| Type |
Details |
Score |
| Publication |
| First Author: |
Kishioka A |
| Year: |
2009 |
| Journal: |
PLoS One |
| Title: |
A novel form of memory for auditory fear conditioning at a low-intensity unconditioned stimulus. |
| Volume: |
4 |
| Issue: |
1 |
| Pages: |
e4157 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jacobitz AW |
| Year: |
2017 |
| Journal: |
Adv Protein Chem Struct Biol |
| Title: |
Sortase Transpeptidases: Structural Biology and Catalytic Mechanism. |
| Volume: |
109 |
|
| Pages: |
223-264 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bradshaw WJ |
| Year: |
2015 |
| Journal: |
FEBS J |
| Title: |
Molecular features of the sortase enzyme family. |
| Volume: |
282 |
| Issue: |
11 |
| Pages: |
2097-114 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Class A sortases are membrane-bound cysteine transpeptidases distributed in Gram-positive bacteria (mainly present in Firmicutes). They perform a housekeeping role in the cell as members of this group are capable of anchoring a large number of functionally distinct surface proteins containing a cell wall sorting signal to an amino group located on the bacterial cell wall. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is cleaved at a conserved cell wall-sorting signal (Class A sortases recognize a canonical LPXTG motif, X can be any amino acid), and covalently linked to peptidoglycan for display on the bacterial surface. The prototypical sortase A protein from Staphylococcus aureus (named Sa-SrtA) cleaves the amide bond between threonine and glycine residues of the canonical LPXTG motif in a wide range of protein substrates with diverse functions that can promote bacterial adhesion, nutrient acquisition, host cell invasion, and immune evasion. Next, it catalyzes a transpeptidation reaction by which the proteins are covalently linked to the peptidoglycan precursor lipid II. SrtA is therefore affects the ability of a pathogen to establish successful infection. SrtA contains an N-terminal hydrophobic segment, a linker region and an extra-cellular C-terminal catalytic domain. The hydrophobic segment functions as both a signal peptide for secretion and a stop-transfer signal for membrane anchoring. The catalytic domain contains the catalytic TLXTC signature sequence where X is usually a valine, isoleucine or a threonine. The gene encoding SrtA is generally not located in the same gene cluster as its substrates while the gene encoding SrtB is usually clustered in the same locus as its substrate [, , ]. |
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•
•
•
|
| Publication |
| First Author: |
Schiepers A |
| Year: |
2023 |
| Journal: |
Nature |
| Title: |
Molecular fate-mapping of serum antibody responses to repeat immunization. |
| Volume: |
615 |
| Issue: |
7952 |
| Pages: |
482-489 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Celada A |
| Year: |
1991 |
| Journal: |
J Immunol |
| Title: |
IFN-gamma induces the expression of the genes for MHC class II I-A beta and tumor necrosis factor through a protein kinase C-independent pathway. |
| Volume: |
146 |
| Issue: |
1 |
| Pages: |
114-20 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Casamassima A |
| Year: |
1997 |
| Journal: |
J Biol Chem |
| Title: |
Tyrosine phosphorylation of p130(cas) by bombesin, lysophosphatidic acid, phorbol esters, and platelet-derived growth factor. Signaling pathways and formation of a p130(cas)-Crk complex. |
| Volume: |
272 |
| Issue: |
14 |
| Pages: |
9363-70 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
421
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1164
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1381
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fernandez-Gonzalez A |
| Year: |
2009 |
| Journal: |
Am J Respir Cell Mol Biol |
| Title: |
Mutation of murine adenylate kinase 7 underlies a primary ciliary dyskinesia phenotype. |
| Volume: |
40 |
| Issue: |
3 |
| Pages: |
305-13 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cederberg A |
| Year: |
2009 |
| Journal: |
Transgenic Res |
| Title: |
In vitro differentiated adipocytes from a Foxc2 reporter knock-in mouse as screening tool. |
| Volume: |
18 |
| Issue: |
6 |
| Pages: |
889-97 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cranston A |
| Year: |
2004 |
| Journal: |
Transgenic Res |
| Title: |
Quantitative phenotyping as an efficient means to estimate C-cell number in a knock-in mouse model of MEN2B. |
| Volume: |
13 |
| Issue: |
4 |
| Pages: |
339-48 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sancho-Balsells A |
| Year: |
2023 |
| Journal: |
Int J Mol Sci |
| Title: |
Cognitive and Emotional Symptoms Induced by Chronic Stress Are Regulated by EGR1 in a Subpopulation of Hippocampal Pyramidal Neurons. |
| Volume: |
24 |
| Issue: |
4 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Boutet A |
| Year: |
2017 |
| Journal: |
Genesis |
| Title: |
A knock-in mouse line conditionally expressing the tumor suppressor WTX/AMER1. |
| Volume: |
55 |
| Issue: |
11 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Niemeier A |
| Year: |
1999 |
| Journal: |
Arterioscler Thromb Vasc Biol |
| Title: |
Identification of megalin/gp330 as a receptor for lipoprotein(a) in vitro. |
| Volume: |
19 |
| Issue: |
3 |
| Pages: |
552-61 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kinzig A |
| Year: |
1999 |
| Journal: |
Genomics |
| Title: |
cDNA cloning, genomic structure, and chromosomal localization of a novel murine epidermis-type lipoxygenase. |
| Volume: |
58 |
| Issue: |
2 |
| Pages: |
158-64 |
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•
•
•
•
|
| Publication |
| First Author: |
Amadeo A |
| Year: |
2018 |
| Journal: |
Neuroscience |
| Title: |
Postnatal Changes in K+/Cl- Cotransporter-2 Expression in the Forebrain of Mice Bearing a Mutant Nicotinic Subunit Linked to Sleep-Related Epilepsy. |
| Volume: |
386 |
|
| Pages: |
91-107 |
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•
•
•
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| Publication |
| First Author: |
Lee JE |
| Year: |
2012 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
RNase H-mediated degradation of toxic RNA in myotonic dystrophy type 1. |
| Volume: |
109 |
| Issue: |
11 |
| Pages: |
4221-6 |
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•
•
•
•
•
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| Publication |
| First Author: |
Perna D |
| Year: |
2015 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
BRAF inhibitor resistance mediated by the AKT pathway in an oncogenic BRAF mouse melanoma model. |
| Volume: |
112 |
| Issue: |
6 |
| Pages: |
E536-45 |
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•
•
•
•
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| Publication |
| First Author: |
Nagy A |
| Year: |
1998 |
| Journal: |
Curr Biol |
| Title: |
Dissecting the role of N-myc in development using a single targeting vector to generate a series of alleles. |
| Volume: |
8 |
| Issue: |
11 |
| Pages: |
661-4 |
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•
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•
•
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| Publication |
| First Author: |
Hernández-Hernández A |
| Year: |
2016 |
| Journal: |
J Cell Sci |
| Title: |
The central element of the synaptonemal complex in mice is organized as a bilayered junction structure. |
| Volume: |
129 |
| Issue: |
11 |
| Pages: |
2239-49 |
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•
•
•
•
|
| Publication |
| First Author: |
Chu VT |
| Year: |
2011 |
| Journal: |
Nat Immunol |
| Title: |
Eosinophils are required for the maintenance of plasma cells in the bone marrow. |
| Volume: |
12 |
| Issue: |
2 |
| Pages: |
151-9 |
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•
•
•
•
•
|
| Publication |
| First Author: |
Fleischmann A |
| Year: |
2013 |
| Journal: |
PLoS Biol |
| Title: |
Functional interrogation of an odorant receptor locus reveals multiple axes of transcriptional regulation. |
| Volume: |
11 |
| Issue: |
5 |
| Pages: |
e1001568 |
|
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•
•
•
•
|
| Publication |
| First Author: |
Waheed A |
| Year: |
2014 |
| Journal: |
Subcell Biochem |
| Title: |
Membrane associated carbonic anhydrase IV (CA IV): a personal and historical perspective. |
| Volume: |
75 |
|
| Pages: |
157-79 |
|
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•
•
•
•
|
| Publication |
| First Author: |
Marshall A |
| Year: |
2008 |
| Journal: |
Exp Cell Res |
| Title: |
Mighty is a novel promyogenic factor in skeletal myogenesis. |
| Volume: |
314 |
| Issue: |
5 |
| Pages: |
1013-29 |
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•
•
•
•
|
| Publication |
| First Author: |
Bolhuis A |
| Year: |
2002 |
| Journal: |
Microbiology |
| Title: |
Protein transport in the halophilic archaeon Halobacterium sp. NRC-1: a major role for the twin-arginine translocation pathway? |
| Volume: |
148 |
| Issue: |
Pt 11 |
| Pages: |
3335-46 |
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•
•
•
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| Publication |
| First Author: |
Silva-Sanchez A |
| Year: |
2023 |
| Journal: |
Sci Immunol |
| Title: |
Activation of regulatory dendritic cells by Mertk coincides with a temporal wave of apoptosis in neonatal lungs. |
| Volume: |
8 |
| Issue: |
84 |
| Pages: |
eadc9081 |
|
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•
•
•
•
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| Publication |
| First Author: |
Pierani A |
| Year: |
1999 |
| Journal: |
Cell |
| Title: |
A sonic hedgehog-independent, retinoid-activated pathway of neurogenesis in the ventral spinal cord. |
| Volume: |
97 |
| Issue: |
7 |
| Pages: |
903-15 |
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•
•
•
•
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| Publication |
| First Author: |
Müllbacher A |
| Year: |
1999 |
| Journal: |
J Virol |
| Title: |
Perforin is essential for control of ectromelia virus but not related poxviruses in mice. |
| Volume: |
73 |
| Issue: |
2 |
| Pages: |
1665-7 |
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•
•
•
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| Publication |
| First Author: |
Muthiah A |
| Year: |
2018 |
| Journal: |
PLoS One |
| Title: |
Biologically anchored knowledge expansion approach uncovers KLF4 as a novel insulin signaling regulator. |
| Volume: |
13 |
| Issue: |
9 |
| Pages: |
e0204100 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Publication |
| First Author: |
UluÄŸ AM |
| Year: |
2011 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Cerebellothalamocortical pathway abnormalities in torsinA DYT1 knock-in mice. |
| Volume: |
108 |
| Issue: |
16 |
| Pages: |
6638-43 |
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•
•
•
•
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| Publication |
| First Author: |
Carrier A |
| Year: |
1999 |
| Journal: |
Immunogenetics |
| Title: |
Differential gene expression in CD3epsilon- and RAG1-deficient thymuses: definition of a set of genes potentially involved in thymocyte maturation. |
| Volume: |
50 |
| Issue: |
5-6 |
| Pages: |
255-70 |
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•
•
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| Publication |
| First Author: |
Mishra A |
| Year: |
2017 |
| Journal: |
Biol Open |
| Title: |
A novel immunodeficient NOD.SCID-rd1 mouse model of retinitis pigmentosa to investigate potential therapeutics and pathogenesis of retinal degeneration. |
| Volume: |
6 |
| Issue: |
4 |
| Pages: |
449-462 |
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•
•
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| Publication |
| First Author: |
Isermann T |
| Year: |
2021 |
| Journal: |
Nat Commun |
| Title: |
Suppression of HSF1 activity by wildtype p53 creates a driving force for p53 loss-of-heterozygosity. |
| Volume: |
12 |
| Issue: |
1 |
| Pages: |
4019 |
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•
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| Publication |
| First Author: |
Chittka A |
| Year: |
2010 |
| Journal: |
PLoS One |
| Title: |
Dynamic distribution of histone H4 arginine 3 methylation marks in the developing murine cortex. |
| Volume: |
5 |
| Issue: |
11 |
| Pages: |
e13807 |
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•
•
•
•
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| Publication |
| First Author: |
Peschiaroli A |
| Year: |
2010 |
| Journal: |
Oncogene |
| Title: |
The ubiquitin-specific protease USP47 is a novel beta-TRCP interactor regulating cell survival. |
| Volume: |
29 |
| Issue: |
9 |
| Pages: |
1384-93 |
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•
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| Publication |
| First Author: |
Aranburu A |
| Year: |
2001 |
| Journal: |
Biochem J |
| Title: |
Transcription factor AP-4 is a ligand for immunoglobulin-kappa promoter E-box elements. |
| Volume: |
354 |
| Issue: |
Pt 2 |
| Pages: |
431-8 |
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•
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| First Author: |
Loregger A |
| Year: |
2020 |
| Journal: |
Nat Commun |
| Title: |
Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism. |
| Volume: |
11 |
| Issue: |
1 |
| Pages: |
1128 |
|
•
•
•
•
•
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
541
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
541
 |
| Fragment?: |
false |
|
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•
•
•
•
|
| Publication |
| First Author: |
Li Y |
| Year: |
2013 |
| Journal: |
Diabetes |
| Title: |
Identification of sucrose non-fermenting-related kinase (SNRK) as a suppressor of adipocyte inflammation. |
| Volume: |
62 |
| Issue: |
7 |
| Pages: |
2396-409 |
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•
•
•
•
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
682
 |
| Fragment?: |
false |
|
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•
•
•
•
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| Publication |
| First Author: |
Sun H |
| Year: |
2013 |
| Journal: |
PLoS One |
| Title: |
A critical regulatory role for macrophage migration inhibitory factor in hyperoxia-induced injury in the developing murine lung. |
| Volume: |
8 |
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4 |
| Pages: |
e60560 |
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•
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| First Author: |
Silva A |
| Year: |
2011 |
| Journal: |
Am J Physiol Gastrointest Liver Physiol |
| Title: |
COX-2 is not required for the development of murine chronic pancreatitis. |
| Volume: |
300 |
| Issue: |
6 |
| Pages: |
G968-75 |
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•
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| First Author: |
Takaoka A |
| Year: |
2007 |
| Journal: |
Nature |
| Title: |
DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response. |
| Volume: |
448 |
| Issue: |
7152 |
| Pages: |
501-5 |
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| First Author: |
Ravel-Chapuis A |
| Year: |
2022 |
| Journal: |
Hum Mol Genet |
| Title: |
A novel CARM1-HuR axis involved in muscle differentiation and plasticity misregulated in spinal muscular atrophy. |
| Volume: |
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9 |
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| First Author: |
Vardi A |
| Year: |
2016 |
| Journal: |
J Pathol |
| Title: |
Delineating pathological pathways in a chemically induced mouse model of Gaucher disease. |
| Volume: |
239 |
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| First Author: |
Verschoor A |
| Year: |
2011 |
| Journal: |
Nat Immunol |
| Title: |
A platelet-mediated system for shuttling blood-borne bacteria to CD8α+ dendritic cells depends on glycoprotein GPIb and complement C3. |
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Vasanthakumar A |
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EMBO Rep |
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A non-canonical function of Ezh2 preserves immune homeostasis. |
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Nakayama A |
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J Biol Chem |
| Title: |
Role for RFX transcription factors in non-neuronal cell-specific inactivation of the microtubule-associated protein MAP1A promoter. |
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Dev Dyn |
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Knockdown of slit signaling during limb development leads to a reduction in humerus length. |
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Proc Natl Acad Sci U S A |
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In vivo genome and base editing of a human PCSK9 knock-in hypercholesterolemic mouse model. |
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PLoS One |
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A genetically targeted ion sensor reveals distinct seizure-related chloride and pH dynamics in GABAergic interneuron populations. |
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A novel role for the beta 2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation. |
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Blood |
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Cell Rep |
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Angiogenesis in the mature mouse cortex is governed in a regional- and Notch1-dependent manner. |
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Hum Mol Genet |
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Late onset neurological phenotype of the X-ALD gene inactivation in mice: a mouse model for adrenomyeloneuropathy. |
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Members of this protein family are found, so far, exclusively in the genus Acinetobacter. Members average just over 600 amino acids in length, including a 22-amino acid C-terminal putative protein sorting recognition sequence, GlyGly-CTERM. The GlyGly-CTERM signal always co-occurs with a subfamily of the rhomboid family intramembrane serine proteases called rhombosortase. Members occur paired with a second rhombosortase target, with which it also shares an N-terminal motif CSLREA. This protein is designated Acinetobacter rhombotarget A (rbtA). |
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