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Search results 901 to 1000 out of 2139 for Lck

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Type Details Score
Genotype
Symbol: Tg(Lck-Tax)53Hall/?
Background: involves: C57BL/6
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Vdac2/Vdac2 Bax/Bax Tg(Lck-cre)1Cwi/?
Background: involves: 129X1/SvJ * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Nmt1/Nmt1 Tg(Lck-cre)1Cwi/?
Background: involves: C57BL/6 * DBA/2 * SJL
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Nmt2/Nmt2 Tg(Lck-cre)1Cwi/?
Background: involves: C57BL/6 * DBA/2 * SJL
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Prkd2/Prkd2 Tg(Lck-cre)1Jtak/?
Background: involves: 129 * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Ppp2r2d/Ppp2r2d Tg(Lck-icre)3779Nik/?
Background: involves: C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Hdac3/Hdac3 Tg(Lck-cre)548Jxm/?
Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
Protein
Organism: Mus musculus/domesticus
Length: 364  
Fragment?: false
Publication
First Author: Swarthout JT
Year: 2005
Journal: J Biol Chem
Title: DHHC9 and GCP16 constitute a human protein fatty acyltransferase with specificity for H- and N-Ras.
Volume: 280
Issue: 35
Pages: 31141-8
Publication
First Author: Kelly AP
Year: 2007
Journal: EMBO J
Title: Notch-induced T cell development requires phosphoinositide-dependent kinase 1.
Volume: 26
Issue: 14
Pages: 3441-50
Publication
First Author: Peng S
Year: 2007
Journal: Eur J Immunol
Title: c-Maf interacts with c-Myb to down-regulate Bcl-2 expression and increase apoptosis in peripheral CD4 cells.
Volume: 37
Issue: 10
Pages: 2868-80
Publication
First Author: Brewer JA
Year: 2003
Journal: Nat Med
Title: T-cell glucocorticoid receptor is required to suppress COX-2-mediated lethal immune activation.
Volume: 9
Issue: 10
Pages: 1318-22
Publication
First Author: Ichii H
Year: 2002
Journal: Nat Immunol
Title: Role for Bcl-6 in the generation and maintenance of memory CD8+ T cells.
Volume: 3
Issue: 6
Pages: 558-63
Publication
First Author: Rajpal A
Year: 2003
Journal: EMBO J
Title: Transcriptional activation of known and novel apoptotic pathways by Nur77 orphan steroid receptor.
Volume: 22
Issue: 24
Pages: 6526-36
Publication
First Author: Heideman MR
Year: 2013
Journal: Blood
Title: Dosage-dependent tumor suppression by histone deacetylases 1 and 2 through regulation of c-Myc collaborating genes and p53 function.
Volume: 121
Issue: 11
Pages: 2038-50
Publication  
First Author: Choi SH
Year: 2022
Journal: Front Immunol
Title: Smad4-deficient T cells promote colitis-associated colon cancer via an IFN-γ-dependent suppression of 15-hydroxyprostaglandin dehydrogenase.
Volume: 13
Pages: 932412
Publication  
First Author: Chinen T
Year: 2011
Journal: Nat Commun
Title: Prostaglandin E2 and SOCS1 have a role in intestinal immune tolerance.
Volume: 2
Pages: 190
Publication
First Author: Liu Y
Year: 2008
Journal: Nat Immunol
Title: A critical function for TGF-beta signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells.
Volume: 9
Issue: 6
Pages: 632-40
Publication
First Author: Li H
Year: 2018
Journal: Pathol Res Pract
Title: TL1A blocking ameliorates intestinal fibrosis in the T cell transfer model of chronic colitis in mice.
Volume: 214
Issue: 2
Pages: 217-227
Publication
First Author: Carey KT
Year: 2013
Journal: Endocrinology
Title: Nfil3 is a glucocorticoid-regulated gene required for glucocorticoid-induced apoptosis in male murine T cells.
Volume: 154
Issue: 4
Pages: 1540-52
Publication
First Author: Perruche S
Year: 2009
Journal: J Immunol
Title: Lethal effect of CD3-specific antibody in mice deficient in TGF-beta1 by uncontrolled flu-like syndrome.
Volume: 183
Issue: 2
Pages: 953-61
Publication
First Author: Barker EC
Year: 2018
Journal: Carcinogenesis
Title: Potent suppression of both spontaneous and carcinogen-induced colitis-associated colorectal cancer in mice by dietary celastrol supplementation.
Volume: 39
Issue: 1
Pages: 36-46
Publication
First Author: Choi SH
Year: 2020
Journal: Oncoimmunology
Title: Loss of p27Kip1 leads to expansion of CD4+ effector memory T cells and accelerates colitis-associated colon cancer in mice with a T cell lineage restricted deletion of Smad4.
Volume: 9
Issue: 1
Pages: 1847832
Publication
First Author: Francia S
Year: 2006
Journal: Curr Biol
Title: Telomere and telomerase modulation by the mammalian Rad9/Rad1/Hus1 DNA-damage-checkpoint complex.
Volume: 16
Issue: 15
Pages: 1551-8
Publication
First Author: Chikuma S
Year: 2012
Journal: Nat Immunol
Title: TRIM28 prevents autoinflammatory T cell development in vivo.
Volume: 13
Issue: 6
Pages: 596-603
Publication
First Author: Carrillo-de Sauvage MÁ
Year: 2013
Journal: Cell Death Differ
Title: Potent and multiple regulatory actions of microglial glucocorticoid receptors during CNS inflammation.
Volume: 20
Issue: 11
Pages: 1546-57
Publication
First Author: Theiss-Suennemann J
Year: 2015
Journal: J Pathol
Title: Glucocorticoids attenuate acute graft-versus-host disease by suppressing the cytotoxic capacity of CD8(+) T cells.
Volume: 235
Issue: 4
Pages: 646-55
Publication  
First Author: Meyer-Heemsoth L
Year: 2023
Journal: Cells
Title: T Cell Energy Metabolism Is a Target of Glucocorticoids in Mice, Healthy Humans, and MS Patients.
Volume: 12
Issue: 3
Publication
First Author: Junt T
Year: 2006
Journal: Eur J Immunol
Title: Expression of lymphotoxin beta governs immunity at two distinct levels.
Volume: 36
Issue: 8
Pages: 2061-75
Publication
First Author: Li C
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: MeCP2 enforces Foxp3 expression to promote regulatory T cells' resilience to inflammation.
Volume: 111
Issue: 27
Pages: E2807-16
Publication
First Author: Xing Y
Year: 2008
Journal: Mol Immunol
Title: Protein phosphatase subunit G5PR that regulates the JNK-mediated apoptosis signal is essential for the survival of CD4 and CD8 double-positive thymocytes.
Volume: 45
Issue: 7
Pages: 2028-37
Publication
First Author: Asari S
Year: 2005
Journal: Exp Hematol
Title: Abnormal erythroid differentiation in neonatal bcl-6-deficient mice.
Volume: 33
Issue: 1
Pages: 26-34
Publication
First Author: Ichii H
Year: 2004
Journal: J Immunol
Title: Bcl6 acts as an amplifier for the generation and proliferative capacity of central memory CD8+ T cells.
Volume: 173
Issue: 2
Pages: 883-91
Strain
Attribute String: targeted mutation, transgenic, mutant strain
Strain
Attribute String: mutant strain, congenic, targeted mutation, transgenic
Publication
First Author: Matsui-Hasumi A
Year: 2017
Journal: Int Immunol
Title: E3 ubiquitin ligases SIAH1/2 regulate hypoxia-inducible factor-1 (HIF-1)-mediated Th17 cell differentiation.
Volume: 29
Issue: 3
Pages: 133-143
Publication
First Author: Burger ML
Year: 2014
Journal: Blood
Title: Premalignant PTEN-deficient thymocytes activate microRNAs miR-146a and miR-146b as a cellular defense against malignant transformation.
Volume: 123
Issue: 26
Pages: 4089-100
Publication
First Author: He MX
Year: 2013
Journal: Cell Death Differ
Title: A role for c-FLIP(L) in the regulation of apoptosis, autophagy, and necroptosis in T lymphocytes.
Volume: 20
Issue: 2
Pages: 188-97
Publication
First Author: Xue L
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice.
Volume: 105
Issue: 6
Pages: 2022-7
Publication
First Author: Cutler CE
Year: 2019
Journal: Glycobiology
Title: Cosmc is required for T cell persistence in the periphery.
Volume: 29
Issue: 11
Pages: 776-788
Publication
First Author: Wu Z
Year: 2023
Journal: Cell Rep
Title: Coupled deglycosylation-ubiquitination cascade in regulating PD-1 degradation by MDM2.
Volume: 42
Issue: 7
Pages: 112693
Publication  
First Author: Li W
Year: 2023
Journal: Front Immunol
Title: Paxbp1 is indispensable for the survival of CD4 and CD8 double-positive thymocytes.
Volume: 14
Pages: 1183367
Publication  
First Author: Jung J
Year: 2018
Journal: JCI Insight
Title: Calnexin is necessary for T cell transmigration into the central nervous system.
Volume: 3
Issue: 5
Publication
First Author: Wong GW
Year: 2012
Journal: Blood
Title: HES1 opposes a PTEN-dependent check on survival, differentiation, and proliferation of TCRβ-selected mouse thymocytes.
Volume: 120
Issue: 7
Pages: 1439-48
Publication
First Author: Wang Y
Year: 2017
Journal: Cell Rep
Title: The Lysine Acetyltransferase GCN5 Is Required for iNKT Cell Development through EGR2 Acetylation.
Volume: 20
Issue: 3
Pages: 600-612
Publication
First Author: Gustafsson KL
Year: 2018
Journal: J Endocrinol
Title: ERα expression in T lymphocytes is dispensable for estrogenic effects in bone.
Volume: 238
Issue: 2
Pages: 129-136
Publication
First Author: Bochenek ML
Year: 2020
Journal: Circ Res
Title: Activated Endothelial TGFβ1 Signaling Promotes Venous Thrombus Nonresolution in Mice Via Endothelin-1: Potential Role for Chronic Thromboembolic Pulmonary Hypertension.
Volume: 126
Issue: 2
Pages: 162-181
Publication
First Author: Wang Y
Year: 2022
Journal: Clin Cancer Res
Title: Cholesterol-Lowering Intervention Decreases mTOR Complex 2 Signaling and Enhances Antitumor Immunity.
Volume: 28
Issue: 2
Pages: 414-424
Publication
First Author: Salmena L
Year: 2005
Journal: J Exp Med
Title: Caspase-8 deficiency in T cells leads to a lethal lymphoinfiltrative immune disorder.
Volume: 202
Issue: 6
Pages: 727-32
Publication
First Author: Gilleron J
Year: 2018
Journal: Cell Rep
Title: Rab4b Deficiency in T Cells Promotes Adipose Treg/Th17 Imbalance, Adipose Tissue Dysfunction, and Insulin Resistance.
Volume: 25
Issue: 12
Pages: 3329-3341.e5
Publication
First Author: Park YJ
Year: 2014
Journal: Diabetologia
Title: The role of caspase-8 in amyloid-induced beta cell death in human and mouse islets.
Volume: 57
Issue: 4
Pages: 765-75
Publication
First Author: Huang X
Year: 2014
Journal: PLoS One
Title: Peroxisome proliferator-activated receptor γ deficiency in T cells accelerates chronic rejection by influencing the differentiation of CD4+ T cells and alternatively activated macrophages.
Volume: 9
Issue: 11
Pages: e112953
Publication
First Author: Zhang N
Year: 2008
Journal: J Immunol
Title: The long isoform of cellular FLIP is essential for T lymphocyte proliferation through an NF-kappaB-independent pathway.
Volume: 180
Issue: 8
Pages: 5506-11
Publication
First Author: Yi Z
Year: 2013
Journal: J Exp Med
Title: TNF receptor associated factor 3 plays a key role in development and function of invariant natural killer T cells.
Volume: 210
Issue: 6
Pages: 1079-86
Publication
First Author: Delfino DV
Year: 2011
Journal: Cell Death Differ
Title: Glucocorticoid-induced activation of caspase-8 protects the glucocorticoid-induced protein Gilz from proteasomal degradation and induces its binding to SUMO-1 in murine thymocytes.
Volume: 18
Issue: 1
Pages: 183-90
Publication
First Author: Liu HH
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Essential role of TAK1 in thymocyte development and activation.
Volume: 103
Issue: 31
Pages: 11677-82
Publication
First Author: Wiede F
Year: 2019
Journal: Diabetes
Title: T-Cell-Specific PTPN2 Deficiency in NOD Mice Accelerates the Development of Type 1 Diabetes and Autoimmune Comorbidities.
Volume: 68
Issue: 6
Pages: 1251-1266
Publication  
First Author: Niu K
Year: 2017
Journal: Sci Rep
Title: BAP31 is involved in T cell activation through TCR signal pathways.
Volume: 7
Pages: 44809
Publication
First Author: Hagenbeek TJ
Year: 2014
Journal: Cancer Lett
Title: Murine Pten(-/-) T-ALL requires non-redundant PI3K/mTOR and DLL4/Notch1 signals for maintenance and γc/TCR signals for thymic exit.
Volume: 346
Issue: 2
Pages: 237-48
Publication
First Author: Wang HY
Year: 2001
Journal: Mol Cell
Title: SC35 plays a role in T cell development and alternative splicing of CD45.
Volume: 7
Issue: 2
Pages: 331-42
Publication
First Author: Rosilio C
Year: 2015
Journal: Leukemia
Title: L-type amino-acid transporter 1 (LAT1): a therapeutic target supporting growth and survival of T-cell lymphoblastic lymphoma/T-cell acute lymphoblastic leukemia.
Volume: 29
Issue: 6
Pages: 1253-66
Publication
First Author: Tsagaratou A
Year: 2011
Journal: Eur J Immunol
Title: Differential requirement of IKK2 for CYLD-dependent representation of thymic and peripheral T-cell populations.
Volume: 41
Issue: 10
Pages: 3054-62
Publication
First Author: Rosilio C
Year: 2013
Journal: Cancer Lett
Title: The metabolic perturbators metformin, phenformin and AICAR interfere with the growth and survival of murine PTEN-deficient T cell lymphomas and human T-ALL/T-LL cancer cells.
Volume: 336
Issue: 1
Pages: 114-26
Publication
First Author: Miyazaki K
Year: 2010
Journal: J Immunol
Title: The role of the basic helix-loop-helix transcription factor Dec1 in the regulatory T cells.
Volume: 185
Issue: 12
Pages: 7330-9
Publication
First Author: Will WM
Year: 2006
Journal: J Immunol
Title: Attenuation of IL-7 receptor signaling is not required for allelic exclusion.
Volume: 176
Issue: 6
Pages: 3350-5
Publication
First Author: Ma C
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Transforming growth factor-β signaling is constantly shaping memory T-cell population.
Volume: 112
Issue: 35
Pages: 11013-7
Publication
First Author: Lin Y
Year: 2016
Journal: Ann Clin Lab Sci
Title: The Protective Effect of HIF-1α in T Lymphocytes on Cardiac Damage in Diabetic Mice.
Volume: 46
Issue: 1
Pages: 32-43
Publication
First Author: Heit JJ
Year: 2006
Journal: Nature
Title: Calcineurin/NFAT signalling regulates pancreatic beta-cell growth and function.
Volume: 443
Issue: 7109
Pages: 345-9
Strain
Attribute String: congenic, mutant strain, transgenic
Strain
Attribute String: mutant strain, transgenic
Publication
First Author: Sentman CL
Year: 1991
Journal: Cell
Title: bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes.
Volume: 67
Issue: 5
Pages: 879-88
Publication
First Author: Van de Wiele CJ
Year: 2007
Journal: Cell Immunol
Title: Impaired thymopoiesis in interleukin-7 receptor transgenic mice is not corrected by Bcl-2.
Volume: 250
Issue: 1-2
Pages: 31-9
Strain
Attribute String: congenic, mutant strain, transgenic
Publication
First Author: Hotchkiss RS
Year: 2006
Journal: J Immunol
Title: TAT-BH4 and TAT-Bcl-xL peptides protect against sepsis-induced lymphocyte apoptosis in vivo.
Volume: 176
Issue: 9
Pages: 5471-7
Publication
First Author: Ruggero D
Year: 2004
Journal: Nat Med
Title: The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis.
Volume: 10
Issue: 5
Pages: 484-6
Publication
First Author: Mack DL
Year: 2002
Journal: Immunology
Title: Down-regulation of the myeloid homeobox protein Hex is essential for normal T-cell development.
Volume: 107
Issue: 4
Pages: 444-51
Publication
First Author: Cekic C
Year: 2013
Journal: J Exp Med
Title: Extracellular adenosine regulates naive T cell development and peripheral maintenance.
Volume: 210
Issue: 12
Pages: 2693-706
Publication
First Author: Chen WT
Year: 2005
Journal: Mol Imaging
Title: Detection of dysplastic intestinal adenomas using a fluorescent folate imaging probe.
Volume: 4
Issue: 1
Pages: 67-74
Publication
First Author: Sun L
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: A mitotic recombination system for mouse chromosome 17.
Volume: 105
Issue: 11
Pages: 4237-41
Publication
First Author: Lyon de Ana C
Year: 2019
Journal: J Immunol
Title: Lack of Ikaros Deregulates Inflammatory Gene Programs in T Cells.
Volume: 202
Issue: 4
Pages: 1112-1123
Publication  
First Author: Dopkins N
Year: 2020
Journal: Front Pharmacol
Title: Tryptamine Attenuates Experimental Multiple Sclerosis Through Activation of Aryl Hydrocarbon Receptor.
Volume: 11
Pages: 619265
Publication
First Author: Hinton HJ
Year: 2004
Journal: Nat Immunol
Title: The serine kinase phosphoinositide-dependent kinase 1 (PDK1) regulates T cell development.
Volume: 5
Issue: 5
Pages: 539-45
Publication
First Author: Lu JV
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity.
Volume: 108
Issue: 37
Pages: 15312-7
Publication
First Author: Aronica MA
Year: 1999
Journal: J Immunol
Title: Preferential role for NF-kappa B/Rel signaling in the type 1 but not type 2 T cell-dependent immune response in vivo.
Volume: 163
Issue: 9
Pages: 5116-24
Strain
Attribute String: coisogenic, transgenic
Publication
First Author: Roderick JE
Year: 2014
Journal: Blood
Title: c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells.
Volume: 123
Issue: 7
Pages: 1040-50
Publication
First Author: Sidhu-Varma M
Year: 2016
Journal: Inflamm Bowel Dis
Title: Differential Levels of Tl1a Affect the Expansion and Function of Regulatory T Cells in Modulating Murine Colitis.
Volume: 22
Issue: 3
Pages: 548-59
Publication
First Author: Shinohara H
Year: 2009
Journal: Int Immunol
Title: Regulation of NF-kappaB-dependent T cell activation and development by MEKK3.
Volume: 21
Issue: 4
Pages: 393-401
Publication
First Author: Johnson K
Year: 2012
Journal: J Immunol
Title: IL-7 functionally segregates the pro-B cell stage by regulating transcription of recombination mediators across cell cycle.
Volume: 188
Issue: 12
Pages: 6084-92
Strain
Attribute String: transgenic, mutant strain
Publication
First Author: Lee K
Year: 2012
Journal: J Exp Med
Title: Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia.
Volume: 209
Issue: 4
Pages: 713-28
Publication
First Author: Mercadante ER
Year: 2017
Journal: J Immunol
Title: T Cells Deficient in the Tyrosine Phosphatase SHP-1 Resist Suppression by Regulatory T Cells.
Volume: 199
Issue: 1
Pages: 129-137
Publication
First Author: Stromnes IM
Year: 2012
Journal: J Immunol
Title: Abrogation of SRC homology region 2 domain-containing phosphatase 1 in tumor-specific T cells improves efficacy of adoptive immunotherapy by enhancing the effector function and accumulation of short-lived effector T cells in vivo.
Volume: 189
Issue: 4
Pages: 1812-25
Allele
Name: transgene insertion A, Joachim R Gothert
Allele Type: Transgenic
Attribute String: Inducible, Inserted expressed sequence
Allele
Name: transgene insertion B, Joachim R Gothert
Allele Type: Transgenic
Attribute String: Inducible, Inserted expressed sequence
Publication
First Author: Lorentsen KJ
Year: 2018
Journal: Nat Commun
Title: Bcl11b is essential for licensing Th2 differentiation during helminth infection and allergic asthma.
Volume: 9
Issue: 1
Pages: 1679
Publication  
First Author: Ma C
Year: 2021
Journal: Mol Metab
Title: Upregulated ethanolamine phospholipid synthesis via selenoprotein I is required for effective metabolic reprogramming during T cell activation.
Volume: 47
Pages: 101170
Publication
First Author: Ma C
Year: 2022
Journal: J Leukoc Biol
Title: Selenoprotein I deficiency in T cells promotes differentiation into tolerant phenotypes while decreasing Th17 pathology.
Volume: 112
Issue: 6
Pages: 1387-1397
Publication
First Author: Shih DQ
Year: 2011
Journal: PLoS One
Title: Constitutive TL1A (TNFSF15) expression on lymphoid or myeloid cells leads to mild intestinal inflammation and fibrosis.
Volume: 6
Issue: 1
Pages: e16090
Publication
First Author: Barrett R
Year: 2012
Journal: Am J Pathol
Title: Constitutive TL1A expression under colitogenic conditions modulates the severity and location of gut mucosal inflammation and induces fibrostenosis.
Volume: 180
Issue: 2
Pages: 636-49