein
I3PQW8
Organism: Mus musculus/domesticus
Length: 184  
Fragment?: false
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Protein
E9PX53
Organism: Mus musculus/domesticus
Length: 934  
Fragment?: false
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Protein
E9QPR5
Organism: Mus musculus/domesticus
Length: 951  
Fragment?: false
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Protein
E0CXK8
Organism: Mus musculus/domesticus
Length: 376  
Fragment?: false
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Protein
F6TLH3
Organism: Mus musculus/domesticus
Length: 189  
Fragment?: true
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Protein
Q3TLM9
Organism: Mus musculus/domesticus
Length: 934  
Fragment?: false
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Protein
E0CYV2
Organism: Mus musculus/domesticus
Length: 154  
Fragment?: true
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Protein Coding Gene
MGI:1321159 | Ppp2ca
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1346858 | Mapk1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1926334 | Ppp2r1a
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1346859 | Mapk3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q76MZ3
Organism: Mus musculus/domesticus
Length: 589  
Fragment?: false
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Protein
P63085
Organism: Mus musculus/domesticus
Length: 358  
Fragment?: false
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Protein
Q63844
Organism: Mus musculus/domesticus
Length: 380  
Fragment?: false
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Protein
P63330
Organism: Mus musculus/domesticus
Length: 309  
Fragment?: false
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Protein
O88878
Organism: Mus musculus/domesticus
Length: 213  
Fragment?: false
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Protein
Q91X58
Organism: Mus musculus/domesticus
Length: 257  
Fragment?: false
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Protein
Q497H0
Organism: Mus musculus/domesticus
Length: 227  
Fragment?: false
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Protein
Q9DCH6
Organism: Mus musculus/domesticus
Length: 223  
Fragment?: false
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Protein
A0A140LIM2
Organism: Mus musculus/domesticus
Length: 217  
Fragment?: true
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Protein
A0A087WPF5
Organism: Mus musculus/domesticus
Length: 255  
Fragment?: true
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Protein
A0A140LI56
Organism: Mus musculus/domesticus
Length: 188  
Fragment?: true
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Protein
E0CY18
Organism: Mus musculus/domesticus
Length: 218  
Fragment?: true
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Protein
A0A140LJF3
Organism: Mus musculus/domesticus
Length: 184  
Fragment?: true
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Protein
P70191
Organism: Mus musculus/domesticus
Length: 558  
Fragment?: false
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Protein
Q60803
Organism: Mus musculus/domesticus
Length: 567  
Fragment?: false
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Protein
Q3U8L1
Organism: Mus musculus/domesticus
Length: 501  
Fragment?: false
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Protein
Q3UHJ1
Organism: Mus musculus/domesticus
Length: 542  
Fragment?: false
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Protein
Q3UMS9
Organism: Mus musculus/domesticus
Length: 558  
Fragment?: false
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Protein
Q8C6X9
Organism: Mus musculus/domesticus
Length: 501  
Fragment?: false
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Protein
Q8CAQ7
Organism: Mus musculus/domesticus
Length: 501  
Fragment?: false
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Protein
Q3UHM2
Organism: Mus musculus/domesticus
Length: 542  
Fragment?: false
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Protein
Q3TWR1
Organism: Mus musculus/domesticus
Length: 501  
Fragment?: false
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Protein
D3Z343
Organism: Mus musculus/domesticus
Length: 97  
Fragment?: true
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Protein
D3Z3C6
Organism: Mus musculus/domesticus
Length: 739  
Fragment?: false
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Protein
K3W4R9
Organism: Mus musculus/domesticus
Length: 758  
Fragment?: false
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Protein
Q9DBV8
Organism: Mus musculus/domesticus
Length: 1008  
Fragment?: false
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Protein
Q60592
Organism: Mus musculus/domesticus
Length: 1734  
Fragment?: false
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Protein
B1AST7
Organism: Mus musculus/domesticus
Length: 1739  
Fragment?: false
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Protein
A0A668KLF8
Organism: Mus musculus/domesticus
Length: 1642  
Fragment?: false
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Protein
B1AST8
Organism: Mus musculus/domesticus
Length: 1733  
Fragment?: false
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Protein
E9Q1Q1
Organism: Mus musculus/domesticus
Length: 1800  
Fragment?: false
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Protein
A0A668KL31
Organism: Mus musculus/domesticus
Length: 1714  
Fragment?: false
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Protein
E9QLW6
Organism: Mus musculus/domesticus
Length: 1794  
Fragment?: false
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Publication
16237670 | J:102328
First Author: Meroni G
Year: 2005
Journal: Bioessays
Title: TRIM/RBCC, a novel class of 'single protein RING finger' E3 ubiquitin ligases.
Volume: 27
Issue: 11
Pages: 1147-57
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Protein Coding Gene
MGI:1925544 | Rps27a
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:98887 | Uba52
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:98888 | Ubb
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:98889 | Ubc
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P62984
Organism: Mus musculus/domesticus
Length: 128  
Fragment?: false
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Protein
P0CG50
Organism: Mus musculus/domesticus
Length: 734  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom