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Search results 901 to 960 out of 960 for Atxn7

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Type Details Score
Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
28584132 | J:244142
First Author: Montero-Conde C
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Transposon mutagenesis identifies chromatin modifiers cooperating with Ras in thyroid tumorigenesis and detects ATXN7 as a cancer gene.
Volume: 114
Issue: 25
Pages: E4951-E4960
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Allele
Tg(Prnp-ATXN7*92Q)6076Als | MGI:2183508
Name: transgene insertion 6076, Albert R La Spada
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(RHO-SCA7)R7EJman | MGI:2447845
Name: transgene insertion R7E, Jean-Louis Mandel
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Pcp2-SCA7)P7EJman | MGI:2447846
Name: transgene insertion P7E, Jean-Louis Mandel
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Atxn7<tm1Hzo> | MGI:2651378
 
Name: ataxin 7; targeted mutation 1, Huda Y Zoghbi
Allele Type: Targeted
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Allele
Tg(Prnp-ATXN7*92Q)1963Als | MGI:5705123
Name: transgene insertion 1963, Albert R La Spada
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(GFAP-ATXN7*92Q)2521Als | MGI:6194621
Name: transgene insertion 2521, Albert La Spada
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(GFAP-ATXN7*92Q)2542Als | MGI:6194622
Name: transgene insertion 2542, Albert La Spada
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Transgene
MGI:2450855 | Tg(Prnp-ATXN7*92Q)6076Als
Type: transgene
Organism: mouse, laboratory
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Transgene
MGI:2653602 | Tg(RHO-SCA7)R7EJman
Type: transgene
Organism: mouse, laboratory
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Transgene
MGI:4398717 | Tg(Pcp2-SCA7)P7EJman
Type: transgene
Organism: mouse, laboratory
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Transgene
MGI:5705121 | Tg(Prnp-ATXN7*92Q)1963Als
Type: transgene
Organism: mouse, laboratory
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Transgene
MGI:6194618 | Tg(GFAP-ATXN7*92Q)2521Als
Type: transgene
Organism: mouse, laboratory
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Transgene
MGI:6194619 | Tg(GFAP-ATXN7*92Q)2542Als
Type: transgene
Organism: mouse, laboratory
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Genotype
Genotype
Symbol: Atxn7/Atxn7<+>
Background: involves: 129S7/SvEvBrd * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Prnp-ATXN7*92Q)6076Als/?
Background: involves: C3H/HeJ * C57BL/6
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Atxn7/Atxn7<+>
Background: involves: 129S7/SvEvBrd * C57BL/6J
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(RHO-SCA7)R7EJman/?
Background: involves: C57BL/6 * SJL
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Pcp2-SCA7)P7EJman/?
Background: involves: C57BL/6 * SJL
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Atxn7/Atxn7<+>
Background: involves: 129S7/SvEvBrd
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Atxn7/Atxn7
Background: involves: 129S7/SvEvBrd
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Atxn7/Atxn7 Kat2a/Kat2a<+>
Background: involves: 129 * 129S7/SvEvBrd
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Prnp-ATXN7*92Q)1963Als/?
Background: B6J.Cg-Tg(Prnp-ATXN7*92Q)1963Als
Zygosity: ot
Has Mutant Allele: true
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DO Term
DOID:0050958 | spinocerebellar ataxia type 7
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Genotype
Genotype
Symbol: Tg(GFAP-ATXN7*92Q)2542Als/?
Background: involves: C3H/HeJ * C57BL/6J
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(GFAP-ATXN7*92Q)2521Als/?
Background: involves: C3H/HeJ * C57BL/6J
Zygosity: ot
Has Mutant Allele: true
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Publication
20600911 | J:163006
First Author: Yefimova MG
Year: 2010
Journal: Neurobiol Dis
Title: Polyglutamine toxicity induces rod photoreceptor division, morphological transformation or death in spinocerebellar ataxia 7 mouse retina.
Volume: 40
Issue: 1
Pages: 311-24
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Protein
A2AWT3
Organism: Mus musculus/domesticus
Length: 347  
Fragment?: false
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Protein
Q8C8K6
Organism: Mus musculus/domesticus
Length: 696  
Fragment?: false
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Protein
B2RW07
Organism: Mus musculus/domesticus
Length: 739  
Fragment?: false
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Protein
F6X2K7
Organism: Mus musculus/domesticus
Length: 824  
Fragment?: false
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Protein
Q3U1F1
Organism: Mus musculus/domesticus
Length: 739  
Fragment?: false
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Protein
B7ZCC3
Organism: Mus musculus/domesticus
Length: 664  
Fragment?: false
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Protein
Z4YN62
Organism: Mus musculus/domesticus
Length: 350  
Fragment?: true
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Protein
F7C0E4
Organism: Mus musculus/domesticus
Length: 927  
Fragment?: false
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Protein
F6RCN9
Organism: Mus musculus/domesticus
Length: 258  
Fragment?: true
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Protein
Q6KAM3
Organism: Mus musculus/domesticus
Length: 410  
Fragment?: true
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Protein
Q5HZJ2
Organism: Mus musculus/domesticus
Length: 697  
Fragment?: true
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Protein
D3Z7I2
Organism: Mus musculus/domesticus
Length: 741  
Fragment?: false
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Protein
B7ZMR6
Organism: Mus musculus/domesticus
Length: 696  
Fragment?: false
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Protein
B7ZCC4
Organism: Mus musculus/domesticus
Length: 661  
Fragment?: false
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Publication
20634802 | -
First Author: Bonnet J
Year: 2010
Journal: EMBO Rep
Title: The structural plasticity of SCA7 domains defines their differential nucleosome-binding properties.
Volume: 11
Issue: 8
Pages: 612-8
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Protein Domain
IPR013243 | SCA7_dom
Type: Domain
Description: SAGA (Spt-Ada-Gcn5 acetyltransferase), a coactivator complex involved inchromatin remodelling, harbours both histone acetylation and deubiquitinationactivities. SAGA-associated factor 73 (Sgf734/ATXN7) and Ataxin-7-like protein 3 (ATXN7L3), two subunits of the SAGA deubiquitinationmodule, contain an ~50-residue SCA7 domain characterised by an atypical zinc-finger (Znf) with a Cys-X(9,10)-Cys-X(5)-Cys-X(2)-His motif and a long sequence insertion between the first two zinccoordinating residues.The SCA7 domain is found exclusively in members of theATXN7 gene family, which includes two distinct subunits of SAGA complexes:ATXN7 and ATXN7L3 orthologues. The analysis of multiple alignments highlightsthe consensus signature for the SCA7 domain, encompassing the putative zinc-coordinating residues, but also reveals the distinct features of the twoproteins. Marked differences are found mostly in the carboxy-terminal of thedomain, suggesting that divergent evolution of the SCA7 Znf domain occurred inorder to achieve specific functions in the SAGA complex. Both SCA7 domainscontain disordered regions, albeit not in the same region. Whereas the firstand last 10 residues of ATXN7-SCA7 are not folded, the N-terminal region of ATXN7L3-SCA7 is well structured and thelast 30 residues of this domain are not folded. In both ATXN7-SCA7 andATXN7L3-SCA7, the large sequence insertion between the first and second zinc-coordinating cysteines corresponds to a protruding extended hairpin structure.The core of the zinc-binding sites shows a conserved structure formed by twoshort adjacent loops located at the bottom of the hairpin. Although the SCA7domains of both ATXN7 and ATXN7L3 contain two α-helices, these are notlocated at similar positions in the sequences. In ATXN7-SCA7, the two alpha-helices are located downstream from the zinc-binding site and are separated bya loop containing a large number of positively charged residues. In ATXN7L3-SCA7, the two helices lie to either side of the zinc-binding site, leading toa different packing of the two helices. In ATXN7-SCA7, the two helices have analmost perpendicular orientation, the alpha2 helix being anchored to the zinc-binding site. In ATXN7L3-SCA7, the helices alpha1 and alpha2 adopt an anti-parallel orientation defined by hydrophobic interactions. The ATXN7-SCA7domain binds to the core or the C-terminal ends of the histone H2A and H2Bdimer, a region located on the lateral face of the nucleosome that containsthe ubiquitinated Lys 120 of H2B. This property is lost in the ATXN7-SCA7domain [, ].This entry represents the SCA7 domain.
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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