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Search results 901 to 1000 out of 1119 for Htt

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Categories

Hits by Pathway

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Hits by Strain

Type Details Score
Strain
MGI:4438745 | FVB-Tg(HTT*97Q)LXwy
Attribute String: coisogenic, mutant strain, transgenic
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Allele
Tg(Prnp-HTT*82Q)52Caro | MGI:5304797
Name: transgene insertion 52, Christopher A Ross
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(HTT*)NXwy | MGI:5635152
Name: transgene insertion N, X William Yang
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(HTT*)LXwy | MGI:5635155
Name: transgene insertion L, X William Yang
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(HTT*)AXwy | MGI:5635157
Name: transgene insertion A, X William Yang
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Strain
MGI:7442517 | B6.129S1-Htt<tm8(HTT*)Szi>/Mmjax
Attribute String: congenic, mutant strain, targeted mutation
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Genotype
Genotype
Symbol: Hm/Hm<+> Del(5D5Mit73-D5Mit351)5Jcs/?
Background: involves: 129S4/SvJae * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Htt/Htt
Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(HTT*97Q)LXwy/?
Background: FVB-Tg(HTT*97Q)LXwy
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(UBC-GFP/HTT*84Q)22Shya/?
Background: involves: FVB
Zygosity: ot
Has Mutant Allele: true
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Protein
P42859
Organism: Mus musculus/domesticus
Length: 3119  
Fragment?: false
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Protein
G3X9H5
Organism: Mus musculus/domesticus
Length: 3120  
Fragment?: false
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Publication
26642438 | J:233176
First Author: Dickey AS
Year: 2016
Journal: Nat Med
Title: PPAR-δ is repressed in Huntington's disease, is required for normal neuronal function and can be targeted therapeutically.
Volume: 22
Issue: 1
Pages: 37-45
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Publication
33310753 | J:301525
First Author: Caron NS
Year: 2021
Journal: J Neurosci
Title: Mutant Huntingtin Is Cleared from the Brain via Active Mechanisms in Huntington Disease.
Volume: 41
Issue: 4
Pages: 780-796
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Publication
11606546 | J:72166
First Author: Clark RM
Year: 2001
Journal: Genetics
Title: Reciprocal mouse and human limb phenotypes caused by gain- and loss-of-function mutations affecting Lmbr1.
Volume: 159
Issue: 2
Pages: 715-26
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Publication
17613541 | J:143144
First Author: Valenza M
Year: 2007
Journal: Hum Mol Genet
Title: Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by huntingtin mutation.
Volume: 16
Issue: 18
Pages: 2187-98
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Allele
Tg(HTT*97Q)IXwy | MGI:3800779
Name: transgene insertion I, X William Yang
Allele Type: Transgenic
Attribute String: Conditional ready, Humanized sequence, Inserted expressed sequence
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Publication
15695335 | J:96839
First Author: Tang TS
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Disturbed Ca2+ signaling and apoptosis of medium spiny neurons in Huntington's disease.
Volume: 102
Issue: 7
Pages: 2602-7
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Strain
MGI:5300536 | FVB-Tg(HTT*)BXwy/J
Attribute String: coisogenic, mutant strain, transgenic
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Strain
MGI:4438746 | FVB-Tg(HTT*)BXwy
Attribute String: transgenic, mutant strain, coisogenic
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Strain
MGI:4438747 | FVB-Tg(HTT*)1Xwy
Attribute String: coisogenic, mutant strain, transgenic
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Strain
MGI:5300535 | FVB-Tg(HTT*)1Xwy/J
Attribute String: transgenic, mutant strain, coisogenic
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Strain
MGI:5637320 | FVB/N-Tg(HTT*)NXwy/J
Attribute String: transgenic, mutant strain, coisogenic
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Strain
MGI:7576101 | B6.Cg-Htt<tm1(HTT*)Chdi> Htt<em1(HTT)Chdi>/J
Attribute String: congenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Lmbr1/Lmbr1<+> Del(5D5Mit73-D5Mit351)5Jcs/?
Background: mixed
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Htt/Htt
Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(HTT*)BXwy/?
Background: FVB-Tg(HTT*)BXwy
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(HTT*)1Xwy/?
Background: FVB-Tg(HTT*)1Xwy
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Htt/Htt Tg(YAC18)18Hay/?
Background: involves: FVB/N
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(HTT*)NXwy/?
Background: involves: FVB/NJ
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(HTT*)LXwy/?
Background: involves: FVB/NJ
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(HTT*)AXwy/?
Background: involves: FVB/NJ
Zygosity: ot
Has Mutant Allele: true
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Publication
31813995 | J:285797
First Author: Roberts SL
Year: 2020
Journal: Hum Mol Genet
Title: Bim contributes to the progression of Huntington's disease-associated phenotypes.
Volume: 29
Issue: 2
Pages: 216-227
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Publication
14625137 | J:102629
First Author: Holmes A
Year: 2003
Journal: Biol Psychiatry
Title: Abnormal behavioral phenotypes of serotonin transporter knockout mice: parallels with human anxiety and depression.
Volume: 54
Issue: 10
Pages: 953-9
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Publication
21775500 | J:175800
First Author: Singaraja RR
Year: 2011
Journal: Hum Mol Genet
Title: Altered palmitoylation and neuropathological deficits in mice lacking HIP14.
Volume: 20
Issue: 20
Pages: 3899-909
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Publication
32780989 | -
First Author: Zhu J
Year: 2020
Journal: Mol Cell
Title: GIT/PIX Condensates Are Modular and Ideal for Distinct Compartmentalized Cell Signaling.
Volume: 79
Issue: 5
Pages: 782-796.e6
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Publication
10461188 | -
First Author: Bagrodia S
Year: 1999
Journal: Trends Cell Biol
Title: Pak to the future.
Volume: 9
Issue: 9
Pages: 350-5
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Publication
12935897 | -
First Author: Flanders JA
Year: 2003
Journal: FEBS Lett
Title: The Cbl proteins are binding partners for the Cool/Pix family of p21-activated kinase-binding proteins.
Volume: 550
Issue: 1-3
Pages: 119-23
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Publication
11741931 | -
First Author: Feng Q
Year: 2002
Journal: J Biol Chem
Title: Regulation of the Cool/Pix proteins: key binding partners of the Cdc42/Rac targets, the p21-activated kinases.
Volume: 277
Issue: 7
Pages: 5644-50
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Publication
19969308 | -
First Author: Eriguchi M
Year: 2010
Journal: J Neurol Sci
Title: alpha Pix enhances mutant huntingtin aggregation.
Volume: 290
Issue: 1-2
Pages: 80-5
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Protein Domain
IPR046376 | PH_Cool_Pix
Type: Domain
Description: There are two forms of Pix proteins: alpha Pix (also called Rho guanine nucleotide exchange factor (GEF) 6, 90Cool-2 or ARHGEF6) and beta Pix (GEF7, p85Cool-1 or ARHGEF7), which activate small GTPases by exchanging bound GDP for free GTP. betaPix contains an N-terminal SH3 domain, a RhoGEF/DH domain, a PH domain, a GIT1 binding domain (GBD), and a C-terminal coiled-coil (CC) domain []. It acts as a GEF for both Cdc42 and Rac1 [], and plays important roles in regulating neuroendocrine exocytosis, focal adhesion maturation, cell migration, synaptic vesicle localization, and insulin secretion [, , , ]. alphaPix differs in that it contains a calponin homology (CH) domain, which interacts with beta-parvin, N-terminal to the SH3 domain. alphaPix is an exchange factor for Rac1 and Cdc42 and mediates Pak activation on cell adhesion to fibronectin. Mutations in alphaPix can cause X-linked mental retardation. alphaPix also interacts with Huntington's disease protein (htt), and enhances the aggregation of mutant htt (muthtt) by facilitating SDS-soluble muthtt-muthtt interactions. The DH-PH domain of a Pix was required for its binding to htt. In the majority of Rho GEF proteins, the DH-PH domain is responsible for the exchange activity [, , , , ].This entry represents the PH domain of ARHGEF6 and ARHGEF7.
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HT Experiment
GSE19289 | Most "dark matter" transcripts are associated with known genes
 
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: GEO
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Publication
16165367 | J:105728
First Author: Shehadeh J
Year: 2006
Journal: Neurobiol Dis
Title: Striatal neuronal apoptosis is preferentially enhanced by NMDA receptor activation in YAC transgenic mouse model of Huntington disease.
Volume: 21
Issue: 2
Pages: 392-403
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Strain
MGI:3801179 | FVB/N-Tg(HTT*97Q)IXwy/J
Attribute String: coisogenic, transgenic
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Strain
MGI:3801162 | FVB-Tg(HTT*97Q)IXwy
Attribute String: transgenic, coisogenic
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Publication
30028018 | J:266500
First Author: Doria JG
Year: 2018
Journal: J Neurochem
Title: The mGluR5 positive allosteric modulator VU0409551 improves synaptic plasticity and memory of a mouse model of Huntington's disease.
Volume: 147
Issue: 2
Pages: 222-239
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Publication
23123142 | J:197076
 
First Author: Abada YS
Year: 2013
Journal: Behav Brain Res
Title: Motor, emotional and cognitive deficits in adult BACHD mice: a model for Huntington's disease.
Volume: 238
Pages: 243-51
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Publication
25616965 | J:220865
First Author: Aharony I
Year: 2015
Journal: Hum Mol Genet
Title: A Huntingtin-based peptide inhibitor of caspase-6 provides protection from mutant Huntingtin-induced motor and behavioral deficits.
Volume: 24
Issue: 9
Pages: 2604-14
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Publication
30076831 | J:269451
 
First Author: Cheng S
Year: 2018
Journal: Exp Neurol
Title: Therapeutic efficacy of regulable GDNF expression for Huntington's and Parkinson's disease by a high-induction, background-free "GeneSwitch" vector.
Volume: 309
Pages: 79-90
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Publication
29212711 | J:253193
 
First Author: Dickey AS
Year: 2017
Journal: Sci Transl Med
Title: PPARδ activation by bexarotene promotes neuroprotection by restoring bioenergetic and quality control homeostasis.
Volume: 9
Issue: 419
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Publication
33906482 | J:347780
 
First Author: Olmo IG
Year: 2021
Journal: ASN Neuro
Title: High-Throughput Sequencing of BACHD Mice Reveals Upregulation of Neuroprotective miRNAs at the Pre-Symptomatic Stage of Huntington's Disease.
Volume: 13
Pages: 17590914211009857
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Publication
26871695 | J:254757
First Author: Kuljis DA
Year: 2016
Journal: PLoS One
Title: Sex Differences in Circadian Dysfunction in the BACHD Mouse Model of Huntington's Disease.
Volume: 11
Issue: 2
Pages: e0147583
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Publication
26908618 | J:233019
First Author: Mantovani S
Year: 2016
Journal: Hum Mol Genet
Title: Motor deficits associated with Huntington's disease occur in the absence of striatal degeneration in BACHD transgenic mice.
Volume: 25
Issue: 9
Pages: 1780-91
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Publication
38909878 | J:351005
 
First Author: Diaz Escarcega R
Year: 2024
Journal: Mol Cell Neurosci
Title: Sphingosine kinase 2 regulates protein ubiquitination networks in neurons.
Volume: 130
Pages: 103948
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Publication
36192390 | J:349950
First Author: Conroy F
Year: 2022
Journal: Nat Commun
Title: Chemical engineering of therapeutic siRNAs for allele-specific gene silencing in Huntington's disease models.
Volume: 13
Issue: 1
Pages: 5802
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Publication
33767215 | J:327806
First Author: Le Cann K
Year: 2021
Journal: Sci Rep
Title: The difficulty to model Huntington's disease in vitro using striatal medium spiny neurons differentiated from human induced pluripotent stem cells.
Volume: 11
Issue: 1
Pages: 6934
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Publication
23756199 | J:201703
 
First Author: Lee W
Year: 2013
Journal: Neurobiol Dis
Title: Enhanced Ca(2+)-dependent glutamate release from astrocytes of the BACHD Huntington's disease mouse model.
Volume: 58
Pages: 192-9
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Publication
26626081 | J:230901
 
First Author: Rocher AB
Year: 2016
Journal: Neurobiol Dis
Title: Synaptic scaling up in medium spiny neurons of aged BACHD mice: A slow-progression model of Huntington's disease.
Volume: 86
Pages: 131-9
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Publication
23697793 | J:199184
First Author: Hult Lundh S
Year: 2013
Journal: Hum Mol Genet
Title: Hypothalamic expression of mutant huntingtin contributes to the development of depressive-like behavior in the BAC transgenic mouse model of Huntington's disease.
Volume: 22
Issue: 17
Pages: 3485-97
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Publication
25740845 | J:221190
First Author: Mattis VB
Year: 2015
Journal: Hum Mol Genet
Title: HD iPSC-derived neural progenitors accumulate in culture and are susceptible to BDNF withdrawal due to glutamate toxicity.
Volume: 24
Issue: 11
Pages: 3257-71
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Publication
26807590 | J:251697
First Author: Schroeder AM
Year: 2016
Journal: PLoS One
Title: Cardiac Dysfunction in the BACHD Mouse Model of Huntington's Disease.
Volume: 11
Issue: 1
Pages: e0147269
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Publication
30802499 | J:281488
 
First Author: Radulescu CI
Year: 2019
Journal: Neurobiol Dis
Title: Manipulation of microbiota reveals altered callosal myelination and white matter plasticity in a model of Huntington disease.
Volume: 127
Pages: 65-75
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Publication
32422281 | J:299193
 
First Author: Gosset P
Year: 2020
Journal: Neurobiol Dis
Title: Evidence for the spread of human-derived mutant huntingtin protein in mice and non-human primates.
Volume: 141
Pages: 104941
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Publication
37090478 | J:348644
 
First Author: Duarte F
Year: 2023
Journal: Mol Ther Methods Clin Dev
Title: Semi-automated workflows to quantify AAV transduction in various brain areas and predict gene editing outcome for neurological disorders.
Volume: 29
Pages: 254-270
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Strain
MGI:7576749 | B6.129S1-Htt<tm8(HTT*)Szi> Htt<em3(HTT)Chdi>/J
Attribute String: congenic, endonuclease-mediated mutation, mutant strain, targeted mutation
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Genotype
Genotype
Symbol: Tg(HTT*97Q)IXwy/?
Background: FVB-Tg(HTT*97Q)IXwy
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Htt/Htt Tg(HTT*)1Xwy/?
Background: involves: 129S/SvEv * FVB
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Htt/Htt Tg(HTT*)BXwy/?
Background: involves: 129S/SvEv * FVB
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Prnp-HTT*82Q)52Caro/?
Background: involves: C3H * C57BL/6
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Htt/Htt Tg(CAG-cre/Esr1*)5Amc/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * Swiss Webster
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Htt/Htt<+> Tyrobp/Tyrobp
Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Publication
16472649 | -
 
First Author: Baird D
Year: 2006
Journal: Methods Enzymol
Title: Biochemical characterization of the Cool (Cloned-out-of-Library)/Pix (Pak-interactive exchange factor) proteins.
Volume: 406
Pages: 58-69
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Publication
27206983 | J:237150
First Author: Kim SH
Year: 2016
Journal: Hum Mol Genet
Title: Allele-specific regulation of mutant Huntingtin by Wig1, a downstream target of p53.
Volume: 25
Issue: 12
Pages: 2514-2524
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Publication
35146388 | J:322625
First Author: Soylu-Kucharz R
Year: 2022
Journal: iScience
Title: IKKβ signaling mediates metabolic changes in the hypothalamus of a Huntington disease mouse model.
Volume: 25
Issue: 2
Pages: 103771
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Publication
18211820 | J:132665
First Author: Ichikawa M
Year: 2008
Journal: Biochem Biophys Res Commun
Title: Expression analysis for inverted effects of serotonin transporter inactivation.
Volume: 368
Issue: 1
Pages: 43-9
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Publication
35044815 | J:355728
First Author: Powell JE
Year: 2022
Journal: Sci Adv
Title: Targeted gene silencing in the nervous system with CRISPR-Cas13.
Volume: 8
Issue: 3
Pages: eabk2485
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Publication
25038828 | J:232467
First Author: Fernández-Nogales M
Year: 2014
Journal: Nat Med
Title: Huntington's disease is a four-repeat tauopathy with tau nuclear rods.
Volume: 20
Issue: 8
Pages: 881-5
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Publication
29902468 | J:268498
 
First Author: Liu SY
Year: 2018
Journal: Brain Res
Title: Intravenous immunoglobulin ameliorates motor and cognitive deficits and neuropathology in R6/2 mouse model of Huntington's disease by decreasing mutant huntingtin protein level and normalizing NF-κB signaling pathway.
Volume: 1697
Pages: 21-33
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Publication
23275441 | J:316809
First Author: Lin JT
Year: 2013
Journal: Mol Cell Biol
Title: Regulation of feedback between protein kinase A and the proteasome system worsens Huntington's disease.
Volume: 33
Issue: 5
Pages: 1073-84
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Publication
29382760 | J:259830
First Author: Dargaei Z
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Restoring GABAergic inhibition rescues memory deficits in a Huntington's disease mouse model.
Volume: 115
Issue: 7
Pages: E1618-E1626
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Publication
32060489 | J:316242
First Author: Nakamori M
Year: 2020
Journal: Nat Genet
Title: A slipped-CAG DNA-binding small molecule induces trinucleotide-repeat contractions in vivo.
Volume: 52
Issue: 2
Pages: 146-159
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Publication
19591939 | J:155029
First Author: Li M
Year: 2009
Journal: Neurobiol Dis
Title: Y-27632 improves rotarod performance and reduces huntingtin levels in R6/2 mice.
Volume: 36
Issue: 3
Pages: 413-20
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Publication
27146268 | J:239573
First Author: Ochaba J
Year: 2016
Journal: Neuron
Title: PIAS1 Regulates Mutant Huntingtin Accumulation and Huntington's Disease-Associated Phenotypes In Vivo.
Volume: 90
Issue: 3
Pages: 507-20
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Publication
37407555 | J:354247
First Author: Ferlazzo GM
Year: 2023
Journal: Nat Commun
Title: Genome-wide screening in pluripotent cells identifies Mtf1 as a suppressor of mutant huntingtin toxicity.
Volume: 14
Issue: 1
Pages: 3962
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Publication
20670829 | J:167868
First Author: Miller JP
Year: 2010
Journal: Neuron
Title: Matrix metalloproteinases are modifiers of huntingtin proteolysis and toxicity in Huntington's disease.
Volume: 67
Issue: 2
Pages: 199-212
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Publication
20147317 | J:158714
First Author: Crittenden JR
Year: 2010
Journal: Hum Mol Genet
Title: CalDAG-GEFI down-regulation in the striatum as a neuroprotective change in Huntington's disease.
Volume: 19
Issue: 9
Pages: 1756-65
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Publication
15837560 | J:116299
First Author: Miller TW
Year: 2005
Journal: Neurobiol Dis
Title: A human single-chain Fv intrabody preferentially targets amino-terminal Huntingtin's fragments in striatal models of Huntington's disease.
Volume: 19
Issue: 1-2
Pages: 47-56
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Publication
24836077 | J:212904
First Author: Yano H
Year: 2014
Journal: Nat Neurosci
Title: Inhibition of mitochondrial protein import by mutant huntingtin.
Volume: 17
Issue: 6
Pages: 822-31
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Publication
15911879 | J:99654
First Author: Luo S
Year: 2005
Journal: J Cell Biol
Title: Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity.
Volume: 169
Issue: 4
Pages: 647-56
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Publication
22786682 | J:186693
First Author: Tsunemi T
Year: 2012
Journal: Sci Transl Med
Title: PGC-1α rescues Huntington's disease proteotoxicity by preventing oxidative stress and promoting TFEB function.
Volume: 4
Issue: 142
Pages: 142ra97
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Publication
17276692 | J:119003
First Author: Van Raamsdonk JM
Year: 2007
Journal: Neurobiol Dis
Title: Phenotypic abnormalities in the YAC128 mouse model of Huntington disease are penetrant on multiple genetic backgrounds and modulated by strain.
Volume: 26
Issue: 1
Pages: 189-200
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Publication
32814053 | J:296126
First Author: Haenig C
Year: 2020
Journal: Cell Rep
Title: Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Volume: 32
Issue: 7
Pages: 108050
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Publication
6202816 | J:7457
First Author: Klyczek KK
Year: 1984
Journal: J Exp Med
Title: T cell surface I-J glycoprotein. Concerted action of chromosome-4 and -17 genes forms an epitope dependent on alpha-D-mannosyl residues.
Volume: 159
Issue: 6
Pages: 1604-17
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Publication
9459551 | J:45104
First Author: Bengel D
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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