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Search results 901 to 1000 out of 1180 for Flt3

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Hits by Pathway

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Hits by Strain

Type Details Score
Strain
MGI:6354781 | C57BL/6JSmoc-Flt3<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Publication
23548639 | -
First Author: Kazi JU
Year: 2013
Journal: Mol Oncol
Title: Suppressor of cytokine signaling 2 (SOCS2) associates with FLT3 and negatively regulates downstream signaling.
Volume: 7
Issue: 3
Pages: 693-703
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Protein Coding Gene
MGI:1201787 | Socs2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1924885 | Socs6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
O35717
Organism: Mus musculus/domesticus
Length: 198  
Fragment?: false
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Strain
MGI:6428655 | C57BL/6JSmoc-Flt3<em2(dre/ERT2)Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Publication
11090077 | -
First Author: Mizuki M
Year: 2000
Journal: Blood
Title: Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways.
Volume: 96
Issue: 12
Pages: 3907-14
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Publication
10080542 | -
First Author: Zhang S
Year: 1999
Journal: J Leukoc Biol
Title: Flt3 signaling involves tyrosyl-phosphorylation of SHP-2 and SHIP and their association with Grb2 and Shc in Baf3/Flt3 cells.
Volume: 65
Issue: 3
Pages: 372-80
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Publication
16684964 | -
First Author: Heiss E
Year: 2006
Journal: Blood
Title: Identification of Y589 and Y599 in the juxtamembrane domain of Flt3 as ligand-induced autophosphorylation sites involved in binding of Src family kinases and the protein tyrosine phosphatase SHP2.
Volume: 108
Issue: 5
Pages: 1542-50
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Publication
11891219 | J:76854
First Author: Pandey A
Year: 2002
Journal: J Biol Chem
Title: A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling.
Volume: 277
Issue: 21
Pages: 19131-8
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Publication
25301707 | J:220791
First Author: Cherpokova D
Year: 2015
Journal: Blood
Title: SLAP/SLAP2 prevent excessive platelet (hem)ITAM signaling in thrombosis and ischemic stroke in mice.
Volume: 125
Issue: 1
Pages: 185-94
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Publication
25446260 | -
First Author: Wybenga-Groot LE
Year: 2015
Journal: Cell Signal
Title: RTK SLAP down: the emerging role of Src-like adaptor protein as a key player in receptor tyrosine kinase signaling.
Volume: 27
Issue: 2
Pages: 267-74
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Protein Domain
IPR035052 | SLAP_SH2
Type: Domain
Description: This entry represents the SH2 domain found in SLAP/SLAP2.Src-like adapter proteins (SLAP and SLAP2) are involved in the regulation of immune cell surface expression and signaling. They negatively regulate T cell receptor signaling []and act as critical inhibitors of platelet (hem)ITAM signaling in the setting of arterial thrombosis and ischemic stroke []. They contain adjacent Src homology 3 (SH3) and Src homology 2 (SH2) domains. SLAP has been shown to regulate receptor tyrosine kinase (RTK) signaling []. It also binds to the receptor tyrosine kinase Flt3 and plays a role in signal transduction downstream of Flt3 []. SLAP2 acts as a negative regulator of FLT3 signaling [].
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Protein Domain
IPR035596 | SLAP_SH3
Type: Domain
Description: This entry represents the SH3 domain of SLAP. Src-like adapter proteins (SLAP and SLAP2) are involved in the regulation of immune cell surface expression and signaling. They negatively regulate T cell receptor signaling []and act as critical inhibitors of platelet (hem)ITAM signaling in the setting of arterial thrombosis and ischemic stroke []. They contain adjacent Src homology 3 (SH3) and Src homology 2 (SH2) domains. SLAP has been shown to regulate receptor tyrosine kinase (RTK) signaling []. It also binds to the receptor tyrosine kinase Flt3 and plays a role in signal transduction downstream of Flt3 []. SLAP2 acts as a negative regulator of FLT3 signaling [].
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Protein Domain
IPR035054 | SLAP2
Type: Family
Description: This entry represents Src-like-adapter 2 (SLAP2).Src-like adapter proteins (SLAP and SLAP2) are involved in the regulation of immune cell surface expression and signaling. They negatively regulate T cell receptor signaling []and act as critical inhibitors of platelet (hem)ITAM signaling in the setting of arterial thrombosis and ischemic stroke []. They contain adjacent Src homology 3 (SH3) and Src homology 2 (SH2) domains. SLAP has been shown to regulate receptor tyrosine kinase (RTK) signaling []. It also binds to the receptor tyrosine kinase Flt3 and plays a role in signal transduction downstream of Flt3 []. SLAP2 acts as a negative regulator of FLT3 signaling [].
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Protein Domain
IPR035055 | SLAP
Type: Family
Description: This entry represents SLAP.Src-like adapter proteins (SLAP and SLAP2) are involved in the regulation of immune cell surface expression and signaling. They negatively regulate T cell receptor signaling []and act as critical inhibitors of platelet (hem)ITAM signaling in the setting of arterial thrombosis and ischemic stroke []. They contain adjacent Src homology 3 (SH3) and Src homology 2 (SH2) domains. SLAP has been shown to regulate receptor tyrosine kinase (RTK) signaling []. It also binds to the receptor tyrosine kinase Flt3 and plays a role in signal transduction downstream of Flt3 []. SLAP2 acts as a negative regulator of FLT3 signaling [].
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HT Experiment
E-MTAB-11217 | Total RNA sequencing for Mus musculus bone marrow lymphoid committed cell populations
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: ArrayExpress
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Protein Coding Gene
MGI:103232 | Grb10
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:893598 | Sh2b3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q60760
Organism: Mus musculus/domesticus
Length: 621  
Fragment?: false
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Protein
O09039
Organism: Mus musculus/domesticus
Length: 548  
Fragment?: false
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Protein Coding Gene
MGI:87860 | Abl2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1333842 | Grap2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:104574 | Ptprj
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
O89100
Organism: Mus musculus/domesticus
Length: 322  
Fragment?: false
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Protein
Q64455
Organism: Mus musculus/domesticus
Length: 1238  
Fragment?: false
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Protein
Q4JIM5
Organism: Mus musculus/domesticus
Length: 1182  
Fragment?: false
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Allele
Tg(Flt3-cre)#Ccb | MGI:4462354
Name: transgene insertion, Conrad C Bleul
Allele Type: Transgenic
Attribute String: Recombinase
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Allele
Tg(Flt3-cre/ERT2)#Ccb | MGI:4462357
Name: transgene insertion, Conrad C Bleul
Allele Type: Transgenic
Attribute String: Inducible, Recombinase
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Strain
MGI:6423867 | B6(129X1)-Tg(Flt3-cre)#Ccb/Ieg
Attribute String: mutant strain, transgenic
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Publication
39021809 | J:351626
First Author: Carrier M
Year: 2024
Journal: iScience
Title: Bone marrow-derived myeloid cells transiently colonize the brain during postnatal development and interact with glutamatergic synapses.
Volume: 27
Issue: 7
Pages: 110037
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Publication
36064961 | J:344147
First Author: Iwanami N
Year: 2022
Journal: Commun Biol
Title: Clonal dynamics underlying the skewed CD4/CD8 ratio of mouse thymocytes revealed by TCR-independent barcoding.
Volume: 5
Issue: 1
Pages: 911
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Allele
Flt3<tm1.1(FLT3*)Rlvn> | MGI:7768128
Name: FMS-like tyrosine kinase 3; targeted mutation 1.1, Ross Levine
Allele Type: Targeted
Attribute String: Conditional ready, Humanized sequence, Inserted expressed sequence
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Publication
21030588 | -
First Author: Zadjali F
Year: 2011
Journal: J Biol Chem
Title: Structural basis for c-KIT inhibition by the suppressor of cytokine signaling 6 (SOCS6) ubiquitin ligase.
Volume: 286
Issue: 1
Pages: 480-90
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Publication
15561106 | J:94595
First Author: Continolo S
Year: 2005
Journal: Exp Cell Res
Title: The proto-oncogene Fgr regulates cell migration and this requires its plasma membrane localization.
Volume: 302
Issue: 2
Pages: 253-69
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Publication
21746961 | J:177211
First Author: Lee JH
Year: 2011
Journal: J Immunol
Title: The Src family kinase Fgr is critical for activation of mast cells and IgE-mediated anaphylaxis in mice.
Volume: 187
Issue: 4
Pages: 1807-15
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Protein
D3Z776
Organism: Mus musculus/domesticus
Length: 180  
Fragment?: true
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Protein
A0A494BA19
Organism: Mus musculus/domesticus
Length: 65  
Fragment?: true
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Publication
10066823 | -
First Author: Brunati AM
Year: 1999
Journal: J Biol Chem
Title: Molecular features underlying the sequential phosphorylation of HS1 protein and its association with c-Fgr protein-tyrosine kinase.
Volume: 274
Issue: 11
Pages: 7557-64
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Protein Domain
IPR028421 | SOCS6
Type: Family
Description: Suppressor of cytokine signaling (SOCS) family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. However, SOCS6 does not interact with cytokine signaling intermediate molecules or inhibit cytokine receptor signaling. SOCS6 can interact with c-KIT, a receptor tyrosine kinase that mediates the cellular response to stem cell factor (SCF). SOCS6 has ubiquitin ligase activity toward c-KIT and regulates c-KIT protein turnover in cells, suppressing c-KIT-dependent pathways []. SOCS6 negatively regulates receptor tyrosine kinase Flt3 activation, the downstream Erk signaling pathway, and cell proliferation [].
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Protein Domain
IPR035865 | SOCS6_SH2
Type: Domain
Description: Suppressor of cytokine signaling (SOCS) family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. However, SOCS6 does not interact with cytokine signaling intermediate molecules or inhibit cytokine receptor signaling. SOCS6 can interact with c-KIT, a receptor tyrosine kinase that mediates the cellular response to stem cell factor (SCF). SOCS6 has ubiquitin ligase activity toward c-KIT and regulates c-KIT protein turnover in cells, suppressing c-KIT-dependent pathways []. SOCS6 negatively regulates receptor tyrosine kinase Flt3 activation, the downstream Erk signaling pathway, and cell proliferation [].This entry represents the SH2 domain of SOCS6.
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Protein Domain
IPR035693 | Fgr_SH2
Type: Domain
Description: Tyrosine-protein kinase Fgr belongs to the SRC family of the Tyr protein kinases. It is a non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration [, , ]. It contains a protein kinase domain, an SH2 domain and an SH3 domain. Fgr interacts with tyrosine phosphorylated SYK, FLT3 and HCLS1 via its SH2 domain [].This entry represents the SH2 domain of Fgr.
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Protein Coding Gene
MGI:1890081 | Foxo3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1333854 | Gab2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:88537 | Csk
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:95560 | Flt3l
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P41241
Organism: Mus musculus/domesticus
Length: 450  
Fragment?: false
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Protein
Q9WVH4
Organism: Mus musculus/domesticus
Length: 672  
Fragment?: false
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Protein
Q9Z1S8
Organism: Mus musculus/domesticus
Length: 665  
Fragment?: false
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Flt3-cre)#Ccb/?
Background: involves: 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Publication
10679268 | J:64951
First Author: Masuhara M
Year: 2000
Journal: Biochem Biophys Res Commun
Title: Molecular cloning of murine STAP-1, the stem-cell-specific adaptor protein containing PH and SH2 domains.
Volume: 268
Issue: 3
Pages: 697-703
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Protein Domain
IPR037345 | SOCS6_SOCS
Type: Domain
Description: This entry represents the SOCS box domain of SOCS6.Suppressor of cytokine signaling (SOCS) family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. However, SOCS6 does not interact with cytokine signaling intermediate molecules or inhibit cytokine receptor signaling. SOCS6 can interact with c-KIT, a receptor tyrosine kinase that mediates the cellular response to stem cell factor (SCF). SOCS6 has ubiquitin ligase activity toward c-KIT and regulates c-KIT protein turnover in cells, suppressing c-KIT-dependent pathways []. SOCS6 negatively regulates receptor tyrosine kinase Flt3 activation, the downstream Erk signaling pathway, and cell proliferation [].The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions [, ].
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Protein Coding Gene
MGI:99515 | Syk
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:96756 | Lck
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:104565 | Cdkn1b
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:88279 | Cbl
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P46414
Organism: Mus musculus/domesticus
Length: 197  
Fragment?: false
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Protein
P22682
Organism: Mus musculus/domesticus
Length: 913  
Fragment?: false
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Protein
P48025
Organism: Mus musculus/domesticus
Length: 629  
Fragment?: false
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Protein
P06240
Organism: Mus musculus/domesticus
Length: 509  
Fragment?: false
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Publication
33440159 | J:304294
First Author: Daemen S
Year: 2021
Journal: Cell Rep
Title: Dynamic Shifts in the Composition of Resident and Recruited Macrophages Influence Tissue Remodeling in NASH.
Volume: 34
Issue: 2
Pages: 108626
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Allele
Tg(Pdx1-itTA)#Fto | MGI:5810712
Name: transgene insertion, Francois Tronche
Allele Type: Transgenic
Attribute String: Transactivator
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Strain
MGI:7768129 | C57BL/6-Flt3<tm1.1(FLT3*)Rlvn>/J
Attribute String: mutant strain, targeted mutation
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Flt3-cre/ERT2)#Ccb/?
Background: involves: 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Publication
10202929 | J:54135
First Author: Fernandez NC
Year: 1999
Journal: Nat Med
Title: Dendritic cells directly trigger NK cell functions: cross-talk relevant in innate anti-tumor immune responses in vivo.
Volume: 5
Issue: 4
Pages: 405-11
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Protein
A0A0R4J247
Organism: Mus musculus/domesticus
Length: 297  
Fragment?: false
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Protein
Q4FJX0
Organism: Mus musculus/domesticus
Length: 281  
Fragment?: false
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Publication
19903482 | J:155307
First Author: Baruzzi A
Year: 2010
Journal: FEBS Lett
Title: c-Abl and Src-family kinases cross-talk in regulation of myeloid cell migration.
Volume: 584
Issue: 1
Pages: 15-21
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Publication
37992684 | J:348905
First Author: Popescu B
Year: 2023
Journal: Cell Rep Med
Title: Allosteric SHP2 inhibition increases apoptotic dependency on BCL2 and synergizes with venetoclax in FLT3- and KIT-mutant AML.
Volume: 4
Issue: 11
Pages: 101290
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Publication
19062318 | J:142682
First Author: Birnberg T
Year: 2008
Journal: Immunity
Title: Lack of conventional dendritic cells is compatible with normal development and T cell homeostasis, but causes myeloid proliferative syndrome.
Volume: 29
Issue: 6
Pages: 986-97
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Publication
20585031 | J:162470
First Author: Fukuyama Y
Year: 2010
Journal: J Immunol
Title: Secretory-IgA antibodies play an important role in the immunity to Streptococcus pneumoniae.
Volume: 185
Issue: 3
Pages: 1755-62
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Publication
33086061 | J:304321
First Author: Gallizioli M
Year: 2020
Journal: Cell Rep
Title: Dendritic Cells and Microglia Have Non-redundant Functions in the Inflamed Brain with Protective Effects of Type 1 cDCs.
Volume: 33
Issue: 3
Pages: 108291
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Publication
14607906 | J:119213
First Author: Kawamura T
Year: 2003
Journal: J Immunol
Title: Differential roles for IL-15R alpha-chain in NK cell development and Ly-49 induction.
Volume: 171
Issue: 10
Pages: 5085-90
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Publication
29773641 | J:265333
First Author: Mitchell K
Year: 2018
Journal: J Exp Med
Title: IL1RAP potentiates multiple oncogenic signaling pathways in AML.
Volume: 215
Issue: 6
Pages: 1709-1727
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Publication
24145513 | J:207729
First Author: Chen YL
Year: 2013
Journal: J Exp Med
Title: A type I IFN-Flt3 ligand axis augments plasmacytoid dendritic cell development from common lymphoid progenitors.
Volume: 210
Issue: 12
Pages: 2515-22
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Publication
38118422 | J:348400
First Author: Régnier P
Year: 2023
Journal: Cell Rep Med
Title: FLT3L-dependent dendritic cells control tumor immunity by modulating Treg and NK cell homeostasis.
Volume: 4
Issue: 12
Pages: 101256
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Publication
16518393 | J:112613
First Author: Yoshida T
Year: 2006
Journal: Nat Immunol
Title: Early hematopoietic lineage restrictions directed by Ikaros.
Volume: 7
Issue: 4
Pages: 382-91
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Publication
21441929 | J:172071
First Author: Vassiliou GS
Year: 2011
Journal: Nat Genet
Title: Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice.
Volume: 43
Issue: 5
Pages: 470-5
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Publication
25135299 | J:218713
First Author: Anandasabapathy N
Year: 2014
Journal: J Exp Med
Title: Classical Flt3L-dependent dendritic cells control immunity to protein vaccine.
Volume: 211
Issue: 9
Pages: 1875-91
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Publication
26365512 | J:239223
First Author: Zhang J
Year: 2015
Journal: Stem Cell Reports
Title: The Phosphatases STS1 and STS2 Regulate Hematopoietic Stem and Progenitor Cell Fitness.
Volume: 5
Issue: 4
Pages: 633-46
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Publication
29925006 | J:271629
First Author: Kirkling ME
Year: 2018
Journal: Cell Rep
Title: Notch Signaling Facilitates In Vitro Generation of Cross-Presenting Classical Dendritic Cells.
Volume: 23
Issue: 12
Pages: 3658-3672.e6
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Publication
33862015 | J:305836
     
First Author: Tian L
Year: 2021
Journal: Immunity
Title: Clonal multi-omics reveals Bcor as a negative regulator of emergency dendritic cell development.
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Publication
22110249 | J:181788
First Author: Singh P
Year: 2012
Journal: Blood
Title: Blockade of prostaglandin E2 signaling through EP1 and EP3 receptors attenuates Flt3L-dependent dendritic cell development from hematopoietic progenitor cells.
Volume: 119
Issue: 7
Pages: 1671-82
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Publication
28213513 | J:241527
First Author: Behrens K
Year: 2017
Journal: J Exp Med
Title: RUNX1 cooperates with FLT3-ITD to induce leukemia.
Volume: 214
Issue: 3
Pages: 737-752
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Publication
18566322 | J:138720
First Author: Slape C
Year: 2008
Journal: Blood
Title: Leukemic transformation in mice expressing a NUP98-HOXD13 transgene is accompanied by spontaneous mutations in Nras, Kras, and Cbl.
Volume: 112
Issue: 5
Pages: 2017-9
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Publication
21474667 | J:174717
First Author: Kashiwada M
Year: 2011
Journal: Blood
Title: NFIL3/E4BP4 is a key transcription factor for CD8α⁺ dendritic cell development.
Volume: 117
Issue: 23
Pages: 6193-7
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Publication
9551906 | J:45174
First Author: Salomon B
Year: 1998
Journal: J Immunol
Title: Three populations of mouse lymph node dendritic cells with different origins and dynamics.
Volume: 160
Issue: 2
Pages: 708-17
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Publication
12753741 | J:83470
First Author: Kim MY
Year: 2003
Journal: Immunity
Title: CD4(+)CD3(-) accessory cells costimulate primed CD4 T cells through OX40 and CD30 at sites where T cells collaborate with B cells.
Volume: 18
Issue: 5
Pages: 643-54
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Publication
17082601 | J:140488
First Author: Furtado GC
Year: 2006
Journal: J Immunol
Title: A novel model of demyelinating encephalomyelitis induced by monocytes and dendritic cells.
Volume: 177
Issue: 10
Pages: 6871-9
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Publication
19345670 | J:149596
First Author: Vu HA
Year: 2009
Journal: Biochem Biophys Res Commun
Title: The juxtamembrane domain in ETV6/FLT3 is critical for PIM-1 up-regulation and cell proliferation.
Volume: 383
Issue: 3
Pages: 308-13
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Publication
29062038 | J:256351
First Author: Marhäll A
Year: 2017
Journal: Sci Rep
Title: The Src family kinase LCK cooperates with oncogenic FLT3/ITD in cellular transformation.
Volume: 7
Issue: 1
Pages: 13734
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Publication
29720585 | J:262915
First Author: Hyrenius-Wittsten A
Year: 2018
Journal: Nat Commun
Title: De novo activating mutations drive clonal evolution and enhance clonal fitness in KMT2A-rearranged leukemia.
Volume: 9
Issue: 1
Pages: 1770
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Publication
37506694 | J:352782
First Author: Liu Z
Year: 2023
Journal: Immunity
Title: Dendritic cell type 3 arises from Ly6C(+) monocyte-dendritic cell progenitors.
Volume: 56
Issue: 8
Pages: 1761-1777.e6
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Publication
39178856 | J:361504
First Author: Alam MS
Year: 2024
Journal: Cell Rep Med
Title: TNFR1 signaling promotes pancreatic tumor growth by limiting dendritic cell number and function.
Volume: 5
Issue: 9
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