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Type Details Score
Publication
First Author: Kishioka A
Year: 2009
Journal: PLoS One
Title: A novel form of memory for auditory fear conditioning at a low-intensity unconditioned stimulus.
Volume: 4
Issue: 1
Pages: e4157
Publication  
First Author: Jacobitz AW
Year: 2017
Journal: Adv Protein Chem Struct Biol
Title: Sortase Transpeptidases: Structural Biology and Catalytic Mechanism.
Volume: 109
Pages: 223-264
Publication
First Author: Bradshaw WJ
Year: 2015
Journal: FEBS J
Title: Molecular features of the sortase enzyme family.
Volume: 282
Issue: 11
Pages: 2097-114
Protein Domain
Type: Family
Description: Class A sortases are membrane-bound cysteine transpeptidases distributed in Gram-positive bacteria (mainly present in Firmicutes). They perform a housekeeping role in the cell as members of this group are capable of anchoring a large number of functionally distinct surface proteins containing a cell wall sorting signal to an amino group located on the bacterial cell wall. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is cleaved at a conserved cell wall-sorting signal (Class A sortases recognize a canonical LPXTG motif, X can be any amino acid), and covalently linked to peptidoglycan for display on the bacterial surface. The prototypical sortase A protein from Staphylococcus aureus (named Sa-SrtA) cleaves the amide bond between threonine and glycine residues of the canonical LPXTG motif in a wide range of protein substrates with diverse functions that can promote bacterial adhesion, nutrient acquisition, host cell invasion, and immune evasion. Next, it catalyzes a transpeptidation reaction by which the proteins are covalently linked to the peptidoglycan precursor lipid II. SrtA is therefore affects the ability of a pathogen to establish successful infection. SrtA contains an N-terminal hydrophobic segment, a linker region and an extra-cellular C-terminal catalytic domain. The hydrophobic segment functions as both a signal peptide for secretion and a stop-transfer signal for membrane anchoring. The catalytic domain contains the catalytic TLXTC signature sequence where X is usually a valine, isoleucine or a threonine. The gene encoding SrtA is generally not located in the same gene cluster as its substrates while the gene encoding SrtB is usually clustered in the same locus as its substrate [, , ].
Publication
First Author: Schiepers A
Year: 2023
Journal: Nature
Title: Molecular fate-mapping of serum antibody responses to repeat immunization.
Volume: 615
Issue: 7952
Pages: 482-489
Publication
First Author: Celada A
Year: 1991
Journal: J Immunol
Title: IFN-gamma induces the expression of the genes for MHC class II I-A beta and tumor necrosis factor through a protein kinase C-independent pathway.
Volume: 146
Issue: 1
Pages: 114-20
Publication
First Author: Casamassima A
Year: 1997
Journal: J Biol Chem
Title: Tyrosine phosphorylation of p130(cas) by bombesin, lysophosphatidic acid, phorbol esters, and platelet-derived growth factor. Signaling pathways and formation of a p130(cas)-Crk complex.
Volume: 272
Issue: 14
Pages: 9363-70
Protein
Organism: Mus musculus/domesticus
Length: 421  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1164  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1381  
Fragment?: false
Publication
First Author: Fernandez-Gonzalez A
Year: 2009
Journal: Am J Respir Cell Mol Biol
Title: Mutation of murine adenylate kinase 7 underlies a primary ciliary dyskinesia phenotype.
Volume: 40
Issue: 3
Pages: 305-13
Publication
First Author: Cederberg A
Year: 2009
Journal: Transgenic Res
Title: In vitro differentiated adipocytes from a Foxc2 reporter knock-in mouse as screening tool.
Volume: 18
Issue: 6
Pages: 889-97
Publication
First Author: Cranston A
Year: 2004
Journal: Transgenic Res
Title: Quantitative phenotyping as an efficient means to estimate C-cell number in a knock-in mouse model of MEN2B.
Volume: 13
Issue: 4
Pages: 339-48
Publication  
First Author: Sancho-Balsells A
Year: 2023
Journal: Int J Mol Sci
Title: Cognitive and Emotional Symptoms Induced by Chronic Stress Are Regulated by EGR1 in a Subpopulation of Hippocampal Pyramidal Neurons.
Volume: 24
Issue: 4
Publication  
First Author: Boutet A
Year: 2017
Journal: Genesis
Title: A knock-in mouse line conditionally expressing the tumor suppressor WTX/AMER1.
Volume: 55
Issue: 11
Publication
First Author: Niemeier A
Year: 1999
Journal: Arterioscler Thromb Vasc Biol
Title: Identification of megalin/gp330 as a receptor for lipoprotein(a) in vitro.
Volume: 19
Issue: 3
Pages: 552-61
Publication
First Author: Kinzig A
Year: 1999
Journal: Genomics
Title: cDNA cloning, genomic structure, and chromosomal localization of a novel murine epidermis-type lipoxygenase.
Volume: 58
Issue: 2
Pages: 158-64
Publication  
First Author: Amadeo A
Year: 2018
Journal: Neuroscience
Title: Postnatal Changes in K+/Cl- Cotransporter-2 Expression in the Forebrain of Mice Bearing a Mutant Nicotinic Subunit Linked to Sleep-Related Epilepsy.
Volume: 386
Pages: 91-107
Publication
First Author: Lee JE
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: RNase H-mediated degradation of toxic RNA in myotonic dystrophy type 1.
Volume: 109
Issue: 11
Pages: 4221-6
Publication
First Author: Perna D
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: BRAF inhibitor resistance mediated by the AKT pathway in an oncogenic BRAF mouse melanoma model.
Volume: 112
Issue: 6
Pages: E536-45
Publication
First Author: Nagy A
Year: 1998
Journal: Curr Biol
Title: Dissecting the role of N-myc in development using a single targeting vector to generate a series of alleles.
Volume: 8
Issue: 11
Pages: 661-4
Publication
First Author: Hernández-Hernández A
Year: 2016
Journal: J Cell Sci
Title: The central element of the synaptonemal complex in mice is organized as a bilayered junction structure.
Volume: 129
Issue: 11
Pages: 2239-49
Publication
First Author: Chu VT
Year: 2011
Journal: Nat Immunol
Title: Eosinophils are required for the maintenance of plasma cells in the bone marrow.
Volume: 12
Issue: 2
Pages: 151-9
Publication
First Author: Fleischmann A
Year: 2013
Journal: PLoS Biol
Title: Functional interrogation of an odorant receptor locus reveals multiple axes of transcriptional regulation.
Volume: 11
Issue: 5
Pages: e1001568
Publication  
First Author: Waheed A
Year: 2014
Journal: Subcell Biochem
Title: Membrane associated carbonic anhydrase IV (CA IV): a personal and historical perspective.
Volume: 75
Pages: 157-79
Publication
First Author: Marshall A
Year: 2008
Journal: Exp Cell Res
Title: Mighty is a novel promyogenic factor in skeletal myogenesis.
Volume: 314
Issue: 5
Pages: 1013-29
Publication
First Author: Bolhuis A
Year: 2002
Journal: Microbiology
Title: Protein transport in the halophilic archaeon Halobacterium sp. NRC-1: a major role for the twin-arginine translocation pathway?
Volume: 148
Issue: Pt 11
Pages: 3335-46
Publication
First Author: Silva-Sanchez A
Year: 2023
Journal: Sci Immunol
Title: Activation of regulatory dendritic cells by Mertk coincides with a temporal wave of apoptosis in neonatal lungs.
Volume: 8
Issue: 84
Pages: eadc9081
Publication
First Author: Pierani A
Year: 1999
Journal: Cell
Title: A sonic hedgehog-independent, retinoid-activated pathway of neurogenesis in the ventral spinal cord.
Volume: 97
Issue: 7
Pages: 903-15
Publication
First Author: Müllbacher A
Year: 1999
Journal: J Virol
Title: Perforin is essential for control of ectromelia virus but not related poxviruses in mice.
Volume: 73
Issue: 2
Pages: 1665-7
Publication
First Author: Muthiah A
Year: 2018
Journal: PLoS One
Title: Biologically anchored knowledge expansion approach uncovers KLF4 as a novel insulin signaling regulator.
Volume: 13
Issue: 9
Pages: e0204100
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: UluÄŸ AM
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Cerebellothalamocortical pathway abnormalities in torsinA DYT1 knock-in mice.
Volume: 108
Issue: 16
Pages: 6638-43
Publication
First Author: Carrier A
Year: 1999
Journal: Immunogenetics
Title: Differential gene expression in CD3epsilon- and RAG1-deficient thymuses: definition of a set of genes potentially involved in thymocyte maturation.
Volume: 50
Issue: 5-6
Pages: 255-70
Publication
First Author: Mishra A
Year: 2017
Journal: Biol Open
Title: A novel immunodeficient NOD.SCID-rd1 mouse model of retinitis pigmentosa to investigate potential therapeutics and pathogenesis of retinal degeneration.
Volume: 6
Issue: 4
Pages: 449-462
Publication
First Author: Isermann T
Year: 2021
Journal: Nat Commun
Title: Suppression of HSF1 activity by wildtype p53 creates a driving force for p53 loss-of-heterozygosity.
Volume: 12
Issue: 1
Pages: 4019
Publication
First Author: Chittka A
Year: 2010
Journal: PLoS One
Title: Dynamic distribution of histone H4 arginine 3 methylation marks in the developing murine cortex.
Volume: 5
Issue: 11
Pages: e13807
Publication
First Author: Peschiaroli A
Year: 2010
Journal: Oncogene
Title: The ubiquitin-specific protease USP47 is a novel beta-TRCP interactor regulating cell survival.
Volume: 29
Issue: 9
Pages: 1384-93
Publication
First Author: Aranburu A
Year: 2001
Journal: Biochem J
Title: Transcription factor AP-4 is a ligand for immunoglobulin-kappa promoter E-box elements.
Volume: 354
Issue: Pt 2
Pages: 431-8
Publication
First Author: Loregger A
Year: 2020
Journal: Nat Commun
Title: Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism.
Volume: 11
Issue: 1
Pages: 1128
Protein
Organism: Mus musculus/domesticus
Length: 541  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 541  
Fragment?: false
Publication
First Author: Li Y
Year: 2013
Journal: Diabetes
Title: Identification of sucrose non-fermenting-related kinase (SNRK) as a suppressor of adipocyte inflammation.
Volume: 62
Issue: 7
Pages: 2396-409
Protein
Organism: Mus musculus/domesticus
Length: 682  
Fragment?: false
Publication
First Author: Sun H
Year: 2013
Journal: PLoS One
Title: A critical regulatory role for macrophage migration inhibitory factor in hyperoxia-induced injury in the developing murine lung.
Volume: 8
Issue: 4
Pages: e60560
Publication
First Author: Silva A
Year: 2011
Journal: Am J Physiol Gastrointest Liver Physiol
Title: COX-2 is not required for the development of murine chronic pancreatitis.
Volume: 300
Issue: 6
Pages: G968-75
Publication
First Author: Takaoka A
Year: 2007
Journal: Nature
Title: DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response.
Volume: 448
Issue: 7152
Pages: 501-5
Publication
First Author: Ravel-Chapuis A
Year: 2022
Journal: Hum Mol Genet
Title: A novel CARM1-HuR axis involved in muscle differentiation and plasticity misregulated in spinal muscular atrophy.
Volume: 31
Issue: 9
Pages: 1453-1470
Publication
First Author: Vardi A
Year: 2016
Journal: J Pathol
Title: Delineating pathological pathways in a chemically induced mouse model of Gaucher disease.
Volume: 239
Issue: 4
Pages: 496-509
Publication
First Author: Verschoor A
Year: 2011
Journal: Nat Immunol
Title: A platelet-mediated system for shuttling blood-borne bacteria to CD8α+ dendritic cells depends on glycoprotein GPIb and complement C3.
Volume: 12
Issue: 12
Pages: 1194-201
Publication
First Author: Vasanthakumar A
Year: 2017
Journal: EMBO Rep
Title: A non-canonical function of Ezh2 preserves immune homeostasis.
Volume: 18
Issue: 4
Pages: 619-631
Publication
First Author: Nakayama A
Year: 2003
Journal: J Biol Chem
Title: Role for RFX transcription factors in non-neuronal cell-specific inactivation of the microtubule-associated protein MAP1A promoter.
Volume: 278
Issue: 1
Pages: 233-40
Publication
First Author: Rafipay A
Year: 2021
Journal: Dev Dyn
Title: Knockdown of slit signaling during limb development leads to a reduction in humerus length.
Volume: 250
Issue: 9
Pages: 1340-1357
Publication
First Author: Moskovitz J
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Methionine sulfoxide reductase (MsrA) is a regulator of antioxidant defense and lifespan in mammals.
Volume: 98
Issue: 23
Pages: 12920-5
Publication
First Author: Carreras A
Year: 2019
Journal: BMC Biol
Title: In vivo genome and base editing of a human PCSK9 knock-in hypercholesterolemic mouse model.
Volume: 17
Issue: 1
Pages: 4
Publication
First Author: Viola A
Year: 2007
Journal: PLoS One
Title: Metabolic fingerprints of altered brain growth, osmoregulation and neurotransmission in a Rett syndrome model.
Volume: 2
Issue: 1
Pages: e157
Publication
First Author: Recober A
Year: 2010
Journal: Neuropharmacology
Title: Induction of multiple photophobic behaviors in a transgenic mouse sensitized to CGRP.
Volume: 58
Issue: 1
Pages: 156-65
Publication
First Author: Rother M
Year: 2001
Journal: Arch Microbiol
Title: Selenium-dependent growth of Treponema denticola: evidence for a clostridial-type glycine reductase.
Volume: 177
Issue: 1
Pages: 113-6
Publication
First Author: Ciechanover A
Year: 1998
Journal: EMBO J
Title: The ubiquitin-proteasome pathway: on protein death and cell life.
Volume: 17
Issue: 24
Pages: 7151-60
Publication
First Author: Meng A
Year: 1999
Journal: Development
Title: A Drosophila doublesex-related gene, terra, is involved in somitogenesis in vertebrates.
Volume: 126
Issue: 6
Pages: 1259-68
Publication
First Author: Călin A
Year: 2023
Journal: iScience
Title: A genetically targeted ion sensor reveals distinct seizure-related chloride and pH dynamics in GABAergic interneuron populations.
Volume: 26
Issue: 4
Pages: 106363
Publication
First Author: Coxon A
Year: 1996
Journal: Immunity
Title: A novel role for the beta 2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation.
Volume: 5
Issue: 6
Pages: 653-66
Publication
First Author: Kasirer-Friede A
Year: 2007
Journal: Blood
Title: ADAP is required for normal alphaIIbbeta3 activation by VWF/GP Ib-IX-V and other agonists.
Volume: 109
Issue: 3
Pages: 1018-25
Publication
First Author: Torremans A
Year: 2005
Journal: J Neurol Sci
Title: Biochemical and behavioural phenotyping of a mouse model for GAMT deficiency.
Volume: 231
Issue: 1-2
Pages: 49-55
Publication
First Author: Raudales A
Year: 2024
Journal: Cell Rep
Title: Angiogenesis in the mature mouse cortex is governed in a regional- and Notch1-dependent manner.
Volume: 43
Issue: 12
Pages: 115029
Publication
First Author: Pujol A
Year: 2002
Journal: Hum Mol Genet
Title: Late onset neurological phenotype of the X-ALD gene inactivation in mice: a mouse model for adrenomyeloneuropathy.
Volume: 11
Issue: 5
Pages: 499-505
Publication
First Author: de La Coste A
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: Somatic mutations of the beta-catenin gene are frequent in mouse and human hepatocellular carcinomas.
Volume: 95
Issue: 15
Pages: 8847-51
Publication
First Author: Schneider A
Year: 1992
Journal: Nature
Title: Uncoupling of hypomyelination and glial cell death by a mutation in the proteolipid protein gene.
Volume: 358
Issue: 6389
Pages: 758-61
Publication      
First Author: Speck NA
Year: 2009
Journal: MGI Direct Data Submission
Title: Generation of a Runx1 floxed allele
Transgene
Type: transgene
Organism: mouse, laboratory
Publication
First Author: Strobel A
Year: 1998
Journal: Nat Genet
Title: A leptin missense mutation associated with hypogonadism and morbid obesity.
Volume: 18
Issue: 3
Pages: 213-5
Publication
First Author: Knoll A
Year: 2000
Journal: Neurosci Lett
Title: Peroxisomal beta-oxidation enzyme gene expression in the developing mouse brain.
Volume: 285
Issue: 3
Pages: 201-4
Publication
First Author: Danchin A
Year: 1997
Journal: DNA Res
Title: Comparison between the Escherichia coli and Bacillus subtilis genomes suggests that a major function of polynucleotide phosphorylase is to synthesize CDP.
Volume: 4
Issue: 1
Pages: 9-18
Publication
First Author: Cole WA
Year: 1980
Journal: Teratology
Title: Gene-teratogen interaction in insulin-induced mouse exencephaly.
Volume: 22
Issue: 1
Pages: 125-39
Publication
First Author: Long HK
Year: 2020
Journal: Cell Stem Cell
Title: Loss of Extreme Long-Range Enhancers in Human Neural Crest Drives a Craniofacial Disorder.
Volume: 27
Issue: 5
Pages: 765-783.e14
Publication
First Author: Toumane A
Year: 1993
Journal: Behav Neural Biol
Title: Time gradient for post-test vulnerability to scopolamine-induced amnesia following the initial acquisition session of a spatial reference memory task in mice.
Volume: 60
Issue: 2
Pages: 139-51
Publication
First Author: Métais A
Year: 2018
Journal: Circ Res
Title: Asb2α-Filamin A Axis Is Essential for Actin Cytoskeleton Remodeling During Heart Development.
Volume: 122
Issue: 6
Pages: e34-e48
Publication
First Author: Nystuen A
Year: 2001
Journal: Neuron
Title: A null mutation in inositol polyphosphate 4-phosphatase type I causes selective neuronal loss in weeble mutant mice.
Volume: 32
Issue: 2
Pages: 203-12
Publication
First Author: Wersäll A
Year: 2018
Journal: Arterioscler Thromb Vasc Biol
Title: Mouse Platelet Ral GTPases Control P-Selectin Surface Expression, Regulating Platelet-Leukocyte Interaction.
Volume: 38
Issue: 4
Pages: 787-800
Publication
First Author: Wu A
Year: 2024
Journal: Am J Physiol Renal Physiol
Title: Macrophage SPAK deletion limits a low potassium-induced kidney inflammatory program.
Volume: 327
Issue: 5
Pages: F899-F909
Publication  
First Author: Lobley A
Year: 2003
Journal: Reprod Biol Endocrinol
Title: Identification of human and mouse CatSper3 and CatSper4 genes: characterisation of a common interaction domain and evidence for expression in testis.
Volume: 1
Pages: 53
Publication
First Author: Halle A
Year: 2008
Journal: Nat Immunol
Title: The NALP3 inflammasome is involved in the innate immune response to amyloid-beta.
Volume: 9
Issue: 8
Pages: 857-65
Publication
First Author: Oh JE
Year: 2019
Journal: Nature
Title: Migrant memory B cells secrete luminal antibody in the vagina.
Volume: 571
Issue: 7763
Pages: 122-126
Publication
First Author: Faget J
Year: 2017
Journal: Cell Rep
Title: Neutrophils and Snail Orchestrate the Establishment of a Pro-tumor Microenvironment in Lung Cancer.
Volume: 21
Issue: 11
Pages: 3190-3204
Protein Domain
Type: Family
Description: Members of this protein family are found, so far, exclusively in the genus Acinetobacter. Members average just over 600 amino acids in length, including a 22-amino acid C-terminal putative protein sorting recognition sequence, GlyGly-CTERM. The GlyGly-CTERM signal always co-occurs with a subfamily of the rhomboid family intramembrane serine proteases called rhombosortase. Members occur paired with a second rhombosortase target, with which it also shares an N-terminal motif CSLREA. This protein is designated Acinetobacter rhombotarget A (rbtA).
Publication
First Author: Kudo E
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Low ambient humidity impairs barrier function and innate resistance against influenza infection.
Volume: 116
Issue: 22
Pages: 10905-10910
Publication  
First Author: Dumoulin A
Year: 2024
Journal: Development
Title: A cell-autonomous role for primary cilium-mediated signaling in long-range commissural axon guidance.
Volume: 151
Issue: 17
Publication
First Author: Andersen OM
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.
Volume: 102
Issue: 38
Pages: 13461-6
Publication
First Author: Raz A
Year: 1989
Journal: Cancer Res
Title: Identification of the metastasis-associated, galactoside-binding lectin as a chimeric gene product with homology to an IgE-binding protein.
Volume: 49
Issue: 13
Pages: 3489-93
Publication
First Author: Mariotto A
Year: 2016
Journal: J Invest Dermatol
Title: HOPX: The Unusual Homeodomain-Containing Protein.
Volume: 136
Issue: 5
Pages: 905-11
Publication
First Author: De Castro SCP
Year: 2018
Journal: Hum Mol Genet
Title: Overexpression of Grainyhead-like 3 causes spina bifida and interacts genetically with mutant alleles of Grhl2 and Vangl2 in mice.
Volume: 27
Issue: 24
Pages: 4218-4230
Publication
First Author: Brown A
Year: 1995
Journal: Nat Genet
Title: The mouse dystonia musculorum gene is a neural isoform of bullous pemphigoid antigen 1.
Volume: 10
Issue: 3
Pages: 301-6
Publication
First Author: Petiot A
Year: 2003
Journal: Development
Title: A crucial role for Fgfr2-IIIb signalling in epidermal development and hair follicle patterning.
Volume: 130
Issue: 22
Pages: 5493-501
Publication
First Author: Dedeoglu A
Year: 2002
Journal: J Neurosci
Title: Therapeutic effects of cystamine in a murine model of Huntington's disease.
Volume: 22
Issue: 20
Pages: 8942-50
Publication
First Author: Cleuren ACA
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: The in vivo endothelial cell translatome is highly heterogeneous across vascular beds.
Volume: 116
Issue: 47
Pages: 23618-23624
Publication
First Author: Holmes A
Year: 2018
Journal: Biochem Biophys Res Commun
Title: A deficiency of the GluN2C subunit of the N-methyl-D-aspartate receptor is neuroprotective in a mouse model of ischemic stroke.
Volume: 495
Issue: 1
Pages: 136-144
Publication
First Author: Falnikar A
Year: 2013
Journal: Curr Biol
Title: Polarity in migrating neurons is related to a mechanism analogous to cytokinesis.
Volume: 23
Issue: 13
Pages: 1215-20
Publication
First Author: Khan MA
Year: 2016
Journal: J Neurosci
Title: Hyperglycemia in Stroke Impairs Polarization of Monocytes/Macrophages to a Protective Noninflammatory Cell Type.
Volume: 36
Issue: 36
Pages: 9313-25
Publication      
First Author: Rantanen A
Year: 2003
Journal: PhD Thesis - Karolinska Institutet, Stockholm, Sweden
Title: Regulation of mitochondrial transcription and mtDNA copy number in mammals
Publication
First Author: Megill A
Year: 2013
Journal: J Neurosci
Title: A tetra(ethylene glycol) derivative of benzothiazole aniline enhances Ras-mediated spinogenesis.
Volume: 33
Issue: 22
Pages: 9306-18