Type |
Details |
Score |
Publication |
First Author: |
Wang N |
Year: |
1998 |
Journal: |
J Biol Chem |
Title: |
Liver-specific overexpression of scavenger receptor BI decreases levels of very low density lipoprotein ApoB, low density lipoprotein ApoB, and high density lipoprotein in transgenic mice. |
Volume: |
273 |
Issue: |
49 |
Pages: |
32920-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wiegman CH |
Year: |
2003 |
Journal: |
Diabetes |
Title: |
Hepatic VLDL production in ob/ob mice is not stimulated by massive de novo lipogenesis but is less sensitive to the suppressive effects of insulin. |
Volume: |
52 |
Issue: |
5 |
Pages: |
1081-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Frick F |
Year: |
2001 |
Journal: |
Am J Physiol Endocrinol Metab |
Title: |
Long-term growth hormone excess induces marked alterations in lipoprotein metabolism in mice. |
Volume: |
281 |
Issue: |
6 |
Pages: |
E1230-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wei E |
Year: |
2007 |
Journal: |
J Lipid Res |
Title: |
Apolipoprotein B and triacylglycerol secretion in human triacylglycerol hydrolase transgenic mice. |
Volume: |
48 |
Issue: |
12 |
Pages: |
2597-606 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nielsen LB |
Year: |
2002 |
Journal: |
J Biol Chem |
Title: |
Overexpression of apolipoprotein B in the heart impedes cardiac triglyceride accumulation and development of cardiac dysfunction in diabetic mice. |
Volume: |
277 |
Issue: |
30 |
Pages: |
27014-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Weiss RM |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
Osteoprotegerin inhibits aortic valve calcification and preserves valve function in hypercholesterolemic mice. |
Volume: |
8 |
Issue: |
6 |
Pages: |
e65201 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang LS |
Year: |
2015 |
Journal: |
Am J Physiol Gastrointest Liver Physiol |
Title: |
Apolipoprotein A-V deficiency enhances chylomicron production in lymph fistula mice. |
Volume: |
308 |
Issue: |
7 |
Pages: |
G634-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fukuhara T |
Year: |
2014 |
Journal: |
PLoS Pathog |
Title: |
Amphipathic α-helices in apolipoproteins are crucial to the formation of infectious hepatitis C virus particles. |
Volume: |
10 |
Issue: |
12 |
Pages: |
e1004534 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang K |
Year: |
2021 |
Journal: |
Atherosclerosis |
Title: |
Inducible phospholipid transfer protein deficiency ameliorates atherosclerosis. |
Volume: |
324 |
|
Pages: |
9-17 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wen D |
Year: |
2023 |
Journal: |
Front Cardiovasc Med |
Title: |
Mechanical injury accentuates lipid deposition in ApoE(-/-) mice and advance aortic valve stenosis: A novel modified aortic valve stenosis model. |
Volume: |
10 |
|
Pages: |
1119746 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gu T |
Year: |
2016 |
Journal: |
Genetics |
Title: |
Genetic Architectures of Quantitative Variation in RNA Editing Pathways. |
Volume: |
202 |
Issue: |
2 |
Pages: |
787-98 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
229
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
229
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
229
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Blanc V |
Year: |
2001 |
Journal: |
J Biol Chem |
Title: |
Identification of GRY-RBP as an apolipoprotein B RNA-binding protein that interacts with both apobec-1 and apobec-1 complementation factor to modulate C to U editing. |
Volume: |
276 |
Issue: |
13 |
Pages: |
10272-83 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tavori H |
Year: |
2016 |
Journal: |
Cardiovasc Res |
Title: |
Human PCSK9 promotes hepatic lipogenesis and atherosclerosis development via apoE- and LDLR-mediated mechanisms. |
Volume: |
110 |
Issue: |
2 |
Pages: |
268-78 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wilson PG |
Year: |
2018 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Serum Amyloid A Is an Exchangeable Apolipoprotein. |
Volume: |
38 |
Issue: |
8 |
Pages: |
1890-1900 |
|
•
•
•
•
•
|
Publication |
First Author: |
González-Navarro H |
Year: |
2004 |
Journal: |
J Biol Chem |
Title: |
The ligand-binding function of hepatic lipase modulates the development of atherosclerosis in transgenic mice. |
Volume: |
279 |
Issue: |
44 |
Pages: |
45312-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bi X |
Year: |
2013 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Liver ABCA1 deletion in LDLrKO mice does not impair macrophage reverse cholesterol transport or exacerbate atherogenesis. |
Volume: |
33 |
Issue: |
10 |
Pages: |
2288-96 |
|
•
•
•
•
•
|
Publication |
First Author: |
Joyce CW |
Year: |
2006 |
Journal: |
J Biol Chem |
Title: |
ABCA1 overexpression in the liver of LDLr-KO mice leads to accumulation of pro-atherogenic lipoproteins and enhanced atherosclerosis. |
Volume: |
281 |
Issue: |
44 |
Pages: |
33053-65 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kanuri G |
Year: |
2011 |
Journal: |
Lab Invest |
Title: |
Fructose-induced steatosis in mice: role of plasminogen activator inhibitor-1, microsomal triglyceride transfer protein and NKT cells. |
Volume: |
91 |
Issue: |
6 |
Pages: |
885-95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vishnyakova TG |
Year: |
2020 |
Journal: |
PLoS One |
Title: |
SR-BI mediates neutral lipid sorting from LDL to lipid droplets and facilitates their formation. |
Volume: |
15 |
Issue: |
10 |
Pages: |
e0240659 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mensenkamp AR |
Year: |
1999 |
Journal: |
J Biol Chem |
Title: |
Apolipoprotein E participates in the regulation of very low density lipoprotein-triglyceride secretion by the liver. |
Volume: |
274 |
Issue: |
50 |
Pages: |
35711-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Khatun I |
Year: |
2012 |
Journal: |
Hepatology |
Title: |
Phospholipid transfer activity of microsomal triglyceride transfer protein produces apolipoprotein B and reduces hepatosteatosis while maintaining low plasma lipids in mice. |
Volume: |
55 |
Issue: |
5 |
Pages: |
1356-68 |
|
•
•
•
•
•
|
Publication |
First Author: |
VerHague MA |
Year: |
2013 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Apolipoprotein A-IV expression in mouse liver enhances triglyceride secretion and reduces hepatic lipid content by promoting very low density lipoprotein particle expansion. |
Volume: |
33 |
Issue: |
11 |
Pages: |
2501-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Laatsch A |
Year: |
2012 |
Journal: |
PLoS One |
Title: |
Low density lipoprotein receptor-related protein 1 dependent endosomal trapping and recycling of apolipoprotein E. |
Volume: |
7 |
Issue: |
1 |
Pages: |
e29385 |
|
•
•
•
•
•
|
Publication |
First Author: |
Behlen JC |
Year: |
2022 |
Journal: |
Antioxidants (Basel) |
Title: |
NRF2-Dependent Placental Effects Vary by Sex and Dose following Gestational Exposure to Ultrafine Particles. |
Volume: |
11 |
Issue: |
2 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Blanc V |
Year: |
2019 |
Journal: |
RNA |
Title: |
Apobec1 complementation factor (A1CF) and RBM47 interact in tissue-specific regulation of C to U RNA editing in mouse intestine and liver. |
Volume: |
25 |
Issue: |
1 |
Pages: |
70-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim HG |
Year: |
2024 |
Journal: |
Sci Rep |
Title: |
Liver-specific Coxsackievirus and adenovirus receptor deletion develop metabolic dysfunction-associated fatty liver disease. |
Volume: |
14 |
Issue: |
1 |
Pages: |
21642 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dichek HL |
Year: |
1998 |
Journal: |
J Biol Chem |
Title: |
Overexpression of hepatic lipase in transgenic mice decreases apolipoprotein B-containing and high density lipoproteins. Evidence that hepatic lipase acts as a ligand for lipoprotein uptake. |
Volume: |
273 |
Issue: |
4 |
Pages: |
1896-903 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kendrick JS |
Year: |
2001 |
Journal: |
Biochem J |
Title: |
Superior role of apolipoprotein B48 over apolipoprotein B100 in chylomicron assembly and fat absorption: an investigation of apobec-1 knock-out and wild-type mice. |
Volume: |
356 |
Issue: |
Pt 3 |
Pages: |
821-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Escolà -Gil JC |
Year: |
2000 |
Journal: |
J Lipid Res |
Title: |
Expression of human apolipoprotein A-II in apolipoprotein E-deficient mice induces features of familial combined hyperlipidemia. |
Volume: |
41 |
Issue: |
8 |
Pages: |
1328-38 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kitagawa K |
Year: |
1994 |
Journal: |
Lab Invest |
Title: |
Age-associated decreases in the messenger ribonucleic acid level and the rate of synthesis of apolipoprotein A-II in murine senile amyloidosis. |
Volume: |
70 |
Issue: |
4 |
Pages: |
565-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Srivastava RA |
Year: |
1995 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Increased apoB100 mRNA in inbred strains of mice by estrogen is caused by decreased RNA editing protein mRNA. |
Volume: |
212 |
Issue: |
2 |
Pages: |
381-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huang Y |
Year: |
1996 |
Journal: |
J Biol Chem |
Title: |
Hypolipidemic and hyperlipidemic phenotypes in transgenic mice expressing human apolipoprotein E2. |
Volume: |
271 |
Issue: |
46 |
Pages: |
29146-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Grunwald KA |
Year: |
1999 |
Journal: |
J Lipid Res |
Title: |
Identification of a novel Arg-->Cys mutation in the LDL receptor that contributes to spontaneous hypercholesterolemia in pigs. |
Volume: |
40 |
Issue: |
3 |
Pages: |
475-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fujino T |
Year: |
1999 |
Journal: |
Nucleic Acids Res |
Title: |
C-->U editing of apolipoprotein B mRNA in marsupials: identification and characterisation of APOBEC-1 from the American opossum Monodelphus domestica. |
Volume: |
27 |
Issue: |
13 |
Pages: |
2662-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lau PP |
Year: |
2003 |
Journal: |
J Biol Chem |
Title: |
Involvement of a chaperone regulator, Bcl2-associated athanogene-4, in apolipoprotein B mRNA editing. |
Volume: |
278 |
Issue: |
52 |
Pages: |
52988-96 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ribas V |
Year: |
2004 |
Journal: |
Circ Res |
Title: |
Human apolipoprotein A-II enrichment displaces paraoxonase from HDL and impairs its antioxidant properties: a new mechanism linking HDL protein composition and antiatherogenic potential. |
Volume: |
95 |
Issue: |
8 |
Pages: |
789-97 |
|
•
•
•
•
•
|
Publication |
First Author: |
Noordmans GA |
Year: |
2014 |
Journal: |
PLoS One |
Title: |
Genetic analysis of intracapillary glomerular lipoprotein deposits in aging mice. |
Volume: |
9 |
Issue: |
10 |
Pages: |
e111308 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ali K |
Year: |
2014 |
Journal: |
PLoS One |
Title: |
A Western-fed diet increases plasma HDL and LDL-cholesterol levels in apoD-/- mice. |
Volume: |
9 |
Issue: |
12 |
Pages: |
e115744 |
|
•
•
•
•
•
|
Publication |
First Author: |
Uemura Y |
Year: |
2017 |
Journal: |
PLoS One |
Title: |
The intratracheal administration of locked nucleic acid containing antisense oligonucleotides induced gene silencing and an immune-stimulatory effect in the murine lung. |
Volume: |
12 |
Issue: |
11 |
Pages: |
e0187286 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gaglione R |
Year: |
2017 |
Journal: |
Biochem Pharmacol |
Title: |
Novel human bioactive peptides identified in Apolipoprotein B: Evaluation of their therapeutic potential. |
Volume: |
130 |
|
Pages: |
34-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nettersheim FS |
Year: |
2021 |
Journal: |
Front Cardiovasc Med |
Title: |
Autoimmune Regulator (AIRE) Deficiency Does Not Affect Atherosclerosis and CD4 T Cell Immune Tolerance to Apolipoprotein B. |
Volume: |
8 |
|
Pages: |
812769 |
|
•
•
•
•
•
|
Publication |
First Author: |
Moraes KC |
Year: |
2006 |
Journal: |
RNA |
Title: |
CUG-BP binds to RNA substrates and recruits PARN deadenylase. |
Volume: |
12 |
Issue: |
6 |
Pages: |
1084-91 |
|
•
•
•
•
•
|
Publication |
First Author: |
Timchenko LT |
Year: |
1996 |
Journal: |
Nucleic Acids Res |
Title: |
Identification of a (CUG)n triplet repeat RNA-binding protein and its expression in myotonic dystrophy. |
Volume: |
24 |
Issue: |
22 |
Pages: |
4407-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Leroy O |
Year: |
2006 |
Journal: |
J Neurosci Res |
Title: |
ETR-3 represses Tau exons 2/3 inclusion, a splicing event abnormally enhanced in myotonic dystrophy type I. |
Volume: |
84 |
Issue: |
4 |
Pages: |
852-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Timchenko NA |
Year: |
2001 |
Journal: |
J Biol Chem |
Title: |
RNA CUG repeats sequester CUGBP1 and alter protein levels and activity of CUGBP1. |
Volume: |
276 |
Issue: |
11 |
Pages: |
7820-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Graindorge A |
Year: |
2008 |
Journal: |
Nucleic Acids Res |
Title: |
Identification of CUG-BP1/EDEN-BP target mRNAs in Xenopus tropicalis. |
Volume: |
36 |
Issue: |
6 |
Pages: |
1861-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cosson B |
Year: |
2006 |
Journal: |
Biol Cell |
Title: |
Oligomerization of EDEN-BP is required for specific mRNA deadenylation and binding. |
Volume: |
98 |
Issue: |
11 |
Pages: |
653-65 |
|
•
•
•
•
•
|
Publication |
First Author: |
Anant S |
Year: |
2001 |
Journal: |
J Biol Chem |
Title: |
Novel role for RNA-binding protein CUGBP2 in mammalian RNA editing. CUGBP2 modulates C to U editing of apolipoprotein B mRNA by interacting with apobec-1 and ACF, the apobec-1 complementation factor. |
Volume: |
276 |
Issue: |
50 |
Pages: |
47338-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ladd AN |
Year: |
2004 |
Journal: |
J Cell Sci |
Title: |
Multiple domains control the subcellular localization and activity of ETR-3, a regulator of nuclear and cytoplasmic RNA processing events. |
Volume: |
117 |
Issue: |
Pt 16 |
Pages: |
3519-29 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
191
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
198
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
440
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
180
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
180
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
396
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
198
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
396
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
180
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
198
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
198
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
373
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
396
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
198
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
392
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
198
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
180
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
198
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
198
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
180
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
97
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
198
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
113
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
191
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
421
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
373
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
198
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
198
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
429
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
429
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
121
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
372
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
180
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
198
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
429
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
297
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
180
 |
Fragment?: |
true |
|
•
•
•
•
•
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Publication |
First Author: |
Yang C |
Year: |
1992 |
Journal: |
Biochemistry |
Title: |
Cloning and nucleotide sequence of the Escherichia coli cytidine deaminase (ccd) gene. |
Volume: |
31 |
Issue: |
17 |
Pages: |
4168-74 |
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•
•
•
•
•
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Protein Domain |
Type: |
Domain |
Description: |
The human CELF family has six members, which can be divided into two subfamilies based on their phylogeny: CELF1-2 and CELF3-6. This entry represents the RNA recognition motif 2 (RRM2) of CELF-1 and CELF-2 protein. CELF-1 and CELF-2 belong to the CELF (CUGBP and ETR-3 Like Factor)/Bruno-like protein family, whose members play important roles in the regulation of alternative splicing and translation. CELF-1 and CELF-2 share sequence similarity to the Drosophila Bruno protein and binds to the Bruno response elements (cis-acting sequences in the 3'-untranslated region (UTR) ofoskar mRNA) [].The human CELF-1 (also known as CUG-BP or BRUNOL-2) binds to RNA substrates and recruits PARN deadenylase []. It preferentially targets UGU-rich mRNA elements []. CELF-1 has been implicated in onset of type 1 myotonic dystrophy (DM1), a neuromuscular disease associated with an unstable CUG triplet expansion in the 3'-UTR (3'-untranslated region) of the DMPK (myotonic dystrophy protein kinase) gene [, ]. CELF-1 contain three highly conserved RNA recognition motifs (RRMs): two consecutive RRMs (RRM1 and RRM2) situated in the N-terminal region followed by a linker region and the third RRM (RRM3) close to the C terminus of the protein. The Xenopus homologue of CELF-1 is EDEN-BP (embryo deadenylation element-binding protein), which mediates sequence-specific deadenylation of Eg5 mRNA. It binds specifically to the EDEN motif in the 3'-untranslated regions of maternal mRNAs and targets these mRNAs for deadenylation and translational repression []. The two N-terminal RRMs of EDEN-BP are necessary for the interaction with EDEN as well as a part of the linker region (between RRM2 and RRM3). Oligomerization of EDEN-BP is required for specific mRNA deadenylation and binding []. CELF-2 (also known as CUGBP2 or ETR-3) shares high sequence identity with CELF-1, but shows different binding specificity; it binds preferentially to sequences with UG repeats and UGUU motifs. It also binds to the 3'-UTR of cyclooxygenase-2 messages, affecting both translation and mRNA stability, and binds to apoB mRNA, regulating its C to U editing []. CELF-2 also contains three highly conserved RRMs. It binds to RNA via the first two RRMs, which are also important for localization in the cytoplasm. The splicing activation or repression activity of CELF-2 on some specific substrates is mediated by RRM1/RRM2. Both, RRM1 and RRM2 of CELF-2, can activate cardiac troponin T (cTNT) exon 5 inclusion. In addition, CELF-2 possesses a typical arginine and lysine-rich nuclear localization signal (NLS) in the C terminus, within RRM3 []. |
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•
•
•
•
•
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Protein Domain |
Type: |
Domain |
Description: |
The human CELF family has six members, which can be divided into two subfamilies based on their phylogeny: CELF1-2 and CELF3-6. This entry represents the RNA recognition motif 3 (RRM3) of CELF-1 andCELF-2 protein. CELF-1 and CELF-2 belong to the CELF (CUGBP and ETR-3 Like Factor)/Bruno-like protein family, whose members play important roles in the regulation of alternative splicing and translation. CELF-1 and CELF-2 share sequence similarity to the Drosophila Bruno protein and binds to the Bruno response elements (cis-acting sequences in the 3'-untranslated region (UTR) ofoskar mRNA) [].The human CELF-1 (also known as CUG-BP or BRUNOL-2) binds to RNA substrates and recruits PARN deadenylase []. It preferentially targets UGU-rich mRNA elements []. CELF-1 has been implicated in onset of type 1 myotonic dystrophy (DM1), a neuromuscular disease associated with an unstable CUG triplet expansion in the 3'-UTR (3'-untranslated region) of the DMPK (myotonic dystrophy protein kinase) gene [, ]. CELF-1 contain three highly conserved RNA recognition motifs (RRMs): two consecutive RRMs (RRM1 and RRM2) situated in the N-terminal region followed by a linker region and the third RRM (RRM3) close to the C terminus of the protein. The Xenopus homologue of CELF-1 is EDEN-BP (embryo deadenylation element-binding protein), which mediates sequence-specific deadenylation of Eg5 mRNA. It binds specifically to the EDEN motif in the 3'-untranslated regions of maternal mRNAs and targets these mRNAs for deadenylation and translational repression []. The two N-terminal RRMs of EDEN-BP are necessary for the interaction with EDEN as well as a part of the linker region (between RRM2 and RRM3). Oligomerization of EDEN-BP is required for specific mRNA deadenylation and binding []. CELF-2 (also known as CUGBP2 or ETR-3) shares high sequenceidentity with CELF-1, but shows different binding specificity; it binds preferentially to sequences with UG repeats and UGUU motifs. It also binds to the 3'-UTR of cyclooxygenase-2 messages, affecting both translation and mRNA stability, and binds to apoB mRNA, regulating its C to U editing []. CELF-2 also contains three highly conserved RRMs. It binds to RNA via the first two RRMs, which are also important for localization in the cytoplasm. The splicing activation or repression activity of CELF-2 on some specific substrates is mediated by RRM1/RRM2. Both, RRM1 and RRM2 of CELF-2, can activate cardiac troponin T (cTNT) exon 5 inclusion. In addition, CELF-2 possesses a typical arginine and lysine-rich nuclear localization signal (NLS) in the C terminus, within RRM3 []. |
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•
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Publication |
First Author: |
Rosenblat M |
Year: |
2010 |
Journal: |
Atherosclerosis |
Title: |
Increased macrophage cholesterol biosynthesis and decreased cellular paraoxonase 2 (PON2) expression in Delta6-desaturase knockout (6-DS KO) mice: beneficial effects of arachidonic acid. |
Volume: |
210 |
Issue: |
2 |
Pages: |
414-21 |
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•
•
•
•
•
|
Publication |
First Author: |
Olzmann JA |
Year: |
2013 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Spatial regulation of UBXD8 and p97/VCP controls ATGL-mediated lipid droplet turnover. |
Volume: |
110 |
Issue: |
4 |
Pages: |
1345-50 |
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•
•
•
•
•
|
Publication |
First Author: |
Nakamuta M |
Year: |
1995 |
Journal: |
J Biol Chem |
Title: |
Alternative mRNA splicing and differential promoter utilization determine tissue-specific expression of the apolipoprotein B mRNA-editing protein (Apobec1) gene in mice. Structure and evolution of Apobec1 and related nucleoside/nucleotide deaminases. |
Volume: |
270 |
Issue: |
22 |
Pages: |
13042-56 |
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•
•
•
•
•
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Publication |
First Author: |
Spencer B |
Year: |
2019 |
Journal: |
Neurobiol Dis |
Title: |
Systemic peptide mediated delivery of an siRNA targeting α-syn in the CNS ameliorates the neurodegenerative process in a transgenic model of Lewy body disease. |
Volume: |
127 |
|
Pages: |
163-177 |
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•
•
•
•
•
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Publication |
First Author: |
Smallwood TL |
Year: |
2014 |
Journal: |
G3 (Bethesda) |
Title: |
High-resolution genetic mapping in the diversity outbred mouse population identifies Apobec1 as a candidate gene for atherosclerosis. |
Volume: |
4 |
Issue: |
12 |
Pages: |
2353-63 |
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•
•
•
•
•
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Publication |
First Author: |
Hersberger M |
Year: |
1999 |
Journal: |
J Biol Chem |
Title: |
Phylogenetic analysis of the apolipoprotein B mRNA-editing region. Evidence for a secondary structure between the mooring sequence and the 3' efficiency element. |
Volume: |
274 |
Issue: |
49 |
Pages: |
34590-7 |
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•
•
•
•
•
|
Publication |
First Author: |
Srivastava RA |
Year: |
1991 |
Journal: |
Biochim Biophys Acta |
Title: |
In vivo regulation of low-density lipoprotein receptor and apolipoprotein B gene expressions by dietary fat and cholesterol in inbred strains of mice. |
Volume: |
1086 |
Issue: |
1 |
Pages: |
29-43 |
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•
•
•
•
•
|
Publication |
First Author: |
Oka K |
Year: |
1997 |
Journal: |
J Biol Chem |
Title: |
Tissue-specific inhibition of apolipoprotein B mRNA editing in the liver by adenovirus-mediated transfer of a dominant negative mutant APOBEC-1 leads to increased low density lipoprotein in mice. |
Volume: |
272 |
Issue: |
3 |
Pages: |
1456-60 |
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•
•
•
•
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