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Search results 8901 to 9000 out of 15062 for F2

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Type Details Score
Publication  
First Author: Shi W
Year: 2024
Journal: Development
Title: CHD4 and SMYD1 repress common transcriptional programs in the developing heart.
Volume: 151
Issue: 8
Publication
First Author: Dose M
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Intrathymic proliferation wave essential for Valpha14+ natural killer T cell development depends on c-Myc.
Volume: 106
Issue: 21
Pages: 8641-6
Publication
First Author: Kuster JE
Year: 1997
Journal: Mamm Genome
Title: IAP insertion in the murine LamB3 gene results in junctional epidermolysis bullosa.
Volume: 8
Issue: 9
Pages: 673-81
Publication
First Author: Privitera L
Year: 2022
Journal: Aging Cell
Title: The MK2 cascade mediates transient alteration in mGluR-LTD and spatial learning in a murine model of Alzheimer's disease.
Volume: 21
Issue: 10
Pages: e13717
Publication  
First Author: Francis N
Year: 2017
Journal: Int J Biochem Cell Biol
Title: A T cell-specific knockout reveals an important role for protease-activated receptor 2 in lymphocyte development.
Volume: 92
Pages: 95-103
Publication
First Author: Johansson JU
Year: 2015
Journal: J Clin Invest
Title: Prostaglandin signaling suppresses beneficial microglial function in Alzheimer's disease models.
Volume: 125
Issue: 1
Pages: 350-64
Publication
First Author: Liang X
Year: 2005
Journal: J Neurosci
Title: Deletion of the prostaglandin E2 EP2 receptor reduces oxidative damage and amyloid burden in a model of Alzheimer's disease.
Volume: 25
Issue: 44
Pages: 10180-7
Publication
First Author: Tomoshige K
Year: 2023
Journal: Cancer Res
Title: FOXA2 Cooperates with Mutant KRAS to Drive Invasive Mucinous Adenocarcinoma of the Lung.
Volume: 83
Issue: 9
Pages: 1443-1458
Publication
First Author: Charles MA
Year: 2006
Journal: Mol Endocrinol
Title: Pituitary-specific Gata2 knockout: effects on gonadotrope and thyrotrope function.
Volume: 20
Issue: 6
Pages: 1366-77
Publication
First Author: Bliss SP
Year: 2009
Journal: Mol Endocrinol
Title: ERK signaling in the pituitary is required for female but not male fertility.
Volume: 23
Issue: 7
Pages: 1092-101
Publication
First Author: Li X
Year: 2021
Journal: Exp Mol Med
Title: Pituitary P62 deficiency leads to female infertility by impairing luteinizing hormone production.
Volume: 53
Issue: 8
Pages: 1238-1249
Publication
First Author: Baker RG
Year: 2009
Journal: Mol Cell Biol
Title: The adapter protein SLP-76 mediates "outside-in" integrin signaling and function in T cells.
Volume: 29
Issue: 20
Pages: 5578-89
Publication
First Author: Yagi R
Year: 2010
Journal: Immunity
Title: The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma.
Volume: 32
Issue: 4
Pages: 507-17
Publication
First Author: Yang Q
Year: 2011
Journal: Eur J Immunol
Title: IL-33 synergizes with TCR and IL-12 signaling to promote the effector function of CD8+ T cells.
Volume: 41
Issue: 11
Pages: 3351-60
Publication
First Author: Rao RR
Year: 2012
Journal: Immunity
Title: Transcription factor Foxo1 represses T-bet-mediated effector functions and promotes memory CD8(+) T cell differentiation.
Volume: 36
Issue: 3
Pages: 374-87
Publication
First Author: Pearce EL
Year: 2009
Journal: Nature
Title: Enhancing CD8 T-cell memory by modulating fatty acid metabolism.
Volume: 460
Issue: 7251
Pages: 103-7
Publication
First Author: Pellegrini M
Year: 2009
Journal: Nat Med
Title: Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies.
Volume: 15
Issue: 5
Pages: 528-36
Publication
First Author: Anderson CK
Year: 2015
Journal: J Immunol
Title: Role of SHIP1 in Invariant NKT Cell Development and Functions.
Volume: 195
Issue: 5
Pages: 2149-2156
Publication
First Author: Tumes D
Year: 2019
Journal: J Allergy Clin Immunol
Title: Ezh2 controls development of natural killer T cells, which cause spontaneous asthma-like pathology.
Volume: 144
Issue: 2
Pages: 549-560.e10
Publication
First Author: Intlekofer AM
Year: 2005
Journal: Nat Immunol
Title: Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin.
Volume: 6
Issue: 12
Pages: 1236-44
Publication
First Author: Kao C
Year: 2011
Journal: Nat Immunol
Title: Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection.
Volume: 12
Issue: 7
Pages: 663-71
Publication
First Author: Mesnard D
Year: 2006
Journal: Development
Title: Nodal specifies embryonic visceral endoderm and sustains pluripotent cells in the epiblast before overt axial patterning.
Volume: 133
Issue: 13
Pages: 2497-505
Publication
First Author: Hosoya-Ohmura S
Year: 2011
Journal: Mol Cell Biol
Title: An NK and T cell enhancer lies 280 kilobase pairs 3' to the gata3 structural gene.
Volume: 31
Issue: 9
Pages: 1894-904
Publication
First Author: Lee K
Year: 2014
Journal: Am J Transplant
Title: Attenuation of donor-reactive T cells allows effective control of allograft rejection using regulatory T cell therapy.
Volume: 14
Issue: 1
Pages: 27-38
Publication  
First Author: Wang X
Year: 2017
Journal: EBioMedicine
Title: Cyclic AMP-Responsive Element-Binding Protein (CREB) is Critical in Autoimmunity by Promoting Th17 but Inhibiting Treg Cell Differentiation.
Volume: 25
Pages: 165-174
Publication
First Author: Welsh M
Year: 2009
Journal: FASEB J
Title: Androgen action via testicular peritubular myoid cells is essential for male fertility.
Volume: 23
Issue: 12
Pages: 4218-30
Publication
First Author: Inta I
Year: 2006
Journal: J Neurosci
Title: Bim and Noxa are candidates to mediate the deleterious effect of the NF-kappa B subunit RelA in cerebral ischemia.
Volume: 26
Issue: 50
Pages: 12896-903
Publication
First Author: Goedhart M
Year: 2019
Journal: Eur J Immunol
Title: CXCR4, but not CXCR3, drives CD8+ T-cell entry into and migration through the murine bone marrow.
Volume: 49
Issue: 4
Pages: 576-589
Publication
First Author: Ricke KM
Year: 2020
Journal: J Neurosci
Title: Neuronal Protein Tyrosine Phosphatase 1B Hastens Amyloid β-Associated Alzheimer's Disease in Mice.
Volume: 40
Issue: 7
Pages: 1581-1593
Publication
First Author: Moriwaki A
Year: 2011
Journal: Am J Respir Cell Mol Biol
Title: T cell treatment with small interfering RNA for suppressor of cytokine signaling 3 modulates allergic airway responses in a murine model of asthma.
Volume: 44
Issue: 4
Pages: 448-55
Publication
First Author: O'Reilly M
Year: 2007
Journal: Am J Hum Genet
Title: RNA interference-mediated suppression and replacement of human rhodopsin in vivo.
Volume: 81
Issue: 1
Pages: 127-35
Publication
First Author: Zikherman J
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Quantitative differences in CD45 expression unmask functions for CD45 in B-cell development, tolerance, and survival.
Volume: 109
Issue: 1
Pages: E3-12
Publication
First Author: Limnander A
Year: 2014
Journal: Mol Cell Biol
Title: Protein kinase Cδ promotes transitional B cell-negative selection and limits proximal B cell receptor signaling to enforce tolerance.
Volume: 34
Issue: 8
Pages: 1474-85
Publication
First Author: Noviski M
Year: 2019
Journal: J Immunol
Title: Optimal Development of Mature B Cells Requires Recognition of Endogenous Antigens.
Volume: 203
Issue: 2
Pages: 418-428
Publication
First Author: Hermiston ML
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Differential impact of the CD45 juxtamembrane wedge on central and peripheral T cell receptor responses.
Volume: 106
Issue: 2
Pages: 546-51
Publication
First Author: Suh J
Year: 2019
Journal: Cell
Title: Loss of Ataxin-1 Potentiates Alzheimer's Pathogenesis by Elevating Cerebral BACE1 Transcription.
Volume: 178
Issue: 5
Pages: 1159-1175.e17
Publication
First Author: Shima Y
Year: 2015
Journal: Mol Endocrinol
Title: Fetal Leydig Cells Persist as an Androgen-Independent Subpopulation in the Postnatal Testis.
Volume: 29
Issue: 11
Pages: 1581-93
Publication
First Author: Eyer J
Year: 1994
Journal: Neuron
Title: Neurofilament-deficient axons and perikaryal aggregates in viable transgenic mice expressing a neurofilament-beta-galactosidase fusion protein.
Volume: 12
Issue: 2
Pages: 389-405
Publication
First Author: Zochodne DW
Year: 2004
Journal: Brain
Title: Accelerated diabetic neuropathy in axons without neurofilaments.
Volume: 127
Issue: Pt 10
Pages: 2193-200
Publication
First Author: Byrne SM
Year: 2012
Journal: J Immunol
Title: Cathepsin B controls the persistence of memory CD8+ T lymphocytes.
Volume: 189
Issue: 3
Pages: 1133-43
Publication
First Author: Myers DR
Year: 2017
Journal: Cell Rep
Title: Tonic LAT-HDAC7 Signals Sustain Nur77 and Irf4 Expression to Tune Naive CD4 T Cells.
Volume: 19
Issue: 8
Pages: 1558-1571
Publication
First Author: Santoni-Rugiu E
Year: 1996
Journal: Am J Pathol
Title: Evolution of neoplastic development in the liver of transgenic mice co-expressing c-myc and transforming growth factor-alpha.
Volume: 149
Issue: 2
Pages: 407-28
Publication
First Author: Lindner J
Year: 2017
Journal: J Immunol
Title: Endogenous Calcitriol Synthesis Controls the Humoral IgE Response in Mice.
Volume: 199
Issue: 12
Pages: 3952-3958
Publication
First Author: Park SG
Year: 2009
Journal: Nat Immunol
Title: The kinase PDK1 integrates T cell antigen receptor and CD28 coreceptor signaling to induce NF-kappaB and activate T cells.
Volume: 10
Issue: 2
Pages: 158-66
Publication
First Author: Berbari NF
Year: 2013
Journal: Cytoskeleton (Hoboken)
Title: Microtubule modifications and stability are altered by cilia perturbation and in cystic kidney disease.
Volume: 70
Issue: 1
Pages: 24-31
Publication
First Author: Hunt RF
Year: 2012
Journal: J Neurosci
Title: LIS1 deficiency promotes dysfunctional synaptic integration of granule cells generated in the developing and adult dentate gyrus.
Volume: 32
Issue: 37
Pages: 12862-75
Publication
First Author: Hanke-Gogokhia C
Year: 2016
Journal: J Biol Chem
Title: Arf-like Protein 3 (ARL3) Regulates Protein Trafficking and Ciliogenesis in Mouse Photoreceptors.
Volume: 291
Issue: 13
Pages: 7142-55
Publication
First Author: Mazzitelli S
Year: 2011
Journal: J Neurosci
Title: The loss of c-Jun N-terminal protein kinase activity prevents the amyloidogenic cleavage of amyloid precursor protein and the formation of amyloid plaques in vivo.
Volume: 31
Issue: 47
Pages: 16969-76
Publication
First Author: Senagolage MD
Year: 2018
Journal: Cell Rep
Title: Loss of Transcriptional Repression by BCL6 Confers Insulin Sensitivity in the Setting of Obesity.
Volume: 25
Issue: 12
Pages: 3283-3298.e6
Publication
First Author: Mohamed TMA
Year: 2018
Journal: Cell
Title: Regulation of Cell Cycle to Stimulate Adult Cardiomyocyte Proliferation and Cardiac Regeneration.
Volume: 173
Issue: 1
Pages: 104-116.e12
Publication  
First Author: Zhang S
Year: 2019
Journal: J Cell Sci
Title: TMEM30A deficiency in endothelial cells impairs cell proliferation and angiogenesis.
Volume: 132
Issue: 7
Publication
First Author: Zamisch M
Year: 2009
Journal: J Exp Med
Title: The transcription factor Ets1 is important for CD4 repression and Runx3 up-regulation during CD8 T cell differentiation in the thymus.
Volume: 206
Issue: 12
Pages: 2685-99
Publication
First Author: Tsao HW
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Ets-1 facilitates nuclear entry of NFAT proteins and their recruitment to the IL-2 promoter.
Volume: 110
Issue: 39
Pages: 15776-81
Publication  
First Author: Lee CG
Year: 2019
Journal: JCI Insight
Title: Ets1 suppresses atopic dermatitis by suppressing pathogenic T cell responses.
Volume: 4
Issue: 5
Publication
First Author: Gómez-Del Arco P
Year: 2024
Journal: Nat Commun
Title: The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and ventricular conduction system development.
Volume: 15
Issue: 1
Pages: 8602
Publication
First Author: Bettigole SE
Year: 2015
Journal: Nat Immunol
Title: The transcription factor XBP1 is selectively required for eosinophil differentiation.
Volume: 16
Issue: 8
Pages: 829-37
Publication  
First Author: Pankaew S
Year: 2022
Journal: Front Immunol
Title: Calcium Signaling Is Impaired in PTEN-Deficient T Cell Acute Lymphoblastic Leukemia.
Volume: 13
Pages: 797244
Publication
First Author: Gordon SM
Year: 2011
Journal: J Immunol
Title: Requirements for eomesodermin and promyelocytic leukemia zinc finger in the development of innate-like CD8+ T cells.
Volume: 186
Issue: 8
Pages: 4573-8
Publication
First Author: Klein-Hessling S
Year: 2017
Journal: Nat Commun
Title: NFATc1 controls the cytotoxicity of CD8+ T cells.
Volume: 8
Issue: 1
Pages: 511
Publication
First Author: Costello P
Year: 2010
Journal: J Immunol
Title: Ternary complex factors SAP-1 and Elk-1, but not net, are functionally equivalent in thymocyte development.
Volume: 185
Issue: 2
Pages: 1082-92
Publication
First Author: Uehara M
Year: 2009
Journal: Genes Dev
Title: Removal of maternal retinoic acid by embryonic CYP26 is required for correct Nodal expression during early embryonic patterning.
Volume: 23
Issue: 14
Pages: 1689-98
Publication
First Author: Evrard M
Year: 2023
Journal: Immunity
Title: Single-cell protein expression profiling resolves circulating and resident memory T cell diversity across tissues and infection contexts.
Volume: 56
Issue: 7
Pages: 1664-1680.e9
Publication
First Author: Marie JC
Year: 2006
Journal: Immunity
Title: Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor.
Volume: 25
Issue: 3
Pages: 441-54
Publication  
First Author: Marshall HD
Year: 2015
Journal: Elife
Title: The transforming growth factor beta signaling pathway is critical for the formation of CD4 T follicular helper cells and isotype-switched antibody responses in the lung mucosa.
Volume: 4
Pages: e04851
Publication
First Author: Chou CK
Year: 2012
Journal: J Immunol
Title: Cell-intrinsic abrogation of TGF-β signaling delays but does not prevent dysfunction of self/tumor-specific CD8 T cells in a murine model of autochthonous prostate cancer.
Volume: 189
Issue: 8
Pages: 3936-46
Publication
First Author: McCarron MJ
Year: 2014
Journal: J Clin Invest
Title: TGF-β prevents T follicular helper cell accumulation and B cell autoreactivity.
Volume: 124
Issue: 10
Pages: 4375-86
Publication
First Author: Bergsbaken T
Year: 2015
Journal: Nat Immunol
Title: Proinflammatory microenvironments within the intestine regulate the differentiation of tissue-resident CD8⁺ T cells responding to infection.
Volume: 16
Issue: 4
Pages: 406-14
Publication
First Author: Ma C
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Transforming growth factor-β signaling is constantly shaping memory T-cell population.
Volume: 112
Issue: 35
Pages: 11013-7
Publication
First Author: Nichol PF
Year: 2011
Journal: J Surg Res
Title: Pitx2 is a critical early regulatory gene in normal cecal development.
Volume: 170
Issue: 1
Pages: 107-11
Publication
First Author: Yun K
Year: 2014
Journal: Hum Mol Genet
Title: Non-canonical Wnt5a/Ror2 signaling regulates kidney morphogenesis by controlling intermediate mesoderm extension.
Volume: 23
Issue: 25
Pages: 6807-14
Publication
First Author: Morita K
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Egr2 and Egr3 in regulatory T cells cooperatively control systemic autoimmunity through Ltbp3-mediated TGF-β3 production.
Volume: 113
Issue: 50
Pages: E8131-E8140
Publication
First Author: Zhu B
Year: 2008
Journal: J Exp Med
Title: Early growth response gene 2 (Egr-2) controls the self-tolerance of T cells and prevents the development of lupuslike autoimmune disease.
Volume: 205
Issue: 10
Pages: 2295-307
Publication
First Author: Shahrabi-Farahani S
Year: 2014
Journal: Lab Invest
Title: Neuropilin 1 expression correlates with differentiation status of epidermal cells and cutaneous squamous cell carcinomas.
Volume: 94
Issue: 7
Pages: 752-65
Publication  
First Author: Kurdi AT
Year: 2016
Journal: Nat Commun
Title: Tiam1/Rac1 complex controls Il17a transcription and autoimmunity.
Volume: 7
Pages: 13048
Publication  
First Author: Moore JR
Year: 2018
Journal: J Neuroimmunol
Title: 1,25-Dihydroxyvitamin D3 increases the methionine cycle, CD4+ T cell DNA methylation and Helios+Foxp3+ T regulatory cells to reverse autoimmune neurodegenerative disease.
Volume: 324
Pages: 100-114
Publication
First Author: McGargill MA
Year: 2009
Journal: J Immunol
Title: Cutting edge: Extracellular signal-related kinase is not required for negative selection of developing T cells.
Volume: 183
Issue: 8
Pages: 4838-42
Publication  
First Author: Penke LR
Year: 2022
Journal: JCI Insight
Title: KLF4 is a therapeutically tractable brake on fibroblast activation that promotes resolution of pulmonary fibrosis.
Volume: 7
Issue: 16
Publication
First Author: Malaab M
Year: 2022
Journal: Ann Rheum Dis
Title: Antifibrotic factor KLF4 is repressed by the miR-10/TFAP2A/TBX5 axis in dermal fibroblasts: insights from twins discordant for systemic sclerosis.
Volume: 81
Issue: 2
Pages: 268-277
Publication
First Author: Trampont P
Year: 2006
Journal: Mol Cell Biol
Title: ShcA mediates the dominant pathway to extracellular signal-regulated kinase activation during early thymic development.
Volume: 26
Issue: 23
Pages: 9035-44
Publication
First Author: Philips RL
Year: 2019
Journal: J Immunol
Title: Cutting Edge: HDAC3 Protects Double-Positive Thymocytes from P2X7 Receptor-Induced Cell Death.
Volume: 202
Issue: 4
Pages: 1033-1038
Publication  
First Author: Zhang S
Year: 2019
Journal: Mol Immunol
Title: SKI and SMAD4 are essential for IL-21-induced Th17 differentiation.
Volume: 114
Pages: 260-268
Publication
First Author: Giordano M
Year: 2015
Journal: EMBO J
Title: Molecular profiling of CD8 T cells in autochthonous melanoma identifies Maf as driver of exhaustion.
Volume: 34
Issue: 15
Pages: 2042-58
Publication
First Author: Lu KT
Year: 2011
Journal: Immunity
Title: Functional and epigenetic studies reveal multistep differentiation and plasticity of in vitro-generated and in vivo-derived follicular T helper cells.
Volume: 35
Issue: 4
Pages: 622-32
Publication
First Author: Pham D
Year: 2014
Journal: J Allergy Clin Immunol
Title: The transcription factor Etv5 controls TH17 cell development and allergic airway inflammation.
Volume: 134
Issue: 1
Pages: 204-14
Publication
First Author: Li Q
Year: 2019
Journal: Nat Commun
Title: Homozygous receptors for insulin and not IGF-1 accelerate intimal hyperplasia in insulin resistance and diabetes.
Volume: 10
Issue: 1
Pages: 4427
Publication
First Author: Xing Z
Year: 2004
Journal: J Exp Med
Title: Essential role of survivin, an inhibitor of apoptosis protein, in T cell development, maturation, and homeostasis.
Volume: 199
Issue: 1
Pages: 69-80
Publication
First Author: Zimdahl B
Year: 2014
Journal: Nat Genet
Title: Lis1 regulates asymmetric division in hematopoietic stem cells and in leukemia.
Volume: 46
Issue: 3
Pages: 245-52
Publication
First Author: Morris SM
Year: 2017
Journal: Int J Cancer
Title: Transposon mutagenesis identifies candidate genes that cooperate with loss of transforming growth factor-beta signaling in mouse intestinal neoplasms.
Volume: 140
Issue: 4
Pages: 853-863
Publication  
First Author: Gong D
Year: 2012
Journal: BMC Immunol
Title: TGFβ signaling plays a critical role in promoting alternative macrophage activation.
Volume: 13
Pages: 31
Publication
First Author: Muri J
Year: 2022
Journal: J Immunol
Title: Peroxisomes Are Critical for the Development and Maintenance of B1 and Marginal Zone B Cells but Dispensable for Follicular B Cells and T Cells.
Volume: 208
Issue: 4
Pages: 839-850
Publication
First Author: Bonilla WV
Year: 2012
Journal: Science
Title: The alarmin interleukin-33 drives protective antiviral CD8⁺ T cell responses.
Volume: 335
Issue: 6071
Pages: 984-9
Publication
First Author: Barnes SE
Year: 2015
Journal: J Immunother Cancer
Title: T cell-NF-κB activation is required for tumor control in vivo.
Volume: 3
Issue: 1
Pages: 1
Publication
First Author: Rahman AH
Year: 2011
Journal: Blood
Title: Antiviral memory CD8 T-cell differentiation, maintenance, and secondary expansion occur independently of MyD88.
Volume: 117
Issue: 11
Pages: 3123-30
Publication
First Author: Ye J
Year: 2017
Journal: J Immunol
Title: TLR7 Signaling Regulates Th17 Cells and Autoimmunity: Novel Potential for Autoimmune Therapy.
Volume: 199
Issue: 3
Pages: 941-954
Publication
First Author: Bedont JL
Year: 2017
Journal: Curr Biol
Title: An LHX1-Regulated Transcriptional Network Controls Sleep/Wake Coupling and Thermal Resistance of the Central Circadian Clockworks.
Volume: 27
Issue: 1
Pages: 128-136
Publication
First Author: Poché RA
Year: 2007
Journal: J Neurosci
Title: Lim1 is essential for the correct laminar positioning of retinal horizontal cells.
Volume: 27
Issue: 51
Pages: 14099-107
Publication
First Author: Drosten M
Year: 2014
Journal: Oncogene
Title: Ras signaling is essential for skin development.
Volume: 33
Issue: 22
Pages: 2857-65
Publication
First Author: Borges da Silva H
Year: 2020
Journal: Immunity
Title: Sensing of ATP via the Purinergic Receptor P2RX7 Promotes CD8+ Trm Cell Generation by Enhancing Their Sensitivity to the Cytokine TGF-β.
Volume: 53
Issue: 1
Pages: 158-171.e6
Publication
First Author: Daniel C
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Enhancement of antigen-specific Treg vaccination in vivo.
Volume: 107
Issue: 37
Pages: 16246-51
Publication
First Author: Macintyre AN
Year: 2011
Journal: Immunity
Title: Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism.
Volume: 34
Issue: 2
Pages: 224-36