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Search results 901 to 1000 out of 1059 for Casp8

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Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:4420592
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823828
Age: embryonic day 14.5
Image: euxassay_001440_06
Specimen Label: euxassay_001440_06
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:4420592
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823828
Age: embryonic day 14.5
Image: euxassay_001440_07
Specimen Label: euxassay_001440_07
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Probe: MGI:4420592
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823828
Age: embryonic day 14.5
Image: euxassay_001440_08
Specimen Label: euxassay_001440_08
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
 
Probe: MGI:4420592
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823828
Age: embryonic day 14.5
Image: euxassay_001440_09
Specimen Label: euxassay_001440_09
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
 
Probe: MGI:4420592
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823828
Age: embryonic day 14.5
Image: euxassay_001440_10
Specimen Label: euxassay_001440_10
Detected: true
Specimen Num: 10
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•
GXD Expression
GXD Expression
 
Probe: MGI:4420592
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823828
Age: embryonic day 14.5
Image: euxassay_001440_11
Specimen Label: euxassay_001440_11
Detected: true
Specimen Num: 11
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•
GXD Expression
GXD Expression
 
Probe: MGI:4420592
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823828
Age: embryonic day 14.5
Image: euxassay_001440_12
Specimen Label: euxassay_001440_12
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
 
Probe: MGI:4420592
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823828
Age: embryonic day 14.5
Image: euxassay_001440_13
Specimen Label: euxassay_001440_13
Detected: true
Specimen Num: 13
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GXD Expression
GXD Expression
 
Probe: MGI:4420592
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823828
Age: embryonic day 14.5
Image: euxassay_001440_14
Specimen Label: euxassay_001440_14
Detected: true
Specimen Num: 14
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GXD Expression
GXD Expression
 
Probe: MGI:4420592
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823828
Age: embryonic day 14.5
Image: euxassay_001440_15
Specimen Label: euxassay_001440_15
Detected: true
Specimen Num: 15
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GXD Expression
GXD Expression
 
Probe: MGI:4420592
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823828
Age: embryonic day 14.5
Image: euxassay_001440_16
Specimen Label: euxassay_001440_16
Detected: true
Specimen Num: 16
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Strain
MGI:6354578 | C57BL/6JSmoc-Casp8<em2Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Allele
Cflar<tm1Mak> | MGI:2159361
Name: CASP8 and FADD-like apoptosis regulator; targeted mutation 1, Tak W Mak
Allele Type: Targeted
Attribute String: Null/knockout
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Strain
MGI:5487288 | B6.129-Cflar<tm1Ywh>/J
Attribute String: congenic, mutant strain, targeted mutation
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Allele
Cflar<tm1a(EUCOMM)Wtsi> | MGI:4433525
Name: CASP8 and FADD-like apoptosis regulator; targeted mutation 1a, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Allele
Cflar<tm1e(EUCOMM)Wtsi> | MGI:4434003
Name: CASP8 and FADD-like apoptosis regulator; targeted mutation 1e, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Cflar<tm1.1Pope> | MGI:4868692
Name: CASP8 and FADD-like apoptosis regulator; targeted mutation 1.1, Richard M Pope
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Cflar<tm1.2Pope> | MGI:4868693
Name: CASP8 and FADD-like apoptosis regulator; targeted mutation 1.2, Richard M Pope
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Cflar<tm1b(EUCOMM)Wtsi> | MGI:5804644
Name: CASP8 and FADD-like apoptosis regulator; targeted mutation 1b, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Cflar<em1Gpt> | MGI:7296886
Name: CASP8 and FADD-like apoptosis regulator; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Allele
Cflar<em5Gpt> | MGI:7296887
Name: CASP8 and FADD-like apoptosis regulator; endonuclease-mediated mutation 5, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Publication
24036366 | J:283854
First Author: Wittkopf N
Year: 2013
Journal: Gastroenterology
Title: Cellular FLICE-like inhibitory protein secures intestinal epithelial cell survival and immune homeostasis by regulating caspase-8.
Volume: 145
Issue: 6
Pages: 1369-79
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Publication
20100735 | J:158533
First Author: Lin YC
Year: 2010
Journal: Toxicol Sci
Title: FasL gene-deficient mice display a limited disruption in spermatogenesis and inhibition of mono-(2-ethylhexyl) phthalate-induced germ cell apoptosis.
Volume: 114
Issue: 2
Pages: 335-45
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Publication
19429865 | J:151173
First Author: Yu Y
Year: 2009
Journal: Blood
Title: Abundant c-Fas-associated death domain-like interleukin-1-converting enzyme inhibitory protein expression determines resistance of T helper 17 cells to activation-induced cell death.
Volume: 114
Issue: 5
Pages: 1026-8
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Publication
19373244 | J:164180
First Author: Zhu JY
Year: 2009
Journal: Cell Death Differ
Title: Rocaglamide sensitizes leukemic T cells to activation-induced cell death by differential regulation of CD95L and c-FLIP expression.
Volume: 16
Issue: 9
Pages: 1289-99
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Allele
Casp8<em1Smoc> | MGI:7288652
Name: caspase 8; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Strain
MGI:6122468 | C57BL/6N-Cflar<tm1a(EUCOMM)Wtsi>/Orl
Attribute String: mutant strain, coisogenic, targeted mutation
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Strain
MGI:6260254 | C57BL/6N-Cflar<tm1b(EUCOMM)Wtsi>/Orl
Attribute String: coisogenic, targeted mutation
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Genotype
Genotype
Symbol: Cflar/Cflar
Background: either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * CD-1)
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cflar/Cflar Tg(Lck-cre)548Jxm/?
Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cflar/Cflar
Background: C57BL/6N-Cflar/Orl
Zygosity: hm
Has Mutant Allele: true
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Publication
19300454 | J:164184
First Author: Huo J
Year: 2009
Journal: Cell Death Differ
Title: Genetic deletion of faim reveals its role in modulating c-FLIP expression during CD95-mediated apoptosis of lymphocytes and hepatocytes.
Volume: 16
Issue: 7
Pages: 1062-70
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Publication
21435442 | J:169857
First Author: Llobet D
Year: 2011
Journal: Am J Pathol
Title: KSR1 is overexpressed in endometrial carcinoma and regulates proliferation and TRAIL-induced apoptosis by modulating FLIP levels.
Volume: 178
Issue: 4
Pages: 1529-43
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Publication
25500368 | J:279553
First Author: Haverkamp JM
Year: 2014
Journal: Immunity
Title: Myeloid-derived suppressor activity is mediated by monocytic lineages maintained by continuous inhibition of extrinsic and intrinsic death pathways.
Volume: 41
Issue: 6
Pages: 947-59
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Genotype
Genotype
Symbol: Cflar/Cflar<+>
Background: C57BL/6N-Cflar/Orl
Zygosity: ht
Has Mutant Allele: true
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Publication
32103006 | J:287252
First Author: Bank U
Year: 2020
Journal: Nat Commun
Title: c-FLIP is crucial for IL-7/IL-15-dependent NKp46+ ILC development and protection from intestinal inflammation in mice.
Volume: 11
Issue: 1
Pages: 1056
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Strain
MGI:6354577 | C57BL/6JSmoc-Casp8<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Publication
35296858 | J:326155
First Author: Maudet C
Year: 2022
Journal: Nature
Title: Bacterial inhibition of Fas-mediated killing promotes neuroinvasion and persistence.
Volume: 603
Issue: 7903
Pages: 900-906
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Publication
12244156 | J:79241
First Author: Chastagner P
Year: 2002
Journal: J Immunol
Title: Lymphoadenopathy in IL-2-deficient mice: further characterization and overexpression of the antiapoptotic molecule cellular FLIP.
Volume: 169
Issue: 7
Pages: 3644-51
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Publication
17581950 | J:122799
First Author: Taoufik E
Year: 2007
Journal: J Neurosci
Title: FLIP(L) protects neurons against in vivo ischemia and in vitro glucose deprivation-induced cell death.
Volume: 27
Issue: 25
Pages: 6633-46
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Publication
23424201 | J:200588
First Author: Ye J
Year: 2013
Journal: J Cell Sci
Title: A pathway involving HDAC5, cFLIP and caspases regulates expression of the splicing regulator polypyrimidine tract binding protein in the heart.
Volume: 126
Issue: Pt 7
Pages: 1682-91
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Publication
21803845 | J:184109
First Author: Tao RH
Year: 2011
Journal: Blood
Title: PMLRARα binds to Fas and suppresses Fas-mediated apoptosis through recruiting c-FLIP in vivo.
Volume: 118
Issue: 11
Pages: 3107-18
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Publication
19587217 | J:152093
First Author: Vesely ED
Year: 2009
Journal: Am J Physiol Cell Physiol
Title: GLUT1-induced cFLIP expression promotes proliferation and prevents apoptosis in vascular smooth muscle cells.
Volume: 297
Issue: 3
Pages: C759-65
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Publication
15282307 | J:92273
First Author: Gilbert S
Year: 2004
Journal: Mol Cell Biol
Title: Keratins modulate c-Flip/extracellular signal-regulated kinase 1 and 2 antiapoptotic signaling in simple epithelial cells.
Volume: 24
Issue: 16
Pages: 7072-81
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Allele
Tg(Casp8,GFP)#Wll | MGI:6781652
Name: transgene insertion, David Wallach
Allele Type: Transgenic
Attribute String: Conditional ready, Epitope tag, Inserted expressed sequence, Reporter
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Genotype
Genotype
Symbol: Cflar/Cflar Lyz2/Lyz2<+>
Background: involves: 129P2/OlaHsd
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cflar/Cflar Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Ripk3/Ripk3
Background: involves: 129S6/SvEvTac * C57BL/6N * C57BL/6NTac
Zygosity: cn
Has Mutant Allele: true
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Protein Coding Gene
MGI:99255 | Fasl
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1341090 | Tnfrsf10b
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:95484 | Fas
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:107414 | Tnfsf10
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:109200 | Tradd
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q3U0V2
Organism: Mus musculus/domesticus
Length: 310  
Fragment?: false
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Protein
P25446
Organism: Mus musculus/domesticus
Length: 327  
Fragment?: false
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Protein
P41047
Organism: Mus musculus/domesticus
Length: 279  
Fragment?: false
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Protein
Q9QZM4
Organism: Mus musculus/domesticus
Length: 381  
Fragment?: false
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Protein
P50592
Organism: Mus musculus/domesticus
Length: 291  
Fragment?: false
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Publication
16783640 | J:110034
First Author: Behnke JM
Year: 2006
Journal: Mamm Genome
Title: High resolution mapping of chromosomal regions controlling resistance to gastrointestinal nematode infections in an advanced intercross line of mice.
Volume: 17
Issue: 6
Pages: 584-97
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Publication
11544288 | J:71496
First Author: Elzey BD
Year: 2001
Journal: J Immunol
Title: Regulation of Fas ligand-induced apoptosis by TNF.
Volume: 167
Issue: 6
Pages: 3049-56
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Publication
20427667 | J:159826
First Author: Moubarak RS
Year: 2010
Journal: J Neurosci
Title: The death receptor antagonist FLIP-L interacts with Trk and is necessary for neurite outgrowth induced by neurotrophins.
Volume: 30
Issue: 17
Pages: 6094-105
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Allele
Tg(Lck-CFLAR)1Zrng | MGI:5317724
Name: transgene insertion 1, Martin Zoernig
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Casp8*D387A,GFP)#Wll | MGI:6781653
Name: transgene insertion, David Wallach
Allele Type: Transgenic
Attribute String: Conditional ready, Epitope tag, Inserted expressed sequence, Reporter
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HT Experiment
GSE254754 | ZBP1 and TRIF trigger lethal necroptosis in mice lacking caspase-8 and TNFR1
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Strain
MGI:5317746 | B6.Cg-Tg(Lck-CFLAR)1Zrng/Ieg
Attribute String: congenic, mutant strain, transgenic
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Protein Coding Gene
MGI:109324 | Fadd
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q61160
Organism: Mus musculus/domesticus
Length: 205  
Fragment?: false
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Publication
9727492 | J:49460
First Author: Li H
Year: 1998
Journal: Cell
Title: Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis.
Volume: 94
Issue: 4
Pages: 491-501
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Publication
26582200 | J:230059
First Author: Urresti J
Year: 2016
Journal: J Biol Chem
Title: Lifeguard Inhibits Fas Ligand-mediated Endoplasmic Reticulum-Calcium Release Mandatory for Apoptosis in Type II Apoptotic Cells.
Volume: 291
Issue: 3
Pages: 1221-34
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Protein Coding Gene
MGI:108212 | Ripk1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q60855
Organism: Mus musculus/domesticus
Length: 656  
Fragment?: false
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Protein
O89110
Organism: Mus musculus/domesticus
Length: 480  
Fragment?: false
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Publication
33271062 | J:302995
First Author: Najafov A
Year: 2021
Journal: Mol Cell
Title: RIPK1 Promotes Energy Sensing by the mTORC1 Pathway.
Volume: 81
Issue: 2
Pages: 370-385.e7
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Publication
33931647 | J:305258
First Author: Supper E
Year: 2021
Journal: Nat Commun
Title: Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia.
Volume: 12
Issue: 1
Pages: 2482
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Publication
19531639 | -
First Author: Fiory F
Year: 2009
Journal: Am J Physiol Endocrinol Metab
Title: Frontiers: PED/PEA-15, a multifunctional protein controlling cell survival and glucose metabolism.
Volume: 297
Issue: 3
Pages: E592-601
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Publication
24710276 | -
First Author: Nagarajan A
Year: 2014
Journal: Mol Cell Biol
Title: PEA15 regulates the DNA damage-induced cell cycle checkpoint and oncogene-directed transformation.
Volume: 34
Issue: 12
Pages: 2264-82
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Publication
10442631 | -
First Author: Condorelli G
Year: 1999
Journal: Oncogene
Title: PED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosis.
Volume: 18
Issue: 31
Pages: 4409-15
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Publication
18541525 | -
First Author: Viparelli F
Year: 2008
Journal: J Biol Chem
Title: Targeting of PED/PEA-15 molecular interaction with phospholipase D1 enhances insulin sensitivity in skeletal muscle cells.
Volume: 283
Issue: 31
Pages: 21769-78
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Protein Domain
IPR029546 | PEA15_DED
Type: Domain
Description: Astrocytic phosphoprotein PEA-15 is a multifunctional protein that is involved in different biological processes and regulates several signalling pathways []. It contains N-terminal death effector domain (DED) and a C-terminal tail with irregular structure []. Expression of PEA-15 oscillates throughout the cell cycle, and the loss of PEA15 accelerates cell cycle progression []. PEA-15 blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade []. It inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis []. It also functions as a tumour suppressor by triggering the DNA damage-induced G2/M checkpoint and inhibiting RAS-mediated transformation []. In humans PEA-15 is regarded as an important target for type 2 diabetes. PEA-15 overexpression impairs insulin regulation of glucose transport, and this is mediated by its interaction with the C-terminal D4 domain of phospholipase D1 (PLD1) and the consequent increase of protein kinase C-alpha activity []. This entry represents the Death Effector Domain (DED) of PEA15.
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Protein Coding Gene
MGI:101835 | Traf2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P39429
Organism: Mus musculus/domesticus
Length: 501  
Fragment?: false
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Publication
27106802 | J:253948
 
First Author: Magarin M
Year: 2016
Journal: J Mol Cell Cardiol
Title: Embryonic cardiomyocytes can orchestrate various cell protective mechanisms to survive mitochondrial stress.
Volume: 97
Pages: 1-14
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Publication
11723074 | J:72900
First Author: Lamhamedi-Cherradi SE
Year: 2001
Journal: Diabetes
Title: Further mapping of the Idd5.1 locus for autoimmune diabetes in NOD mice.
Volume: 50
Issue: 12
Pages: 2874-8
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Publication
21876153 | J:176448
First Author: Lu JV
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity.
Volume: 108
Issue: 37
Pages: 15312-7
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Publication
39625985 | J:359779
First Author: Bernabé-Rubio M
Year: 2024
Journal: Proc Natl Acad Sci U S A
Title: Caspase-8-dependent autophagy regulates neutrophil infiltration in oral squamous cell carcinoma.
Volume: 121
Issue: 50
Pages: e2406944121
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Publication
33769609 | J:309250
First Author: Zhang Z
Year: 2021
Journal: FASEB J
Title: CDKN2A deregulation in fatty liver disease and its accelerative role in the process of lipogenesis.
Volume: 35
Issue: 4
Pages: e21230
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Publication
37965338 | J:342611
 
First Author: Hägglöf T
Year: 2023
Journal: Front Immunol
Title: RIPK1 deficiency prevents thymic NK1.1 expression and subsequent iNKT cell development.
Volume: 14
Pages: 1103591
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Publication
31132747 | J:286073
 
First Author: Shindo R
Year: 2019
Journal: iScience
Title: Necroptosis of Intestinal Epithelial Cells Induces Type 3 Innate Lymphoid Cell-Dependent Lethal Ileitis.
Volume: 15
Pages: 536-551
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Publication
30653446 | J:341773
First Author: Niu C
Year: 2019
Journal: Autophagy
Title: Metformin alleviates hyperglycemia-induced endothelial impairment by downregulating autophagy via the Hedgehog pathway.
Volume: 15
Issue: 5
Pages: 843-870
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Protein
Q62048
Organism: Mus musculus/domesticus
Length: 130  
Fragment?: false
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Protein
Q5QHR8
Organism: Mus musculus/domesticus
Length: 127  
Fragment?: false
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Protein
D3Z375
Organism: Mus musculus/domesticus
Length: 92  
Fragment?: true
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Publication
9880531 | -
First Author: Scaffidi C
Year: 1999
Journal: J Biol Chem
Title: The role of c-FLIP in modulation of CD95-induced apoptosis.
Volume: 274
Issue: 3
Pages: 1541-8
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Publication
16498450 | -
First Author: Budd RC
Year: 2006
Journal: Nat Rev Immunol
Title: cFLIP regulation of lymphocyte activation and development.
Volume: 6
Issue: 3
Pages: 196-204
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Protein Domain
IPR002398 | Pept_C14
Type: Family
Description: This group of sequences represent the p45 (45kDa) precursor of caspases, which can be processed to produce the active p20 (20kDa) and p10 (10kDa) subunits. Caspases (Cysteine-dependent ASPartyl-specific proteASE) are cysteine peptidases that belong to the MEROPS peptidase family C14 (caspase family, clan CD) based on the architecture of their catalytic dyad or triad []. Caspases are tightly regulated proteins that require zymogen activation to become active, and once active can be regulated by caspase inhibitors. Activated caspases act as cysteine proteases, using the sulphydryl group of a cysteine side chain for catalysing peptide bond cleavage at aspartyl residues in their substrates. The catalytic cysteine and histidine residues are on the p20 subunit after cleavage of the p45 precursor.Caspases are mainly involved in mediating cell death (apoptosis) [, , ]. They have two main roles within the apoptosis cascade: as initiators that trigger the cell death process, and as effectors of the process itself. Caspase-mediated apoptosis follows two main pathways, one extrinsic and the other intrinsic or mitochondrial-mediated. The extrinsic pathway involves the stimulation of various TNF (tumour necrosis factor) cell surface receptors on cells targeted to die by various TNF cytokines that are produced by cells such as cytotoxic T cells. The activated receptor transmits the signal to the cytoplasm by recruiting FADD, which forms a death-inducing signalling complex (DISC) with caspase-8. The subsequent activation of caspase-8 initiates the apoptosis cascade involving caspases 3, 4, 6, 7, 9 and 10. The intrinsic pathway arises from signals that originate within the cell as a consequence of cellular stress or DNA damage. The stimulation or inhibition of different Bcl-2 family receptors results in the leakage of cytochrome c from the mitochondria, and the formation of an apoptosome composed of cytochrome c, Apaf1 and caspase-9. The subsequent activation of caspase-9 initiates the apoptosis cascade involving caspases 3 and 7, among others. At the end of the cascade, caspases act on a variety of signal transduction proteins, cytoskeletal and nuclear proteins, chromatin-modifying proteins, DNA repair proteins and endonucleases that destroy the cell by disintegrating its contents, including its DNA. The different caspases have different domain architectures depending upon where they fit into the apoptosis cascades, however they all carry the catalytic p10 and p20 subunits.Caspases can have roles other than in apoptosis, such as caspase-1 (interleukin-1 beta convertase) (), which is involved in the inflammatory process. The activation of apoptosis can sometimes lead to caspase-1 activation, providing a link between apoptosis and inflammation, such as during the targeting of infected cells. Caspases may also be involved in cell differentiation [].There are non-peptidase homologues in the caspase family, such as CASP8 and FADD-like apoptosis regulator (CASH/c-FLIP), which suppresses death receptor induced apoptosis and TCR activation induced cell death by inhibiting caspase-8 activation [, , ].
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Protein
I6L890
Organism: Mus musculus/domesticus
Length: 176  
Fragment?: false
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Protein
E0CY92
Organism: Mus musculus/domesticus
Length: 93  
Fragment?: true
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Publication
23012479 | J:190322
First Author: Archambaud C
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Impact of lactobacilli on orally acquired listeriosis.
Volume: 109
Issue: 41
Pages: 16684-9
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Protein
Q9EPB4
Organism: Mus musculus/domesticus
Length: 193  
Fragment?: false
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Protein
Q54AA2
Organism: Mus musculus/domesticus
Length: 193  
Fragment?: false
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Protein
A0A0U1RQ20
Organism: Mus musculus/domesticus
Length: 151  
Fragment?: true
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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