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Search results 901 to 1000 out of 1013 for Braf

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Hits by Pathway

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Hits by Strain

Type Details Score
Genotype
Genotype
Symbol: Braf/Braf<+> Tg(GFP/KRAS2/ALPP)1Brn/? Tg(Tyr-cre/ERT2)1Lru/?
Background: involves: C57BL/6 * DBA/2 * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf Kras/Kras<+>
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Tg(Vil1-cre)997Gum/? Trp53/Trp53
Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Tg(CAG-cre)2Osb/?
Background: involves: BALB/c * C57BL * C57BL/6J * DBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Tg(CAG-cre)2Osb/?
Background: involves: C57BL * C57BL/6J * DBA * ICR
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Ezh2/Ezh2<+> Tg(Tyr-cre/ERT2)13Bos/?
Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB
Zygosity: cn
Has Mutant Allele: true
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Publication
22318779 | J:189130
First Author: Rebocho AP
Year: 2011
Journal: Cancer Discov
Title: New insight puts CRAF in sight as a therapeutic target.
Volume: 1
Issue: 2
Pages: 98-9
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Allele
Tg(TG-BRAF*V600E)3Jaf | MGI:5524235
Name: transgene insertion 3, James A Fagin
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Gt(ROSA)26Sor<tm2(tTA,CMV*1-KIAA1549/BRAF,-EGFP)Gtm> | MGI:5543802
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, David H Gutmann
Allele Type: Targeted
Attribute String: Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter, Transactivator
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Allele
Gt(ROSA)26Sor<tm1(tetO-tdTomato,-BRAF*)Mmok> | MGI:5707503
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Markus Morkel
Allele Type: Targeted
Attribute String: Humanized sequence, Inducible, Inserted expressed sequence, Reporter
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Protein
C4IXV3
Organism: Mus musculus/domesticus
Length: 330  
Fragment?: false
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Genotype
Genotype
Symbol: Braf/Braf Meox2/Meox2<+>
Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf Raf1/Raf1<+> Tg(Nes-cre)1Kln/?
Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf Raf1/Raf1<+> Tg(Nes-cre)1Kln/?
Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf Raf1/Raf1 Tg(Nes-cre)1Kln/?
Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Kras/Kras<+> Tg(Tyr-cre/ERT2)1Lru/?
Background: involves: 129S4/SvJae * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Tyr-cre/ERT2)13Bos/? TgTn(sb-T2/Onc)#Dla/?
Background: involves: 129S6/SvEvTac * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Kras/Kras<+>
Background: involves: 129S4/SvJae * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf Polr2a/Polr2a Raf1/Raf1
Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf Kras/Kras<+> Polr2a/Polr2a
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Cdkn2a/Cdkn2a Tg(Vil1-cre)997Gum/?
Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf Raf1/Raf1 H2az2/H2az2<+>
Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J
Zygosity: cn
Has Mutant Allele: true
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Publication
23893969 | J:204469
First Author: Kaul A
Year: 2013
Journal: Genesis
Title: Conditional KIAA1549:BRAF mice reveal brain region- and cell type-specific effects.
Volume: 51
Issue: 10
Pages: 708-16
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Protein Domain
IPR042712 | RNF149_RING-H2
Type: Domain
Description: RNF149, also known as DNA polymerase-transactivated protein 2, is an E3 ubiquitin-protein ligase that interacts with wild-type v-Raf murine sarcoma viral oncogene homologue B1 (BRAF), a RING domain-containing E3 ubiquitin ligase involved in control of gene transcription, translation, cytoskeletal organization, cell adhesion, and epithelial development. RNF149 induces the ubiquitination of wild-type BRAF and promotes its proteasome-dependent degradation. Mutated RNF149 has been found in some human breast, ovarian, and colorectal cancers. RNF149 contains an N-terminal signal peptide, a protease-associated (PA) domain, a transmembrane (TM) domain and a C-terminal C3H2C3-type RING-H2 finger domain followed by a putative PEST sequence [].
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Publication
22340588 | J:181465
First Author: Cox AD
Year: 2012
Journal: Cancer Cell
Title: The RAF inhibitor paradox revisited.
Volume: 21
Issue: 2
Pages: 147-9
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Publication
23845435 | J:199225
First Author: Rustgi AK
Year: 2013
Journal: Cancer Cell
Title: BRAF: a driver of the serrated pathway in colon cancer.
Volume: 24
Issue: 1
Pages: 1-2
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Publication
25584887 | J:218896
First Author: Souroullas GP
Year: 2015
Journal: Cancer Cell
Title: mTOR signaling in melanoma: oncogene-induced pseudo-senescence?
Volume: 27
Issue: 1
Pages: 3-5
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Allele
Tg(TG-BRAF*V600E)2Jaf | MGI:5524234
Name: transgene insertion 2, James A Fagin
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Strain
MGI:5526854 | FVB/N-Tg(TG-BRAF*V600E)2Jaf
Attribute String: insertion, mutant strain, coisogenic
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Strain
MGI:5526853 | FVB/N-Tg(TG-BRAF*V600E)3Jaf
Attribute String: coisogenic, mutant strain, transgenic, insertion
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Genotype
Genotype
Symbol: Tg(TG-BRAF*V600E)2Jaf/?
Background: FVB/N-Tg(TG-BRAF*V600E)2Jaf
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(TG-BRAF*V600E)3Jaf/?
Background: FVB/N-Tg(TG-BRAF*V600E)3Jaf
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(tetO-BRAF*V600E)26Jaf/? Tg(TG-rtTA)30Jaf/?
Background: involves: FVB/N
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129S6/SvEvTac * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Publication
27261482 | J:236808
First Author: Virós A
Year: 2016
Journal: Cancer Discov
Title: So You Can Teach Old Fibroblasts New Tricks.
Volume: 6
Issue: 6
Pages: 581-3
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Genotype
Genotype
Symbol: Braf/Braf Raf1/Raf1 Tg(Nes-cre)1Kln/?
Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf Kras/Kras<+> Polr2a/Polr2a Raf1/Raf1
Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Allele
Gt(ROSA)26Sor<tm2(RNAi:Braf)Rkuhn> | MGI:3785790
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Ralf Kuhn
Allele Type: Targeted
Attribute String: Knockdown, RMCE-ready
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(GFAP-cre)#Gtm/?
Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Publication
23152448 | J:191207
First Author: Kaul A
Year: 2012
Journal: Genes Dev
Title: Pediatric glioma-associated KIAA1549:BRAF expression regulates neuroglial cell growth in a cell type-specific and mTOR-dependent manner.
Volume: 26
Issue: 23
Pages: 2561-6
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Publication
24860158 | J:217846
First Author: Strohecker AM
Year: 2014
Journal: Cancer Discov
Title: Targeting mitochondrial metabolism by inhibiting autophagy in BRAF-driven cancers.
Volume: 4
Issue: 7
Pages: 766-72
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Allele
Hprt1<tm1(sb-Onco-Array)Peli> | MGI:4843327
Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 1, Pentao Liu
Allele Type: Targeted
Attribute String: RMCE-ready, Transposon concatemer
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Protein
Q61097
Organism: Mus musculus/domesticus
Length: 873  
Fragment?: false
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Protein
Q3UVC0
Organism: Mus musculus/domesticus
Length: 959  
Fragment?: false
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Protein
Q5SXE4
Organism: Mus musculus/domesticus
Length: 637  
Fragment?: false
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Protein
A5X3G4
Organism: Mus musculus/domesticus
Length: 947  
Fragment?: false
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Protein
M0QW59
Organism: Mus musculus/domesticus
Length: 951  
Fragment?: false
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Publication
15716956 | J:96202
First Author: Carreira S
Year: 2005
Journal: Nature
Title: Mitf cooperates with Rb1 and activates p21Cip1 expression to regulate cell cycle progression.
Volume: 433
Issue: 7027
Pages: 764-9
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Publication
39059397 | J:353294
First Author: Huang P
Year: 2024
Journal: Cell Host Microbe
Title: Peptostreptococcus stomatis promotes colonic tumorigenesis and receptor tyrosine kinase inhibitor resistance by activating ERBB2-MAPK.
Volume: 32
Issue: 8
Pages: 1365-1379.e10
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Publication
22820643 | J:317304
First Author: Gembarska A
Year: 2012
Journal: Nat Med
Title: MDM4 is a key therapeutic target in cutaneous melanoma.
Volume: 18
Issue: 8
Pages: 1239-47
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Publication
33674596 | J:304975
First Author: Ischenko I
Year: 2021
Journal: Nat Commun
Title: KRAS drives immune evasion in a genetic model of pancreatic cancer.
Volume: 12
Issue: 1
Pages: 1482
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Publication
28514651 | J:255883
First Author: Kwong LN
Year: 2017
Journal: Cell Rep
Title: Modeling Genomic Instability and Selection Pressure in a Mouse Model of Melanoma.
Volume: 19
Issue: 7
Pages: 1304-1312
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Publication
29654229 | J:261939
First Author: Oldrini B
Year: 2018
Journal: Nat Commun
Title: Somatic genome editing with the RCAS-TVA-CRISPR-Cas9 system for precision tumor modeling.
Volume: 9
Issue: 1
Pages: 1466
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Publication
15024079 | J:89066
First Author: Goodall J
Year: 2004
Journal: Mol Cell Biol
Title: Brn-2 expression controls melanoma proliferation and is directly regulated by beta-catenin.
Volume: 24
Issue: 7
Pages: 2915-22
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Publication
23178117 | J:196210
First Author: Huang S
Year: 2012
Journal: Cell
Title: MED12 controls the response to multiple cancer drugs through regulation of TGF-β receptor signaling.
Volume: 151
Issue: 5
Pages: 937-50
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Publication
21835307 | J:189266
First Author: Abu-Safieh L
Year: 2011
Journal: Am J Hum Genet
Title: Mutation of IGFBP7 causes upregulation of BRAF/MEK/ERK pathway and familial retinal arterial macroaneurysms.
Volume: 89
Issue: 2
Pages: 313-9
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Publication
23069660 | J:199972
First Author: Fedorenko IV
Year: 2013
Journal: Oncogene
Title: NRAS mutant melanoma: biological behavior and future strategies for therapeutic management.
Volume: 32
Issue: 25
Pages: 3009-18
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Publication
30061422 | J:266274
First Author: Yang Y
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Central role of autophagic UVRAG in melanogenesis and the suntan response.
Volume: 115
Issue: 33
Pages: E7728-E7737
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Publication
31302002 | J:279873
First Author: Colomer C
Year: 2019
Journal: Mol Cell
Title: IKKα Kinase Regulates the DNA Damage Response and Drives Chemo-resistance in Cancer.
Volume: 75
Issue: 4
Pages: 669-682.e5
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Publication
31940493 | J:287418
First Author: Rosenbaum SR
Year: 2020
Journal: Cell Rep
Title: FOXD3 Regulates VISTA Expression in Melanoma.
Volume: 30
Issue: 2
Pages: 510-524.e6
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Publication
30471144 | J:321181
First Author: Moon H
Year: 2019
Journal: Exp Dermatol
Title: Sirt5 is dispensable for BrafV600E -mediated cutaneous melanoma development and growth in vivo.
Volume: 28
Issue: 1
Pages: 83-85
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Publication
35332119 | J:322998
First Author: Zhang P
Year: 2022
Journal: Nat Commun
Title: Targeting myeloid derived suppressor cells reverts immune suppression and sensitizes BRAF-mutant papillary thyroid cancer to MAPK inhibitors.
Volume: 13
Issue: 1
Pages: 1588
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Publication
38092754 | J:343423
First Author: Muta Y
Year: 2023
Journal: Nat Commun
Title: Enhanced SREBP2-driven cholesterol biosynthesis by PKCλ/ι deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis.
Volume: 14
Issue: 1
Pages: 8075
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Protein
Q5SXE1
Organism: Mus musculus/domesticus
Length: 80  
Fragment?: true
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Protein
Q5SXE2
Organism: Mus musculus/domesticus
Length: 205  
Fragment?: true
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Publication
29523762 | J:261905
First Author: Peyret V
Year: 2018
Journal: Mol Cancer Res
Title: Functional Toll-like Receptor 4 Overexpression in Papillary Thyroid Cancer by MAPK/ERK-Induced ETS1 Transcriptional Activity.
Volume: 16
Issue: 5
Pages: 833-845
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Fabp7-cre,-lacZ)3Gtm/?
Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Publication
16510579 | J:106704
First Author: van Schanke A
Year: 2006
Journal: Cancer Res
Title: Induction of nevi and skin tumors in Ink4a/Arf Xpa knockout mice by neonatal, intermittent, or chronic UVB exposures.
Volume: 66
Issue: 5
Pages: 2608-15
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Publication
21203491 | J:167512
First Author: Shah M
Year: 2010
Journal: PLoS Genet
Title: A role for ATF2 in regulating MITF and melanoma development.
Volume: 6
Issue: 12
Pages: e1001258
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Publication
18472967 | J:138670
First Author: Lyustikman Y
Year: 2008
Journal: Neoplasia
Title: Constitutive activation of Raf-1 induces glioma formation in mice.
Volume: 10
Issue: 5
Pages: 501-10
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Publication
17575131 | J:122413
First Author: Yang G
Year: 2007
Journal: Cancer Res
Title: Loss of xeroderma pigmentosum C (Xpc) enhances melanoma photocarcinogenesis in Ink4a-Arf-deficient mice.
Volume: 67
Issue: 12
Pages: 5649-57
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Publication
22983396 | J:238049
First Author: Kwong LN
Year: 2012
Journal: Nat Med
Title: Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma.
Volume: 18
Issue: 10
Pages: 1503-10
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Publication
23603816 | J:198505
First Author: Jameson KL
Year: 2013
Journal: Nat Med
Title: IQGAP1 scaffold-kinase interaction blockade selectively targets RAS-MAP kinase-driven tumors.
Volume: 19
Issue: 5
Pages: 626-630
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Publication
38182748 | J:344309
First Author: Tzenaki N
Year: 2024
Journal: Commun Biol
Title: A combined opposite targeting of p110δ PI3K and RhoA abrogates skin cancer.
Volume: 7
Issue: 1
Pages: 26
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Publication
21734707 | J:287767
First Author: DeNicola GM
Year: 2011
Journal: Nature
Title: Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis.
Volume: 475
Issue: 7354
Pages: 106-9
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Publication
29748372 | J:264288
First Author: Wang Q
Year: 2018
Journal: Cancer Res
Title: TRAF1 Is Critical for Regulating the BRAF/MEK/ERK Pathway in Non-Small Cell Lung Carcinogenesis.
Volume: 78
Issue: 14
Pages: 3982-3994
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Publication
38548338 | J:352233
 
First Author: Ingersoll MA
Year: 2024
Journal: J Neurosci
Title: KSR1 Knockout Mouse Model Demonstrates MAPK Pathway's Key Role in Cisplatin- and Noise-induced Hearing Loss.
Volume: 44
Issue: 18
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Publication
28263969 | J:243371
First Author: Yang H
Year: 2017
Journal: Oncogene
Title: Activated MEK cooperates with Cdkn2a and Pten loss to promote the development and maintenance of melanoma.
Volume: 36
Issue: 27
Pages: 3842-3851
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Publication
24129679 | J:206060
First Author: Doma E
Year: 2013
Journal: Cancer Res
Title: Skin tumorigenesis stimulated by Raf inhibitors relies upon Raf functions that are dependent and independent of ERK.
Volume: 73
Issue: 23
Pages: 6926-37
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Publication
29885461 | J:271171
 
First Author: Hutchenreuther J
Year: 2018
Journal: Matrix Biol
Title: Activation of cancer-associated fibroblasts is required for tumor neovascularization in a murine model of melanoma.
Volume: 74
Pages: 52-61
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Publication
26168233 | J:226336
First Author: Hutchenreuther J
Year: 2015
Journal: J Invest Dermatol
Title: CCN2 Expression by Tumor Stroma Is Required for Melanoma Metastasis.
Volume: 135
Issue: 11
Pages: 2805-2813
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Publication
30987979 | J:274179
First Author: Shah R
Year: 2019
Journal: Cancer Res
Title: Concurrent Targeting of Glutaminolysis and Metabotropic Glutamate Receptor 1 (GRM1) Reduces Glutamate Bioavailability in GRM1+ Melanoma.
Volume: 79
Issue: 8
Pages: 1799-1809
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Publication
28450382 | J:243438
First Author: Young HL
Year: 2017
Journal: J Exp Med
Title: An adaptive signaling network in melanoma inflammatory niches confers tolerance to MAPK signaling inhibition.
Volume: 214
Issue: 6
Pages: 1691-1710
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Publication
23893239 | J:212616
First Author: Albinet V
Year: 2014
Journal: Oncogene
Title: Dual role of sphingosine kinase-1 in promoting the differentiation of dermal fibroblasts and the dissemination of melanoma cells.
Volume: 33
Issue: 26
Pages: 3364-73
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Publication
37833251 | J:344096
First Author: Hao W
Year: 2023
Journal: Cell Death Dis
Title: Critical role of VHL/BICD2/STAT1 axis in crystal-associated kidney disease.
Volume: 14
Issue: 10
Pages: 680
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Publication
23222297 | J:194374
First Author: Marais R
Year: 2013
Journal: Cancer Res
Title: Twenty-fourth annual Pezcoller symposium: Molecular basis for resistance to targeted agents.
Volume: 73
Issue: 3
Pages: 1046-9
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Publication
25597784 | J:219971
First Author: Strickland LR
Year: 2015
Journal: Cancer Lett
Title: Targeting drivers of melanoma with synthetic small molecules and phytochemicals.
Volume: 359
Issue: 1
Pages: 20-35
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Publication
25395294 | J:220618
First Author: Wargo JA
Year: 2014
Journal: Cancer Discov
Title: Universes collide: combining immunotherapy with targeted therapy for cancer.
Volume: 4
Issue: 12
Pages: 1377-86
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Publication
26603897 | J:227251
First Author: Feng Y
Year: 2015
Journal: Cancer Res
Title: SBI-0640756 Attenuates the Growth of Clinically Unresponsive Melanomas by Disrupting the eIF4F Translation Initiation Complex.
Volume: 75
Issue: 24
Pages: 5211-8
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