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Search results 901 to 1000 out of 1045 for Brca2

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0.033s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Protein
A0A0U1RNQ4
Organism: Mus musculus/domesticus
Length: 235  
Fragment?: true
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Protein
Q3USB6
Organism: Mus musculus/domesticus
Length: 123  
Fragment?: false
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Protein
A0A0U1RQ63
Organism: Mus musculus/domesticus
Length: 246  
Fragment?: true
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Publication
21276791 | J:170858
First Author: Cappelli E
Year: 2011
Journal: Exp Cell Res
Title: Homologous recombination proteins are associated with centrosomes and are required for mitotic stability.
Volume: 317
Issue: 8
Pages: 1203-13
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Publication
19131338 | -
First Author: Garapaty S
Year: 2009
Journal: J Biol Chem
Title: Identification and characterization of a novel nuclear protein complex involved in nuclear hormone receptor-mediated gene regulation.
Volume: 284
Issue: 12
Pages: 7542-52
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Publication
26841866 | J:232727
First Author: Varier RA
Year: 2016
Journal: J Biol Chem
Title: Recruitment of the Mammalian Histone-modifying EMSY Complex to Target Genes Is Regulated by ZNF131.
Volume: 291
Issue: 14
Pages: 7313-24
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Protein Domain
IPR030547 | XRCC2
Type: Family
Description: DNA repair protein XRCC2 is a RAD51 paralogue. In humans, it is part of the protein complex BCDX2 (contains RAD51B, RAD51C, RAD51D, and XRCC2), which acts in the BRCA1-BRCA2-dependent homologous recombination pathway [, ]. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA []. Interestingly, XRCC2 and other homologous recombination proteins are associated with centrosomes and are required for mitotic stability [].
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Protein Domain
IPR015205 | Tower_dom
Type: Domain
Description: This domain adopts a secondary structure consisting of a pair of long, antiparallel α-helices (thestem) that support a three-helix bundle (3HB) at their end. The 3HB contains a helix-turn-helix motif and is similar to the DNA binding domains of the bacterial site-specific recombinases, and of eukaryotic Myb and homeodomain transcription factors. The Tower domain has an important role in the tumour suppressor function of BRCA2, and is essential for appropriate binding of BRCA2 to DNA [].
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Protein Domain
IPR033482 | EMSY
Type: Family
Description: EMSY was originally reported as a transcriptional repressor and breast cancer-associated protein that interacts with the BRCA2 protein []. It contains an N-terminal ENT domain which can bind BRCA2. It is involved in DNA damage repair, genomic instability, and chromatin remodeling []. EMSY can function as an integral component of an NIF-1 complex and play an important role in the regulation of nuclear receptor-mediated transcription []. It is also part of the EMSY/KDM5A/SIN3B complex that may function as a transcriptional repressor [].
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Protein Domain
IPR015187 | BRCA2_OB_1
Type: Domain
Description: BRCA2 participates in homologous recombination-mediated repair of double-strand DNA breaks [, ]. It stimulates the displacement of Replication protein A (RPA), the most abundant eukaryotic ssDNA binding protein []. Mutations that map throughout the BRCA2 protein are associated with breast cancer susceptibility []. BRCA2 is a large nuclear protein and its most conserved region is the C-terminal BRCA2DBD. BRCA2DBD binds ssDNA in vitro, and is composed of five structural domains, three of which are OB folds (OB1, OB2, and OB3). BRCA2DBD OB2 and OB3 are arranged in tandem, and their mode of binding can be considered qualitatively similar to two OB folds of RPA1, DBD-A and DBD-B (the major DBDs of RPA) []. This entry represents OB1, which consists of a highly curved five-stranded β-sheet that closes on itself to form a β-barrel. OB1 has a shallow groove formed by one face of the curved sheet and is demarcated by two loops, one between beta 1 and beta 2 and another between beta 4 and beta 5, which allows for weak single strand DNA binding. The domain also binds the 70-amino acid DSS1 (deleted in split-hand/split foot syndrome) protein, which was originally identified as one of three genes that map to a 1.5-Mb locus deleted in an inherited developmental malformation syndrome [].
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Protein Domain
IPR015188 | BRCA2_OB_3
Type: Domain
Description: BRCA2 participates in homologous recombination-mediated repair of double-strand DNA breaks [, ]. It stimulates the displacement of Replication protein A (RPA), the most abundant eukaryotic ssDNA binding protein []. Mutations that map throughout the BRCA2 protein are associated with breast cancer susceptibility []. BRCA2 is a large nuclear protein and its most conserved region is the C-terminal BRCA2DBD. BRCA2DBD binds ssDNA in vitro, and is composed of five structural domains, three of which are OB folds (OB1, OB2, and OB3). BRCA2DBD OB2 and OB3 are arranged in tandem, and their mode of binding can be considered qualitatively similar to two OB folds of RPA1, DBD-A and DBD-B (the major DBDs of RPA) []. This entry represents OB3, which consists of a highly curved five-stranded β-sheet that closes on itself to form a β-barrel. OB3 has a pronounced groove formed by one face of the curved sheet and is demarcated by two loops, one between beta 1 and beta 2 and another between beta 4 and beta 5, which allows for strong ssDNA binding [].
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Protein Coding Gene
MGI:1924203 | Emsy
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CAROLIEiJ_G0030019 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0032541 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0032515 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0032451 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0032526 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0032241 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1924203 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0033024 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0031568 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0032208 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0032360 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0032317 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0032449 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0032349 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0033046 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0031286 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0031685 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0013240 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0031129 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
8589722 | J:31760
First Author: Jensen RA
Year: 1996
Journal: Nat Genet
Title: BRCA1 is secreted and exhibits properties of a granin.
Volume: 12
Issue: 3
Pages: 303-8
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Protein Domain
IPR015252 | BRCA2_hlx
Type: Domain
Description: This entry represents a domain found in BRCA2 proteins. This domain adopts a helical structure, consisting of a four-helix cluster core (alpha 1, alpha 8, alpha 9, alpha 10) and two successive β-hairpins (beta 1 to beta 4). An approximately 50-amino acid segment that contains four short helices (alpha 2 to alpha 4), meanders around the surface of the core structure. In BRCA2, the alpha 9 and alpha 10 helices pack with BRCA-2_OB1 () through van der Waals contacts involving hydrophobic and aromatic residues, and also through side-chain and backbone hydrogen bonds. This domain binds the 70-amino acid DSS1 (deleted in split-hand/split foot syndrome) protein, which was originally identified as one of three genes that map to a 1.5-Mb locus deleted in an inherited developmental malformation syndrome [].
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Publication
10673337 | J:60693
First Author: Yabuta N
Year: 2000
Journal: Genomics
Title: Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts.
Volume: 63
Issue: 2
Pages: 263-70
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Publication
36307435 | J:330825
First Author: Yoshinaga M
Year: 2022
Journal: Nat Commun
Title: The N(6)-methyladenosine methyltransferase METTL16 enables erythropoiesis through safeguarding genome integrity.
Volume: 13
Issue: 1
Pages: 6435
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Publication
28912125 | J:249302
First Author: Patel DS
Year: 2017
Journal: J Cell Biol
Title: BLM helicase regulates DNA repair by counteracting RAD51 loading at DNA double-strand break sites.
Volume: 216
Issue: 11
Pages: 3521-3534
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Publication
28122244 | J:240315
First Author: Mgbemena VE
Year: 2017
Journal: Cell Rep
Title: Distinct Brca1 Mutations Differentially Reduce Hematopoietic Stem Cell Function.
Volume: 18
Issue: 4
Pages: 947-960
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Publication
26584049 | J:231698
First Author: García-Rubio ML
Year: 2015
Journal: PLoS Genet
Title: The Fanconi Anemia Pathway Protects Genome Integrity from R-loops.
Volume: 11
Issue: 11
Pages: e1005674
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Publication
32726637 | J:304325
First Author: Zhang F
Year: 2020
Journal: Cell Rep
Title: L ARP7 Is a BRCA1 Ubiquitinase Substrate and Regulates Genome Stability and Tumorigenesis.
Volume: 32
Issue: 4
Pages: 107974
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Publication
9466696 | J:46984
First Author: Vispé S
Year: 1997
Journal: Biochimie
Title: Mammalian Rad51 protein: a RecA homologue with pleiotropic functions.
Volume: 79
Issue: 9-10
Pages: 587-92
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Publication
10445022 | J:56701
First Author: Lee H
Year: 1999
Journal: Mol Cell
Title: Mitotic checkpoint inactivation fosters transformation in cells lacking the breast cancer susceptibility gene, Brca2.
Volume: 4
Issue: 1
Pages: 1-10
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Publication
12668615 | J:82935
First Author: Rafii S
Year: 2003
Journal: Hum Mol Genet
Title: A naturally occurring mutation in an ATP-binding domain of the recombination repair gene XRCC3 ablates its function without causing cancer susceptibility.
Volume: 12
Issue: 8
Pages: 915-23
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Publication
16123586 | J:105121
First Author: Helleday T
Year: 2005
Journal: Cell Cycle
Title: Poly(ADP-ribose) polymerase (PARP-1) in homologous recombination and as a target for cancer therapy.
Volume: 4
Issue: 9
Pages: 1176-8
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Publication
10918303 | J:114832
First Author: Deng CX
Year: 2000
Journal: Bioessays
Title: Roles of BRCA1 and its interacting proteins.
Volume: 22
Issue: 8
Pages: 728-37
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Publication
21357745 | J:170686
First Author: Agarwal S
Year: 2011
Journal: J Cell Biol
Title: ATP-dependent and independent functions of Rad54 in genome maintenance.
Volume: 192
Issue: 5
Pages: 735-50
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Publication
22193408 | J:179374
First Author: Roy R
Year: 2011
Journal: Nat Rev Cancer
Title: BRCA1 and BRCA2: different roles in a common pathway of genome protection.
Volume: 12
Issue: 1
Pages: 68-78
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Publication
22344029 | J:185069
First Author: Adamson B
Year: 2012
Journal: Nat Cell Biol
Title: A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response.
Volume: 14
Issue: 3
Pages: 318-28
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Publication
24870022 | J:215229
First Author: Pauty J
Year: 2014
Journal: Biochem J
Title: Exploring the roles of PALB2 at the crossroads of DNA repair and cancer.
Volume: 460
Issue: 3
Pages: 331-42
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Publication
28714471 | J:250323
 
First Author: Schoonen PM
Year: 2017
Journal: Nat Commun
Title: Progression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells.
Volume: 8
Pages: 15981
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Publication
29416040 | J:257935
First Author: Biswas K
Year: 2018
Journal: Nat Commun
Title: BRE/BRCC45 regulates CDC25A stability by recruiting USP7 in response to DNA damage.
Volume: 9
Issue: 1
Pages: 537
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Protein Coding Gene
MGI:1341190 | Hmg20b
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
A0A0U1RPN4
Organism: Mus musculus/domesticus
Length: 200  
Fragment?: true
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Publication
11751635 | -
First Author: Masson JY
Year: 2001
Journal: Genes Dev
Title: Identification and purification of two distinct complexes containing the five RAD51 paralogs.
Volume: 15
Issue: 24
Pages: 3296-307
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Publication
23149936 | -
First Author: Chun J
Year: 2013
Journal: Mol Cell Biol
Title: Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway.
Volume: 33
Issue: 2
Pages: 387-95
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Publication
15947784 | J:99579
First Author: Ekblad CM
Year: 2005
Journal: EMBO Rep
Title: Binding of EMSY to HP1beta: implications for recruitment of HP1beta and BS69.
Volume: 6
Issue: 7
Pages: 675-80
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Publication
11410366 | J:70804
First Author: Leasure CS
Year: 2001
Journal: Gene
Title: Sequence, chromosomal location and expression analysis of the murine homologue of human RAD51L2/RAD51C.
Volume: 271
Issue: 1
Pages: 59-67
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Publication
12973351 | J:86047
First Author: Meetei AR
Year: 2003
Journal: Nat Genet
Title: A novel ubiquitin ligase is deficient in Fanconi anemia.
Volume: 35
Issue: 2
Pages: 165-70
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Publication
24748377 | J:215184
First Author: Szabova L
Year: 2014
Journal: PLoS One
Title: Pathway-specific engineered mouse allograft models functionally recapitulate human serous epithelial ovarian cancer.
Volume: 9
Issue: 4
Pages: e95649
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Publication
36976649 | J:352694
 
First Author: Oh G
Year: 2023
Journal: J Clin Invest
Title: POLQ inhibition elicits an immune response in homologous recombination-deficient pancreatic adenocarcinoma via cGAS/STING signaling.
Volume: 133
Issue: 11
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Publication
19770520 | J:154631
First Author: Chang S
Year: 2009
Journal: J Clin Invest
Title: Expression of human BRCA1 variants in mouse ES cells allows functional analysis of BRCA1 mutations.
Volume: 119
Issue: 10
Pages: 3160-71
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Publication
32053991 | J:297946
 
First Author: Hámori L
Year: 2020
Journal: Int J Mol Sci
Title: Establishment and Characterization of a Brca1-/-, p53-/- Mouse Mammary Tumor Cell Line.
Volume: 21
Issue: 4
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Publication
20631063 | J:162234
First Author: Issaeva N
Year: 2010
Journal: Cancer Res
Title: 6-thioguanine selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistance.
Volume: 70
Issue: 15
Pages: 6268-76
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Publication
19383921 | J:148266
First Author: Hay T
Year: 2009
Journal: Cancer Res
Title: Poly(ADP-ribose) polymerase-1 inhibitor treatment regresses autochthonous Brca2/p53-mutant mammary tumors in vivo and delays tumor relapse in combination with carboplatin.
Volume: 69
Issue: 9
Pages: 3850-5
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Publication
27241552 | J:312831
First Author: Sigl V
Year: 2016
Journal: Cell Res
Title: RANKL/RANK control Brca1 mutation- .
Volume: 26
Issue: 7
Pages: 761-74
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Publication
16192306 | J:102705
First Author: Thangaraju M
Year: 2005
Journal: Development
Title: C/EBPdelta is a crucial regulator of pro-apoptotic gene expression during mammary gland involution.
Volume: 132
Issue: 21
Pages: 4675-85
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Publication
31919902 | J:296743
First Author: Dakup PP
Year: 2020
Journal: FASEB J
Title: The circadian clock protects against ionizing radiation-induced cardiotoxicity.
Volume: 34
Issue: 2
Pages: 3347-3358
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Publication
9398856 | J:44390
First Author: Jhappan C
Year: 1997
Journal: Nat Genet
Title: DNA-PKcs: a T-cell tumour suppressor encoded at the mouse scid locus.
Volume: 17
Issue: 4
Pages: 483-6
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Publication
31757807 | J:284953
First Author: Morales C
Year: 2020
Journal: J Biol Chem
Title: PDS5 proteins are required for proper cohesin dynamics and participate in replication fork protection.
Volume: 295
Issue: 1
Pages: 146-157
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Publication
34548335 | J:316877
First Author: Pulver EM
Year: 2021
Journal: Cancer Res
Title: A BRCA1 Coiled-Coil Domain Variant Disrupting PALB2 Interaction Promotes the Development of Mammary Tumors and Confers a Targetable Defect in Homologous Recombination Repair.
Volume: 81
Issue: 24
Pages: 6171-6182
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Publication
11850831 | J:74727
First Author: Takata M
Year: 2002
Journal: Oncogene
Title: Conserved domains in the chicken homologue of BRCA2.
Volume: 21
Issue: 7
Pages: 1130-4
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Publication
10630641 | J:60026
First Author: Dasika GK
Year: 1999
Journal: Oncogene
Title: DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis.
Volume: 18
Issue: 55
Pages: 7883-99
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Publication
10195418 | J:54149
First Author: Irminger-Finger I
Year: 1999
Journal: Biol Chem
Title: The functions of breast cancer susceptibility gene 1 (BRCA1) product and its associated proteins.
Volume: 380
Issue: 2
Pages: 117-28
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Publication
11921187 | J:75758
First Author: Medina D
Year: 2002
Journal: Environ Mol Mutagen
Title: Environmental carcinogens and p53 tumor-suppressor gene interactions in a transgenic mouse model for mammary carcinogenesis.
Volume: 39
Issue: 2-3
Pages: 178-83
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Publication
15650050 | J:96119
First Author: Nakanishi K
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair.
Volume: 102
Issue: 4
Pages: 1110-5
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Publication
19109974 | J:168932
First Author: Damrot J
Year: 2009
Journal: J Mol Biol
Title: DNA replication arrest in response to genotoxic stress provokes early activation of stress-activated protein kinases (SAPK/JNK).
Volume: 385
Issue: 5
Pages: 1409-21
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Publication
22735704 | J:199695
First Author: Mauro M
Year: 2012
Journal: Nucleic Acids Res
Title: p21 promotes error-free replication-coupled DNA double-strand break repair.
Volume: 40
Issue: 17
Pages: 8348-60
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Publication
24776801 | J:212935
First Author: Willis NA
Year: 2014
Journal: Nature
Title: BRCA1 controls homologous recombination at Tus/Ter-stalled mammalian replication forks.
Volume: 510
Issue: 7506
Pages: 556-9
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Publication
29035360 | J:251677
First Author: Rondinelli B
Year: 2017
Journal: Nat Cell Biol
Title: EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation.
Volume: 19
Issue: 11
Pages: 1371-1378
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Publication
29021281 | J:252687
First Author: Ding X
Year: 2017
Journal: Genetics
Title: Survival of BRCA2-Deficient Cells Is Promoted by GIPC3, a Novel Genetic Interactor of BRCA2.
Volume: 207
Issue: 4
Pages: 1335-1345
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Publication
33716297 | J:305476
First Author: Patel PS
Year: 2021
Journal: Oncogene
Title: Exploiting synthetic lethality to target BRCA1/2-deficient tumors: where we stand.
Volume: 40
Issue: 17
Pages: 3001-3014
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Publication
36812344 | J:334327
First Author: Bhardwaj P
Year: 2023
Journal: Sci Transl Med
Title: Obesity promotes breast epithelium DNA damage in women carrying a germline mutation in BRCA1 or BRCA2.
Volume: 15
Issue: 684
Pages: eade1857
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Protein
Q8BMB0
Organism: Mus musculus/domesticus
Length: 1264  
Fragment?: false
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Protein
A0A0U1RPK1
Organism: Mus musculus/domesticus
Length: 1070  
Fragment?: false
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Protein
A0A0U1RNN7
Organism: Mus musculus/domesticus
Length: 316  
Fragment?: true
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Protein
A0A0U1RPW3
Organism: Mus musculus/domesticus
Length: 735  
Fragment?: true
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Publication
15978617 | -
First Author: Chavali GB
Year: 2005
Journal: J Mol Biol
Title: Crystal structure of the ENT domain of human EMSY.
Volume: 350
Issue: 5
Pages: 964-73
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Publication
2662307 | -
First Author: Felder RA
Year: 1989
Journal: Semin Nephrol
Title: Role of endogenous dopamine on renal sodium excretion.
Volume: 9
Issue: 1
Pages: 91-3
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Publication
16364921 | -
First Author: Joshi AA
Year: 2005
Journal: Mol Cell
Title: Eaf3 chromodomain interaction with methylated H3-K36 links histone deacetylation to Pol II elongation.
Volume: 20
Issue: 6
Pages: 971-8
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Publication
20536842 | -
 
First Author: Chen M
Year: 2010
Journal: Ann N Y Acad Sci
Title: Emerging role of the MORF/MRG gene family in various biological processes, including aging.
Volume: 1197
Pages: 134-41
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Publication
17173057 | -
First Author: Straub T
Year: 2007
Journal: Nat Rev Genet
Title: Dosage compensation: the beginning and end of generalization.
Volume: 8
Issue: 1
Pages: 47-57
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Publication
22421046 | -
First Author: Conrad T
Year: 2012
Journal: Dev Cell
Title: The MOF chromobarrel domain controls genome-wide H4K16 acetylation and spreading of the MSL complex.
Volume: 22
Issue: 3
Pages: 610-24
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Publication
22285924 | -
First Author: Eissenberg JC
Year: 2012
Journal: Gene
Title: Structural biology of the chromodomain: form and function.
Volume: 496
Issue: 2
Pages: 69-78
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Protein Domain
IPR008676 | MRG
Type: Family
Description: This entry represents MRG protein family, whose members include MORF4L1/2 (MRG15/MRGX) and MSL3L1/2 from humans, ESA1-associated factor 3 (Eaf3) from yeasts and male-specific lethal 3 (MSL3) from flies. They contain an N-terminal chromodomain that binds H3K36me3, a histone mark associated with transcription elongation []. Saccharomyces cerevisiae Eaf3 is a component of both NuA4 histone acetyltransferase and Rpd3S histone deacetylase complexes [, ]. It was found that Eaf3 mediates preferential deacetylation of coding regions through an interaction between the Eaf3 chromodomain and methylated H3-K36 that presumably results in preferential association of the Rpd3 complex []. The Drosophila MSL proteins (MSL1, MSL2, MSL3, MLE, and MOF) are essential for elevating transcription of the single X chromosome in the male (X chromosome dosage compensation) []. Together with two partlyredundant non-coding RNAs, roX1 and roX2, they form the MSL complex, also known as dosage compensation complex or DCC. MSL complex upregulates transcription by spreading the histone H4 Lys16 (H4K16) acetyl mark []and allows compensation for the loss of one X-chromosomal allele by increasing the transcription from the retained allele []. The MSL3 chromodomain has been shown to bind DNA and methylated H4K20 in vitro []. Human MORF4L1, also known as MRG15, is a component of the NuA4 histone acetyltransferase complex that transcriptional activates genes by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. NuA4 complex may also play a direct role in DNA repair when directly recruited to sites of DNA damage. MRG15 is also a component of the mSin3A/Pf1/HDAC complex which acts to repress transcription by deacetylation of nucleosomal histones. MRG15 was found to interact with PALB2, a tumour suppressor protein that plays a crucial role in DNA damage repair by homologous recombination []. Furthermore, MRG15 play a role in the response to double strand breaks (DSBs) by recruiting the BRCA complex (BRCA1, PALB2, BRCA2 and RAD51) to sites of damaged DNA [, ].
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Publication
20107607 | J:156371
First Author: Liang Y
Year: 2010
Journal: PLoS Genet
Title: BRIT1/MCPH1 is essential for mitotic and meiotic recombination DNA repair and maintaining genomic stability in mice.
Volume: 6
Issue: 1
Pages: e1000826
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Publication
20657587 | -
First Author: Kim D
Year: 2010
Journal: Nat Struct Mol Biol
Title: Corecognition of DNA and a methylated histone tail by the MSL3 chromodomain.
Volume: 17
Issue: 8
Pages: 1027-9
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Publication
16110338 | J:107820
First Author: Corbo JC
Year: 2005
Journal: PLoS Genet
Title: A hybrid photoreceptor expressing both rod and cone genes in a mouse model of enhanced S-cone syndrome.
Volume: 1
Issue: 2
Pages: e11
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Protein
A2AEB6
Organism: Mus musculus/domesticus
Length: 68  
Fragment?: true
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Publication
12773392 | -
First Author: Nakayama J
Year: 2003
Journal: EMBO J
Title: Alp13, an MRG family protein, is a component of fission yeast Clr6 histone deacetylase required for genomic integrity.
Volume: 22
Issue: 11
Pages: 2776-87
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Publication
20332121 | -
First Author: Hayakawa T
Year: 2010
Journal: J Cell Sci
Title: MRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaks.
Volume: 123
Issue: Pt 7
Pages: 1124-30
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Protein
Q9R0Q4
Organism: Mus musculus/domesticus
Length: 288  
Fragment?: false
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