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Search results 901 to 1000 out of 1157 for Cftr

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Type Details Score
Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Pathway
R-MMU-5627083 | RHO GTPases regulate CFTR trafficking
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Publication
27833020 | J:240972
First Author: Shin YH
Year: 2016
Journal: Biochem Biophys Res Commun
Title: Epigenetic regulation of CFTR in salivary gland.
Volume: 481
Issue: 1-2
Pages: 31-37
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HT Experiment
E-GEOD-75996 | CFTR is a tumor suppressor gene in murine and human intestinal cancer [microarray]
Series Id: GSE75996
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
11274233 | J:103279
First Author: Nakanishi K
Year: 2001
Journal: J Am Soc Nephrol
Title: Role of CFTR in autosomal recessive polycystic kidney disease.
Volume: 12
Issue: 4
Pages: 719-25
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Publication
18385427 | J:323261
First Author: Yang B
Year: 2008
Journal: J Am Soc Nephrol
Title: Small-molecule CFTR inhibitors slow cyst growth in polycystic kidney disease.
Volume: 19
Issue: 7
Pages: 1300-10
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GO Term
GO:0005260 | intracellularly ATP-gated chloride channel activity
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HT Experiment
E-GEOD-5715 | Transcription profiling of mouse cystic fibrosis model Cftr knockouts ileum were analysed to investigate intestinal phenotypes
Series Id: GSE5715
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
28384194 | J:242346
First Author: Wang YY
Year: 2017
Journal: PLoS Genet
Title: Loss of SLC9A3 decreases CFTR protein and causes obstructed azoospermia in mice.
Volume: 13
Issue: 4
Pages: e1006715
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Publication
7540563 | J:26077
First Author: Manavalan P
Year: 1995
Journal: FEBS Lett
Title: Sequence homologies between nucleotide binding regions of CFTR and G-proteins suggest structural and functional similarities.
Volume: 366
Issue: 2-3
Pages: 87-91
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Publication
36545778 | J:341371
First Author: Prieto S
Year: 2023
Journal: EMBO Rep
Title: CDK8 and CDK19 act redundantly to control the CFTR pathway in the intestinal epithelium.
Volume: 24
Issue: 2
Pages: e54261
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Publication
11020351 | J:94885
First Author: Chow YH
Year: 2000
Journal: Mol Ther
Title: Targeting transgene expression to airway epithelia and submucosal glands, prominent sites of human CFTR expression.
Volume: 2
Issue: 4
Pages: 359-67
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Publication
11448937 | J:133123
First Author: Rowntree RK
Year: 2001
Journal: Hum Mol Genet
Title: An element in intron 1 of the CFTR gene augments intestinal expression in vivo.
Volume: 10
Issue: 14
Pages: 1455-64
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Publication
19328185 | J:149235
First Author: Hegedus T
Year: 2009
Journal: Biochim Biophys Acta
Title: Role of individual R domain phosphorylation sites in CFTR regulation by protein kinase A.
Volume: 1788
Issue: 6
Pages: 1341-9
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Publication
39315713 | J:358112
First Author: Kulhankova K
Year: 2024
Journal: Nucleic Acids Res
Title: Amphiphilic shuttle peptide delivers base editor ribonucleoprotein to correct the CFTR R553X mutation in well-differentiated airway epithelial cells.
Volume: 52
Issue: 19
Pages: 11911-11925
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Publication
19910374 | J:173009
First Author: Haque A
Year: 2010
Journal: Nucleic Acids Res
Title: Functional properties and evolutionary splicing constraints on a composite exonic regulatory element of splicing in CFTR exon 12.
Volume: 38
Issue: 2
Pages: 647-59
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Interaction Experiment
Wang X (2006)
Description: Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis.
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Publication
29875161 | J:267093
First Author: Yanda MK
Year: 2018
Journal: J Biol Chem
Title: A potential strategy for reducing cysts in autosomal dominant polycystic kidney disease with a CFTR corrector.
Volume: 293
Issue: 29
Pages: 11513-11526
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Allele
Cftr<em1Smoc> | MGI:7288949
Name: cystic fibrosis transmembrane conductance regulator; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Cftr<tm1(CFTR)Smoc> | MGI:7786835
Name: cystic fibrosis transmembrane conductance regulator; targeted mutation 1, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence
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Publication
18565999 | J:176390
First Author: Shcheynikov N
Year: 2008
Journal: J Physiol
Title: The Slc26a4 transporter functions as an electroneutral Cl-/I-/HCO3- exchanger: role of Slc26a4 and Slc26a6 in I- and HCO3- secretion and in regulation of CFTR in the parotid duct.
Volume: 586
Issue: 16
Pages: 3813-24
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Publication
23148214 | J:219060
First Author: Abdulrahman BA
Year: 2013
Journal: J Biol Chem
Title: Depletion of the ubiquitin-binding adaptor molecule SQSTM1/p62 from macrophages harboring cftr ΔF508 mutation improves the delivery of Burkholderia cenocepacia to the autophagic machinery.
Volume: 288
Issue: 3
Pages: 2049-58
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Publication
31408507 | -
First Author: Kim Chiaw P
Year: 2019
Journal: PLoS One
Title: Hsp70 and DNAJA2 limit CFTR levels through degradation.
Volume: 14
Issue: 8
Pages: e0220984
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Allele
Cftr<tm1Kth> | MGI:1857151
Name: cystic fibrosis transmembrane conductance regulator; targeted mutation 1, Kirk R Thomas
Allele Type: Targeted
Attribute String: Hypomorph
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Publication
11435397 | -
First Author: Dean M
Year: 2001
Journal: Genome Res
Title: The human ATP-binding cassette (ABC) transporter superfamily.
Volume: 11
Issue: 7
Pages: 1156-66
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CL Term
CL:0017000 | pulmonary ionocyte
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Strain
MGI:6770652 | C57BL/6JSmoc-Cftr<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:7788660 | C57BL/6JSmoc-Cftr<tm1(CFTR)Smoc>/Smoc
Attribute String: coisogenic, mutant strain, targeted mutation
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Protein
Q8BH60
Organism: Mus musculus/domesticus
Length: 463  
Fragment?: false
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DO Term
DOID:0111864 | autosomal recessive congenital bilateral absence of vas deferens
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GO Term
GO:0034662 | CFTR-NHERF-ezrin complex
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Publication
15619636 | -
First Author: Thibodeau PH
Year: 2005
Journal: Nat Struct Mol Biol
Title: Side chain and backbone contributions of Phe508 to CFTR folding.
Volume: 12
Issue: 1
Pages: 10-6
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Protein
E9PVD7
Organism: Mus musculus/domesticus
Length: 1446  
Fragment?: false
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Allele
Cftr<tm1(CFTR)Cya> | MGI:7657226
Name: cystic fibrosis transmembrane conductance regulator; targeted mutation 1, Cyagen Biosciences
Allele Type: Targeted
Attribute String: Inserted expressed sequence, Null/knockout
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Allele
Cftr<tm1Unc> | MGI:1856709
Name: cystic fibrosis transmembrane conductance regulator; targeted mutation 1, University of North Carolina
Allele Type: Targeted
Attribute String: Null/knockout
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Protein Coding Gene
MGI:2149946 | Gopc
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1931553 | Rhoq
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q8R527
Organism: Mus musculus/domesticus
Length: 205  
Fragment?: false
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Protein
P26361-3
Organism: Mus musculus/domesticus
Length: 600  
Fragment?: false
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Protein
P26361-2
Organism: Mus musculus/domesticus
Length: 576  
Fragment?: false
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Publication
22265409 | -
First Author: Mendoza JL
Year: 2012
Journal: Cell
Title: Requirements for efficient correction of ΔF508 CFTR revealed by analyses of evolved sequences.
Volume: 148
Issue: 1-2
Pages: 164-74
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Publication
17110338 | -
First Author: Wang X
Year: 2006
Journal: Cell
Title: Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis.
Volume: 127
Issue: 4
Pages: 803-15
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Allele
Tg(Fabp2-CFTR*)1Wsh | MGI:5308021
Name: transgene insertion 1, Michael J Welsh
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Strain
MGI:7657663 | C57BL/6N-Cftr<tm1(CFTR)Cya>/Cya
Attribute String: coisogenic, targeted mutation, mutant strain
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Publication
30659401 | -
First Author: Sharma S
Year: 2019
Journal: J Mol Histol
Title: Mapping the sites of localization of epithelial sodium channel (ENaC) and CFTR in segments of the mammalian epididymis.
Volume: 50
Issue: 2
Pages: 141-154
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Strain
MGI:5308251 | STOCK Tg(Fabp2-CFTR*)1Wsh/J
Attribute String: transgenic, mutant stock
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Ontology Term
- | Chloride channel impairing toxin
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Publication
22121115 | J:181151
First Author: Rode B
Year: 2012
Journal: Hum Mol Genet
Title: The testis anion transporter TAT1 (SLC26A8) physically and functionally interacts with the cystic fibrosis transmembrane conductance regulator channel: a potential role during sperm capacitation.
Volume: 21
Issue: 6
Pages: 1287-98
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Allele
Cftr<em3Cwr> | MGI:6192450
Name: cystic fibrosis transmembrane conductance regulator; endonuclease-mediated mutation 3, Case Western Reserve University
Allele Type: Endonuclease-mediated
Attribute String: Hypomorph
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Strain
MGI:6276348 | C57BL/6J-Cftr<em3Cwr>/Cwr
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Cftr/Cftr
Background: C57BL/6J-Cftr/Cwr
Zygosity: hm
Has Mutant Allele: true
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HT Experiment
GSE238000 | Prominent role of gut dysbiosis in the pathogenesis of cystic fibrosis-related liver disease in mice
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Allele
Tg(Scgb1a1-CFTR)6Unc | MGI:3606222
Name: transgene insertion 6, University of North Carolina
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Publication
15358775 | -
First Author: He J
Year: 2004
Journal: J Biol Chem
Title: Interaction with cystic fibrosis transmembrane conductance regulator-associated ligand (CAL) inhibits beta1-adrenergic receptor surface expression.
Volume: 279
Issue: 48
Pages: 50190-6
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Protein
A0A1W2P7A5
Organism: Mus musculus/domesticus
Length: 103  
Fragment?: true
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Protein
Q3TAF1
Organism: Mus musculus/domesticus
Length: 166  
Fragment?: false
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Publication
11439350 | -
First Author: Soncini C
Year: 2001
Journal: Oncogene
Title: Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10, a novel human ubiquitin specific protease.
Volume: 20
Issue: 29
Pages: 3869-79
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Publication
20096447 | -
First Author: Yuan J
Year: 2010
Journal: Cell
Title: USP10 regulates p53 localization and stability by deubiquitinating p53.
Volume: 140
Issue: 3
Pages: 384-96
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Publication
19398555 | -
First Author: Bomberger JM
Year: 2009
Journal: J Biol Chem
Title: The deubiquitinating enzyme USP10 regulates the post-endocytic sorting of cystic fibrosis transmembrane conductance regulator in airway epithelial cells.
Volume: 284
Issue: 28
Pages: 18778-89
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Publication
14570915 | -
First Author: Cheng J
Year: 2004
Journal: J Biol Chem
Title: Modulation of mature cystic fibrosis transmembrane regulator protein by the PDZ domain protein CAL.
Volume: 279
Issue: 3
Pages: 1892-8
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Protein Domain
IPR028767 | USP10
Type: Family
Description: Ubiquitin carboxyl-terminal hydrolase 10 (USP10) isa hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR []. It regulates the localisation and stability of p53 by de-ubiquitinatiing p53 []. It is also implicated in vesicular transport and trafficking of membrane proteins [].
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Protein Domain
IPR038879 | GOPC
Type: Family
Description: GOPC, also known as PIST or CAL, is primarily localized to the Golgi apparatus. It binds the G protein-coupled receptor beta1AR and modulates beta1AR intracellular trafficking []. GOPC also interacts with cystic fibrosis transmembrane regulator (CFTR), retains CFTR in the cell and targets it for degradation [].
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Allele
Cftr<tm1Cam> | MGI:1857544
Name: cystic fibrosis transmembrane conductance regulator; targeted mutation 1, University of Cambridge
Allele Type: Targeted
Attribute String: Null/knockout
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Publication
17517695 | J:125103
First Author: Touré A
Year: 2007
Journal: Hum Mol Genet
Title: The testis anion transporter 1 (Slc26a8) is required for sperm terminal differentiation and male fertility in the mouse.
Volume: 16
Issue: 15
Pages: 1783-93
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Publication
11278976 | -
First Author: Toure A
Year: 2001
Journal: J Biol Chem
Title: Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling.
Volume: 276
Issue: 23
Pages: 20309-15
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Protein Domain
IPR030303 | SLC26A8
Type: Family
Description: The testis anion transporter TAT1 (solute carrier family 26 member 8; SLC26A8) mediates chloride, sulfate and oxalate transport and is specifically expressed in male germ cells and mature sperms [, ]. It is essential for correct sperm tail differentiation and motility, and hence male fertility []. TAT1 and CFTR (cystic fibrosis transmembrane conductance regulator) seem to cooperate in the regulation of the Cl-/HCO3- fluxes required for motility and capacitation of sperm [].
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Publication
25330774 | -
First Author: Pasyk S
Year: 2015
Journal: Proteomics
Title: The major cystic fibrosis causing mutation exhibits defective propensity for phosphorylation.
Volume: 15
Issue: 2-3
Pages: 447-61
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Protein Domain
IPR009147 | CFTR/ABCC7
Type: Family
Description: The ABC transporter family is a group of membrane proteins that use the hydrolysis of ATP to power the translocation of a wide variety of substrates across cellular membranes. ABC transporters minimally consist of two conserved regions: a highly conserved nucleotide-binding domain (NBD) and a less conserved transmembrane domain (TMD). Eukaryotic ABC proteins are usually organised either as full transporters (containing two NBDs and two TMDs), or as half transporters (containing one NBD and one TMD), that have to form homo- or heterodimers in order to constitute a functional protein [].Cystic fibrosis transmembrane conductance regulator (CFTR, also known as ABCC7) is an eukaryotic protein belonging to the ABC-C subfamily of the ABC transporter family. CFTR protein is a chloride ion channel controlled by phosphorylation. It has a major role in electrolyte and fluid secretion. CFTR is important in the determination of fluid flow, ion concentration and transepithelial salttransport. Dysfunction of the CFTR channel causes the life-threateningdisease, cystic fibrosis, in which trans-epithelial ion transport is disrupted []. Defective phosphorylation has been seen to be a cause for this altered activity [].
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Publication
26261085 | J:226644
First Author: Arora K
Year: 2015
Journal: Am J Pathol
Title: Altered cGMP dynamics at the plasma membrane contribute to diarrhea in ulcerative colitis.
Volume: 185
Issue: 10
Pages: 2790-804
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Genotype
Genotype
Symbol: Cftr/Cftr
Background: involves: 129S/SvEv
Zygosity: hm
Has Mutant Allele: true
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HT Experiment
GSE102580 | A single cell atlas of the airway epithelium reveals the CFTR-rich pulmonary ionocyte
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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Publication
9270304 | J:42256
First Author: Lohmann SM
Year: 1997
Journal: Trends Biochem Sci
Title: Distinct and specific functions of cGMP-dependent protein kinases.
Volume: 22
Issue: 8
Pages: 307-12
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Publication
21820390 | -
First Author: Groen A
Year: 2011
Journal: Gastroenterology
Title: Complementary functions of the flippase ATP8B1 and the floppase ABCB4 in maintaining canalicular membrane integrity.
Volume: 141
Issue: 5
Pages: 1927-37.e1-4
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Protein
Q923U1
Organism: Mus musculus/domesticus
Length: 103  
Fragment?: true
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Publication
9500542 | -
First Author: Bull LN
Year: 1998
Journal: Nat Genet
Title: A gene encoding a P-type ATPase mutated in two forms of hereditary cholestasis.
Volume: 18
Issue: 3
Pages: 219-24
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Publication
20512993 | -
First Author: Verhulst PM
Year: 2010
Journal: Hepatology
Title: A flippase-independent function of ATP8B1, the protein affected in familial intrahepatic cholestasis type 1, is required for apical protein expression and microvillus formation in polarized epithelial cells.
Volume: 51
Issue: 6
Pages: 2049-60
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Publication
17948906 | -
First Author: Paulusma CC
Year: 2008
Journal: Hepatology
Title: ATP8B1 requires an accessory protein for endoplasmic reticulum exit and plasma membrane lipid flippase activity.
Volume: 47
Issue: 1
Pages: 268-78
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Protein Domain
IPR030346 | ATP8B1
Type: Family
Description: Phospholipid-transporting ATPase IC (also known as ATP8B1 or ATPIC) belongs to subfamily IV of the P-type ATPases family, whose members transport phospholipids across the membrane. ATP8B1 can bind either CDC50A or CDC50B as its accessory protein for endoplasmic reticulum exit and plasma membrane lipid flippase activity [, , ].In hepatocytes, ATP8B1 localises in the canalicular membrane, where it may maintain the membrane integrity and to the function of ABCB4, an ABC floppase that play a role in bile export []. In the epithelial Caco-2 cells, ATP8B1 is required for apical protein expression and microvillus formation in polarised epithelial cells []. Mutations in ATP8B1 cause two forms of intrahepatic cholestasis, progressive familial intrahepatic cholestasis (PFIC) and benign recurrent intrahepatic cholestasis (BFIC) []. It is involved in the correct apical membrane localization of CDC42, CFTR and SLC10A2 [].
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