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Search results 8101 to 8200 out of 8780 for Shh

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Hits by Pathway

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Hits by Strain

Type Details Score
Genotype
Genotype
Symbol: Shh/Shh<+> Sulf1/Sulf1 Sulf2/Sulf2
Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/10
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ssq/?
Background: involves: C57BL/6 * C57BL/10 * CBA
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ssq/Ssq
Background: involves: C57BL/6 * C57BL/10 * CBA
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hhat/Hhat<+> Shh/Shh<+>
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rr26/Rr26 Shh/Shh<+>
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Shh/Shh Zic2/Zic2
Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cAnNCrl * C3H/HeH
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Shh<+>/Shh Zic2/Zic2<+>
Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cAnNCrl * C3H/HeH
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Shh/Shh Tg(Prrx1-cre)1Cjt/?
Background: involves: 129 * C57BL/6J * FVB/N * SJL/J
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli3/Gli3<+> Shh/Shh
Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6 * CD-1
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli3/Gli3 Shh/Shh
Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6 * CD-1
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli3/Gli3 Shh/Shh<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6 * CD-1
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli3/Gli3 Shh/Shh
Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli3/Gli3 Shh/Shh
Background: involves: 129S1/Sv * 129X1/SvJ * C3H/FeJLe * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli3/Gli3 Shh/Shh
Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli3/Gli3<+> Shh/Shh
Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6 * Swiss Webster
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli3/Gli3<+> Shh/Shh
Background: involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli3/Gli3 Shh/Shh
Background: involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Arl13b/Arl13b Shh/Shh
Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli3/Gli3 Shh/Shh
Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * CD-1
Zygosity: cx
Has Mutant Allele: true
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Protein
Q9D1G3
Organism: Mus musculus/domesticus
Length: 503  
Fragment?: false
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Protein
Q8BMT9
Organism: Mus musculus/domesticus
Length: 499  
Fragment?: false
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Protein
Q9Z0P7
Organism: Mus musculus/domesticus
Length: 484  
Fragment?: false
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Protein
Q8BWF5
Organism: Mus musculus/domesticus
Length: 367  
Fragment?: true
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Protein
D3Z7B6
Organism: Mus musculus/domesticus
Length: 467  
Fragment?: false
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Protein
A0A0A6YWJ4
Organism: Mus musculus/domesticus
Length: 507  
Fragment?: false
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Protein
Q3U0Z8
Organism: Mus musculus/domesticus
Length: 485  
Fragment?: false
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Protein Domain
IPR020941 | SUFU-like_domain
Type: Domain
Description: Sufu, encoding the human ortholog of Drosophila suppressor of fused, appears to have a conserved role in the repression of Hedgehog signalling []. It is a repressor of the Gli and Ci transcription factors of the Hedgehog signalling cascade [], and functions by binding these proteins and preventing their translocation to the nucleus. Sufu has been found to be a tumour-suppressor gene that predisposes individuals to medulloblastoma by modulating the SHH signalling pathway []. Homologues of Sufu have been found in bacteria, though their function is not currently known.This entry represents a domain found in Sufu and its homologues. It is also found in other proteins that are functionally uncharacterised. In eukaryotic Sufu, an additional domain () is found at the C terminus of the protein. This domain binds to the C-terminal domain of the Gli/Ci transcription factors, inhibiting their activity [].This domain is also found in Immunity protein YqcF from B. subtilis, a component of one of 6 LXG toxin-immunity modules. It neutralizes the toxic activity of cognate toxin YqcG [, ].
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HT Experiment
E-GEOD-21278 | A genomic atlas of mouse hypothalamic development
Series Id: GSE21278
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
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HT Experiment
E-GEOD-30078 | Eliminating SF-1 (Nr5a1) Sumoylation In Vivo Results in Ectopic Hedgehog Signaling and Disruption of Endocrine Development
Series Id: GSE30078
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
E-GEOD-75696 | Apical complex protein Pals1 is required to maintain cerebellar progenitor cells in a proliferative state
Series Id: GSE75696
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
GSE217373 | Ptch1/Shh signaling control cochlear marginal cell differentiation and stria vascularis formation
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE273804 | A single-cell atlas of spatial and temporal gene expression in the mouse cranial neural plate
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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Publication
9708734 | J:49089
First Author: Piedra ME
Year: 1998
Journal: Cell
Title: Pitx2 participates in the late phase of the pathway controlling left-right asymmetry.
Volume: 94
Issue: 3
Pages: 319-24
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Publication
15367681 | -
First Author: Merchant M
Year: 2004
Journal: Mol Cell Biol
Title: Suppressor of fused regulates Gli activity through a dual binding mechanism.
Volume: 24
Issue: 19
Pages: 8627-41
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Publication
22200572 | -
First Author: Holberger LE
Year: 2012
Journal: FEBS Lett
Title: A novel family of toxin/antitoxin proteins in Bacillus species.
Volume: 586
Issue: 2
Pages: 132-6
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Publication
11535289 | J:102565
First Author: Aoki T
Year: 2001
Journal: Neurosci Res
Title: Callosal commissural neurons of Dab1 deficient mutant mouse, yotari.
Volume: 41
Issue: 1
Pages: 13-23
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Publication
12722105 | J:83585
First Author: Yamamoto T
Year: 2003
Journal: J Comp Neurol
Title: Ectopic corticospinal tract and corticothalamic tract neurons in the cerebral cortex of yotari and reeler mice.
Volume: 461
Issue: 1
Pages: 61-75
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Genotype
Genotype
Symbol: Gli2/Gli2 Shh/Shh
Background: either: (involves: 129) or (involves: 129 * Black Swiss)
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Shh/Shh Tg(Mef2c-cre)2Blk/?
Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Shh/Shh Tg(Hoxb7-cre)13Amc/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ptch1/Ptch1<+> Rab23/Rab23 Shh/Shh
Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ptch1/Ptch1<+> Shh/Shh
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli1/Gli1<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Shh/Shh
Background: involves: 129S/Sv * 129X1/SvJ * Black Swiss * Swiss Webster
Zygosity: cn
Has Mutant Allele: true
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HT Experiment
E-GEOD-44325 | Sost and its paralog Sostdc1 coordinate digit number in a Gli3-dependent manner
Series Id: GSE44325
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
E-GEOD-40511 | MiR-34a is dispensable for normal development but its loss accelerates medulloblastoma formation
Series Id: GSE40511
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
GSE108803 | Genome-wide chromatin accessibility and transcriptome profiling shows that minimal epigenome changes lead to coordinated transcriptional dysregulation of hedgehog signaling in Danforth's short tail mice (RNA-seq)
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Protein
P35288
Organism: Mus musculus/domesticus
Length: 237  
Fragment?: false
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Protein
Q9D4I9
Organism: Mus musculus/domesticus
Length: 237  
Fragment?: false
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Protein
Q0PD32
Organism: Mus musculus/domesticus
Length: 237  
Fragment?: false
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Publication
20530674 | J:161601
First Author: Heine VM
Year: 2010
Journal: Cancer Res
Title: Dexamethasone destabilizes Nmyc to inhibit the growth of hedgehog-associated medulloblastoma.
Volume: 70
Issue: 13
Pages: 5220-5
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Publication
9707115 | J:49337
First Author: Ryan AK
Year: 1998
Journal: Nature
Title: Pitx2 determines left-right asymmetry of internal organs in vertebrates.
Volume: 394
Issue: 6693
Pages: 545-51
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Publication
15545630 | J:94048
First Author: Callahan CA
Year: 2004
Journal: Genes Dev
Title: MIM/BEG4, a Sonic hedgehog-responsive gene that potentiates Gli-dependent transcription.
Volume: 18
Issue: 22
Pages: 2724-9
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HT Experiment
E-GEOD-32321 | A Wnt-Bmp feedback circuit controls inter-tissue signaling dynamics in tooth organogenesis
Series Id: GSE32321
Experiment Type: transcription profiling by array
Study Type: Baseline and WT vs. Mutant
Source: ArrayExpress
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Publication
30044992 | J:271138
First Author: Coulter ME
Year: 2018
Journal: Cell Rep
Title: The ESCRT-III Protein CHMP1A Mediates Secretion of Sonic Hedgehog on a Distinctive Subtype of Extracellular Vesicles.
Volume: 24
Issue: 4
Pages: 973-986.e8
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Publication
17088561 | -
First Author: Wang X
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: A subunit of the mediator complex regulates vertebrate neuronal development.
Volume: 103
Issue: 46
Pages: 17284-9
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Publication
18394596 | -
First Author: Shin CH
Year: 2008
Journal: Dev Biol
Title: Multiple roles for Med12 in vertebrate endoderm development.
Volume: 317
Issue: 2
Pages: 467-79
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Protein Domain
IPR019035 | Mediator_Med12
Type: Domain
Description: The Mediator complex is a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. On recruitment the Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins. The Mediator complex is composed of at least 31 subunits: MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The subunits form at least three structurally distinct submodules. The head and the middle modules interact directly with RNA polymerase II, whereas the elongated tail module interacts with gene-specific regulatory proteins. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation.The head module contains: MED6, MED8, MED11, SRB4/MED17, SRB5/MED18, ROX3/MED19, SRB2/MED20 and SRB6/MED22. The middle module contains: MED1, MED4, NUT1/MED5, MED7, CSE2/MED9, NUT2/MED10, SRB7/MED21 and SOH1/MED31. CSE2/MED9 interacts directly with MED4. The tail module contains: MED2, PGD1/MED3, RGR1/MED14, GAL11/MED15 and SIN4/MED16. The CDK8 module contains: MED12, MED13, CCNC and CDK8. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.Med12 is a component of the evolutionarily conserved Mediator complex []. The Med12 subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. Med12 is a negative regulator of the Gli3-dependent sonic hedgehog signaling pathway via its interaction with Gli3 within the Mediator. A complex is formed between Med12, Med13, CDK8 and CycC which is responsible for suppression of transcription [].
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HT Experiment
E-MTAB-42 | Transcription profiling of first molar tooth germ in PPAR-alpha knock-out and wild type mice
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
17089410 | J:116657
First Author: Muto A
Year: 2007
Journal: Dev Dyn
Title: Mouse Rab11-FIP4 regulates proliferation and differentiation of retinal progenitors in a Rab11-independent manner.
Volume: 236
Issue: 1
Pages: 214-25
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Publication
16245339 | J:102854
First Author: Lancman JJ
Year: 2005
Journal: Dev Dyn
Title: Analysis of the regulation of lin-41 during chick and mouse limb development.
Volume: 234
Issue: 4
Pages: 948-60
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Publication
16229832 | J:103514
First Author: May SR
Year: 2005
Journal: Dev Biol
Title: Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli.
Volume: 287
Issue: 2
Pages: 378-89
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Publication
24062445 | J:201190
First Author: Marazziti D
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Precocious cerebellum development and improved motor functions in mice lacking the astrocyte cilium-, patched 1-associated Gpr37l1 receptor.
Volume: 110
Issue: 41
Pages: 16486-91
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Publication
10830170 | J:133641
First Author: Briscoe J
Year: 2000
Journal: Cell
Title: A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube.
Volume: 101
Issue: 4
Pages: 435-45
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Publication
26150391 | J:226932
First Author: Gerhardt C
Year: 2015
Journal: J Cell Biol
Title: The transition zone protein Rpgrip1l regulates proteasomal activity at the primary cilium.
Volume: 210
Issue: 1
Pages: 115-33
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Publication
21856776 | J:176253
First Author: Vacik T
Year: 2011
Journal: Genes Dev
Title: A novel mechanism for the transcriptional regulation of Wnt signaling in development.
Volume: 25
Issue: 17
Pages: 1783-95
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Publication
21698230 | J:214792
First Author: Massinen S
Year: 2011
Journal: PLoS One
Title: Increased expression of the dyslexia candidate gene DCDC2 affects length and signaling of primary cilia in neurons.
Volume: 6
Issue: 6
Pages: e20580
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Publication
12490554 | J:81151
First Author: Rodrigo I
Year: 2003
Journal: Development
Title: Pax1 and Pax9 activate Bapx1 to induce chondrogenic differentiation in the sclerotome.
Volume: 130
Issue: 3
Pages: 473-82
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Publication
9778501 | J:50307
First Author: Takahashi M
Year: 1998
Journal: Development
Title: The role of Alx-4 in the establishment of anteroposterior polarity during vertebrate limb development.
Volume: 125
Issue: 22
Pages: 4417-25
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Publication
31036156 | J:278764
   
First Author: Kim S
Year: 2019
Journal: Elife
Title: Epigenetic regulation of mammalian Hedgehog signaling to the stroma determines the molecular subtype of bladder cancer.
Volume: 8
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Publication
16950124 | J:112802
First Author: Lei Q
Year: 2006
Journal: Dev Cell
Title: Wnt signaling inhibitors regulate the transcriptional response to morphogenetic Shh-Gli signaling in the neural tube.
Volume: 11
Issue: 3
Pages: 325-37
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Publication
10588713 | J:58952
First Author: Kioussi C
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: Pax6 is essential for establishing ventral-dorsal cell boundaries in pituitary gland development.
Volume: 96
Issue: 25
Pages: 14378-82
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Publication
34752747 | J:314131
First Author: Fujii K
Year: 2021
Journal: Dev Cell
Title: Controlling tissue patterning by translational regulation of signaling transcripts through the core translation factor eIF3c.
Volume: 56
Issue: 21
Pages: 2928-2937.e9
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Publication
19121383 | J:155785
First Author: Brinkmeier ML
Year: 2009
Journal: Genomics
Title: Discovery of transcriptional regulators and signaling pathways in the developing pituitary gland by bioinformatic and genomic approaches.
Volume: 93
Issue: 5
Pages: 449-60
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Publication
35857834 | J:327233
First Author: Swiderska-Syn M
Year: 2022
Journal: Sci Adv
Title: Noncanonical activation of GLI signaling in SOX2+ cells drives medulloblastoma relapse.
Volume: 8
Issue: 29
Pages: eabj9138
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Publication
17452975 | J:125534
First Author: Lee Y
Year: 2007
Journal: Oncogene
Title: Loss of suppressor-of-fused function promotes tumorigenesis.
Volume: 26
Issue: 44
Pages: 6442-7
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Publication
32294450 | J:305768
First Author: Selvadurai HJ
Year: 2020
Journal: Cell Rep
Title: Medulloblastoma Arises from the Persistence of a Rare and Transient Sox2+ Granule Neuron Precursor.
Volume: 31
Issue: 2
Pages: 107511
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Publication
18381430 | J:133329
First Author: Becher OJ
Year: 2008
Journal: Cancer Res
Title: Gli activity correlates with tumor grade in platelet-derived growth factor-induced gliomas.
Volume: 68
Issue: 7
Pages: 2241-9
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Publication
11718263 | J:73000
First Author: Corcoran RB
Year: 2001
Journal: J Neurooncol
Title: A mouse model for medulloblastoma and basal cell nevus syndrome.
Volume: 53
Issue: 3
Pages: 307-18
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Publication
28986380 | J:252299
First Author: Liu Y
Year: 2017
Journal: Cancer Res
Title: Astrocytes Promote Medulloblastoma Progression through Hedgehog Secretion.
Volume: 77
Issue: 23
Pages: 6692-6703
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Publication
18955550 | J:141416
First Author: Leonard JM
Year: 2008
Journal: J Cell Biol
Title: Sonic Hedgehog signaling impairs ionizing radiation-induced checkpoint activation and induces genomic instability.
Volume: 183
Issue: 3
Pages: 385-91
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Publication
19285468 | J:155074
First Author: Agalliu D
Year: 2009
Journal: Neuron
Title: Motor neurons with axial muscle projections specified by Wnt4/5 signaling.
Volume: 61
Issue: 5
Pages: 708-20
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Publication
21544870 | J:171649
First Author: Zhang X
Year: 2011
Journal: Glia
Title: Differentiation of postnatal cerebellar glial progenitors is controlled by Bmi1 through BMP pathway inhibition.
Volume: 59
Issue: 7
Pages: 1118-31
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Publication
29875630 | J:288864
 
First Author: Antonelli F
Year: 2018
Journal: Front Mol Neurosci
Title: Alterations in Morphology and Adult Neurogenesis in the Dentate Gyrus of Patched1 Heterozygous Mice.
Volume: 11
Pages: 168
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Publication
12438220 | J:80299
First Author: Weiner HL
Year: 2002
Journal: Cancer Res
Title: Induction of medulloblastomas in mice by sonic hedgehog, independent of Gli1.
Volume: 62
Issue: 22
Pages: 6385-9
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Publication
36960826 | J:334527
 
First Author: Weiss AC
Year: 2023
Journal: Development
Title: Permissive ureter specification by TBX18-mediated repression of metanephric gene expression.
Volume: 150
Issue: 6
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Publication
32553121 | J:296045
First Author: Patmore DM
Year: 2020
Journal: Dev Cell
Title: DDX3X Suppresses the Susceptibility of Hindbrain Lineages to Medulloblastoma.
Volume: 54
Issue: 4
Pages: 455-470.e5
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