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Search results 8001 to 8100 out of 8780 for Shh

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Type Details Score
HT Experiment
E-GEOD-60415 | The G-protein Alpha Subunit Gs alpha Is A Tumor Suppressor In Sonic Hedgehog-driven Medulloblastoma [RNA-Seq]
Series Id: GSE60415
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
14617350 | -
First Author: Evans TM
Year: 2003
Journal: Traffic
Title: Rab23, a negative regulator of hedgehog signaling, localizes to the plasma membrane and the endocytic pathway.
Volume: 4
Issue: 12
Pages: 869-84
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Publication
14612978 | -
First Author: Marcos I
Year: 2003
Journal: Int J Mol Med
Title: Molecular cloning and characterization of human RAB23, a member of the group of Rab GTPases.
Volume: 12
Issue: 6
Pages: 983-7
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Protein Domain
IPR034114 | Rab23
Type: Family
Description: Rab23 is a member of the Rab family of small GTPases. In mouse, Rab23 has been shown to function as a negative regulator in the sonic hedgehog (Shh) signaling pathway. Rab23 mediates the activity of Gli2 and Gli3, transcription factors that regulate Shh signaling in the spinal cord, primarily by preventing Gli2 activation in the absence of Shh ligand []. Rab23 also regulates a step in the cytoplasmic signal transduction pathway that mediates the effect of Smoothened (one of two integral membrane proteins that are essential components of the Shh signaling pathway in vertebrates) [, ].In humans, Rab23 is expressed in the retina []. Mice contain an isoform that shares 93% sequence identity with the human Rab23 and an alternative splicing isoform that is specific to the brain. This isoform causes the murine open brain phenotype, indicating it may have a role in the development of the central nervous system [, ]. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is essential for membrane attachment, a key feature of most Rab proteins [].
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GXD Expression
GXD Expression
Probe: MGI:5795620
Assay Type: RNA in situ
Annotation Date: 2016-09-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640617
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:5795655
Age: embryonic day 10.5
Image: 3A
Note: Expression was strongest in the anterior region of the limb bud and expanding distally and down the posterior regions. Expression did not completely reach the posterior limb boundary. There was no staining in the zone of polarizing activity (ZPA) compared with Shh staining. There was staining in the progress zone by comparison to Fgf10 staining.
Specimen Label: 3A
Detected: true
Specimen Num: 3
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HT Experiment
GSE143211 | Geminin is required for Hox gene regulation to pattern the developing limb
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE240381 | The ERK signaling drives evolutionary expansion of the mammalian cerebral cortex
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
21322837 | J:169061
First Author: McCarthy N
Year: 2011
Journal: Nat Rev Cancer
Title: Medulloblastoma: origins.
Volume: 11
Issue: 2
Pages: 79
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HT Experiment
GSE66171 | Epithelial inactivation of Yy1 abrogates lung branching morphogenesis
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
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Protein Domain
IPR016591 | Suppressor_of_fused_euk
Type: Family
Description: Sufu, encoding the human ortholog of Drosophila suppressor of fused, appears to have a conserved role in the repression of Hedgehog signalling []. It is a repressor of the Gli and Ci transcription factors of the Hedgehog signalling cascade [], and functions by binding these proteins and preventing their translocation to the nucleus. Sufu has been found to be a tumour-suppressor gene that predisposes individuals to medulloblastoma by modulating the SHH signalling pathway []. Homologues of Sufu have been found in bacteria, though their function is not currently known.This entry is specific for the eukaryotic Sufu proteins and does not include any homolgous bacterial sequences.
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Protein Domain
IPR007768 | Suppressor_of_fused
Type: Family
Description: Sufu, encoding the human ortholog of Drosophila suppressor of fused, appears to have a conserved role in the repression of Hedgehog signalling []. It is a repressor of the Gli and Ci transcription factors of the Hedgehog signalling cascade [], and functions by binding these proteins and preventing their translocation to the nucleus. Sufu has been found to be a tumour-suppressor gene that predisposes individuals to medulloblastoma by modulating the SHH signalling pathway []. Homologues of Sufu have been found in bacteria, though their function is not currently known.This entry represents the eukaryotic suppressor of fused proteins and their bacterial homologues.
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Protein Domain
IPR017429 | Suppressor_of_fused_bac
Type: Family
Description: Sufu, encoding the human ortholog of Drosophila suppressor of fused, appears to have a conserved role in the repression of Hedgehog signalling []. It is a repressor of the Gli and Ci transcription factors of the Hedgehog signalling cascade [], and functions by binding these proteins and preventing their translocation to the nucleus. Sufu has been found to be a tumour-suppressor gene that predisposes individuals to medulloblastoma by modulating the SHH signalling pathway []. Homologues of Sufu have been found in bacteria, though their function is not currently known.This entry represents a set of bacterial Sufu homologues which are predicted to function as transcriptional regulators.
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HT Experiment
E-GEOD-60932 | Gene expression changes in limb buds of Nipbl-haploinsufficient mice
Series Id: GSE60932
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
GSE121086 | Comparison of DNA methyltransferase-1 (Dnmt1) deleted urogenital sinus epithelium compared to wildtype urogenital sinus epithelium
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE81726 | Molecular characterization of the genital organizer: Gene expression profile of the mouse urethral plate epithelium (GUDMAP Series ID: 51)
 
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: GEO
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Strain
MGI:3664463 | B6.Cg-Hm +/+ Reln<rl>/NemOdaRbrc
Attribute String: spontaneous mutation, mutant strain, congenic
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Publication
7506500 | J:16839
First Author: Yuasa S
Year: 1993
Journal: Anat Embryol (Berl)
Title: Obstructed migration of Purkinje cells in the developing cerebellum of the reeler mutant mouse.
Volume: 188
Issue: 4
Pages: 317-29
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Publication
16139369 | J:103543
First Author: Takaoka Y
Year: 2005
Journal: Brain Res Dev Brain Res
Title: Expression of reelin in the dorsal cochlear nucleus of the mouse.
Volume: 159
Issue: 2
Pages: 127-34
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Strain
MGI:5649932 | (STOCK Hm Pgm2<b> Vps33a<bf> Gusb<b> Mdh2<a> x STOCK + Pgm2<a> + Gusb<a> Mdh2<b>)F1
Attribute String: F1 hybrid, mutant stock
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Allele
Shh<Dsh> | MGI:1861186
 
Name: sonic hedgehog; short digits
Allele Type: Radiation induced
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Strain
MGI:3583802 | B10Rl.Cg-Shh<Dsh>
Attribute String: mutant strain, radiation induced mutation, congenic
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Publication
10508592 | J:114162
First Author: Chautan M
Year: 1999
Journal: Curr Biol
Title: Interdigital cell death can occur through a necrotic and caspase-independent pathway.
Volume: 9
Issue: 17
Pages: 967-70
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Allele
Rr29<Dz> | MGI:3851923
Name: regulatory region 29; preaxial polydactyly
Allele Type: Chemically induced (ENU)
Attribute String: Modified regulatory region
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Strain
MGI:5700020 | FVB.Cg-Tg(Wap-Shh)119Mig/Cnbc
Attribute String: congenic, mutant strain, transgenic
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Strain
MGI:6122521 | B6.Cg-Tg(Wap-Shh)119Mig/Cnbc
Attribute String: mutant strain, congenic, transgenic
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Strain
MGI:5700019 | D2.Cg-Tg(Wap-Shh)186Mig/Cnbc
Attribute String: mutant strain, transgenic, congenic
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Allele
Gt(ROSA)26Sor<tm1(tetO-SHH,-ZsGreen)Rhr> | MGI:6763413
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Roger H Reeves
Allele Type: Targeted
Attribute String: Inducible, Inserted expressed sequence, Reporter
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Strain
MGI:6865886 | B6.Cg-Gt(ROSA26)Sor<tm1(tetO-SHH,-ZsGreen)Rhr>/Mmjax
Attribute String: congenic, mutant strain, targeted mutation
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Allele
Rr29<em6Axvi> | MGI:7334961
Name: regulatory region 29; endonuclease-mediated mutation 6, Axel Visel
Allele Type: Endonuclease-mediated
Attribute String: Modified regulatory region, Null/knockout
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Allele
Rr29<em7Axvi> | MGI:7715223
Name: regulatory region 29; endonuclease-mediated mutation 7, Axel Visel
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence, Modified regulatory region
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Allele
Rr29<em2Andg> | MGI:7703771
Name: regulatory region 29; endonuclease-mediated mutation 2, Guillaume Andrey
Allele Type: Endonuclease-mediated
Attribute String: Modified regulatory region
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Genotype
Genotype
Symbol: Fkbp8/Fkbp8 Shh/Shh
Background: involves: C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Shh/Shh<+>
Background: involves: 101 * C3H * C57BL * SEC
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Shh/Shh<+>
Background: B10Rl.Cg-Shh
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Shh/Shh
Background: involves: 101 * C3H * C57BL * SEC
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Shh/Shh
Background: B10Rl.Cg-Shh
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Shh)#Dje/?
Background: involves: CD-1
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Shh)#Dje/?
Background: involves: Swiss Webster
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli3/Gli3<+> Shh/Shh
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tctn1/Tctn1 Shh/Shh
Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Six3/Six3<+> Shh/Shh<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Shh/Shh Tg(Prrx1-Sox9,-lacZ)1Haak/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ift122/Ift122 Shh/Shh
Background: involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Shh/Shh
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Shh/Shh Tmem107/Tmem107
Background: involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Shh-cre/ERT2)#aYjg/Tg(Shh-cre/ERT2)#aYjg
Background: involves: FVB/N
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Shh/Shh<+> Vps25/Vps25
Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rr45/Rr45<+> Shh/Shh<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA/JNCrlj
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rr115/Rr115<+> Shh/Shh<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gas1/Gas1 Shh/Shh<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gas1/Gas1 Shh/Shh
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dbf/Dbf<+> Shh/Shh
Background: involves: 101/H * 129S1/Sv * 129X1/SvJ * C3H/HeH * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rab23/Rab23 Shh/Shh
Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Shh/Shh
Background: involves: 101 * C3H
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sox9/Sox9 Shh/Shh<+>
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Shh/Shh Tctn1/Tctn1<+>
Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli3/Gli3 Shh/Shh<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli3/Gli3 Shh/Shh
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Irx3/Irx3 Irx5/Irx5 Shh/Shh<+>
Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dlx2/Dlx2<+> Shh/Shh
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Shh/Shh Six1/Six1<+>
Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: En1/En1<+> Shh/Shh
Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * Swiss Webster)
Zygosity: cx
Has Mutant Allele: true
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Publication
12150819 | -
First Author: Rubin JB
Year: 2002
Journal: Cancer Cell
Title: Medulloblastoma: a problem of developmental biology.
Volume: 2
Issue: 1
Pages: 7-8
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Publication
12068298 | -
First Author: Taylor MD
Year: 2002
Journal: Nat Genet
Title: Mutations in SUFU predispose to medulloblastoma.
Volume: 31
Issue: 3
Pages: 306-10
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HT Experiment
GSE77197 | Signaling networks of developing hair follicles
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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Protein
A0A0R4J1M0
Organism: Mus musculus/domesticus
Length: 297  
Fragment?: false
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Protein Domain
IPR037181 | SUFU_N
Type: Homologous_superfamily
Description: Sufu, encoding the human ortholog of Drosophila suppressor of fused, appears to have a conserved role in the repression of Hedgehog signalling []. It is a repressor of the Gli and Ci transcription factors of the Hedgehog signalling cascade [], and functions by binding these proteins and preventing their translocation to the nucleus. Sufu has been found to be a tumour-suppressor gene that predisposes individuals to medulloblastoma by modulating the SHH signalling pathway []. Homologues of Sufu have been found in bacteria, though their function is not currently known.Sufu contains at least two distinct domains: a highly conserved carboxy-terminal region required for binding to the amino-terminal ends of the Gli proteins and a unique amino-terminal domain that binds the carboxy-terminal tail of Gli1 []. This entry represents the N-terminal domain of Sufu. Its structure has an unusual fold composed of bifurcated β-sheet with left-handed β-α-β unit.
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HT Experiment
GSE74576 | Expression data from gall bladder and cystic duct in wild type and Sox17+/-mice at 15 dpc
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE86478 | Expression data from E12 mouse lumbar motor neuron subsets
 
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: GEO
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HT Experiment
GSE183470 | Controlling tissue patterning by translational regulation of signaling transcripts through the core translation factor eIF3c [I]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE192485 | Identification of TBX3 and shared HAND2-TBX3 target gene in early mouse limb buds [RNA-seq]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE156633 | Combined single-cell and spatial transcriptomics reveal the precise cellular states of postnatal cerebellar granule cells and connection with medulloblastoma
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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HT Experiment
E-GEOD-14470 | MicroRNA profiling in mouse medulloblastomas and normal cerebellar tissues
Series Id: GSE14470
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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Strain
MGI:3711115 | C3Fe.Cg-Hm +/+ Rr29<Hx>
Attribute String: congenic, mutant strain, spontaneous mutation
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Allele
Ssq | MGI:1889614
 
Name: sasquatch
Allele Type: Transgenic
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Strain
MGI:3852075 | C57BL/6J-Rr29<Dz>
Attribute String: chemically induced mutation, coisogenic, mutant strain
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Strain
MGI:5656750 | (C57BL/6J-Rr29<Dz> x CAST/Ei)F1
Attribute String: F1 hybrid, chemically induced mutation
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Genotype
Genotype
Symbol: Hm/Hm<+> Del(5D5Mit73-D5Mit351)5Jcs/?
Background: involves: 129S4/SvJae * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Shh/Shh Tg(SFTPC-rtTA)5Jaw/? Tg(tetO-Shh)1Jaw/?
Background: involves: FVB/N
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Shh/Shh
Background: involves: 101 * 129S1/Sv * 129X1/SvJ * C3H * C57BL/10Rl
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Shh/Shh<+> Tg(Shh)#Dje/?
Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hm/Hm<+> Rr29/Rr29<+>
Background: C3Fe.Cg-Hm +/+ Rr29
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli2/Gli2 Shh/Shh
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli2/Gli2 Shh/Shh
Background: either: (involves: 129) or (involves: 129 * Black Swiss)
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli2/Gli2<+> Shh/Shh
Background: either: (involves: 129) or (involves: 129 * Black Swiss)
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rr29/Rr29<+>
Background: (C57BL/6J-Rr29 x CAST/Ei)F1
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rr29/Rr29<+>
Background: C57BL/6J-Rr29
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rr29/Rr29
Background: C57BL/6J-Rr29
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Shh/Shh Nkx2-5/Nkx2-5<+>
Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rr29/Rr29<+> Shh/Shh<+>
Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Shh/Shh
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli1/Gli1<+> Shh/Shh
Background: involves: 129 * Black Swiss * Swiss Webster
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ptch1/Ptch1<+> Shh/Shh
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cx
Has Mutant Allele: true
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Publication
28965847 | -
First Author: De Mori R
Year: 2017
Journal: Am J Hum Genet
Title: Hypomorphic Recessive Variants in SUFU Impair the Sonic Hedgehog Pathway and Cause Joubert Syndrome with Cranio-facial and Skeletal Defects.
Volume: 101
Issue: 4
Pages: 552-563
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Publication
8785047 | J:150634
First Author: Itasaki N
Year: 1996
Journal: Neuron
Title: Reprogramming Hox expression in the vertebrate hindbrain: influence of paraxial mesoderm and rhombomere transposition.
Volume: 16
Issue: 3
Pages: 487-500
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Genotype
Genotype
Symbol: Tg(UAS-Shh)1Rth/? Tg(Wnt1-GAL4)1Rth/?
Background: involves: C57BL/6J * CBA/J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ccd/Ccd<+> Shh/Shh<+>
Background: involves: 101 * C3H * C57BL * C57BL/10Rl * SEC
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ndst1/Ndst1<+> Shh/Shh<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ndst1/Ndst1 Shh/Shh<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ptch1/Ptch1<+> Tg(Shh)#Dje/?
Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster
Zygosity: cx
Has Mutant Allele: true
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