| Type |
Details |
Score |
| Publication |
| First Author: |
Chen C |
| Year: |
2008 |
| Journal: |
J Exp Med |
| Title: |
TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species. |
| Volume: |
205 |
| Issue: |
10 |
| Pages: |
2397-408 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Darido C |
| Year: |
2018 |
| Journal: |
Cell Death Differ |
| Title: |
Stage-dependent therapeutic efficacy in PI3K/mTOR-driven squamous cell carcinoma of the skin. |
| Volume: |
25 |
| Issue: |
6 |
| Pages: |
1146-1159 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cao R |
| Year: |
2013 |
| Journal: |
Neuron |
| Title: |
Translational control of entrainment and synchrony of the suprachiasmatic circadian clock by mTOR/4E-BP1 signaling. |
| Volume: |
79 |
| Issue: |
4 |
| Pages: |
712-24 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bartolomé A |
| Year: |
2014 |
| Journal: |
Diabetes |
| Title: |
Pancreatic β-cell failure mediated by mTORC1 hyperactivity and autophagic impairment. |
| Volume: |
63 |
| Issue: |
9 |
| Pages: |
2996-3008 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Koyanagi M |
| Year: |
2011 |
| Journal: |
PLoS One |
| Title: |
Ablation of TSC2 enhances insulin secretion by increasing the number of mitochondria through activation of mTORC1. |
| Volume: |
6 |
| Issue: |
8 |
| Pages: |
e23238 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mao J |
| Year: |
2014 |
| Journal: |
Am J Physiol Renal Physiol |
| Title: |
Mammalian target of rapamycin complex 1 activation in podocytes promotes cellular crescent formation. |
| Volume: |
307 |
| Issue: |
9 |
| Pages: |
F1023-32 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang C |
| Year: |
2016 |
| Journal: |
Biol Reprod |
| Title: |
mTORC1 Activation Promotes Spermatogonial Differentiation and Causes Subfertility in Mice. |
| Volume: |
95 |
| Issue: |
5 |
| Pages: |
97 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Uhlmann EJ |
| Year: |
2004 |
| Journal: |
Glia |
| Title: |
Loss of tuberous sclerosis complex 1 (Tsc1) expression results in increased Rheb/S6K pathway signaling important for astrocyte cell size regulation. |
| Volume: |
47 |
| Issue: |
2 |
| Pages: |
180-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gwon DH |
| Year: |
2021 |
| Journal: |
Int J Mol Sci |
| Title: |
NFAT5 Deficiency Alleviates Formalin-Induced Inflammatory Pain Through mTOR. |
| Volume: |
22 |
| Issue: |
5 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Diao F |
| Year: |
2016 |
| Journal: |
Sci Rep |
| Title: |
Alteration of protein prenylation promotes spermatogonial differentiation and exhausts spermatogonial stem cells in newborn mice. |
| Volume: |
6 |
|
| Pages: |
28917 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Efeyan A |
| Year: |
2013 |
| Journal: |
Nature |
| Title: |
Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival. |
| Volume: |
493 |
| Issue: |
7434 |
| Pages: |
679-83 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kearney AL |
| Year: |
2019 |
| Journal: |
J Biol Chem |
| Title: |
Serine 474 phosphorylation is essential for maximal Akt2 kinase activity in adipocytes. |
| Volume: |
294 |
| Issue: |
45 |
| Pages: |
16729-16739 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lu ZH |
| Year: |
2010 |
| Journal: |
Cancer Res |
| Title: |
Mammalian target of rapamycin activator RHEB is frequently overexpressed in human carcinomas and is critical and sufficient for skin epithelial carcinogenesis. |
| Volume: |
70 |
| Issue: |
8 |
| Pages: |
3287-98 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Young RM |
| Year: |
2013 |
| Journal: |
Genes Dev |
| Title: |
Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stress. |
| Volume: |
27 |
| Issue: |
10 |
| Pages: |
1115-31 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yamada D |
| Year: |
2016 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
mTORC1 is a critical mediator of oncogenic Semaphorin3A signaling. |
| Volume: |
476 |
| Issue: |
4 |
| Pages: |
475-480 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yano T |
| Year: |
2014 |
| Journal: |
Circ Res |
| Title: |
Pivotal role of mTORC2 and involvement of ribosomal protein S6 in cardioprotective signaling. |
| Volume: |
114 |
| Issue: |
8 |
| Pages: |
1268-80 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Guenther GG |
| Year: |
2014 |
| Journal: |
Oncogene |
| Title: |
Loss of TSC2 confers resistance to ceramide and nutrient deprivation. |
| Volume: |
33 |
| Issue: |
14 |
| Pages: |
1776-87 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fu X |
| Year: |
2022 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Activation of Rictor/mTORC2 signaling acts as a pivotal strategy to protect against sensorineural hearing loss. |
| Volume: |
119 |
| Issue: |
10 |
| Pages: |
e2107357119 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zeng H |
| Year: |
2018 |
| Journal: |
Sci Adv |
| Title: |
Discrete roles and bifurcation of PTEN signaling and mTORC1-mediated anabolic metabolism underlie IL-7-driven B lymphopoiesis. |
| Volume: |
4 |
| Issue: |
1 |
| Pages: |
eaar5701 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Karmaus PWF |
| Year: |
2017 |
| Journal: |
J Exp Med |
| Title: |
Critical roles of mTORC1 signaling and metabolic reprogramming for M-CSF-mediated myelopoiesis. |
| Volume: |
214 |
| Issue: |
9 |
| Pages: |
2629-2647 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mills JR |
| Year: |
2008 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
mTORC1 promotes survival through translational control of Mcl-1. |
| Volume: |
105 |
| Issue: |
31 |
| Pages: |
10853-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bidinosti M |
| Year: |
2010 |
| Journal: |
Mol Cell |
| Title: |
Postnatal deamidation of 4E-BP2 in brain enhances its association with raptor and alters kinetics of excitatory synaptic transmission. |
| Volume: |
37 |
| Issue: |
6 |
| Pages: |
797-808 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Stover CM |
| Year: |
2004 |
| Journal: |
Mamm Genome |
| Title: |
Organization of the MASP2 locus and its expression profile in mouse and rat. |
| Volume: |
15 |
| Issue: |
11 |
| Pages: |
887-900 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chornoguz O |
| Year: |
2017 |
| Journal: |
J Immunol |
| Title: |
mTORC1 Promotes T-bet Phosphorylation To Regulate Th1 Differentiation. |
| Volume: |
198 |
| Issue: |
10 |
| Pages: |
3939-3948 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Valvezan AJ |
| Year: |
2014 |
| Journal: |
Dis Model Mech |
| Title: |
Oncogenic mutations in adenomatous polyposis coli (Apc) activate mechanistic target of rapamycin complex 1 (mTORC1) in mice and zebrafish. |
| Volume: |
7 |
| Issue: |
1 |
| Pages: |
63-71 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Henderson JG |
| Year: |
2015 |
| Journal: |
Immunity |
| Title: |
CD5 instructs extrathymic regulatory T cell development in response to self and tolerizing antigens. |
| Volume: |
42 |
| Issue: |
3 |
| Pages: |
471-83 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cheng SC |
| Year: |
2014 |
| Journal: |
Science |
| Title: |
mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity. |
| Volume: |
345 |
| Issue: |
6204 |
| Pages: |
1250684 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chow DK |
| Year: |
2009 |
| Journal: |
Nat Neurosci |
| Title: |
Laminar and compartmental regulation of dendritic growth in mature cortex. |
| Volume: |
12 |
| Issue: |
2 |
| Pages: |
116-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Eifert T |
| Year: |
2023 |
| Journal: |
Leukemia |
| Title: |
Cell fate determinant Llgl1 is required for propagation of acute myeloid leukemia. |
| Volume: |
37 |
| Issue: |
10 |
| Pages: |
2027-2035 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang CY |
| Year: |
2009 |
| Journal: |
Sci Signal |
| Title: |
Obesity increases vascular senescence and susceptibility to ischemic injury through chronic activation of Akt and mTOR. |
| Volume: |
2 |
| Issue: |
62 |
| Pages: |
ra11 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bermudez-Silva FJ |
| Year: |
2016 |
| Journal: |
Dis Model Mech |
| Title: |
The cannabinoid CB1 receptor and mTORC1 signalling pathways interact to modulate glucose homeostasis in mice. |
| Volume: |
9 |
| Issue: |
1 |
| Pages: |
51-61 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Deng L |
| Year: |
2010 |
| Journal: |
Am J Pathol |
| Title: |
A novel mouse model of inflammatory bowel disease links mammalian target of rapamycin-dependent hyperproliferation of colonic epithelium to inflammation-associated tumorigenesis. |
| Volume: |
176 |
| Issue: |
2 |
| Pages: |
952-67 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Li X |
| Year: |
2016 |
| Journal: |
J Biol Chem |
| Title: |
Tumor Progression Locus 2 (Tpl2) Activates the Mammalian Target of Rapamycin (mTOR) Pathway, Inhibits Forkhead Box P3 (FoxP3) Expression, and Limits Regulatory T Cell (Treg) Immunosuppressive Functions. |
| Volume: |
291 |
| Issue: |
32 |
| Pages: |
16802-15 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yamada T |
| Year: |
2010 |
| Journal: |
J Immunol |
| Title: |
Cutting edge: Expression of the transcription factor E74-like factor 4 is regulated by the mammalian target of rapamycin pathway in CD8+ T cells. |
| Volume: |
185 |
| Issue: |
7 |
| Pages: |
3824-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ikeda H |
| Year: |
2011 |
| Journal: |
Mol Cell Biol |
| Title: |
Increased Akt-mTOR signaling in lung epithelium is associated with respiratory distress syndrome in mice. |
| Volume: |
31 |
| Issue: |
5 |
| Pages: |
1054-65 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shigesada N |
| Year: |
2024 |
| Journal: |
Cell Mol Life Sci |
| Title: |
Combination of blockade of endothelin signalling and compensation of IGF1 expression protects the retina from degeneration. |
| Volume: |
81 |
| Issue: |
1 |
| Pages: |
51 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kather JN |
| Year: |
2014 |
| Journal: |
Invest Ophthalmol Vis Sci |
| Title: |
Angiopoietin-1 is regulated by miR-204 and contributes to corneal neovascularization in KLEIP-deficient mice. |
| Volume: |
55 |
| Issue: |
7 |
| Pages: |
4295-303 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Valapala M |
| Year: |
2014 |
| Journal: |
Autophagy |
| Title: |
Lysosomal-mediated waste clearance in retinal pigment epithelial cells is regulated by CRYBA1/βA3/A1-crystallin via V-ATPase-MTORC1 signaling. |
| Volume: |
10 |
| Issue: |
3 |
| Pages: |
480-96 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tian W |
| Year: |
2015 |
| Journal: |
FEBS Lett |
| Title: |
Phosphorylation of ULK1 by AMPK regulates translocation of ULK1 to mitochondria and mitophagy. |
| Volume: |
589 |
| Issue: |
15 |
| Pages: |
1847-54 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Humphrey SJ |
| Year: |
2013 |
| Journal: |
Cell Metab |
| Title: |
Dynamic adipocyte phosphoproteome reveals that Akt directly regulates mTORC2. |
| Volume: |
17 |
| Issue: |
6 |
| Pages: |
1009-1020 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Roffé M |
| Year: |
2010 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Prion protein interaction with stress-inducible protein 1 enhances neuronal protein synthesis via mTOR. |
| Volume: |
107 |
| Issue: |
29 |
| Pages: |
13147-52 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Liu X |
| Year: |
2012 |
| Journal: |
Biochim Biophys Acta |
| Title: |
The role of AMPK/mTOR/S6K1 signaling axis in mediating the physiological process of exercise-induced insulin sensitization in skeletal muscle of C57BL/6 mice. |
| Volume: |
1822 |
| Issue: |
11 |
| Pages: |
1716-26 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jewell JL |
| Year: |
2015 |
| Journal: |
Science |
| Title: |
Metabolism. Differential regulation of mTORC1 by leucine and glutamine. |
| Volume: |
347 |
| Issue: |
6218 |
| Pages: |
194-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tu TH |
| Year: |
2015 |
| Journal: |
FEBS J |
| Title: |
4-1BBL signaling promotes cell proliferation through reprogramming of glucose metabolism in monocytes/macrophages. |
| Volume: |
282 |
| Issue: |
8 |
| Pages: |
1468-80 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lozovaya N |
| Year: |
2014 |
| Journal: |
Nat Commun |
| Title: |
Selective suppression of excessive GluN2C expression rescues early epilepsy in a tuberous sclerosis murine model. |
| Volume: |
5 |
|
| Pages: |
4563 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gong Q |
| Year: |
2016 |
| Journal: |
Hepatology |
| Title: |
Fibroblast growth factor 21 improves hepatic insulin sensitivity by inhibiting mammalian target of rapamycin complex 1 in mice. |
| Volume: |
64 |
| Issue: |
2 |
| Pages: |
425-38 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dennis MD |
| Year: |
2013 |
| Journal: |
J Biol Chem |
| Title: |
Mechanistic target of rapamycin complex 1 (mTORC1)-mediated phosphorylation is governed by competition between substrates for interaction with raptor. |
| Volume: |
288 |
| Issue: |
1 |
| Pages: |
10-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gan X |
| Year: |
2012 |
| Journal: |
Nat Cell Biol |
| Title: |
PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12. |
| Volume: |
14 |
| Issue: |
7 |
| Pages: |
686-96 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yang Q |
| Year: |
2006 |
| Journal: |
Genes Dev |
| Title: |
Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity. |
| Volume: |
20 |
| Issue: |
20 |
| Pages: |
2820-32 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
So L |
| Year: |
2016 |
| Journal: |
Sci Signal |
| Title: |
The 4E-BP-eIF4E axis promotes rapamycin-sensitive growth and proliferation in lymphocytes. |
| Volume: |
9 |
| Issue: |
430 |
| Pages: |
ra57 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chen Y |
| Year: |
2015 |
| Journal: |
J Neurosci |
| Title: |
Pten Mutations Alter Brain Growth Trajectory and Allocation of Cell Types through Elevated β-Catenin Signaling. |
| Volume: |
35 |
| Issue: |
28 |
| Pages: |
10252-67 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Liu P |
| Year: |
2014 |
| Journal: |
Nature |
| Title: |
Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus. |
| Volume: |
508 |
| Issue: |
7497 |
| Pages: |
541-5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Guri Y |
| Year: |
2017 |
| Journal: |
Cancer Cell |
| Title: |
mTORC2 Promotes Tumorigenesis via Lipid Synthesis. |
| Volume: |
32 |
| Issue: |
6 |
| Pages: |
807-823.e12 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hagiwara A |
| Year: |
2012 |
| Journal: |
Cell Metab |
| Title: |
Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c. |
| Volume: |
15 |
| Issue: |
5 |
| Pages: |
725-38 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yilmaz ÖH |
| Year: |
2012 |
| Journal: |
Nature |
| Title: |
mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake. |
| Volume: |
486 |
| Issue: |
7404 |
| Pages: |
490-5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Facchinetti V |
| Year: |
2008 |
| Journal: |
EMBO J |
| Title: |
The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C. |
| Volume: |
27 |
| Issue: |
14 |
| Pages: |
1932-43 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kroczynska B |
| Year: |
2016 |
| Journal: |
J Biol Chem |
| Title: |
Interferon γ (IFNγ) Signaling via Mechanistic Target of Rapamycin Complex 2 (mTORC2) and Regulatory Effects in the Generation of Type II Interferon Biological Responses. |
| Volume: |
291 |
| Issue: |
5 |
| Pages: |
2389-96 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Liemburg-Apers DC |
| Year: |
2016 |
| Journal: |
J Cell Sci |
| Title: |
Acute stimulation of glucose influx upon mitoenergetic dysfunction requires LKB1, AMPK, Sirt2 and mTOR-RAPTOR. |
| Volume: |
129 |
| Issue: |
23 |
| Pages: |
4411-4423 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1335
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Babetto E |
| Year: |
2020 |
| Journal: |
Nat Neurosci |
| Title: |
A glycolytic shift in Schwann cells supports injured axons. |
| Volume: |
23 |
| Issue: |
10 |
| Pages: |
1215-1228 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zamfirescu RC |
| Year: |
2021 |
| Journal: |
Am J Physiol Cell Physiol |
| Title: |
mTORC1/2 signaling is downregulated by amino acid-free culture of mouse preimplantation embryos and is only partially restored by amino acid readdition. |
| Volume: |
320 |
| Issue: |
1 |
| Pages: |
C30-C44 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Vadysirisack DD |
| Year: |
2011 |
| Journal: |
Mol Cell Biol |
| Title: |
Feedback control of p53 translation by REDD1 and mTORC1 limits the p53-dependent DNA damage response. |
| Volume: |
31 |
| Issue: |
21 |
| Pages: |
4356-65 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Villanueva EC |
| Year: |
2009 |
| Journal: |
Endocrinology |
| Title: |
Complex regulation of mammalian target of rapamycin complex 1 in the basomedial hypothalamus by leptin and nutritional status. |
| Volume: |
150 |
| Issue: |
10 |
| Pages: |
4541-51 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Uno K |
| Year: |
2015 |
| Journal: |
Nat Commun |
| Title: |
A hepatic amino acid/mTOR/S6K-dependent signalling pathway modulates systemic lipid metabolism via neuronal signals. |
| Volume: |
6 |
|
| Pages: |
7940 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Punzo C |
| Year: |
2009 |
| Journal: |
Nat Neurosci |
| Title: |
Stimulation of the insulin/mTOR pathway delays cone death in a mouse model of retinitis pigmentosa. |
| Volume: |
12 |
| Issue: |
1 |
| Pages: |
44-52 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
D'Souza AD |
| Year: |
2011 |
| Journal: |
Am J Pathol |
| Title: |
Aberrant CD8+ T-cell responses and memory differentiation upon viral infection of an ataxia-telangiectasia mouse model driven by hyper-activated Akt and mTORC1 signaling. |
| Volume: |
178 |
| Issue: |
6 |
| Pages: |
2740-51 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Layman AAK |
| Year: |
2017 |
| Journal: |
Nat Commun |
| Title: |
Ndfip1 restricts mTORC1 signalling and glycolysis in regulatory T cells to prevent autoinflammatory disease. |
| Volume: |
8 |
|
| Pages: |
15677 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang Y |
| Year: |
2016 |
| Journal: |
Immunity |
| Title: |
Histone Deacetylase SIRT1 Negatively Regulates the Differentiation of Interleukin-9-Producing CD4(+) T Cells. |
| Volume: |
44 |
| Issue: |
6 |
| Pages: |
1337-49 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Valvezan AJ |
| Year: |
2017 |
| Journal: |
Cancer Cell |
| Title: |
mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability. |
| Volume: |
32 |
| Issue: |
5 |
| Pages: |
624-638.e5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ren S |
| Year: |
2016 |
| Journal: |
Am J Pathol |
| Title: |
Inactivation of Tsc2 in Mesoderm-Derived Cells Causes Polycystic Kidney Lesions and Impairs Lung Alveolarization. |
| Volume: |
186 |
| Issue: |
12 |
| Pages: |
3261-3272 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhou J |
| Year: |
2009 |
| Journal: |
Hum Mol Genet |
| Title: |
Loss of Tsc1, but not Pten, in renal tubular cells causes polycystic kidney disease by activating mTORC1. |
| Volume: |
18 |
| Issue: |
22 |
| Pages: |
4428-41 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hirota Y |
| Year: |
2011 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Heightened uterine mammalian target of rapamycin complex 1 (mTORC1) signaling provokes preterm birth in mice. |
| Volume: |
108 |
| Issue: |
44 |
| Pages: |
18073-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Deng W |
| Year: |
2016 |
| Journal: |
J Clin Invest |
| Title: |
p53 coordinates decidual sestrin 2/AMPK/mTORC1 signaling to govern parturition timing. |
| Volume: |
126 |
| Issue: |
8 |
| Pages: |
2941-54 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Meena NK |
| Year: |
2018 |
| Journal: |
Immunology |
| Title: |
mTORC1 activation in B cells confers impairment of marginal zone microarchitecture by exaggerating cathepsin activity. |
| Volume: |
155 |
| Issue: |
4 |
| Pages: |
505-518 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ikejiri A |
| Year: |
2012 |
| Journal: |
Int Immunol |
| Title: |
Dynamic regulation of Th17 differentiation by oxygen concentrations. |
| Volume: |
24 |
| Issue: |
3 |
| Pages: |
137-46 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang Q |
| Year: |
2016 |
| Journal: |
Pharmacol Res |
| Title: |
mTOR-Independent autophagy inducer trehalose rescues against insulin resistance-induced myocardial contractile anomalies: Role of p38 MAPK and Foxo1. |
| Volume: |
111 |
|
| Pages: |
357-373 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yecies JL |
| Year: |
2011 |
| Journal: |
Cell Metab |
| Title: |
Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways. |
| Volume: |
14 |
| Issue: |
1 |
| Pages: |
21-32 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang H |
| Year: |
2019 |
| Journal: |
J Cell Physiol |
| Title: |
Chondrocyte mTORC1 activation stimulates miR-483-5p via HDAC4 in osteoarthritis progression. |
| Volume: |
234 |
| Issue: |
3 |
| Pages: |
2730-2740 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tamai T |
| Year: |
2013 |
| Journal: |
J Biol Chem |
| Title: |
Rheb (Ras homologue enriched in brain)-dependent mammalian target of rapamycin complex 1 (mTORC1) activation becomes indispensable for cardiac hypertrophic growth after early postnatal period. |
| Volume: |
288 |
| Issue: |
14 |
| Pages: |
10176-87 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tseng YT |
| Year: |
2016 |
| Journal: |
Pharmacol Res |
| Title: |
Loganin possesses neuroprotective properties, restores SMN protein and activates protein synthesis positive regulator Akt/mTOR in experimental models of spinal muscular atrophy. |
| Volume: |
111 |
|
| Pages: |
58-75 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Riddle RC |
| Year: |
2011 |
| Journal: |
J Biol Chem |
| Title: |
Hypoxia-inducible factor-1α protein negatively regulates load-induced bone formation. |
| Volume: |
286 |
| Issue: |
52 |
| Pages: |
44449-56 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cui Y |
| Year: |
2016 |
| Journal: |
Cell Rep |
| Title: |
Uhrf1 Controls iNKT Cell Survival and Differentiation through the Akt-mTOR Axis. |
| Volume: |
15 |
| Issue: |
2 |
| Pages: |
256-63 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Center for Animal Resources and Development |
| Year: |
2004 |
| Journal: |
Unpublished |
| Title: |
Information obtained from the Center for Animal Resources and Development (CARD), Kumamoto University, 2-2-1 Honjo, Kumamoto 860-0811, Japan |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Herrema H |
| Year: |
2014 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
IRS1Ser³⁰⁷ phosphorylation does not mediate mTORC1-induced insulin resistance. |
| Volume: |
443 |
| Issue: |
2 |
| Pages: |
689-93 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sun S |
| Year: |
2015 |
| Journal: |
Cancer Cell |
| Title: |
Constitutive Activation of mTORC1 in Endothelial Cells Leads to the Development and Progression of Lymphangiosarcoma through VEGF Autocrine Signaling. |
| Volume: |
28 |
| Issue: |
6 |
| Pages: |
758-772 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chen Y |
| Year: |
2014 |
| Journal: |
J Biol Chem |
| Title: |
Hyperactivation of mammalian target of rapamycin complex 1 (mTORC1) promotes breast cancer progression through enhancing glucose starvation-induced autophagy and Akt signaling. |
| Volume: |
289 |
| Issue: |
2 |
| Pages: |
1164-73 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yalcin S |
| Year: |
2010 |
| Journal: |
EMBO J |
| Title: |
ROS-mediated amplification of AKT/mTOR signalling pathway leads to myeloproliferative syndrome in Foxo3(-/-) mice. |
| Volume: |
29 |
| Issue: |
24 |
| Pages: |
4118-31 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fishwick KJ |
| Year: |
2010 |
| Journal: |
Dev Biol |
| Title: |
Initiation of neuronal differentiation requires PI3-kinase/TOR signalling in the vertebrate neural tube. |
| Volume: |
338 |
| Issue: |
2 |
| Pages: |
215-25 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pearson HB |
| Year: |
2008 |
| Journal: |
Cancer Res |
| Title: |
Lkb1 deficiency causes prostate neoplasia in the mouse. |
| Volume: |
68 |
| Issue: |
7 |
| Pages: |
2223-32 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hoytema van Konijnenburg DP |
| Year: |
2017 |
| Journal: |
Cell |
| Title: |
Intestinal Epithelial and Intraepithelial T Cell Crosstalk Mediates a Dynamic Response to Infection. |
| Volume: |
171 |
| Issue: |
4 |
| Pages: |
783-794.e13 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gao L |
| Year: |
2017 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
KLF15 protects against isoproterenol-induced cardiac hypertrophy via regulation of cell death and inhibition of Akt/mTOR signaling. |
| Volume: |
487 |
| Issue: |
1 |
| Pages: |
22-27 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wu Y |
| Year: |
2015 |
| Journal: |
Nat Cell Biol |
| Title: |
Autophagy and mTORC1 regulate the stochastic phase of somatic cell reprogramming. |
| Volume: |
17 |
| Issue: |
6 |
| Pages: |
715-25 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shaheen ZR |
| Year: |
2015 |
| Journal: |
J Immunol |
| Title: |
CCR5-Dependent Activation of mTORC1 Regulates Translation of Inducible NO Synthase and COX-2 during Encephalomyocarditis Virus Infection. |
| Volume: |
195 |
| Issue: |
9 |
| Pages: |
4406-14 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hodge SH |
| Year: |
2023 |
| Journal: |
J Exp Med |
| Title: |
Amino acid availability acts as a metabolic rheostat to determine the magnitude of ILC2 responses. |
| Volume: |
220 |
| Issue: |
3 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Selvaraj S |
| Year: |
2012 |
| Journal: |
J Clin Invest |
| Title: |
Neurotoxin-induced ER stress in mouse dopaminergic neurons involves downregulation of TRPC1 and inhibition of AKT/mTOR signaling. |
| Volume: |
122 |
| Issue: |
4 |
| Pages: |
1354-67 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mao Z |
| Year: |
2019 |
| Journal: |
Mol Cell Endocrinol |
| Title: |
ETV5 regulates GOAT/ghrelin system in an mTORC1-dependent manner. |
| Volume: |
485 |
|
| Pages: |
72-80 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chakrabarti P |
| Year: |
2013 |
| Journal: |
Mol Cell Biol |
| Title: |
Insulin inhibits lipolysis in adipocytes via the evolutionarily conserved mTORC1-Egr1-ATGL-mediated pathway. |
| Volume: |
33 |
| Issue: |
18 |
| Pages: |
3659-66 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sosanya NM |
| Year: |
2013 |
| Journal: |
J Cell Biol |
| Title: |
Degradation of high affinity HuD targets releases Kv1.1 mRNA from miR-129 repression by mTORC1. |
| Volume: |
202 |
| Issue: |
1 |
| Pages: |
53-69 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rui YN |
| Year: |
2015 |
| Journal: |
Nat Cell Biol |
| Title: |
Huntingtin functions as a scaffold for selective macroautophagy. |
| Volume: |
17 |
| Issue: |
3 |
| Pages: |
262-75 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cohen JS |
| Year: |
1995 |
| Journal: |
J Clin Psychiatry |
| Title: |
Provide fluoxetine information vital to clinicians. |
| Volume: |
56 |
| Issue: |
12 |
| Pages: |
591 |
|
•
•
•
•
•
|