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Search results 801 to 894 out of 894 for Vdr

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Type Details Score
Allele
Name: vitamin D (1,25-dihydroxyvitamin D3) receptor; targeted mutation 1, Shigeaki Kato
Allele Type: Targeted
Attribute String: Null/knockout
Strain
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
Allele
Name: vitamin D (1,25-dihydroxyvitamin D3) receptor; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
Allele
Name: vitamin D (1,25-dihydroxyvitamin D3) receptor; endonuclease-mediated mutation 1, Stephanie Sisley
Allele Type: Endonuclease-mediated
Attribute String: Recombinase
GO Term
Publication
First Author: Shaffer PL
Year: 2002
Journal: EMBO J
Title: Structural basis of VDR-DNA interactions on direct repeat response elements.
Volume: 21
Issue: 9
Pages: 2242-52
Publication
First Author: Owen GI
Year: 2000
Journal: Cell Mol Life Sci
Title: Origins and evolutionary diversification of the nuclear receptor superfamily.
Volume: 57
Issue: 5
Pages: 809-27
Publication
First Author: Gronemeyer H
Year: 2004
Journal: Nat Rev Drug Discov
Title: Principles for modulation of the nuclear receptor superfamily.
Volume: 3
Issue: 11
Pages: 950-64
Publication
First Author: Carlberg C
Year: 2006
Journal: Curr Top Med Chem
Title: Detailed molecular understanding of agonistic and antagonistic vitamin D receptor ligands.
Volume: 6
Issue: 12
Pages: 1243-53
Publication
First Author: Davis PJ
Year: 1992
Journal: Quintessence Int
Title: Incisor spacing: a sequential orthodontic restorative treatment approach.
Volume: 23
Issue: 10
Pages: 689-93
Protein Domain
Type: Domain
Description: This entry represents the DNA-binding domain of vitamin D receptors (VDR). It is composed of two C4-type zinc fingers. Each zinc finger contains a group of four Cys residues which coordinates a single zinc atom. VDR interacts with a VDR response element, a direct repeat of GGTTCA DNA site with 3 bp spacer upstream of the target gene, and modulates the rate of transcriptional initiation []. VDR is a member of the nuclear receptor (NR) superfamily that functions as classical endocrine receptors. VDR controls a wide range of biological activities including calcium metabolism, cell proliferation and differentiation, and immunomodulation. VDR is a high-affinity receptor for the biologically most active Vitamin D metabolite, 1alpha,25-dihydroxyvitamin D3 (1alpha,25(OH)2D3) []. The binding of the ligand to the receptor induces a conformational change of the ligand binding domain (LBD) with consequent dissociation of corepressors. Upon ligand binding, VDR forms a heterodimer with the retinoid X receptor (RXR) that binds to vitamin D response elements (VDREs), recruits coactivators. This leads to the expression of a large number of genes. Approximately 200 human genes are considered to be primary targets of VDR and even more genes are regulated indirectly []. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, VDR has a central well conserved DNA binding domain (DBD) [], a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD) [, ].
HT Experiment
Series Id: GSE68725
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment
Series Id: GSE68724
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment
Series Id: GSE68723
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
GO Term
GO Term
Allele
Name: transgene insertion T807, J Wesley Pike
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence, Reporter
Publication  
First Author: Claessens F
Year: 2004
Journal: Essays Biochem
Title: DNA recognition by nuclear receptors.
Volume: 40
Pages: 59-72
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Vdr/Vdr<+>
Background: involves: 129S6/SvEvTac * C57BL/6N
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Tg(VDR*L233S,luc)T807Pike/? Vdr/Vdr
Background: involves: 129S4/SvJae * C57BL/6
Zygosity: cx
Has Mutant Allele: true
Protein Domain
Type: Family
Description: Steroid or nuclear hormone receptors (NRs) constitute an important super-family of transcription regulators that are involved in widely diverse physiological functions, including control of embryonic development, celldifferentiation and homeostasis. Members of the superfamily include thesteroid hormone receptors and receptors for thyroid hormone, retinoids, 1,25-dihydroxy-vitamin D3 and a variety of other ligands. The proteins function as dimeric molecules in nuclei to regulate the transcription of target genes in a ligand-responsive manner [, ]. In addition to C-terminalligand-binding domains, these nuclear receptors contain a highly-conserved,N-terminal zinc-finger that mediates specific binding to target DNA sequences, termed ligand-responsive elements. In the absence of ligand,steroid hormone receptors are thought to be weakly associated with nuclearcomponents; hormone binding greatly increases receptor affinity.NRs are extremely important in medical research, a large number of thembeing implicated in diseases such as cancer, diabetes, hormone resistancesyndromes, etc. While several NRs act as ligand-inducible transcriptionfactors, many do not yet have a defined ligand and are accordingly termed "orphan"receptors. During the last decade, more than 300 NRs have beendescribed, many of which are orphans, which cannot easily be named due to current nomenclature confusions in the literature. However, a new system has recently been introduced in an attempt to rationalise the increasingly complex set of names used to describe superfamily members.The vitamin D receptor (VDR) mediates the signal of 1-a,25-dihydroxyvitamin D3 by binding to vitamin D responsive elements - it functions either as a homodimer, or as a heterodimer of vitamin D and retinoid X receptorsubunits. Deficiency of VDR causes type IIA rickets [].
Protein
Organism: Mus musculus/domesticus
Length: 422  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 422  
Fragment?: false
Publication
First Author: Morró M
Year: 2020
Journal: Diabetes
Title: Vitamin D Receptor Overexpression in β-Cells Ameliorates Diabetes in Mice.
Volume: 69
Issue: 5
Pages: 927-939
Publication
First Author: Durk MR
Year: 2014
Journal: J Neurosci
Title: 1α,25-Dihydroxyvitamin D3 reduces cerebral amyloid-β accumulation and improves cognition in mouse models of Alzheimer's disease.
Volume: 34
Issue: 21
Pages: 7091-101
Publication
First Author: Khazan N
Year: 2022
Journal: J Med Chem
Title: Identification of a Vitamin-D Receptor Antagonist, MeTC7, which Inhibits the Growth of Xenograft and Transgenic Tumors In Vivo.
Volume: 65
Issue: 8
Pages: 6039-6055
Publication
First Author: Zhang L
Year: 2011
Journal: Cell Stem Cell
Title: Specific microRNAs are preferentially expressed by skin stem cells to balance self-renewal and early lineage commitment.
Volume: 8
Issue: 3
Pages: 294-308
Publication
First Author: Kim JY
Year: 2009
Journal: Biochem Biophys Res Commun
Title: A role of helix 12 of the vitamin D receptor in SMRT corepressor interaction.
Volume: 379
Issue: 3
Pages: 780-4
Publication
First Author: Liu L
Year: 1996
Journal: Am J Physiol
Title: RT-PCR microlocalization of mRNAs for calbindin D28k and vitamin D receptor in the murine nephron.
Volume: 270
Issue: 4 Pt 2
Pages: F677-81
Publication
First Author: Fujita A
Year: 1999
Journal: Biochem Biophys Res Commun
Title: Differential regulation of ligand-dependent and ligand-independent functions of the mouse retinoid X receptor beta by alternative splicing.
Volume: 255
Issue: 3
Pages: 625-30
Publication
First Author: St-Arnaud R
Year: 2011
Journal: Mol Cell Endocrinol
Title: Vitamin D metabolism, cartilage and bone fracture repair.
Volume: 347
Issue: 1-2
Pages: 48-54
Publication
First Author: Fernandez Lahore G
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Vitamin D3 receptor polymorphisms regulate T cells and T cell-dependent inflammatory diseases.
Volume: 117
Issue: 40
Pages: 24986-24997
Publication
First Author: Li X
Year: 2023
Journal: iScience
Title: MYCT1 attenuates renal fibrosis and tubular injury in diabetic kidney disease.
Volume: 26
Issue: 9
Pages: 107609
Publication
First Author: vom Baur E
Year: 1996
Journal: EMBO J
Title: Differential ligand-dependent interactions between the AF-2 activating domain of nuclear receptors and the putative transcriptional intermediary factors mSUG1 and TIF1.
Volume: 15
Issue: 1
Pages: 110-24
Publication
First Author: Ignat M
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Arterial calcifications and increased expression of vitamin D receptor targets in mice lacking TIF1alpha.
Volume: 105
Issue: 7
Pages: 2598-603
Publication
First Author: Prasad R
Year: 1997
Journal: Oncogene
Title: Structure and expression pattern of human ALR, a novel gene with strong homology to ALL-1 involved in acute leukemia and to Drosophila trithorax.
Volume: 15
Issue: 5
Pages: 549-60
Publication
First Author: McCary LC
Year: 1996
Journal: Endocrinology
Title: Osteopetrotic (op/op) mice are unable to maintain serum calcium levels despite hyperabsorption of calcium.
Volume: 137
Issue: 3
Pages: 1049-56
Publication
First Author: Gonzalez-Sanchez E
Year: 2017
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Expression patterns of nuclear receptors in parenchymal and non-parenchymal mouse liver cells and their modulation in cholestasis.
Volume: 1863
Issue: 7
Pages: 1699-1708
Publication
First Author: Tang JY
Year: 2011
Journal: Cancer Prev Res (Phila)
Title: Vitamin D3 inhibits hedgehog signaling and proliferation in murine Basal cell carcinomas.
Volume: 4
Issue: 5
Pages: 744-51
Publication
First Author: Urahama N
Year: 2005
Journal: Genes Cells
Title: The role of transcriptional coactivator TRAP220 in myelomonocytic differentiation.
Volume: 10
Issue: 12
Pages: 1127-37
Publication
First Author: Yoshida T
Year: 2002
Journal: Endocrinology
Title: Mediation of unusually high concentrations of 1,25-dihydroxyvitamin D in homozygous klotho mutant mice by increased expression of renal 1alpha-hydroxylase gene.
Volume: 143
Issue: 2
Pages: 683-9
Publication
First Author: He B
Year: 2024
Journal: Cell Death Dis
Title: Epigenetic priming targets tumor heterogeneity to shift transcriptomic phenotype of pancreatic ductal adenocarcinoma towards a Vitamin D susceptible state.
Volume: 15
Issue: 1
Pages: 89
Publication
First Author: Hassan N
Year: 2017
Journal: PLoS One
Title: Titanium biomaterials with complex surfaces induced aberrant peripheral circadian rhythms in bone marrow mesenchymal stromal cells.
Volume: 12
Issue: 8
Pages: e0183359
Publication
First Author: Takasu H
Year: 2006
Journal: J Clin Invest
Title: c-Fos protein as a target of anti-osteoclastogenic action of vitamin D, and synthesis of new analogs.
Volume: 116
Issue: 2
Pages: 528-35
Publication
First Author: Meyer MB
Year: 2019
Journal: J Biol Chem
Title: A chromatin-based mechanism controls differential regulation of the cytochrome P450 gene Cyp24a1 in renal and non-renal tissues.
Volume: 294
Issue: 39
Pages: 14467-14481
Publication
First Author: Masuda S
Year: 2005
Journal: Endocrinology
Title: Altered pharmacokinetics of 1alpha,25-dihydroxyvitamin D3 and 25-hydroxyvitamin D3 in the blood and tissues of the 25-hydroxyvitamin D-24-hydroxylase (Cyp24a1) null mouse.
Volume: 146
Issue: 2
Pages: 825-34
Publication
First Author: Alam C
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Upregulation of reduced folate carrier by vitamin D enhances brain folate uptake in mice lacking folate receptor alpha.
Volume: 116
Issue: 35
Pages: 17531-17540
Publication  
First Author: Kawai M
Year: 2019
Journal: JCI Insight
Title: Intestinal clock system regulates skeletal homeostasis.
Volume: 4
Issue: 5
Publication
First Author: Zhang Y
Year: 2020
Journal: Am J Physiol Cell Physiol
Title: RNA-binding protein HuR regulates translation of vitamin D receptor modulating rapid epithelial restitution after wounding.
Volume: 319
Issue: 1
Pages: C208-C217
Publication
First Author: Kosinsky RL
Year: 2021
Journal: Cell Death Differ
Title: RNF20 and RNF40 regulate vitamin D receptor-dependent signaling in inflammatory bowel disease.
Volume: 28
Issue: 11
Pages: 3161-3175
Publication
First Author: Lai RH
Year: 2021
Journal: Aging Cell
Title: Non-genomic rewiring of vitamin D receptor to p53 as a key to Alzheimer's disease.
Volume: 20
Issue: 12
Pages: e13509
Publication
First Author: Healy KD
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Parathyroid hormone decreases renal vitamin D receptor expression in vivo.
Volume: 102
Issue: 13
Pages: 4724-8
Publication
First Author: Nam Y
Year: 2006
Journal: Genomics
Title: A novel missense mutation in the mouse hairless gene causes irreversible hair loss: genetic and molecular analyses of Hr m1Enu.
Volume: 87
Issue: 4
Pages: 520-6
Publication
First Author: Dougherty U
Year: 2019
Journal: Cancer Prev Res (Phila)
Title: Losartan and Vitamin D Inhibit Colonic Tumor Development in a Conditional Apc-Deleted Mouse Model of Sporadic Colon Cancer.
Volume: 12
Issue: 7
Pages: 433-448
Publication
First Author: Bach FC
Year: 2014
Journal: J Cell Physiol
Title: The paracrine feedback loop between vitamin D₃ (1,25(OH)₂D₃) and PTHrP in prehypertrophic chondrocytes.
Volume: 229
Issue: 12
Pages: 1999-2014
Publication
First Author: Kim E
Year: 2020
Journal: Transl Psychiatry
Title: Coexistence of perseveration and apathy in the TDP-43Q331K knock-in mouse model of ALS-FTD.
Volume: 10
Issue: 1
Pages: 377
Publication  
First Author: Yang H
Year: 2017
Journal: Mol Cell Endocrinol
Title: NCKX3 was compensated by calcium transporting genes and bone resorption in a NCKX3 KO mouse model.
Volume: 454
Pages: 93-102
Publication
First Author: Slavkin HC
Year: 1992
Journal: Crit Rev Eukaryot Gene Expr
Title: Gene expression, signal transduction and tissue-specific biomineralization during mammalian tooth development.
Volume: 2
Issue: 4
Pages: 315-29
Publication
First Author: Pereira FA
Year: 1995
Journal: J Steroid Biochem Mol Biol
Title: Chicken ovalbumin upstream promoter transcription factor (COUP-TF): expression during mouse embryogenesis.
Volume: 53
Issue: 1-6
Pages: 503-8
Publication
First Author: Nguyen TM
Year: 1997
Journal: Endocrinology
Title: Changes in 1,25-(OH)2D3 synthesis and its receptor expression in spleen cell subpopulations of mice infected with LPBM5 retrovirus.
Volume: 138
Issue: 12
Pages: 5505-10
Publication
First Author: Yanagi Y
Year: 1999
Journal: J Biol Chem
Title: Positive and negative modulation of vitamin D receptor function by transforming growth factor-beta signaling through smad proteins.
Volume: 274
Issue: 19
Pages: 12971-4
Publication
First Author: Welsh J
Year: 2004
Journal: Am J Clin Nutr
Title: Vitamin D and breast cancer: insights from animal models.
Volume: 80
Issue: 6 Suppl
Pages: 1721S-4S
Publication
First Author: Eckey M
Year: 2007
Journal: Mol Cell Biol
Title: The nucleosome assembly activity of NAP1 is enhanced by Alien.
Volume: 27
Issue: 10
Pages: 3557-68
Publication
First Author: St-Arnaud R
Year: 2008
Journal: Arch Biochem Biophys
Title: The direct role of vitamin D on bone homeostasis.
Volume: 473
Issue: 2
Pages: 225-30
Publication
First Author: Han S
Year: 2010
Journal: Mol Endocrinol
Title: A novel bile acid-activated vitamin D receptor signaling in human hepatocytes.
Volume: 24
Issue: 6
Pages: 1151-64
Publication
First Author: Cui J
Year: 2011
Journal: Mol Cell Endocrinol
Title: A novel interaction between insulin-like growth factor binding protein-6 and the vitamin D receptor inhibits the role of vitamin D3 in osteoblast differentiation.
Volume: 338
Issue: 1-2
Pages: 84-92
Publication
First Author: Lundqvist J
Year: 2012
Journal: Biochim Biophys Acta
Title: Vitamin D-mediated regulation of CYP21A2 transcription - a novel mechanism for vitamin D action.
Volume: 1820
Issue: 10
Pages: 1553-9
Publication
First Author: Welsh J
Year: 2012
Journal: Arch Biochem Biophys
Title: Cellular and molecular effects of vitamin D on carcinogenesis.
Volume: 523
Issue: 1
Pages: 107-14
Publication
First Author: Mehta RG
Year: 2013
Journal: Cancer Lett
Title: Vitamin D and breast cancer: emerging concepts.
Volume: 334
Issue: 1
Pages: 95-100
Publication
First Author: Hill NT
Year: 2014
Journal: PLoS One
Title: Role of vitamin D3 in modulation of ΔNp63α expression during UVB induced tumor formation in SKH-1 mice.
Volume: 9
Issue: 9
Pages: e107052
Publication
First Author: Pols TWH
Year: 2017
Journal: PLoS One
Title: Lithocholic acid controls adaptive immune responses by inhibition of Th1 activation through the Vitamin D receptor.
Volume: 12
Issue: 5
Pages: e0176715
Publication
First Author: Hasan N
Year: 2019
Journal: Sci Rep
Title: Vitamin D3 constrains estrogen's effects and influences mammary epithelial organization in 3D cultures.
Volume: 9
Issue: 1
Pages: 7423
Publication
First Author: Ashcroft SP
Year: 2020
Journal: Am J Physiol Cell Physiol
Title: The vitamin D receptor regulates mitochondrial function in C2C12 myoblasts.
Volume: 318
Issue: 3
Pages: C536-C541
Publication    
First Author: Yu M
Year: 2021
Journal: J Biol Chem
Title: Vitamin D receptor inhibits EMT via regulation of epithelial mitochondrial function in intestinal fibrosis.
Pages: 100531
Publication
First Author: Griffin AC 3rd
Year: 2012
Journal: Mol Endocrinol
Title: MKP-1 is essential for canonical vitamin D-induced signaling through nuclear import and regulates RANKL expression and function.
Volume: 26
Issue: 10
Pages: 1682-93
Publication  
First Author: Beck J
Year: 2022
Journal: Front Endocrinol (Lausanne)
Title: Paraventricular Vitamin D Receptors Are Required for Glucose Tolerance in Males but Not Females.
Volume: 13
Pages: 869678
Publication  
First Author: Gao H
Year: 2023
Journal: Front Immunol
Title: Vitamin D3 alleviates inflammation in ulcerative colitis by activating the VDR-NLRP6 signaling pathway.
Volume: 14
Pages: 1135930
Publication  
First Author: Dai Q
Year: 2023
Journal: Front Physiol
Title: Vitamin D-VDR (vitamin D receptor) alleviates glucose metabolism reprogramming in lipopolysaccharide-induced acute kidney injury.
Volume: 14
Pages: 1083643
Publication  
First Author: Brideau G
Year: 2024
Journal: Int J Mol Sci
Title: Claudin-10 Expression and the Gene Expression Pattern of Thick Ascending Limb Cells.
Volume: 25
Issue: 7
Publication
First Author: Yamamoto H
Year: 1999
Journal: J Bone Miner Res
Title: The caudal-related homeodomain protein Cdx-2 regulates vitamin D receptor gene expression in the small intestine.
Volume: 14
Issue: 2
Pages: 240-7
Publication
First Author: Becker LE
Year: 2011
Journal: Am J Physiol Renal Physiol
Title: Effect of paricalcitol and calcitriol on aortic wall remodeling in uninephrectomized ApoE knockout mice.
Volume: 300
Issue: 3
Pages: F772-82
Publication
First Author: Boyan BD
Year: 2006
Journal: J Bone Miner Res
Title: Regulation of growth plate chondrocytes by 1,25-dihydroxyvitamin D3 requires caveolae and caveolin-1.
Volume: 21
Issue: 10
Pages: 1637-47
Publication  
First Author: Meyer MB
Year: 2024
Journal: Endocrinology
Title: In Vivo Contribution of Cyp24a1 Promoter Vitamin D Response Elements.
Volume: 165
Issue: 11
Publication
First Author: Rotkiewicz P
Year: 2001
Journal: Proteins
Title: Model of three-dimensional structure of vitamin D receptor and its binding mechanism with 1alpha,25-dihydroxyvitamin D(3).
Volume: 44
Issue: 3
Pages: 188-99
Publication
First Author: Baldock PA
Year: 2006
Journal: J Bone Miner Res
Title: Vitamin D action and regulation of bone remodeling: suppression of osteoclastogenesis by the mature osteoblast.
Volume: 21
Issue: 10
Pages: 1618-26
Publication  
First Author: Guo YX
Year: 2016
Journal: Neuroscience
Title: 1,25-Dihydroxyvitamin D3 regulates expression of LRP1 and RAGE in vitro and in vivo, enhancing Aβ1-40 brain-to-blood efflux and peripheral uptake transport.
Volume: 322
Pages: 28-38
Publication  
First Author: Reichrath J
Year: 2017
Journal: Mol Cell Endocrinol
Title: Endocrine actions of vitamin D in skin: Relevance for photocarcinogenesis of non-melanoma skin cancer, and beyond.
Volume: 453
Pages: 96-102
Publication
First Author: Hariri H
Year: 2023
Journal: J Bone Miner Res
Title: USP53 Regulates Bone Homeostasis by Controlling Rankl Expression in Osteoblasts and Bone Marrow Adipocytes.
Volume: 38
Issue: 4
Pages: 578-596
Protein
Organism: Mus musculus/domesticus
Length: 75  
Fragment?: true
Publication  
First Author: Wang P
Year: 2023
Journal: J Orthop Translat
Title: Sirt1 protects against intervertebral disc degeneration induced by 1,25-dihydroxyvitamin D insufficiency in mice by inhibiting the NF-κB inflammatory pathway.
Volume: 40
Pages: 13-26
Publication  
First Author: Haussler MR
Year: 1997
Journal: J Endocrinol
Title: The vitamin D hormone and its nuclear receptor: molecular actions and disease states.
Volume: 154 Suppl
Pages: S57-73
Publication
First Author: Nishikawa J
Year: 1995
Journal: Nucleic Acids Res
Title: Vitamin D receptor contains multiple dimerization interfaces that are functionally different.
Volume: 23
Issue: 4
Pages: 606-11
Publication
First Author: De Vos P
Year: 1994
Journal: Nucleic Acids Res
Title: Human androgen receptor expressed in HeLa cells activates transcription in vitro.
Volume: 22
Issue: 7
Pages: 1161-6