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Search results 901 to 1000 out of 1056 for Cdk2

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Type Details Score
Publication
10926775 | J:64024
First Author: Liu D
Year: 2000
Journal: Dev Biol
Title: A role for cyclin A1 in the activation of MPF and G2-M transition during meiosis of male germ cells in mice.
Volume: 224
Issue: 2
Pages: 388-400
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Publication
12657672 | J:82675
First Author: Nguyen MD
Year: 2003
Journal: J Neurosci
Title: Cell cycle regulators in the neuronal death pathway of amyotrophic lateral sclerosis caused by mutant superoxide dismutase 1.
Volume: 23
Issue: 6
Pages: 2131-40
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Publication
25050737 | J:214618
First Author: Huang M
Year: 2014
Journal: Cancer Lett
Title: Rottlerin suppresses growth of human pancreatic tumors in nude mice, and pancreatic cancer cells isolated from Kras(G12D) mice.
Volume: 353
Issue: 1
Pages: 32-40
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Publication
22479189 | J:183606
First Author: Duong MT
Year: 2012
Journal: PLoS Genet
Title: LMW-E/CDK2 deregulates acinar morphogenesis, induces tumorigenesis, and associates with the activated b-Raf-ERK1/2-mTOR pathway in breast cancer patients.
Volume: 8
Issue: 3
Pages: e1002538
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Publication
15150278 | J:343383
First Author: Munir S
Year: 2004
Journal: J Biol Chem
Title: Nodal and ALK7 inhibit proliferation and induce apoptosis in human trophoblast cells.
Volume: 279
Issue: 30
Pages: 31277-86
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Publication
11281653 | J:68481
First Author: Salatino M
Year: 2001
Journal: Exp Cell Res
Title: Mechanisms of cell cycle arrest in response to TGF-beta in progestin-dependent and -independent growth of mammary tumors.
Volume: 265
Issue: 1
Pages: 152-66
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Publication
10618723 | J:59355
First Author: Karsunky H
Year: 1999
Journal: Oncogene
Title: Oncogenic potential of cyclin E in T-cell lymphomagenesis in transgenic mice: evidence for cooperation between cyclin E and Ras but not Myc.
Volume: 18
Issue: 54
Pages: 7816-24
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Publication
8187822 | J:18509
First Author: Jahn L
Year: 1994
Journal: Exp Cell Res
Title: Cyclins and cyclin-dependent kinases are differentially regulated during terminal differentiation of C2C12 muscle cells.
Volume: 212
Issue: 2
Pages: 297-307
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Publication
8816442 | J:35352
First Author: Tiainen M
Year: 1996
Journal: Mol Cell Biol
Title: Expression of E1A in terminally differentiated muscle cells reactivates the cell cycle and suppresses tissue-specific genes by separable mechanisms.
Volume: 16
Issue: 10
Pages: 5302-12
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Publication
10022811 | J:53213
First Author: Balasubramanian S
Year: 1999
Journal: Oncogene
Title: Activation of telomerase and its association with G1-phase of the cell cycle during UVB-induced skin tumorigenesis in SKH-1 hairless mouse.
Volume: 18
Issue: 6
Pages: 1297-302
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Publication
12642875 | J:82785
First Author: Geisen C
Year: 2003
Journal: Oncogene
Title: Loss of p27(Kip1) cooperates with cyclin E in T-cell lymphomagenesis.
Volume: 22
Issue: 11
Pages: 1724-9
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Protein
P25322
Organism: Mus musculus/domesticus
Length: 295  
Fragment?: false
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Protein
Q810T2
Organism: Mus musculus/domesticus
Length: 1396  
Fragment?: false
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Protein
Q920C4
Organism: Mus musculus/domesticus
Length: 213  
Fragment?: false
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Protein
P30280
Organism: Mus musculus/domesticus
Length: 289  
Fragment?: false
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Protein
P30282
Organism: Mus musculus/domesticus
Length: 292  
Fragment?: false
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Protein
Q3TC96
Organism: Mus musculus/domesticus
Length: 295  
Fragment?: false
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Protein
A2AEP2
Organism: Mus musculus/domesticus
Length: 1396  
Fragment?: false
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Protein
S4R240
Organism: Mus musculus/domesticus
Length: 214  
Fragment?: true
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Protein
Q3TYT4
Organism: Mus musculus/domesticus
Length: 168  
Fragment?: false
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Protein
A0A2I3BPS7
Organism: Mus musculus/domesticus
Length: 197  
Fragment?: false
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Protein
S4R2N5
Organism: Mus musculus/domesticus
Length: 243  
Fragment?: true
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Protein
S4R1D9
Organism: Mus musculus/domesticus
Length: 250  
Fragment?: true
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Protein
Q3TWY0
Organism: Mus musculus/domesticus
Length: 292  
Fragment?: false
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Protein
Q05DI8
Organism: Mus musculus/domesticus
Length: 176  
Fragment?: false
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Protein
B2M0W7
Organism: Mus musculus/domesticus
Length: 310  
Fragment?: false
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Protein
Q790L7
Organism: Mus musculus/domesticus
Length: 295  
Fragment?: false
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Protein
Q810H7
Organism: Mus musculus/domesticus
Length: 213  
Fragment?: false
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Protein
Q3TSW4
Organism: Mus musculus/domesticus
Length: 292  
Fragment?: false
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Protein
Q4FK45
Organism: Mus musculus/domesticus
Length: 289  
Fragment?: false
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Protein
Q53ZU3
Organism: Mus musculus/domesticus
Length: 213  
Fragment?: false
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Publication
15197472 | -
First Author: Torres Acosta JA
Year: 2004
Journal: Cell Mol Life Sci
Title: Molecular characterization of Arabidopsis PHO80-like proteins, a novel class of CDKA;1-interacting cyclins.
Volume: 61
Issue: 12
Pages: 1485-97
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Protein
Q5SRT8
Organism: Mus musculus/domesticus
Length: 387  
Fragment?: false
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Protein
Q3TZI6
Organism: Mus musculus/domesticus
Length: 379  
Fragment?: false
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Protein
P30276
Organism: Mus musculus/domesticus
Length: 398  
Fragment?: false
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Protein
P24860
Organism: Mus musculus/domesticus
Length: 430  
Fragment?: false
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Protein
P51943
Organism: Mus musculus/domesticus
Length: 422  
Fragment?: false
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Protein
Q61456
Organism: Mus musculus/domesticus
Length: 421  
Fragment?: false
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Protein
Q3TQW9
Organism: Mus musculus/domesticus
Length: 430  
Fragment?: false
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Protein
S4R2N1
Organism: Mus musculus/domesticus
Length: 119  
Fragment?: true
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Protein
S4R1C8
Organism: Mus musculus/domesticus
Length: 99  
Fragment?: true
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Protein
G3UY65
Organism: Mus musculus/domesticus
Length: 393  
Fragment?: false
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Protein
S4R275
Organism: Mus musculus/domesticus
Length: 75  
Fragment?: true
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Protein
A0A0G2JEY1
Organism: Mus musculus/domesticus
Length: 285  
Fragment?: false
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Protein
S4R1R1
Organism: Mus musculus/domesticus
Length: 125  
Fragment?: true
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Protein
Q3UWL3
Organism: Mus musculus/domesticus
Length: 430  
Fragment?: false
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Protein
C5IGX4
Organism: Mus musculus/domesticus
Length: 369  
Fragment?: false
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Protein
Q9CYU2
Organism: Mus musculus/domesticus
Length: 398  
Fragment?: false
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Protein
Q3TFV6
Organism: Mus musculus/domesticus
Length: 430  
Fragment?: false
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Protein
Q8VDC7
Organism: Mus musculus/domesticus
Length: 52  
Fragment?: true
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Protein
S4R216
Organism: Mus musculus/domesticus
Length: 96  
Fragment?: false
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Protein
A0A0J9YU51
Organism: Mus musculus/domesticus
Length: 189  
Fragment?: true
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Protein
A0A0G2JEB5
Organism: Mus musculus/domesticus
Length: 250  
Fragment?: true
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Protein
Q68EM3
Organism: Mus musculus/domesticus
Length: 369  
Fragment?: false
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Protein
Q9D8L9
Organism: Mus musculus/domesticus
Length: 156  
Fragment?: false
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Publication
11056549 | -
First Author: Hardwick JM
Year: 2000
Journal: Nat Cell Biol
Title: Cyclin' on the viral path to destruction.
Volume: 2
Issue: 11
Pages: E203-4
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Protein
P51944
Organism: Mus musculus/domesticus
Length: 777  
Fragment?: false
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Publication
12185076 | J:79874
First Author: Nguyen TB
Year: 2002
Journal: J Biol Chem
Title: Characterization and expression of mammalian cyclin b3, a prepachytene meiotic cyclin.
Volume: 277
Issue: 44
Pages: 41960-9
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Protein
Q8K3M5
Organism: Mus musculus/domesticus
Length: 476  
Fragment?: false
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Protein
Q9ESJ1
Organism: Mus musculus/domesticus
Length: 568  
Fragment?: false
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Protein
Q3TYS6
Organism: Mus musculus/domesticus
Length: 594  
Fragment?: false
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Protein
B2RWU9
Organism: Mus musculus/domesticus
Length: 568  
Fragment?: false
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Protein
Q3U148
Organism: Mus musculus/domesticus
Length: 594  
Fragment?: false
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Protein
Q8BNI1
Organism: Mus musculus/domesticus
Length: 180  
Fragment?: true
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Protein
Q8R3U5
Organism: Mus musculus/domesticus
Length: 149  
Fragment?: true
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Protein
Q7TSU3
Organism: Mus musculus/domesticus
Length: 213  
Fragment?: false
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Publication
10024882 | -
First Author: Tirode F
Year: 1999
Journal: Mol Cell
Title: Reconstitution of the transcription factor TFIIH: assignment of functions for the three enzymatic subunits, XPB, XPD, and cdk7.
Volume: 3
Issue: 1
Pages: 87-95
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Publication
11780147 | -
First Author: Stroud JC
Year: 2002
Journal: Nat Struct Biol
Title: Structure of a TonEBP-DNA complex reveals DNA encircled by a transcription factor.
Volume: 9
Issue: 2
Pages: 90-4
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Publication
8313904 | -
First Author: Gallant P
Year: 1994
Journal: EMBO J
Title: Identification of a novel vertebrate cyclin: cyclin B3 shares properties with both A- and B-type cyclins.
Volume: 13
Issue: 3
Pages: 595-605
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Publication
9852112 | -
First Author: Kershnar E
Year: 1998
Journal: J Biol Chem
Title: Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes.
Volume: 273
Issue: 51
Pages: 34444-53
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Publication
11113184 | -
First Author: Garrett S
Year: 2001
Journal: Mol Cell Biol
Title: Reciprocal activation by cyclin-dependent kinases 2 and 7 is directed by substrate specificity determinants outside the T loop.
Volume: 21
Issue: 1
Pages: 88-99
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Protein Domain
IPR006572 | Znf_DBF
Type: Domain
Description: Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. Some of these domains bind zinc, but many do not; instead binding other metals such as iron, or no metal at all. For example, some family members form salt bridges to stabilise the finger-like folds. They were first identified as a DNA-binding motif in transcription factor TFIIIA from Xenopus laevis (African clawed frog), however they are now recognised to bind DNA, RNA, protein and/or lipid substrates [, , , , ]. Their binding properties depend on the amino acid sequence of the finger domains and of the linker between fingers, as well as on the higher-order structures and the number of fingers. Znf domainsare often found in clusters, where fingers can have different binding specificities. There are many superfamilies of Znf motifs, varying in both sequence and structure. They display considerable versatility in binding modes, even between members of the same class (e.g. some bind DNA, others protein), suggesting that Znf motifs are stable scaffolds that have evolved specialised functions. For example, Znf-containing proteins function in gene transcription, translation, mRNA trafficking, cytoskeleton organisation, epithelial development, cell adhesion, protein folding, chromatin remodelling and zinc sensing, to name but a few []. Zinc-binding motifs are stable structures, and they rarely undergo conformational changes upon binding their target. In eukaryotes, initiation of DNA replication requires the assembly of pre-replication complexes (pre-RCs) on chromatin during the G1 phase. In the S phase, pre-RCs are activated by two protein kinases, Cdk2 and Cdc7, which results in the loading of replication factors and the unwinding of replication origins by the MCM helicase complex []. Cdc7 is a serine/threonine kinase that is conserved from yeast to human. It is regulated by its association with a regulatory subunit, the Dbf4 protein. This complex is often referred to as DDK (Dbf4-dependent kinase) [].DBF4 contains an N-terminal BRCT domain and a C-terminal conserved region that could potentially coordinate one zinc atom, the DBF4-type zinc finger. This entry represents the zinc finger, which is important for the interaction with Cdc7 [, ].
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Protein Domain
IPR015452 | Cyclin_B3
Type: Family
Description: Cyclins are eukaryotic proteins that play an active role in controlling nuclear cell division cycles [], and regulate cyclin dependent kinases (CDKs). Cyclins, together with the p34 (cdc2) or cdk2 kinases, form the Maturation Promoting Factor (MPF). There are two main groups of cyclins, G1/S cyclins, which are essential for the control of the cell cycle at the G1/S (start) transition, and G2/M cyclins, which are essential for the control of the cell cycle at the G2/M (mitosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed as cells exit from mitosis (at the end of the M-phase). In most species, there are multiple forms ofG1 and G2 cyclins. For example, in vertebrates, there are two G2 cyclins, A and B, and at least three G1 cyclins, C, D, and E.Cyclin homologues have been found in various viruses, including Saimiriine herpesvirus 2 (Herpesvirus saimiri) and Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus). These viral homologues differ from their cellular counterparts in that the viral proteins have gained new functions and eliminated others to harness the cell and benefit the virus [].Cyclin B3 is conserved from Caenorhabditis elegans to Homo sapiens (Human) and has an undefined meiotic function in female, but not male Drosophila melanogaster (Fruit fly). Cyclin B3 interacts with cdk2, is localised to the nucleus, and is degraded during anaphase entry after the degradation of cyclin B1. Degradation is dependent on sequences conserved in a destruction box motif. Over expression of nondegradable cyclin B3 blocks the mitotic cell cycle in late anaphase, and at higher doses it can interfere with progression through G(1) and entry into S phase. The expression pattern of mammalian cyclin B3 suggests that it may be important for events occurring in early meiotic prophase I [].In vertebrates, cyclins B1 and B2 function during M phase, whereas cyclin A is required for S phase as well as the G2 to M phase transition. The assignment of cyclin B3 to the B-type subfamily is based on cDNA-derived sequence and its pattern of expression in synchronised cells, both suggesting a distant relationship to other B-type cyclins. Interestingly, however, cyclin B3 also displays properties that resemble those of A- rather than B-type cyclins [].
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Protein
Q52KE7
Organism: Mus musculus/domesticus
Length: 532  
Fragment?: false
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Protein
O88874
Organism: Mus musculus/domesticus
Length: 554  
Fragment?: false
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Protein
Q9QZ41
Organism: Mus musculus/domesticus
Length: 663  
Fragment?: false
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Protein
Q9JJA7
Organism: Mus musculus/domesticus
Length: 518  
Fragment?: false
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Protein
Q810P3
Organism: Mus musculus/domesticus
Length: 211  
Fragment?: false
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Protein
Q3U3H2
Organism: Mus musculus/domesticus
Length: 331  
Fragment?: true
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Protein
B2RS44
Organism: Mus musculus/domesticus
Length: 663  
Fragment?: false
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Protein
Q3U3M5
Organism: Mus musculus/domesticus
Length: 582  
Fragment?: false
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Protein
Q9QWV9
Organism: Mus musculus/domesticus
Length: 724  
Fragment?: false
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Publication
1827757 | J:14776
First Author: Matsushime H
Year: 1991
Journal: Cell
Title: Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle.
Volume: 65
Issue: 4
Pages: 701-13
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Protein
Q61458
Organism: Mus musculus/domesticus
Length: 323  
Fragment?: false
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Protein
Q7TQK0
Organism: Mus musculus/domesticus
Length: 723  
Fragment?: false
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Protein
Q62447
Organism: Mus musculus/domesticus
Length: 283  
Fragment?: false
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Protein
Q8QZR8
Organism: Mus musculus/domesticus
Length: 250  
Fragment?: false
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Protein
F6WYR6
Organism: Mus musculus/domesticus
Length: 178  
Fragment?: false
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Protein
Q3U6Q7
Organism: Mus musculus/domesticus
Length: 253  
Fragment?: false
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Protein
Q497T2
Organism: Mus musculus/domesticus
Length: 335  
Fragment?: true
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Protein
A4FUU8
Organism: Mus musculus/domesticus
Length: 150  
Fragment?: true
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Protein
F6WST0
Organism: Mus musculus/domesticus
Length: 146  
Fragment?: true
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Protein
Q5PPR1
Organism: Mus musculus/domesticus
Length: 320  
Fragment?: true
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Protein
Q8CD22
Organism: Mus musculus/domesticus
Length: 278  
Fragment?: false
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Protein
Q05BN1
Organism: Mus musculus/domesticus
Length: 311  
Fragment?: true
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Protein
E9PW04
Organism: Mus musculus/domesticus
Length: 356  
Fragment?: false
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Protein
E9Q7A7
Organism: Mus musculus/domesticus
Length: 184  
Fragment?: false
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Protein
E9PWD3
Organism: Mus musculus/domesticus
Length: 287  
Fragment?: false
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Protein
Q3U832
Organism: Mus musculus/domesticus
Length: 723  
Fragment?: false
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Protein
Q9D814
Organism: Mus musculus/domesticus
Length: 191  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom