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Search results 901 to 1000 out of 1171 for Pkd1

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Type Details Score
Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
29133434 | J:255684
First Author: Cen C
Year: 2018
Journal: J Neurosci
Title: PKD1 Promotes Functional Synapse Formation Coordinated with N-Cadherin in Hippocampus.
Volume: 38
Issue: 1
Pages: 183-199
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Publication
33521594 | J:306832
First Author: Fleming Martinez AK
Year: 2021
Journal: iScience
Title: Dysfunctional EGFR and oxidative stress-induced PKD1 signaling drive formation of DCLK1+ pancreatic stem cells.
Volume: 24
Issue: 1
Pages: 102019
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Publication
26192751 | J:244762
First Author: Johnson KR
Year: 2015
Journal: PLoS One
Title: Genome-Wide Gene Expression Analysis Shows AKAP13-Mediated PKD1 Signaling Regulates the Transcriptional Response to Cardiac Hypertrophy.
Volume: 10
Issue: 7
Pages: e0132474
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Publication
28408623 | J:243667
First Author: Chang JK
Year: 2017
Journal: J Biol Chem
Title: Protein kinase D1 (PKD1) phosphorylation on Ser203 by type I p21-activated kinase (PAK) regulates PKD1 localization.
Volume: 292
Issue: 23
Pages: 9523-9539
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Publication
31591827 | J:295483
First Author: Khan S
Year: 2019
Journal: Physiol Rep
Title: A role for PKD1 in insulin secretion downstream of P2Y1 receptor activation in mouse and human islets.
Volume: 7
Issue: 19
Pages: e14250
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Publication
31517390 | J:299863
First Author: Li J
Year: 2020
Journal: J Cell Physiol
Title: Upregulated microRNA-31 inhibits oxidative stress-induced neuronal injury through the JAK/STAT3 pathway by binding to PKD1 in mice with ischemic stroke.
Volume: 235
Issue: 3
Pages: 2414-2428
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Allele
Pkd1<tm1.1Fqi> | MGI:5470234
 
Name: polycystin 1, transient receptor potential channel interacting; targeted mutation 1.1, Feng Qian
Allele Type: Targeted
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Allele
Tg(Pkd1*)39Mtru | MGI:5519083
Name: transgene insertion 39, Marie Trudel
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Publication
38449738 | J:345890
 
First Author: Ay M
Year: 2024
Journal: Front Neurosci
Title: Mito-metformin protects against mitochondrial dysfunction and dopaminergic neuronal degeneration by activating upstream PKD1 signaling in cell culture and MitoPark animal models of Parkinson's disease.
Volume: 18
Pages: 1356703
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Protein Coding Gene
MGI:99879 | Prkd1
Type: protein_coding_gene
Organism: mouse, laboratory
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Allele
Pkd1<em1Smoc> | MGI:7291670
Name: polycystin 1, transient receptor potential channel interacting; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Genotype
Genotype
Symbol: Pkd1/Pkd1
Background: involves: 129S6/SvEvTac
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Pkd1*)39Mtru/?
Background: involves: C57BL/6J * CBA/J
Zygosity: ot
Has Mutant Allele: true
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Publication
10469604 | -
First Author: Bateman A
Year: 1999
Journal: Curr Biol
Title: The PLAT domain: a new piece in the PKD1 puzzle.
Volume: 9
Issue: 16
Pages: R588-90
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Genotype
Genotype
Symbol: Gpsm1/Gpsm1 Pkd1/Pkd1
Background: involves: 129S6/SvEvTac
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pkd1/Pkd1<+> Tg(Pkd1*)39Mtru/?
Background: involves: 129/Sv * C57BL/6J * CBA/J * SJL
Zygosity: cx
Has Mutant Allele: true
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Interaction Experiment
Bhunia AK (2002)
Description: PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2.
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Strain
MGI:6476028 | C57BL/6JSmoc-Pkd1<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Pkd1<tm1Jzh> | MGI:1857562
Name: polycystin 1, transient receptor potential channel interacting; targeted mutation 1, Jing Zhou
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Pkd1<tm1Rsa> | MGI:2152589
Name: polycystin 1, transient receptor potential channel interacting; targeted mutation 1, Richard Sandford
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Pkd1<tm2Jzh> | MGI:2182840
Name: polycystin 1, transient receptor potential channel interacting; targeted mutation 2, Jing Zhou
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Pkd1<tm1Shh> | MGI:2183431
Name: polycystin 1, transient receptor potential channel interacting; targeted mutation 1, Shigeo Horie
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Pkd1<tm1Djmp> | MGI:3521583
Name: polycystin 1, transient receptor potential channel interacting; targeted mutation 1, Dorien JM Peters
Allele Type: Targeted
Attribute String: Conditional ready, Hypomorph
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Allele
Pkd1<tm1Ggg> | MGI:3612339
Name: polycystin 1, transient receptor potential channel interacting; targeted mutation 1, Gregory G Germino
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Pkd1<tm2Ggg> | MGI:3612341
Name: polycystin 1, transient receptor potential channel interacting; targeted mutation 2, Gregory G Germino
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Pkd1<tm2.1Ggg> | MGI:3617325
Name: polycystin 1, transient receptor potential channel interacting; targeted mutation 2.1, Gregory G Germino
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Pkd1<tm1Bdgz> | MGI:3714781
 
Name: polycystin 1, transient receptor potential channel interacting; targeted mutation 1, William Dackowski
Allele Type: Targeted
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Allele
Pkd1<tm2Som> | MGI:3793791
Name: polycystin 1, transient receptor potential channel interacting; targeted mutation 2, Stefan Somlo
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Pkd1<tm2.1Som> | MGI:3793792
Name: polycystin 1, transient receptor potential channel interacting; targeted mutation 2.1, Stefan Somlo
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Pkd1<tm3Jzh> | MGI:3811233
Name: polycystin 1, transient receptor potential channel interacting; targeted mutation 3, Jing Zhou
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Pkd1<tm3.1Jzh> | MGI:3811234
Name: polycystin 1, transient receptor potential channel interacting; targeted mutation 3.1, Jing Zhou
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Pkd1<tm1Gztn> | MGI:4437121
Name: polycystin 1, transient receptor potential channel interacting; targeted mutation 1, Thomas Natoli
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Pkd1<tm1.1Pcha> | MGI:5476822
 
Name: polycystin 1, transient receptor potential channel interacting; targeted mutation 1.1, Peter Harris
Allele Type: Targeted
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Publication
22508176 | -
First Author: Audrézet MP
Year: 2012
Journal: Hum Mutat
Title: Autosomal dominant polycystic kidney disease: comprehensive mutation analysis of PKD1 and PKD2 in 700 unrelated patients.
Volume: 33
Issue: 8
Pages: 1239-50
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Allele
Pkd1<em4Smoc> | MGI:7291671
Name: polycystin 1, transient receptor potential channel interacting; endonuclease-mediated mutation 4, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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HT Experiment
E-GEOD-24352 | Systems biology approach to identify transcriptional reprogramming and microRNA targets during the progression of Polycystic Kidney Disease
Series Id: GSE24352
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Transgene
MGI:5519082 | Tg(Pkd1*)39Mtru
Type: transgene
Organism: mouse, laboratory
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Genotype
Genotype
Symbol: Pkd1/Pkd1
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pkd1/Pkd1
Background: either: (involves: 129S4/SvJae * C57BL/6) or (involves: 129S4/SvJae * BALB/c)
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pkd1/Pkd1<+>
Background: either: (involves: 129S4/SvJae * C57BL/6) or (involves: 129S4/SvJae * BALB/c)
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pkd1/Pkd1<+>
Background: involves: 129S4/SvJaeSor
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pkd1/Pkd1
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pkd1/Pkd1
Background: involves: 129S4/SvJae * Black Swiss * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pkd1/Pkd1 Tg(MMTV-cre)4Mam/?
Background: involves: 129S4/SvJae * FVB
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pkd1/Pkd1
Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pkd1/Pkd1<+>
Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pkd1/Pkd1<+>
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pkd1/Pkd1 Tg(Cdh16-cre)91Igr/?
Background: involves: C57BL/6 * ICR * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pkd1/Pkd1 Tg(Ggt1-cre)M3Egn/?
Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pkd1/Pkd1
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pkd1/Pkd1
Background: involves: 129S4/SvJae * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pkd1/Pkd1 Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129S/Sv * 129S7/SvEvBrd * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pkd1/Pkd1 Tg(Nes-cre)Wme/?
Background: involves: 129S4/SvJae * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pkd1/Pkd1
Background: involves: 129S1/Sv * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pkd1/Pkd1
Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pkd1/Pkd1 Tg(Col1a1-cre)1Bek/?
Background: involves: 129S4/SvJae * CD-1
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pkd1/Pkd1 Tg(Hoxb7-cre)13Amc/?
Background: involves: 129S4/SvJae * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pkd1/Pkd1 Tg(Cdh16-cre)91Igr/?
Background: involves: 129S4/SvJae * C57BL/6 * ICR
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pkd1/Pkd1 Tg(Cdh16-cre)91Igr/?
Background: involves: 129 * 129S4/SvJae * C57BL/6 * ICR
Zygosity: cn
Has Mutant Allele: true
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HT Experiment
GSE207957 | Effect of global Caspase-1 (Casp1) knockout (KO) on kidney gene expression in an orthologous mouse model of polycystic kidney disease (PKD)
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Sample
GSM600322 1
Organism Name: mouse, laboratory
Sex: Not Specified
Age: embryonic day 14.5
Stage: 22
Structure . Name: metanephros
Notes: Two alleles were created in the paper referenced for the Pkd1 allele; these authors did not specify which was used for these array studies. It is possible this embryo carried the Pkd1 allele instead.
Curation Status: Curated
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HT Sample
GSM600323 1
Organism Name: mouse, laboratory
Sex: Not Specified
Age: embryonic day 14.5
Stage: 22
Structure . Name: metanephros
Notes: Two alleles were created in the paper referenced for the Pkd1 allele; these authors did not specify which was used for these array studies. It is possible this embryo carried the Pkd1 allele instead.
Curation Status: Curated
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HT Sample
GSM600324 1
Organism Name: mouse, laboratory
Sex: Not Specified
Age: embryonic day 14.5
Stage: 22
Structure . Name: metanephros
Notes: Two alleles were created in the paper referenced for the Pkd1 allele; these authors did not specify which was used for these array studies. It is possible this embryo carried the Pkd1 allele instead.
Curation Status: Curated
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HT Sample
GSM600328 1
Organism Name: mouse, laboratory
Sex: Not Specified
Age: embryonic day 17.5
Stage: 25
Structure . Name: metanephros
Notes: Two alleles were created in the paper referenced for the Pkd1 allele; these authors did not specify which was used for these array studies. It is possible this embryo carried the Pkd1 allele instead.
Curation Status: Curated
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HT Sample
GSM600329 1
Organism Name: mouse, laboratory
Sex: Not Specified
Age: embryonic day 17.5
Stage: 25
Structure . Name: metanephros
Notes: Two alleles were created in the paper referenced for the Pkd1 allele; these authors did not specify which was used for these array studies. It is possible this embryo carried the Pkd1 allele instead.
Curation Status: Curated
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HT Sample
GSM600330 1
Organism Name: mouse, laboratory
Sex: Not Specified
Age: embryonic day 17.5
Stage: 25
Structure . Name: metanephros
Notes: Two alleles were created in the paper referenced for the Pkd1 allele; these authors did not specify which was used for these array studies. It is possible this embryo carried the Pkd1 allele instead.
Curation Status: Curated
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Allele
Kif3a<tm2Gsn> | MGI:2386464
Name: kinesin family member 3A; targeted mutation 2, Lawrence SB Goldstein
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Pkd1<b2b1585Clo> | MGI:5438059
 
Name: polycystin 1, transient receptor potential channel interacting; Bench to Bassinet Program (B2B/CVDC), mutation 1585 Cecilia Lo
Allele Type: Chemically induced (ENU)
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Strain
MGI:6429362 | C57BL/6JSmoc-Pkd1<em4Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Genotype
Genotype
Symbol: Pkd1/Pkd1
Background: C57BL/6J-Pkd1
Zygosity: hm
Has Mutant Allele: true
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HT Experiment
GSE108864 | Long noncoding RNA Hoxb3os is dysregulated in autosomal dominant polycystic kidney disease and regulates mTOR signaling
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Strain
MGI:5470420 | B6.129S6-Pkd1<tm1.1Fqi>
Attribute String: congenic, mutant strain, targeted mutation
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Genotype
Genotype
Symbol: Pkd1/Pkd1
Background: B6.129S6-Pkd1
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gpsm1/Gpsm1<+> Pkd1/Pkd1
Background: involves: 129S6/SvEvTac
Zygosity: cx
Has Mutant Allele: true
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Protein
Q8C0Z9
Organism: Mus musculus/domesticus
Length: 199  
Fragment?: true
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Publication
11013137 | -
First Author: Bassi MT
Year: 2000
Journal: Am J Hum Genet
Title: Cloning of the gene encoding a novel integral membrane protein, mucolipidin-and identification of the two major founder mutations causing mucolipidosis type IV.
Volume: 67
Issue: 5
Pages: 1110-20
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Publication
12459486 | -
First Author: LaPlante JM
Year: 2002
Journal: FEBS Lett
Title: Identification and characterization of the single channel function of human mucolipin-1 implicated in mucolipidosis type IV, a disorder affecting the lysosomal pathway.
Volume: 532
Issue: 1-2
Pages: 183-7
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Publication
14749347 | -
First Author: Raychowdhury MK
Year: 2004
Journal: Hum Mol Genet
Title: Molecular pathophysiology of mucolipidosis type IV: pH dysregulation of the mucolipin-1 cation channel.
Volume: 13
Issue: 6
Pages: 617-27
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Protein Domain
IPR013122 | PKD1_2_channel
Type: Domain
Description: Polycystic kidney diseases (PKD) are disorders characterised by large numbers of cysts distributed throughout grossly-enlarged kidneys. Cystdevelopment is associated with impairment of kidney function, and ultimately kidney failure and death [, ]. Most cases of autosomal dominant PKD result from mutations in the PKD1 gene that cause premature protein termination. A second gene for autosomal dominant polycystic kidney disease has been identified by positional cloning []. The predicted 968-amino acid sequence of the PKD2 gene product (polycystin-2) contains 6 transmembrane domains, with intracellular N- and C-termini. Polycystin-2 shares some similarity with the family of voltage-activated calcium (and sodium) channels, and contains a potential calcium-binding domain [].Polycystin-2 is strongly expressed in ovary, foetal and adult kidney, testis, and small intestine. Polycystin-1 requires the presence of this protein for stable expression and is believed to interact with it via its C terminus. All mutations between exons 1 and 11 result in a truncated polycystin-2 that lacks a calcium-binding EF-hand domain and the cytoplasmic domains required for the interaction of polycystin-2 with polycystin-1 []. PKD2, although clinically milder than PKD1, has a deleterious impact on life expectancy.This entry contains proteins belonging to the polycystin family including Mucolipin and Polycystin-1 and -2 (PKD1 and PKD2). The domain contains the cation channel region of PKD1 and PKD2 proteins. PKD1 and PKD2 may function through a common signalling pathway that is necessary for normal tubulogenesis. The PKD2 gene product has six transmembrane spans with intracellular amino- and carboxyl-termini [].Mucolipin is a cationic channel which probably plays a role in the endocytic pathway and in the control of membrane trafficking of proteins and lipids. It could play a major role in the calcium ion transport regulating lysosomal exocytosis [, , ].
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HT Experiment
E-MTAB-6423 | Renal transcriptome profiling by RNAseq in Bicc1 WT and KO mice
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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Protein
Q8R4F0
Organism: Mus musculus/domesticus
Length: 553  
Fragment?: false
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Protein
Q8K595
Organism: Mus musculus/domesticus
Length: 566  
Fragment?: false
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Protein
Q99J21
Organism: Mus musculus/domesticus
Length: 580  
Fragment?: false
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Protein
Q3U652
Organism: Mus musculus/domesticus
Length: 566  
Fragment?: false
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Protein
Q925J2
Organism: Mus musculus/domesticus
Length: 584  
Fragment?: true
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Protein
Q3KP77
Organism: Mus musculus/domesticus
Length: 553  
Fragment?: false
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Protein
Q3KP78
Organism: Mus musculus/domesticus
Length: 553  
Fragment?: false
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Protein
Q3TTV4
Organism: Mus musculus/domesticus
Length: 681  
Fragment?: true
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Publication
27245420 | J:322402
First Author: Zhang T
Year: 2016
Journal: Cell Cycle
Title: PKD3 deficiency causes alterations in microtubule dynamics during the cell cycle.
Volume: 15
Issue: 14
Pages: 1844-54
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Publication
17369396 | J:119479
First Author: Parra M
Year: 2007
Journal: Genes Dev
Title: Myosin phosphatase dephosphorylates HDAC7, controls its nucleocytoplasmic shuttling, and inhibits apoptosis in thymocytes.
Volume: 21
Issue: 6
Pages: 638-43
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Publication
2714795 | J:9759
First Author: Callen DF
Year: 1989
Journal: Genomics
Title: Mapping the short arm of human chromosome 16.
Volume: 4
Issue: 3
Pages: 348-54
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Publication
8921388 | J:36020
First Author: Van Raay TJ
Year: 1996
Journal: Genomics
Title: A novel ribosomal protein L3-like gene (RPL3L) maps to the autosomal dominant polycystic kidney disease gene region.
Volume: 37
Issue: 2
Pages: 172-6
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Protein
Q9JLG4
Organism: Mus musculus/domesticus
Length: 621  
Fragment?: false
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Publication
29567962 | J:283187
First Author: Su Q
Year: 2018
Journal: Nat Commun
Title: Cryo-EM structure of the polycystic kidney disease-like channel PKD2L1.
Volume: 9
Issue: 1
Pages: 1192
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Publication
9949214 | J:53798
First Author: Hughes J
Year: 1999
Journal: Hum Mol Genet
Title: Identification of a human homologue of the sea urchin receptor for egg jelly: a polycystic kidney disease-like protein.
Volume: 8
Issue: 3
Pages: 543-9
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Protein
Q3V2I4
Organism: Mus musculus/domesticus
Length: 520  
Fragment?: true
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Protein
A0A1D5RLT9
Organism: Mus musculus/domesticus
Length: 816  
Fragment?: true
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•
•
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•
Protein
Q3V056
Organism: Mus musculus/domesticus
Length: 621  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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