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Search results 901 to 1000 out of 1201 for Pax5

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Hits by Pathway

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Hits by Strain

Type Details Score
Allele
Tcf12<tm2Zhu> | MGI:3707160
Name: transcription factor 12; targeted mutation 2, Yuan Zhuang
Allele Type: Targeted
Attribute String: Dominant negative, Inserted expressed sequence
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Allele
Sh3bp2<tm1Rtpl> | MGI:3711412
Name: SH3-domain binding protein 2; targeted mutation 1, Robert Rottapel
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Igh<tm1.2Rsky> | MGI:3760662
Name: immunoglobulin heavy chain complex; targeted mutation 1.2, Klaus Rajewsky
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Pgm3<mld1> | MGI:3758645
 
Name: phosphoglucomutase 3; multilineage defect 1
Allele Type: Chemically induced (ENU)
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Allele
Ppp2r3c<tm1Imku> | MGI:3759678
Name: protein phosphatase 2, regulatory subunit B'', gamma; targeted mutation 1, Nobuo Sakaguchi
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Racgap1<tm1Mahi> | MGI:3803293
Name: Rac GTPase-activating protein 1; targeted mutation 1, Masaki Hikida
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Tg(Ly6a-SET/NUP214)2969Gcg | MGI:3822861
Name: transgene insertion 2969, Gerard C Grosveld
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Rag1<tm1Jsek> | MGI:3840831
Name: recombination activating 1; targeted mutation 1, JoAnne Sekiguchi
Allele Type: Targeted
Attribute String: Hypomorph
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Allele
Tet2<Gt(AN0709)Wtsi> | MGI:4345275
Name: tet methylcytosine dioxygenase 2; gene trap AN0709, Wellcome Trust Sanger Institute
Allele Type: Gene trapped
Attribute String: Null/knockout, Reporter
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Complex Cluster Region
MGI:5315448 | Mirc30
Type: biological_region
Organism: mouse, laboratory
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Allele
Dck<tm1.1Radu> | MGI:4440453
Name: deoxycytidine kinase; targeted mutation 1.1, Caius G Radu
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Tet2<tm1Ics> | MGI:5141225
Name: tet methylcytosine dioxygenase 2; targeted mutation 1, Mouse Clinical Institute
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Gt(ROSA)26Sor<tm11(Lmp1)Rsky> | MGI:5314030
 
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 11, Klaus Rajewsky
Allele Type: Targeted
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Allele
Ezh1<tm1Sgon> | MGI:5474772
Name: enhancer of zeste 1 polycomb repressive complex 2 subunit; targeted mutation 1, Susana Gonzalez
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Wbp1l<tm2a(EUCOMM)Hmgu> | MGI:5511627
Name: WW domain binding protein 1 like; targeted mutation 2a, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Transgene
MGI:5555969 | Tg(Igh-Mir210)#aKgcs
Type: transgene
Organism: mouse, laboratory
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Allele
Slc39a10<tm1.1Tfk> | MGI:5642299
Name: solute carrier family 39 (zinc transporter), member 10; targeted mutation 1.1, Toshiyuki Fukada
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Arid3b<tm1c(KOMP)Wtsi> | MGI:5812005
Name: AT-rich interaction domain 3B; targeted mutation 1c, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready
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Allele
Mirc11<tm1Rdhl> | MGI:6117136
Name: microRNA cluster 11, including Mir23a through Mir24-2; targeted mutation 1, Richard Dahl
Allele Type: Targeted
Attribute String: Null/knockout
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Genotype
Genotype
Symbol: Tg(SV40-Ahr)1Poe/?
Background: involves: C57BL/6 * CBA
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ikzf1/Ikzf1<+>
Background: C57BL/6JSfdAnu-Ikzf1
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nlk/Nlk
Background: 129S1/Sv-Nlk
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pim1/Pim1 Pim2/Pim2 Pim3/Pim3
Background: involves: 129P/Ola * FVB/N
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cdh17/Cdh17
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cxcr4/Cxcr4
Background: involves: 129X1/SvJ
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Igll1/Igll1
Background: involves: 129S2/SvPas * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sh3bp2/Sh3bp2
Background: B6.129P2-Sh3bp2
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Kmt2a/Kmt2a
Background: involves: 129P2/OlaHsd * C57BL/6 * FVB
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Igh/Igh
Background: BALB/c-Igh
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd79a/Cd79a Igh/Igh
Background: involves: 129 * BALB/c * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd79b/Cd79b
Background: involves: 129/Sv * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Plcg2/Plcg2 Tg(Mx1-cre)1Cgn/?
Background: involves: C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(IghelMD4)4Ccg/?
Background: C57BL/6-Tg(IghelMD4)4Ccg
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(IghelMD4)4Ccg/? Tg(ML5sHEL)5Ccg/?
Background: C57BL/6-Tg(IghelMD4)4Ccg Tg(ML5sHEL)5Ccg
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Plcg2/Plcg2
Background: involves: 129P2/OlaHsd
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Racgap1/Racgap1 Tg(Mx1-cre)1Cgn/?
Background: involves: C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ifnb1/Ifnb1
Background: involves: 129P2/OlaHsd
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dclre1c/Dclre1c
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Blnk/Blnk
Background: involves: 129P2/OlaHsd
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Kat6a/Kat6a
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Igh-J/Igh-J<+>
Background: Not Specified
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cxcl12/Cxcl12<+>
Background: B6.Cg-Cxcl12
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Trp53/Trp53
Background: involves: C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Cd19/Cd19<+>
Background: involves: 129P2/OlaHsd * BALB/cJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bcl11a/Bcl11a Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129P2/OlaHsd * 129S1/Sv
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Igh-Mir210)#aKgcs/Tg(Igh-Mir210)#aKgcs
Background: B6.Cg-Tg(Igh-Mir210)#aKgcs
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nbn/Nbn Tg(VAV1-cre)1Graf/?
Background: involves: 129P2/OlaHsd
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pclaf/Pclaf
Background: C57BL/6N-Pclaf/Wtsi
Zygosity: hm
Has Mutant Allele: true
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Protein Coding Gene
MGI:96431 | Cd79b
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR001523 | Paired_dom
Type: Domain
Description: The paired domain is an approximately 126 amino acid DNA-binding domain, which is found in eukaryotic transcription regulatory proteins involved in embryogenesis. The domain was originally described as the 'paired box' in the Drosophila protein paired (prd) [, ]. The paired domain is generally located in the N-terminal part. An octapeptide []and/or a homeodomain can occur C-terminal to the paired domain, as well as a Pro-Ser-Thr-rich C terminus.Paired domain proteins can function as transcription repressors or activators. The paired domain contains three subdomains, which show functional differences in DNA-binding. The crystal structures of prd and Pax proteins show that the DNA-bound paired domain is bipartite, consisting of an N-terminal subdomain (PAI or NTD) and a C-terminal subdomain (RED or CTD), connected by a linker. PAI and RED each form a three-helical fold, with the most C-terminal helices comprising a helix-turn-helix (HTH) motif that binds the DNA major groove. In addition, the PAI subdomain encompasses an N-terminal β-turn andβ-hairpin, also named 'wing', participating in DNA-binding. The linker canbind into the DNA minor groove. Different Pax proteins and their alternativelyspliced isoforms use different (sub)domains for DNA-binding to mediate thespecificity of sequence recognition [, ].Some proteins known to contain a paired domain:Drosophila paired (prd), a segmentation pair-rule class protein.Drosophila gooseberry proximal (gsb-p) and gooseberry distal (gsb-d),segmentation polarity class proteins.Drosophila Pox-meso and Pox-neuro proteins.The Pax proteins:Mammalian protein Pax1, which may play a role in the formation of segmented structures in the embryo. In mouse, mutations in Pax1 produce the undulated phenotype, characterised by vertebral malformations along the entire rostro-caudal axis.Mammalian protein Pax2, a probable transcription factor that may have arole in kidney cell differentiation.Mammalian protein Pax3. Pax3 is expressed during early neurogenesis. In humans, defects in Pax3 are the cause of Waardenburg's syndrome (WS), anautosomal dominant combination of deafness and pigmentary disturbance.Mammalian protein Pax4 pays an important role in the differentiation and development of pancreatic islet beta cells. It binds to a common element in the glucagon, insulin and somatostatin promoters. In humans, it has been related to the rare, familial, clinically and genetically heterogeneous form of diabetes MODY (maturity-onset diabetes of the young).Mammalian protein Pax5, also known as B-cell specific transcription factor(BSAP). Pax5 is involved in the regulation of the CD19 gene. It plays animportant role in B-cell differentiation as well as neural development andspermatogenesis.Mammalian protein Pax6 (oculorhombin). Pax6 is a transcription factor withimportant functions in eye and nasal development. In Man, defects in Pax6are the cause of aniridia type II (AN2), an autosomal dominant disordercharacterised by complete or partial absence of the iris.Mammalian protein Pax7 is involved in the regulation of muscle stem cells proliferation, playing a role in myogenesis and muscle regeneration.Mammalian protein Pax8, required in thyroid development.Mammalian protein Pax9, required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs. In man, defects in Pax9 cause oligodontia.Zebrafish protein Paired box protein Pax-2a, involved in the development of the midbrain/hindbrain boundary organizer and specification of neuronal cell fates.Xenopus laevis protein Paired box protein Pax-3-A, which promotes both hatching gland and neural crest cell fates, two of the cell populations that arise from the neural plate border.
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Protein Coding Gene
MGI:1335091 | Zbtb7a
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2183438 | Ell2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1917579 | Gon4l
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:101877 | Tcf12
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1341902 | Ccr9
Type: protein_coding_gene
Organism: mouse, laboratory
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Allele
Ikzf1<tm2Kge> | MGI:2158690
Name: IKAROS family zinc finger 1; targeted mutation 2, Katia Georgopoulos
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Plcg2<tm1Jni> | MGI:2386100
Name: phospholipase C, gamma 2; targeted mutation 1, James N Ihle
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Rad50<tm2Jpt> | MGI:2387857
Name: RAD50 double strand break repair protein; targeted mutation 2, John H J Petrini
Allele Type: Targeted
Attribute String: Not Specified
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Allele
Arid5b<tm1Pjh> | MGI:2445941
Name: AT-rich interaction domain 5B; targeted mutation 1, Paul J Hertzog
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Spi1<tm1.3Dgt> | MGI:3619530
Name: Spi-1 proto-oncogene; targeted mutation 1.3, Daniel G Tenen
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Cyld<tm1.1Awai> | MGI:3761624
Name: CYLD lysine 63 deubiquitinase; targeted mutation 1.1, Ari Waisman
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Flt3<tm1Dosm> | MGI:3783339
Name: FMS-like tyrosine kinase 3; targeted mutation 1, Donald Small
Allele Type: Targeted
Attribute String: Conditional ready, Constitutively active
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Transgene
MGI:3822839 | Tg(Ly6a-SET/NUP214)2969Gcg
Type: transgene
Organism: mouse, laboratory
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Allele
Kmt2e<tm1.1Hjf> | MGI:3835538
Name: lysine (K)-specific methyltransferase 2E; targeted mutation 1.1, H J Fehling
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Ighm<tm1.1(IGH-2)Cog> | MGI:4437126
 
Name: immunoglobulin heavy constant mu; targeted mutation 1.1, Michel Cogne
Allele Type: Targeted
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Allele
Atp11c<ambr> | MGI:4456247
 
Name: ATPase, class VI, type 11C; ambrosius
Allele Type: Chemically induced (ENU)
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Allele
Nfkbia<tm1.1Smiy> | MGI:4941306
 
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha; targeted mutation 1.1, Shigeki Miyamoto
Allele Type: Targeted
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Allele
Hax1<tm1.1Gach> | MGI:5056144
Name: HCLS1 associated X-1; targeted mutation 1.1, Gernot Achatz
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Igh<tm1.1Twin> | MGI:5140396
Name: immunoglobulin heavy chain complex; targeted mutation 1.1, Thomas H Winkler
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Complex Cluster Region
MGI:5295773 | Mirc11
Type: biological_region
Organism: mouse, laboratory
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Allele
Gt(ROSA)26Sor<tm1Jus> | MGI:5502574
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Monica Justice
Allele Type: Targeted
Attribute String: Conditional ready, Inserted expressed sequence, Reporter
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Allele
Flt3<tm2.1Dosm> | MGI:5565506
Name: FMS-like tyrosine kinase 3; targeted mutation 2.1, Donald Small
Allele Type: Targeted
Attribute String: Constitutively active
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Allele
Runx1<tm2.1Gss> | MGI:5613812
 
Name: runt related transcription factor 1; targeted mutation 2.1, Gary S Stein
Allele Type: Targeted
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Allele
Noc2l<tm1.1Arte> | MGI:5662104
Name: NOC2 like nucleolar associated transcriptional repressor; targeted mutation 1.1, TaconicArtemis
Allele Type: Targeted
Attribute String: Conditional ready
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Allele
Phf6<em1Wencc> | MGI:7280677
Name: PHD finger protein 6; endonuclease-mediated mutation 1, Wen-Chien Chou
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Genotype
Genotype
Symbol: Cd72/Cd72
Background: either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sox4/Sox4
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Igh/Igh
Background: BALB/c-Igh
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cxcl12/Cxcl12
Background: involves: 129P2/OlaHsd
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Fzd9/Fzd9
Background: involves: 129S6/SvEvTac * 129X1/SvJ
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bak1/Bak1 Bax/Bax Cd19/Cd19<+>
Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bcl2l11/Bcl2l11 Bik/Bik
Background: B6.Cg-Bcl2l11 Bik
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Spi1/Spi1
Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Flt3/Flt3 Kit/Kit
Background: involves: 129S/SvEv * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tcf12/Tcf12
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Kmt2a/Kmt2a<+>
Background: involves: 129S1/Sv * C57BL/6 * FVB
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pgm3/Pgm3
Background: C57BL/6-Pgm3
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pgm3/Pgm3
Background: involves: 129S1/Sv * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pik3r1/Pik3r1
Background: involves: C57BL/6 * CBA
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Ly6a-SET/NUP214)2969Gcg/?
Background: involves: FVB/NJ
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Inpp5d/Inpp5d
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rag1/Rag1
Background: involves: 129S6/SvEvTac
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pbx1/Pbx1 Tg(Tek-cre)1Ywa/?
Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Igh-J/Igh-J
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dck/Dck
Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6 * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gon4l/Gon4l
Background: C3HeB/FeJ-Gon4l
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tet2/Tet2
Background: B6.129P2-Tet2
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Cd19/Cd19<+>
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Fnip1/Fnip1
Background: involves: C57BL/6 * C57BL/6J * FVB/N * SJL
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Fnip1/Fnip1
Background: involves: 129P2/OlaHsd * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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