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Search results 901 to 1000 out of 1271 for Fgfr4

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Type Details Score
Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Pathway
R-MMU-5654712 | FRS-mediated FGFR4 signaling
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Pathway
R-MMU-5654743 | Signaling by FGFR4
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Pathway
R-MMU-5654228 | Phospholipase C-mediated cascade; FGFR4
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Pathway
R-MMU-5654716 | Downstream signaling of activated FGFR4
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Pathway
R-MMU-5654733 | Negative regulation of FGFR4 signaling
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Pathway
R-MMU-190322 | FGFR4 ligand binding and activation
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Allele
Fgfr4<em1Smoc> | MGI:7289690
Name: fibroblast growth factor receptor 4; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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HT Experiment
E-GEOD-15452 | Expression data from lung of mice bearing mutations of FGFR3 and FGFR4
Series Id: GSE15452
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Strain
MGI:6428651 | C57BL/6JSmoc-Fgfr4<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Allele
Fgfr4<tm1Smoc> | MGI:7786858
Name: fibroblast growth factor receptor 4; targeted mutation 1, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Strain
MGI:7788689 | C57BL/6JSmoc-Fgfr4<tm1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, targeted mutation
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Allele
Fgfr4<M1Btlr> | MGI:6199491
Name: fibroblast growth factor receptor 4; mutation 1, Bruce Beutler
Allele Type: Chemically induced (ENU)
Attribute String: Not Specified
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Strain
MGI:6199496 | C57BL/6J-Fgfr4<M1Btlr>
Attribute String: mutant strain, chemically induced mutation, coisogenic
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Genotype
Genotype
Symbol: Fgfr4/Fgfr4
Background: C57BL/6J-Fgfr4
Zygosity: hm
Has Mutant Allele: true
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Publication
16875743 | J:116006
First Author: Armand AS
Year: 2006
Journal: Biochim Biophys Acta
Title: FGF6 in myogenesis.
Volume: 1763
Issue: 8
Pages: 773-8
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Protein
O35622
Organism: Mus musculus/domesticus
Length: 218  
Fragment?: false
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Protein Coding Gene
MGI:1345138 | Spry2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:894316 | Mknk1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
O08605
Organism: Mus musculus/domesticus
Length: 427  
Fragment?: false
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Protein
Q9QXV8
Organism: Mus musculus/domesticus
Length: 315  
Fragment?: false
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Protein
Q9ESL8
Organism: Mus musculus/domesticus
Length: 207  
Fragment?: false
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Protein
P21658
Organism: Mus musculus/domesticus
Length: 208  
Fragment?: false
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Publication
8428519 | J:3992
First Author: Keegan K
Year: 1993
Journal: Cytogenet Cell Genet
Title: The fibroblast growth factor receptor 3 gene (FGFR3) is assigned to human chromosome 4.
Volume: 62
Issue: 2-3
Pages: 172-5
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Protein
Q9EPC2
Organism: Mus musculus/domesticus
Length: 251  
Fragment?: false
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Protein
O89101
Organism: Mus musculus/domesticus
Length: 207  
Fragment?: false
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Protein
P11403
Organism: Mus musculus/domesticus
Length: 202  
Fragment?: false
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Protein
P15655
Organism: Mus musculus/domesticus
Length: 154  
Fragment?: false
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Protein
Q9ESL9
Organism: Mus musculus/domesticus
Length: 211  
Fragment?: false
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Protein
P63075
Organism: Mus musculus/domesticus
Length: 216  
Fragment?: false
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Protein
P61148
Organism: Mus musculus/domesticus
Length: 155  
Fragment?: false
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Protein
P37237
Organism: Mus musculus/domesticus
Length: 268  
Fragment?: false
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Protein
Q03142
Organism: Mus musculus/domesticus
Length: 799  
Fragment?: false
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Protein
P54130
Organism: Mus musculus/domesticus
Length: 208  
Fragment?: false
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Publication
1398143 | J:60851
First Author: Horlick RA
Year: 1992
Journal: Gene
Title: Cloning, expression and tissue distribution of the gene encoding rat fibroblast growth factor receptor subtype 4.
Volume: 120
Issue: 2
Pages: 291-5
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Protein Coding Gene
MGI:2135965 | Frs3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1932466 | Klb
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:88190 | Braf
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1096383 | Fgf15
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P28028
Organism: Mus musculus/domesticus
Length: 751  
Fragment?: false
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Protein
Q91WJ0
Organism: Mus musculus/domesticus
Length: 492  
Fragment?: false
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Protein
Q99N32
Organism: Mus musculus/domesticus
Length: 1043  
Fragment?: false
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Publication
8199350 | J:19588
First Author: Coulier F
Year: 1994
Journal: Prog Growth Factor Res
Title: The human and mouse fibroblast growth factor 6 (FGF6) genes and their products: possible implication in muscle development.
Volume: 5
Issue: 1
Pages: 1-14
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Publication
23243496 | J:206773
 
First Author: Boshnjaku V
Year: 2012
Journal: Sci Rep
Title: Nuclear localization of folate receptor alpha: a new role as a transcription factor.
Volume: 2
Pages: 980
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Publication
30745141 | J:272595
First Author: Ji S
Year: 2019
Journal: Dev Cell
Title: FGF15 Activates Hippo Signaling to Suppress Bile Acid Metabolism and Liver Tumorigenesis.
Volume: 48
Issue: 4
Pages: 460-474.e9
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Protein Coding Gene
MGI:108088 | Gab1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:88279 | Cbl
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P22682
Organism: Mus musculus/domesticus
Length: 913  
Fragment?: false
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Protein
Q9QYY0
Organism: Mus musculus/domesticus
Length: 695  
Fragment?: false
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Publication
15672378 | -
First Author: Armand AS
Year: 2005
Journal: J Cell Physiol
Title: FGF6 regulates muscle differentiation through a calcineurin-dependent pathway in regenerating soleus of adult mice.
Volume: 204
Issue: 1
Pages: 297-308
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Publication
20458746 | -
First Author: Bosetti M
Year: 2010
Journal: J Cell Physiol
Title: Regulation of osteoblast and osteoclast functions by FGF-6.
Volume: 225
Issue: 2
Pages: 466-71
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Publication
7687739 | -
First Author: Yan G
Year: 1993
Journal: Mol Cell Biol
Title: Exon switching and activation of stromal and embryonic fibroblast growth factor (FGF)-FGF receptor genes in prostate epithelial cells accompany stromal independence and malignancy.
Volume: 13
Issue: 8
Pages: 4513-22
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Publication
7768185 | J:23136
First Author: Crossley PH
Year: 1995
Journal: Development
Title: The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo.
Volume: 121
Issue: 2
Pages: 439-51
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Publication
22273727 | -
First Author: Liu SB
Year: 2012
Journal: Toxicology
Title: The role of androgen-induced growth factor (FGF8) on genital tubercle development in a hypospadiac male rat model of prenatal exposure to di-n-butyl phthalate.
Volume: 293
Issue: 1-3
Pages: 53-8
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Publication
11420691 | -
First Author: Mattila MM
Year: 2001
Journal: Oncogene
Title: FGF-8b increases angiogenic capacity and tumor growth of androgen-regulated S115 breast cancer cells.
Volume: 20
Issue: 22
Pages: 2791-804
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Publication
9332670 | J:43312
First Author: Yoshiura K
Year: 1997
Journal: Am J Med Genet
Title: Genomic structure, sequence, and mapping of human FGF8 with no evidence for its role in craniosynostosis/limb defect syndromes.
Volume: 72
Issue: 3
Pages: 354-62
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Publication
10766846 | -
First Author: Konishi M
Year: 2000
Journal: J Biol Chem
Title: Fibroblast growth factor-16 is a growth factor for embryonic brown adipocytes.
Volume: 275
Issue: 16
Pages: 12119-22
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Protein Domain
IPR028285 | FGF16
Type: Family
Description: Fibroblast growth factors (FGFs) [, ]are a family of multifunctional proteins, often referred to as 'promiscuous growth factors' due to their diverse actions on multiple cell types [, ]. FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The function of FGFs in developmental processes include mesoderm induction, anterior-posterior patterning, limb development, and neural induction and development. In mature tissues, they are involved in diverse processes including keratinocyte organisation and wound healing [, , , , , ]. FGF involvement is critical during normal development of both vertebrates and invertebrates, and irregularities in their function leads to a range of developmental defects [, , , ]. Fibroblast growth factors are heparin-binding proteins and interactions with cell-surface-associated heparan sulfate proteoglycans have been shown to be essential for FGF signal transduction. FGFs have internal pseudo-threefold symmetry (β-trefoil topology) []. There are currently over 20 different FGF family members that have been identified in mammals, all of which are structurally related signaling molecules [, ]. They exert their effects through four distinct membrane fibroblast growth factor receptors (FGFRs), FGFR1 to FGFR4 [], which belong to the tyrosine kinase superfamily. Upon binding to FGF, the receptors dimerize and their intracellular tyrosine kinase domains become active [].This entry represents fibroblast growth factor 16 (FGF16). The protein plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation, and is required for normal cardiomyocyte proliferation and heart development []. In rat embryos, FGF16 is detected predominantly in brown adipose tissue, where it shows significant mitogenic activity for primary brown adipocytes, mediated by activation of FGFR4 [].
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Protein Domain
IPR028242 | FGF6
Type: Family
Description: Fibroblast growth factors (FGFs) [, ]are a family of multifunctional proteins, often referred to as 'promiscuous growth factors' due to their diverse actions on multiple cell types [, ]. FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The function of FGFs in developmental processes include mesoderm induction, anterior-posterior patterning, limb development, and neural induction and development. In mature tissues, they are involved in diverse processes including keratinocyte organisation and wound healing [, , , , , ]. FGF involvement is critical during normal development of both vertebrates and invertebrates, and irregularities in their function leads to a range of developmental defects [, , , ]. Fibroblast growth factors are heparin-binding proteins and interactions with cell-surface-associated heparan sulfate proteoglycans have been shown to be essential for FGF signal transduction. FGFs have internal pseudo-threefold symmetry (β-trefoil topology) []. There are currently over 20 different FGF family members that have been identified in mammals, all of which are structurally related signaling molecules [, ]. They exert their effects through four distinct membrane fibroblast growth factor receptors (FGFRs), FGFR1 to FGFR4 [], which belong to the tyrosine kinase superfamily. Upon binding to FGF, the receptors dimerize and their intracellular tyrosine kinase domains become active [].This entry represents fibroblast growth factor 6 (FGF6). This protein plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis, and is required for normal muscle regeneration [, , ]. It may also regulate bone metabolism, as shown by its activity on both osteoblasts and osteoclasts []. FGF6 has a high affinity for FGFR1, FGFR2 and FGFR4 [].
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Protein Domain
IPR028249 | FGF8
Type: Family
Description: Fibroblast growth factors (FGFs) [, ]are a family of multifunctional proteins, often referred to as 'promiscuous growth factors' due to their diverse actions on multiple cell types [, ]. FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The function of FGFs in developmental processes include mesoderm induction, anterior-posterior patterning, limb development, and neural induction and development. In mature tissues, they are involved in diverse processes including keratinocyte organisation and wound healing [, , , , , ]. FGF involvement is critical during normal development of both vertebrates and invertebrates, and irregularities in their function leads to a range of developmental defects [, , , ]. Fibroblast growth factors are heparin-binding proteins and interactions with cell-surface-associated heparan sulfate proteoglycans have been shown to be essential for FGF signal transduction. FGFs have internal pseudo-threefold symmetry (β-trefoil topology) []. There are currently over 20 different FGF family members that have been identified in mammals, all of which are structurally related signaling molecules [, ]. They exert their effects through four distinct membrane fibroblast growth factor receptors (FGFRs), FGFR1 to FGFR4 [], which belong to the tyrosine kinase superfamily. Upon binding to FGF, the receptors dimerize and their intracellular tyrosine kinase domains become active [].This entry represents fibroblast growth factor 8 (FGF8), also known as androgen-induced growth factor. It plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. FGF8 is also required for normal brain, eye, ear and limb development during embryogenesis, and is required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system [, , , , ]. Fibroblast growth factor 8 also supports androgen and anchorage independent growth of mammary tumor cells []. FGF8 has an affinity for the all the growth factor receptors, but has the highest affinity with FGFR3 and FGFR4 [, ].This entry also includes the orthologous Fibroblast growth factor 8b from zebrafish.
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Publication
19100251 | J:145168
First Author: Dude CM
Year: 2009
Journal: Dev Biol
Title: Activation of Pax3 target genes is necessary but not sufficient for neurogenesis in the ophthalmic trigeminal placode.
Volume: 326
Issue: 2
Pages: 314-26
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Publication
26138642 | J:232527
First Author: McGowan SE
Year: 2015
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Fibroblast growth factor signaling in myofibroblasts differs from lipofibroblasts during alveolar septation in mice.
Volume: 309
Issue: 5
Pages: L463-74
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Publication
30809795 | J:353145
First Author: Hultman K
Year: 2019
Journal: J Comp Neurol
Title: The central fibroblast growth factor receptor/beta klotho system: Comprehensive mapping in Mus musculus and comparisons to nonhuman primate and human samples using an automated in situ hybridization platform.
Volume: 527
Issue: 12
Pages: 2069-2085
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Publication
29735309 | J:264682
First Author: Pastor-Arroyo EM
Year: 2018
Journal: Kidney Int
Title: The elevation of circulating fibroblast growth factor 23 without kidney disease does not increase cardiovascular disease risk.
Volume: 94
Issue: 1
Pages: 49-59
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Publication
8432397 | J:3825
First Author: Peters K
Year: 1993
Journal: Dev Biol
Title: Unique expression pattern of the FGF receptor 3 gene during mouse organogenesis.
Volume: 155
Issue: 2
Pages: 423-30
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Publication
8375495 | J:14511
First Author: Avivi A
Year: 1993
Journal: FEBS Lett
Title: A novel form of FGF receptor-3 using an alternative exon in the immunoglobulin domain III.
Volume: 330
Issue: 3
Pages: 249-52
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Publication
7896824 | J:23914
First Author: Mathieu M
Year: 1995
Journal: J Biol Chem
Title: Fibroblast growth factor (FGF) 3 from Xenopus laevis (XFGF3) binds with high affinity to FGF receptor 2.
Volume: 270
Issue: 12
Pages: 6779-87
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Publication
7563129 | J:28780
First Author: Rousset D
Year: 1995
Journal: J Mol Evol
Title: Molecular evolution of the genes encoding receptor tyrosine kinase with immunoglobulinlike domains.
Volume: 41
Issue: 4
Pages: 421-9
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Publication
16452204 | J:106673
First Author: Huang X
Year: 2006
Journal: Cancer Res
Title: Ectopic activity of fibroblast growth factor receptor 1 in hepatocytes accelerates hepatocarcinogenesis by driving proliferation and vascular endothelial growth factor-induced angiogenesis.
Volume: 66
Issue: 3
Pages: 1481-90
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Publication
25346390 | J:221991
First Author: Uriarte I
Year: 2015
Journal: Int J Cancer
Title: Ileal FGF15 contributes to fibrosis-associated hepatocellular carcinoma development.
Volume: 136
Issue: 10
Pages: 2469-75
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Publication
29866768 | J:265785
First Author: Saucedo L
Year: 2018
Journal: Reproduction
Title: Involvement of fibroblast growth factor 2 (FGF2) and its receptors in the regulation of mouse sperm physiology.
Volume: 156
Issue: 2
Pages: 163-172
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Publication
36919699 | J:334070
 
First Author: Chia L
Year: 2023
Journal: J Clin Invest
Title: HMGA1 induces FGF19 to drive pancreatic carcinogenesis and stroma formation.
Volume: 133
Issue: 6
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Protein Coding Gene
MGI:1100860 | Frs2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1277980 | Fgf18
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:104723 | Fgf9
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1202401 | Fgf17
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:95515 | Fgf1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:99604 | Fgf8
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:97615 | Plcg1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:95516 | Fgf2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:95520 | Fgf6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1891427 | Fgf23
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:95518 | Fgf4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1891346 | Fgf20
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1931627 | Fgf16
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q8C180
Organism: Mus musculus/domesticus
Length: 508  
Fragment?: false
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Protein
P98083-3
Organism: Mus musculus/domesticus
Length: 424  
Fragment?: false
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Protein
Q62077
Organism: Mus musculus/domesticus
Length: 1302  
Fragment?: false
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Protein
A0A7U3L4H7
Organism: Mus musculus/domesticus
Length: 208  
Fragment?: false
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Protein
Q8C399
Organism: Mus musculus/domesticus
Length: 195  
Fragment?: true
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Protein
A0A7U3JW97
Organism: Mus musculus/domesticus
Length: 207  
Fragment?: false
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Protein
Q60757
Organism: Mus musculus/domesticus
Length: 159  
Fragment?: true
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Protein Coding Gene
MGI:97376 | Nras
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:99511 | Ptpn11
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:96680 | Kras
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:96224 | Hras
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q61411
Organism: Mus musculus/domesticus
Length: 189  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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Cambridge CB2 3EH, United Kingdom