| Type |
Details |
Score |
| Genotype |
| Symbol: |
Tg(Lck-Tax)53Hall/? |
| Background: |
involves: C57BL/6 |
| Zygosity: |
ot |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Vdac2/Vdac2 Bax/Bax Tg(Lck-cre)1Cwi/? |
| Background: |
involves: 129X1/SvJ * C57BL/6 * DBA/2 |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Nmt1/Nmt1 Tg(Lck-cre)1Cwi/? |
| Background: |
involves: C57BL/6 * DBA/2 * SJL |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Nmt2/Nmt2 Tg(Lck-cre)1Cwi/? |
| Background: |
involves: C57BL/6 * DBA/2 * SJL |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Prkd2/Prkd2 Tg(Lck-cre)1Jtak/? |
| Background: |
involves: 129 * C57BL/6 |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Ppp2r2d/Ppp2r2d Tg(Lck-icre)3779Nik/? |
| Background: |
involves: C57BL/6 * DBA/2 |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Hdac3/Hdac3 Tg(Lck-cre)548Jxm/? |
| Background: |
involves: 129S6/SvEvTac * C57BL/6 * CBA |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
364
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Swarthout JT |
| Year: |
2005 |
| Journal: |
J Biol Chem |
| Title: |
DHHC9 and GCP16 constitute a human protein fatty acyltransferase with specificity for H- and N-Ras. |
| Volume: |
280 |
| Issue: |
35 |
| Pages: |
31141-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kelly AP |
| Year: |
2007 |
| Journal: |
EMBO J |
| Title: |
Notch-induced T cell development requires phosphoinositide-dependent kinase 1. |
| Volume: |
26 |
| Issue: |
14 |
| Pages: |
3441-50 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Peng S |
| Year: |
2007 |
| Journal: |
Eur J Immunol |
| Title: |
c-Maf interacts with c-Myb to down-regulate Bcl-2 expression and increase apoptosis in peripheral CD4 cells. |
| Volume: |
37 |
| Issue: |
10 |
| Pages: |
2868-80 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Brewer JA |
| Year: |
2003 |
| Journal: |
Nat Med |
| Title: |
T-cell glucocorticoid receptor is required to suppress COX-2-mediated lethal immune activation. |
| Volume: |
9 |
| Issue: |
10 |
| Pages: |
1318-22 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ichii H |
| Year: |
2002 |
| Journal: |
Nat Immunol |
| Title: |
Role for Bcl-6 in the generation and maintenance of memory CD8+ T cells. |
| Volume: |
3 |
| Issue: |
6 |
| Pages: |
558-63 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rajpal A |
| Year: |
2003 |
| Journal: |
EMBO J |
| Title: |
Transcriptional activation of known and novel apoptotic pathways by Nur77 orphan steroid receptor. |
| Volume: |
22 |
| Issue: |
24 |
| Pages: |
6526-36 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Heideman MR |
| Year: |
2013 |
| Journal: |
Blood |
| Title: |
Dosage-dependent tumor suppression by histone deacetylases 1 and 2 through regulation of c-Myc collaborating genes and p53 function. |
| Volume: |
121 |
| Issue: |
11 |
| Pages: |
2038-50 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Choi SH |
| Year: |
2022 |
| Journal: |
Front Immunol |
| Title: |
Smad4-deficient T cells promote colitis-associated colon cancer via an IFN-γ-dependent suppression of 15-hydroxyprostaglandin dehydrogenase. |
| Volume: |
13 |
|
| Pages: |
932412 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chinen T |
| Year: |
2011 |
| Journal: |
Nat Commun |
| Title: |
Prostaglandin E2 and SOCS1 have a role in intestinal immune tolerance. |
| Volume: |
2 |
|
| Pages: |
190 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Liu Y |
| Year: |
2008 |
| Journal: |
Nat Immunol |
| Title: |
A critical function for TGF-beta signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells. |
| Volume: |
9 |
| Issue: |
6 |
| Pages: |
632-40 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Li H |
| Year: |
2018 |
| Journal: |
Pathol Res Pract |
| Title: |
TL1A blocking ameliorates intestinal fibrosis in the T cell transfer model of chronic colitis in mice. |
| Volume: |
214 |
| Issue: |
2 |
| Pages: |
217-227 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Carey KT |
| Year: |
2013 |
| Journal: |
Endocrinology |
| Title: |
Nfil3 is a glucocorticoid-regulated gene required for glucocorticoid-induced apoptosis in male murine T cells. |
| Volume: |
154 |
| Issue: |
4 |
| Pages: |
1540-52 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Perruche S |
| Year: |
2009 |
| Journal: |
J Immunol |
| Title: |
Lethal effect of CD3-specific antibody in mice deficient in TGF-beta1 by uncontrolled flu-like syndrome. |
| Volume: |
183 |
| Issue: |
2 |
| Pages: |
953-61 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Barker EC |
| Year: |
2018 |
| Journal: |
Carcinogenesis |
| Title: |
Potent suppression of both spontaneous and carcinogen-induced colitis-associated colorectal cancer in mice by dietary celastrol supplementation. |
| Volume: |
39 |
| Issue: |
1 |
| Pages: |
36-46 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Choi SH |
| Year: |
2020 |
| Journal: |
Oncoimmunology |
| Title: |
Loss of p27Kip1 leads to expansion of CD4+ effector memory T cells and accelerates colitis-associated colon cancer in mice with a T cell lineage restricted deletion of Smad4. |
| Volume: |
9 |
| Issue: |
1 |
| Pages: |
1847832 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Francia S |
| Year: |
2006 |
| Journal: |
Curr Biol |
| Title: |
Telomere and telomerase modulation by the mammalian Rad9/Rad1/Hus1 DNA-damage-checkpoint complex. |
| Volume: |
16 |
| Issue: |
15 |
| Pages: |
1551-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chikuma S |
| Year: |
2012 |
| Journal: |
Nat Immunol |
| Title: |
TRIM28 prevents autoinflammatory T cell development in vivo. |
| Volume: |
13 |
| Issue: |
6 |
| Pages: |
596-603 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Carrillo-de Sauvage MÁ |
| Year: |
2013 |
| Journal: |
Cell Death Differ |
| Title: |
Potent and multiple regulatory actions of microglial glucocorticoid receptors during CNS inflammation. |
| Volume: |
20 |
| Issue: |
11 |
| Pages: |
1546-57 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Theiss-Suennemann J |
| Year: |
2015 |
| Journal: |
J Pathol |
| Title: |
Glucocorticoids attenuate acute graft-versus-host disease by suppressing the cytotoxic capacity of CD8(+) T cells. |
| Volume: |
235 |
| Issue: |
4 |
| Pages: |
646-55 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Meyer-Heemsoth L |
| Year: |
2023 |
| Journal: |
Cells |
| Title: |
T Cell Energy Metabolism Is a Target of Glucocorticoids in Mice, Healthy Humans, and MS Patients. |
| Volume: |
12 |
| Issue: |
3 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Junt T |
| Year: |
2006 |
| Journal: |
Eur J Immunol |
| Title: |
Expression of lymphotoxin beta governs immunity at two distinct levels. |
| Volume: |
36 |
| Issue: |
8 |
| Pages: |
2061-75 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Li C |
| Year: |
2014 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
MeCP2 enforces Foxp3 expression to promote regulatory T cells' resilience to inflammation. |
| Volume: |
111 |
| Issue: |
27 |
| Pages: |
E2807-16 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Xing Y |
| Year: |
2008 |
| Journal: |
Mol Immunol |
| Title: |
Protein phosphatase subunit G5PR that regulates the JNK-mediated apoptosis signal is essential for the survival of CD4 and CD8 double-positive thymocytes. |
| Volume: |
45 |
| Issue: |
7 |
| Pages: |
2028-37 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Asari S |
| Year: |
2005 |
| Journal: |
Exp Hematol |
| Title: |
Abnormal erythroid differentiation in neonatal bcl-6-deficient mice. |
| Volume: |
33 |
| Issue: |
1 |
| Pages: |
26-34 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ichii H |
| Year: |
2004 |
| Journal: |
J Immunol |
| Title: |
Bcl6 acts as an amplifier for the generation and proliferative capacity of central memory CD8+ T cells. |
| Volume: |
173 |
| Issue: |
2 |
| Pages: |
883-91 |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
targeted mutation, transgenic, mutant strain |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant strain, congenic, targeted mutation, transgenic |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Matsui-Hasumi A |
| Year: |
2017 |
| Journal: |
Int Immunol |
| Title: |
E3 ubiquitin ligases SIAH1/2 regulate hypoxia-inducible factor-1 (HIF-1)-mediated Th17 cell differentiation. |
| Volume: |
29 |
| Issue: |
3 |
| Pages: |
133-143 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Burger ML |
| Year: |
2014 |
| Journal: |
Blood |
| Title: |
Premalignant PTEN-deficient thymocytes activate microRNAs miR-146a and miR-146b as a cellular defense against malignant transformation. |
| Volume: |
123 |
| Issue: |
26 |
| Pages: |
4089-100 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
He MX |
| Year: |
2013 |
| Journal: |
Cell Death Differ |
| Title: |
A role for c-FLIP(L) in the regulation of apoptosis, autophagy, and necroptosis in T lymphocytes. |
| Volume: |
20 |
| Issue: |
2 |
| Pages: |
188-97 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Xue L |
| Year: |
2008 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice. |
| Volume: |
105 |
| Issue: |
6 |
| Pages: |
2022-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cutler CE |
| Year: |
2019 |
| Journal: |
Glycobiology |
| Title: |
Cosmc is required for T cell persistence in the periphery. |
| Volume: |
29 |
| Issue: |
11 |
| Pages: |
776-788 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wu Z |
| Year: |
2023 |
| Journal: |
Cell Rep |
| Title: |
Coupled deglycosylation-ubiquitination cascade in regulating PD-1 degradation by MDM2. |
| Volume: |
42 |
| Issue: |
7 |
| Pages: |
112693 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Li W |
| Year: |
2023 |
| Journal: |
Front Immunol |
| Title: |
Paxbp1 is indispensable for the survival of CD4 and CD8 double-positive thymocytes. |
| Volume: |
14 |
|
| Pages: |
1183367 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jung J |
| Year: |
2018 |
| Journal: |
JCI Insight |
| Title: |
Calnexin is necessary for T cell transmigration into the central nervous system. |
| Volume: |
3 |
| Issue: |
5 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wong GW |
| Year: |
2012 |
| Journal: |
Blood |
| Title: |
HES1 opposes a PTEN-dependent check on survival, differentiation, and proliferation of TCRβ-selected mouse thymocytes. |
| Volume: |
120 |
| Issue: |
7 |
| Pages: |
1439-48 |
|
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•
•
•
•
|
| Publication |
| First Author: |
Wang Y |
| Year: |
2017 |
| Journal: |
Cell Rep |
| Title: |
The Lysine Acetyltransferase GCN5 Is Required for iNKT Cell Development through EGR2 Acetylation. |
| Volume: |
20 |
| Issue: |
3 |
| Pages: |
600-612 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gustafsson KL |
| Year: |
2018 |
| Journal: |
J Endocrinol |
| Title: |
ERα expression in T lymphocytes is dispensable for estrogenic effects in bone. |
| Volume: |
238 |
| Issue: |
2 |
| Pages: |
129-136 |
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•
•
•
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| Publication |
| First Author: |
Bochenek ML |
| Year: |
2020 |
| Journal: |
Circ Res |
| Title: |
Activated Endothelial TGFβ1 Signaling Promotes Venous Thrombus Nonresolution in Mice Via Endothelin-1: Potential Role for Chronic Thromboembolic Pulmonary Hypertension. |
| Volume: |
126 |
| Issue: |
2 |
| Pages: |
162-181 |
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•
•
•
•
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| Publication |
| First Author: |
Wang Y |
| Year: |
2022 |
| Journal: |
Clin Cancer Res |
| Title: |
Cholesterol-Lowering Intervention Decreases mTOR Complex 2 Signaling and Enhances Antitumor Immunity. |
| Volume: |
28 |
| Issue: |
2 |
| Pages: |
414-424 |
|
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•
•
•
•
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| Publication |
| First Author: |
Salmena L |
| Year: |
2005 |
| Journal: |
J Exp Med |
| Title: |
Caspase-8 deficiency in T cells leads to a lethal lymphoinfiltrative immune disorder. |
| Volume: |
202 |
| Issue: |
6 |
| Pages: |
727-32 |
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•
•
•
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| Publication |
| First Author: |
Gilleron J |
| Year: |
2018 |
| Journal: |
Cell Rep |
| Title: |
Rab4b Deficiency in T Cells Promotes Adipose Treg/Th17 Imbalance, Adipose Tissue Dysfunction, and Insulin Resistance. |
| Volume: |
25 |
| Issue: |
12 |
| Pages: |
3329-3341.e5 |
|
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•
•
•
•
|
| Publication |
| First Author: |
Park YJ |
| Year: |
2014 |
| Journal: |
Diabetologia |
| Title: |
The role of caspase-8 in amyloid-induced beta cell death in human and mouse islets. |
| Volume: |
57 |
| Issue: |
4 |
| Pages: |
765-75 |
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•
•
•
•
•
|
| Publication |
| First Author: |
Huang X |
| Year: |
2014 |
| Journal: |
PLoS One |
| Title: |
Peroxisome proliferator-activated receptor γ deficiency in T cells accelerates chronic rejection by influencing the differentiation of CD4+ T cells and alternatively activated macrophages. |
| Volume: |
9 |
| Issue: |
11 |
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e112953 |
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•
•
•
•
|
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| First Author: |
Zhang N |
| Year: |
2008 |
| Journal: |
J Immunol |
| Title: |
The long isoform of cellular FLIP is essential for T lymphocyte proliferation through an NF-kappaB-independent pathway. |
| Volume: |
180 |
| Issue: |
8 |
| Pages: |
5506-11 |
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•
•
•
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| First Author: |
Yi Z |
| Year: |
2013 |
| Journal: |
J Exp Med |
| Title: |
TNF receptor associated factor 3 plays a key role in development and function of invariant natural killer T cells. |
| Volume: |
210 |
| Issue: |
6 |
| Pages: |
1079-86 |
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•
•
•
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| Publication |
| First Author: |
Delfino DV |
| Year: |
2011 |
| Journal: |
Cell Death Differ |
| Title: |
Glucocorticoid-induced activation of caspase-8 protects the glucocorticoid-induced protein Gilz from proteasomal degradation and induces its binding to SUMO-1 in murine thymocytes. |
| Volume: |
18 |
| Issue: |
1 |
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•
•
•
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| First Author: |
Liu HH |
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2006 |
| Journal: |
Proc Natl Acad Sci U S A |
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Essential role of TAK1 in thymocyte development and activation. |
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103 |
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31 |
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•
•
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| First Author: |
Wiede F |
| Year: |
2019 |
| Journal: |
Diabetes |
| Title: |
T-Cell-Specific PTPN2 Deficiency in NOD Mice Accelerates the Development of Type 1 Diabetes and Autoimmune Comorbidities. |
| Volume: |
68 |
| Issue: |
6 |
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1251-1266 |
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•
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| First Author: |
Niu K |
| Year: |
2017 |
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Sci Rep |
| Title: |
BAP31 is involved in T cell activation through TCR signal pathways. |
| Volume: |
7 |
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•
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| First Author: |
Hagenbeek TJ |
| Year: |
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| Journal: |
Cancer Lett |
| Title: |
Murine Pten(-/-) T-ALL requires non-redundant PI3K/mTOR and DLL4/Notch1 signals for maintenance and γc/TCR signals for thymic exit. |
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2 |
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Wang HY |
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Mol Cell |
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SC35 plays a role in T cell development and alternative splicing of CD45. |
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7 |
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2 |
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Rosilio C |
| Year: |
2015 |
| Journal: |
Leukemia |
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L-type amino-acid transporter 1 (LAT1): a therapeutic target supporting growth and survival of T-cell lymphoblastic lymphoma/T-cell acute lymphoblastic leukemia. |
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29 |
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6 |
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Tsagaratou A |
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Eur J Immunol |
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Differential requirement of IKK2 for CYLD-dependent representation of thymic and peripheral T-cell populations. |
| Volume: |
41 |
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10 |
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| First Author: |
Rosilio C |
| Year: |
2013 |
| Journal: |
Cancer Lett |
| Title: |
The metabolic perturbators metformin, phenformin and AICAR interfere with the growth and survival of murine PTEN-deficient T cell lymphomas and human T-ALL/T-LL cancer cells. |
| Volume: |
336 |
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1 |
| Pages: |
114-26 |
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•
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| First Author: |
Miyazaki K |
| Year: |
2010 |
| Journal: |
J Immunol |
| Title: |
The role of the basic helix-loop-helix transcription factor Dec1 in the regulatory T cells. |
| Volume: |
185 |
| Issue: |
12 |
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7330-9 |
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•
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| First Author: |
Will WM |
| Year: |
2006 |
| Journal: |
J Immunol |
| Title: |
Attenuation of IL-7 receptor signaling is not required for allelic exclusion. |
| Volume: |
176 |
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6 |
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3350-5 |
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Ma C |
| Year: |
2015 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Transforming growth factor-β signaling is constantly shaping memory T-cell population. |
| Volume: |
112 |
| Issue: |
35 |
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•
•
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| First Author: |
Lin Y |
| Year: |
2016 |
| Journal: |
Ann Clin Lab Sci |
| Title: |
The Protective Effect of HIF-1α in T Lymphocytes on Cardiac Damage in Diabetic Mice. |
| Volume: |
46 |
| Issue: |
1 |
| Pages: |
32-43 |
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•
•
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| First Author: |
Heit JJ |
| Year: |
2006 |
| Journal: |
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| Name: |
transgene insertion B, Joachim R Gothert |
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Transgenic |
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Inducible, Inserted expressed sequence |
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