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Search results 901 to 1000 out of 1084 for Erbb4

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Genotype
Genotype
Symbol: Erbb4/Erbb4 Tg(Myh6-ERBB4)HT2Gass/?
Background: B6.Cg-Erbb4 Tg(Myh6-ERBB4)HT2Gass
Zygosity: cn
Has Mutant Allele: true
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Protein Coding Gene
MGI:96070 | Hbegf
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:103036 | Stat5a
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1861728 | Wwp1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1931237 | Wwox
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P42230
Organism: Mus musculus/domesticus
Length: 793  
Fragment?: false
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Protein
Q8BZZ3
Organism: Mus musculus/domesticus
Length: 918  
Fragment?: false
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Protein
Q91WL8
Organism: Mus musculus/domesticus
Length: 414  
Fragment?: false
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Protein
A0A140LHZ9
Organism: Mus musculus/domesticus
Length: 858  
Fragment?: false
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Protein
P56974
Organism: Mus musculus/domesticus
Length: 756  
Fragment?: false
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Protein Coding Gene
MGI:95411 | Erbb3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:97297 | Nedd4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q61526
Organism: Mus musculus/domesticus
Length: 1339  
Fragment?: false
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Protein
P46935
Organism: Mus musculus/domesticus
Length: 887  
Fragment?: false
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Protein Coding Gene
MGI:1933833 | Nrg4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1891700 | Ncstn
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:109284 | Psen2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1202717 | Psen1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2385110 | Aph1a
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1913590 | Psenen
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:103262 | Yap1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:3522097 | Aph1b
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q61527
Organism: Mus musculus/domesticus
Length: 1308  
Fragment?: false
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Protein
Q8C7N7
Organism: Mus musculus/domesticus
Length: 257  
Fragment?: false
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Protein
O35181
Organism: Mus musculus/domesticus
Length: 713  
Fragment?: false
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Protein
Q9CQR7
Organism: Mus musculus/domesticus
Length: 101  
Fragment?: false
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Protein
Q8BVF7
Organism: Mus musculus/domesticus
Length: 265  
Fragment?: false
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Protein
P49769
Organism: Mus musculus/domesticus
Length: 467  
Fragment?: false
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Protein
P57716
Organism: Mus musculus/domesticus
Length: 708  
Fragment?: false
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Protein
P46938
Organism: Mus musculus/domesticus
Length: 488  
Fragment?: false
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Protein
Q61144
Organism: Mus musculus/domesticus
Length: 448  
Fragment?: false
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Allele
Erbb4<tm1.1(cre/ERT2)Aibs> | MGI:4421788
Name: erb-b2 receptor tyrosine kinase 4; targeted mutation 1.1, Allen Institute for Brain Science
Allele Type: Targeted
Attribute String: Inducible, Recombinase
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Publication
18478032 | J:175354
First Author: Mei L
Year: 2008
Journal: Nat Rev Neurosci
Title: Neuregulin 1 in neural development, synaptic plasticity and schizophrenia.
Volume: 9
Issue: 6
Pages: 437-52
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Protein Coding Gene
MGI:1352467 | Esr1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1202301 | Itch
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:95290 | Egf
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q05928
Organism: Mus musculus/domesticus
Length: 177  
Fragment?: false
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Protein
P01132
Organism: Mus musculus/domesticus
Length: 1217  
Fragment?: false
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Protein
Q06186
Organism: Mus musculus/domesticus
Length: 208  
Fragment?: false
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Protein
Q61521
Organism: Mus musculus/domesticus
Length: 162  
Fragment?: false
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Protein
Q8C863
Organism: Mus musculus/domesticus
Length: 864  
Fragment?: false
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Protein
P19785
Organism: Mus musculus/domesticus
Length: 599  
Fragment?: false
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Protein Domain
IPR002154 | Neuregulin_C
Type: Domain
Description: Neuregulins are a sub-family of EGF-like molecules that have been shown to play multiple essential roles in vertebrate embryogenesis including: cardiac development, Schwann cell and oligodendrocyte differentiation, some aspects of neuronal development, as well as the formation of neuromuscular synapses [, ]. Included in the family are heregulin; neu differentiation factor; acetylcholine receptor synthesis stimulator; glial growth factor; and sensory and motor-neuron derived factor []. Multiple family members are generated by alternate splicing or by use of several cell type-specific transcription initiation sites. In general, they bind to and activate the erbB family of receptor tyrosine kinases (erbB2 (HER2), erbB3 (HER3), and erbB4 (HER4)), functioning both as heterodimers and homodimers.The transmembrane forms of neuregulin 1 (NRG1) are present within synaptic vesicles, including those containing glutamate []. After exocytosis, NRG1 is in the presynaptic membrane, where the ectodomain of NRG1 may be cleaved off. The ectodomain then migrates across the synaptic cleft and binds to and activates a member of the EGF-receptor family on the postsynaptic membrane. This has been shown to increase the expression of certain glutamate-receptor subunits. NRG1 appears to signal for glutamate-receptor subunit expression, localisation, and /or phosphorylation facilitating subsequent glutamate transmission. The NRG1 gene has been identified as a potential gene determining susceptibility to schizophrenia by a combination of genetic linkage and association approaches []. Membrane-anchored Nrg-1 isoforms consist of a variable N-terminal extracellular domain and a conserved transmembrane and C-terminal cytoplasmic domains []. This entry represents the C-terminal, intracellular domain.
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Protein Domain
IPR018250 | NRG1
Type: Family
Description: Neuregulins are a sub-family of EGF-like molecules that have been shown to play multiple essential roles in vertebrate embryogenesis including: cardiac development, Schwann cell and oligodendrocyte differentiation, some aspects of neuronal development, as well as the formation of neuromuscular synapses [, ]. Included in the family are heregulin; neu differentiation factor; acetylcholine receptor synthesis stimulator; glial growth factor; and sensory and motor-neuron derived factor []. Multiple family members are generated by alternate splicing or by use of several cell type-specific transcription initiation sites. In general, they bind to and activate the erbB family of receptor tyrosine kinases (erbB2 (HER2), erbB3 (HER3), and erbB4 (HER4)), functioning both as heterodimers and homodimers.The transmembrane forms of neuregulin 1 (NRG1) are present within synaptic vesicles, including those containing glutamate []. After exocytosis, NRG1 is in the presynaptic membrane, where the ectodomain of NRG1 may be cleaved off. The ectodomain then migrates across the synaptic cleft and binds to and activates a member of the EGF-receptor family on the postsynaptic membrane. This has been shown to increase the expression of certain glutamate-receptor subunits. NRG1 appears to signal for glutamate-receptor subunit expression, localisation, and /or phosphorylation facilitating subsequent glutamate transmission. The NRG1 gene has been identified as a potential gene determining susceptibility to schizophrenia by a combination of genetic linkage and association approaches [].
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Publication
9362461 | J:45302
First Author: Erickson SL
Year: 1997
Journal: Development
Title: ErbB3 is required for normal cerebellar and cardiac development: a comparison with ErbB2-and heregulin-deficient mice.
Volume: 124
Issue: 24
Pages: 4999-5011
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Publication
10521398 | J:58105
First Author: Woldeyesus MT
Year: 1999
Journal: Genes Dev
Title: Peripheral nervous system defects in erbB2 mutants following genetic rescue of heart development.
Volume: 13
Issue: 19
Pages: 2538-48
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Publication
33320083 | J:299110
   
First Author: Exposito-Alonso D
Year: 2020
Journal: Elife
Title: Subcellular sorting of neuregulins controls the assembly of excitatory-inhibitory cortical circuits.
Volume: 9
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Strain
MGI:4439276 | B6.Cg-Erbb4<tm1.1(cre/ERT2)Aibs>/J
Attribute String: congenic, mutant strain, targeted mutation
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Genotype
Genotype
Symbol: Erbb4/Erbb4<+>
Background: involves: C3H * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Protein Coding Gene
MGI:95294 | Egfr
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q01279
Organism: Mus musculus/domesticus
Length: 1210  
Fragment?: false
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Protein
P98083-3
Organism: Mus musculus/domesticus
Length: 424  
Fragment?: false
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Protein Coding Gene
MGP_CAROLIEiJ_G0029647 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0032156 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0032135 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0032071 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0032147 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0031863 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_3644563 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0032639 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0031191 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0031827 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0031985 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0031936 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0032063 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0031973 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0032655 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0030914 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0031308 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0012878 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0030751 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
36183038 | J:332462
First Author: Liang T
Year: 2022
Journal: Sci Rep
Title: Enamel defects in Acp4(R110C/R110C) mice and human ACP4 mutations.
Volume: 12
Issue: 1
Pages: 16477
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Publication
9804837 | -
First Author: Schroering A
Year: 1998
Journal: J Biol Chem
Title: Sensory and motor neuron-derived factor is a transmembrane heregulin that is expressed on the plasma membrane with the active domain exposed to the extracellular environment.
Volume: 273
Issue: 46
Pages: 30643-50
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Publication
9208852 | -
First Author: Burden S
Year: 1997
Journal: Neuron
Title: Neuregulins and their receptors: a versatile signaling module in organogenesis and oncogenesis.
Volume: 18
Issue: 6
Pages: 847-55
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Publication
9892702 | J:52282
First Author: Vartanian T
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: Failure of spinal cord oligodendrocyte development in mice lacking neuregulin.
Volume: 96
Issue: 2
Pages: 731-5
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Genotype
Genotype
Symbol: Erbb4/Erbb4<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129S6/SvEvTac * C57BL/6NCrl
Zygosity: cn
Has Mutant Allele: true
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Protein Coding Gene
MGI:97376 | Nras
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:96680 | Kras
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:96224 | Hras
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q61411
Organism: Mus musculus/domesticus
Length: 189  
Fragment?: false
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Protein
P32883
Organism: Mus musculus/domesticus
Length: 189  
Fragment?: false
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Protein
P08556
Organism: Mus musculus/domesticus
Length: 189  
Fragment?: false
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Publication
24870235 | J:211338
First Author: Karayannis T
Year: 2014
Journal: Nature
Title: Cntnap4 differentially contributes to GABAergic and dopaminergic synaptic transmission.
Volume: 511
Issue: 7508
Pages: 236-40
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Publication
15314180 | J:92790
First Author: Wu X
Year: 2004
Journal: Mol Cell Biol
Title: Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8.
Volume: 24
Issue: 17
Pages: 7748-57
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Publication
26926925 | J:259555
 
First Author: Buonfiglio DC
Year: 2016
Journal: Sci Rep
Title: Obesity impairs lactation performance in mice by inducing prolactin resistance.
Volume: 6
Pages: 22421
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Publication
19690388 | J:152703
First Author: Lee D
Year: 2009
Journal: J Clin Invest
Title: Tumor-specific apoptosis caused by deletion of the ERBB3 pseudo-kinase in mouse intestinal epithelium.
Volume: 119
Issue: 9
Pages: 2702-13
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Publication
26786778 | J:236128
First Author: Vandekerckhove L
Year: 2016
Journal: Am J Physiol Endocrinol Metab
Title: Neuregulin-1 attenuates development of nephropathy in a type 1 diabetes mouse model with high cardiovascular risk.
Volume: 310
Issue: 7
Pages: E495-504
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Publication
23999525 | J:270201
First Author: Turner JR
Year: 2014
Journal: Mol Psychiatry
Title: Evidence from mouse and man for a role of neuregulin 3 in nicotine dependence.
Volume: 19
Issue: 7
Pages: 801-10
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Publication
12072561 | J:77347
First Author: Ozcelik C
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy.
Volume: 99
Issue: 13
Pages: 8880-5
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Publication
16481445 | J:105749
First Author: Atanasoski S
Year: 2006
Journal: J Neurosci
Title: ErbB2 signaling in Schwann cells is mostly dispensable for maintenance of myelinated peripheral nerves and proliferation of adult Schwann cells after injury.
Volume: 26
Issue: 7
Pages: 2124-31
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Publication
15833803 | J:100313
First Author: Liu FF
Year: 2005
Journal: Am J Physiol Heart Circ Physiol
Title: Heterozygous knockout of neuregulin-1 gene in mice exacerbates doxorubicin-induced heart failure.
Volume: 289
Issue: 2
Pages: H660-6
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Publication
12951658 | J:104810
First Author: Schmucker J
Year: 2003
Journal: Glia
Title: erbB3 is dispensable for oligodendrocyte development in vitro and in vivo.
Volume: 44
Issue: 1
Pages: 67-75
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Publication
29191600 | J:278491
 
First Author: Liu J
Year: 2017
Journal: Lung Cancer
Title: Mig-6 deficiency cooperates with oncogenic Kras to promote mouse lung tumorigenesis.
Volume: 112
Pages: 47-56
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Publication
28322273 | J:301708
First Author: Yan L
Year: 2018
Journal: Mol Psychiatry
Title: Neuregulin-2 ablation results in dopamine dysregulation and severe behavioral phenotypes relevant to psychiatric disorders.
Volume: 23
Issue: 5
Pages: 1233-1243
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Publication
36175956 | J:334599
First Author: Ma Y
Year: 2022
Journal: Microbiome
Title: Estrogen receptor β deficiency impairs gut microbiota: a possible mechanism of IBD-induced anxiety-like behavior.
Volume: 10
Issue: 1
Pages: 160
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Publication
24586582 | J:213763
First Author: Sanz-Moreno A
Year: 2014
Journal: PLoS One
Title: Miz1 deficiency in the mammary gland causes a lactation defect by attenuated Stat5 expression and phosphorylation.
Volume: 9
Issue: 2
Pages: e89187
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Publication
32531902 | J:351234
 
First Author: Ang MJ
Year: 2020
Journal: Int J Mol Sci
Title: Transcriptome Profiling Reveals Novel Candidate Genes Related to Hippocampal Dysfunction in SREBP-1c Knockout Mice.
Volume: 21
Issue: 11
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Publication
29740596 | J:263284
 
First Author: Kotzadimitriou D
Year: 2018
Journal: eNeuro
Title: Neuregulin 1 Type I Overexpression Is Associated with Reduced NMDA Receptor-Mediated Synaptic Signaling in Hippocampal Interneurons Expressing PV or CCK.
Volume: 5
Issue: 2
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Publication
25713103 | J:224417
First Author: Hasegawa D
Year: 2015
Journal: Mol Cell Biol
Title: Epithelial Xbp1 is required for cellular proliferation and differentiation during mammary gland development.
Volume: 35
Issue: 9
Pages: 1543-56
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Publication
29463705 | J:260594
First Author: Wang YN
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Controlling of glutamate release by neuregulin3 via inhibiting the assembly of the SNARE complex.
Volume: 115
Issue: 10
Pages: 2508-2513
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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