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Search results 901 to 1000 out of 1044 for Rel

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Type Details Score
Publication
29246443 | J:259282
First Author: Man K
Year: 2017
Journal: Immunity
Title: Transcription Factor IRF4 Promotes CD8+ T Cell Exhaustion and Limits the Development of Memory-like T Cells during Chronic Infection.
Volume: 47
Issue: 6
Pages: 1129-1141.e5
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Publication
29395922 | -
First Author: Essuman K
Year: 2018
Journal: Curr Biol
Title: TIR Domain Proteins Are an Ancient Family of NAD+-Consuming Enzymes.
Volume: 28
Issue: 3
Pages: 421-430.e4
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Publication
34184985 | -
   
First Author: Loring HS
Year: 2021
Journal: Elife
Title: A phase transition enhances the catalytic activity of SARM1, an NAD+ glycohydrolase involved in neurodegeneration.
Volume: 10
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Protein Domain
IPR000157 | TIR_dom
Type: Domain
Description: This entry represents the Toll/interleukin-1 receptor (TIR) domain, which is the conserved cytoplasmic domain of approximately 200 amino acids, found in Toll-like receptors (TLRs) and their adaptors. Proteins containing this domain can also be found in plants, where they mediate disease resistance [], and in bacteria, where they have been associated with virulence. Interestingly, the TIR domains from proteins present in all three major domains of life have been shown to cleave nicotinamide adenine dinucleotide (NAD+). In plants, TIR domains require self-association interfaces and a putative catalytic glutamic acid that is conserved in both bacterial TIR NAD+-cleaving enzymes (NADases) and the mammalian SARM1 (sterile alpha and TIR motif containing 1) NADase for cell death induction and NAD+ cleavage activity [, ]. It has been suggested that the primordial function of the TIR domain is the enzymatic cleavage of NAD+ and that the scaffolding function, which is best characterised in mammalian TIR domains involved in innate immunity, may be a more recent evolutionary adaptation [].Toll proteins or Toll-like receptors (TLRs) and the interleukin-1 receptor (IL-1R) superfamily are both involved in innate antibacterial and antifungalimmunity in insects as well as in mammals. These receptors share a conserved cytoplasmic domain of approximately 200 amino acids, known as the Toll/IL-1R homologous region (TIR). The similarity between TLRs and IL-1Rs is not restricted to sequence homology since these proteins also share a similar signalling pathway. They both induce the activation of a Rel type transcription factor via an adaptor protein and a protein kinase []. Interestingly, MyD88, a cytoplasmic adaptor protein found in mammals, contains a TIR domain associated to a DEATH domain [, , ]. Besides the mammalian and Drosophila proteins, a TIR domain is also found in a number of plant cytoplasmic proteins implicated in host defense [].Site directed mutagenesis and deletion analysis have shown that the TIR domain is essential for Toll and IL-1R activities. Sequence analysis have revealed the presence of three highly conserved regions among the different members of the family: box 1 (FDAFISY), box 2 (GYKLC-RD-PG), and box 3 (a conserved W surrounded by basic residues). It has been proposed that boxes 1 and 2 are involved in the binding of proteins involved in signalling, whereas box 3 is primarily involved in directing localization of receptor, perhaps through interactions with cytoskeletal element [].Resolution of the crystal structures of the TIR domains of human Toll-like receptors 1 and 2 has shown that they contain a central five-stranded parallel β-sheet that is surrounded by a total of five helices on both sides, with connecting loop structures []. The loop regions appear to play an important role in mediating the specificity of protein-protein interactions [, ].
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Protein
Q80VH0
Organism: Mus musculus/domesticus
Length: 783  
Fragment?: false
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Protein
Q9EQ32
Organism: Mus musculus/domesticus
Length: 811  
Fragment?: false
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Protein
Q80UF7
Organism: Mus musculus/domesticus
Length: 732  
Fragment?: false
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Publication
10231569 | J:54928
First Author: Takeuchi O
Year: 1999
Journal: Gene
Title: TLR6: A novel member of an expanding toll-like receptor family.
Volume: 231
Issue: 1-2
Pages: 59-65
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Protein
Q8BJQ4
Organism: Mus musculus/domesticus
Length: 232  
Fragment?: false
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Protein
Q99JY1
Organism: Mus musculus/domesticus
Length: 241  
Fragment?: false
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Protein
G3GHZ8
Organism: Mus musculus/domesticus
Length: 132  
Fragment?: true
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Protein
H3BKL1
Organism: Mus musculus/domesticus
Length: 249  
Fragment?: false
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Protein
G3GHZ7
Organism: Mus musculus/domesticus
Length: 132  
Fragment?: true
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Protein
Q0P699
Organism: Mus musculus/domesticus
Length: 783  
Fragment?: false
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Protein
H3BLC8
Organism: Mus musculus/domesticus
Length: 219  
Fragment?: true
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Protein
Q3UB38
Organism: Mus musculus/domesticus
Length: 241  
Fragment?: false
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Protein
A0A1S5WLF0
Organism: Mus musculus/domesticus
Length: 119  
Fragment?: false
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Protein
Q542S6
Organism: Mus musculus/domesticus
Length: 241  
Fragment?: false
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Publication
8621445 | -
First Author: Mitcham JL
Year: 1996
Journal: J Biol Chem
Title: T1/ST2 signaling establishes it as a member of an expanding interleukin-1 receptor family.
Volume: 271
Issue: 10
Pages: 5777-83
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Publication
9374458 | -
First Author: Muzio M
Year: 1997
Journal: Science
Title: IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling.
Volume: 278
Issue: 5343
Pages: 1612-5
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Publication
10679407 | -
First Author: Anderson KV
Year: 2000
Journal: Curr Opin Immunol
Title: Toll signaling pathways in the innate immune response.
Volume: 12
Issue: 1
Pages: 13-9
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Publication
9868361 | -
First Author: Van der Biezen EA
Year: 1998
Journal: Trends Biochem Sci
Title: Plant disease-resistance proteins and the gene-for-gene concept.
Volume: 23
Issue: 12
Pages: 454-6
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Publication
10671496 | -
First Author: Slack JL
Year: 2000
Journal: J Biol Chem
Title: Identification of two major sites in the type I interleukin-1 receptor cytoplasmic region responsible for coupling to pro-inflammatory signaling pathways.
Volume: 275
Issue: 7
Pages: 4670-8
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Publication
11081518 | J:114793
First Author: Xu Y
Year: 2000
Journal: Nature
Title: Structural basis for signal transduction by the Toll/interleukin-1 receptor domains.
Volume: 408
Issue: 6808
Pages: 111-5
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Publication
31439792 | -
First Author: Horsefield S
Year: 2019
Journal: Science
Title: NAD+ cleavage activity by animal and plant TIR domains in cell death pathways.
Volume: 365
Issue: 6455
Pages: 793-799
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Publication
28723569 | J:254238
First Author: Lawlor KE
Year: 2017
Journal: Cell Rep
Title: XIAP Loss Triggers RIPK3- and Caspase-8-Driven IL-1β Activation and Cell Death as a Consequence of TLR-MyD88-Induced cIAP1-TRAF2 Degradation.
Volume: 20
Issue: 3
Pages: 668-682
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Publication
19078986 | J:150224
First Author: Jin H
Year: 2009
Journal: J Invest Dermatol
Title: Animal models of atopic dermatitis.
Volume: 129
Issue: 1
Pages: 31-40
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Publication
38457343 | J:346703
First Author: Bülow S
Year: 2024
Journal: Cell Rep
Title: Bactericidal/permeability-increasing protein instructs dendritic cells to elicit Th22 cell response.
Volume: 43
Issue: 3
Pages: 113929
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Publication
24473265 | J:208441
First Author: Bautista DM
Year: 2014
Journal: Nat Neurosci
Title: Why we scratch an itch: the molecules, cells and circuits of itch.
Volume: 17
Issue: 2
Pages: 175-82
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Protein
G3XA78
Organism: Mus musculus/domesticus
Length: 166  
Fragment?: true
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Publication
31439793 | -
First Author: Wan L
Year: 2019
Journal: Science
Title: TIR domains of plant immune receptors are NAD+-cleaving enzymes that promote cell death.
Volume: 365
Issue: 6455
Pages: 799-803
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Protein Coding Gene
MGI:1350917 | Rps3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P22366
Organism: Mus musculus/domesticus
Length: 296  
Fragment?: false
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Protein
Q9JLZ8
Organism: Mus musculus/domesticus
Length: 409  
Fragment?: false
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Protein
Q9EQU3
Organism: Mus musculus/domesticus
Length: 1032  
Fragment?: false
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Protein
P58681
Organism: Mus musculus/domesticus
Length: 1050  
Fragment?: false
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Protein
P58682
Organism: Mus musculus/domesticus
Length: 1032  
Fragment?: false
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Protein
Q6PDS3
Organism: Mus musculus/domesticus
Length: 724  
Fragment?: false
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Protein
Q3U7M4
Organism: Mus musculus/domesticus
Length: 296  
Fragment?: false
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Protein
U5LLB3
Organism: Mus musculus/domesticus
Length: 1049  
Fragment?: true
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Protein
Q0PM15
Organism: Mus musculus/domesticus
Length: 296  
Fragment?: false
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Protein
A0A1B0GS40
Organism: Mus musculus/domesticus
Length: 306  
Fragment?: true
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Protein
Q3UDG9
Organism: Mus musculus/domesticus
Length: 284  
Fragment?: true
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Protein
Q3TIB3
Organism: Mus musculus/domesticus
Length: 296  
Fragment?: false
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Protein
Q3UKS3
Organism: Mus musculus/domesticus
Length: 409  
Fragment?: false
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Protein
Q3U6W5
Organism: Mus musculus/domesticus
Length: 296  
Fragment?: false
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Protein
A0PJL3
Organism: Mus musculus/domesticus
Length: 704  
Fragment?: true
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Protein
Q0PM16
Organism: Mus musculus/domesticus
Length: 296  
Fragment?: false
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Protein
Q3V005
Organism: Mus musculus/domesticus
Length: 409  
Fragment?: false
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Protein
U5LLA9
Organism: Mus musculus/domesticus
Length: 1049  
Fragment?: true
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Protein
U5LI18
Organism: Mus musculus/domesticus
Length: 1049  
Fragment?: true
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Protein
Q548J0
Organism: Mus musculus/domesticus
Length: 1050  
Fragment?: false
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Publication
21419662 | J:169863
First Author: Powolny-Budnicka I
Year: 2011
Journal: Immunity
Title: RelA and RelB transcription factors in distinct thymocyte populations control lymphotoxin-dependent interleukin-17 production in γδ T cells.
Volume: 34
Issue: 3
Pages: 364-74
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Publication
23422957 | J:195312
First Author: Mancino A
Year: 2013
Journal: EMBO J
Title: I kappa B kinase alpha (IKKα) activity is required for functional maturation of dendritic cells and acquired immunity to infection.
Volume: 32
Issue: 6
Pages: 816-28
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Protein Coding Gene
MGI:103290 | Rela
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P59823
Organism: Mus musculus/domesticus
Length: 695  
Fragment?: false
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Protein
Q61098
Organism: Mus musculus/domesticus
Length: 537  
Fragment?: false
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Protein
Q9Z2B1
Organism: Mus musculus/domesticus
Length: 614  
Fragment?: false
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Protein
P14719
Organism: Mus musculus/domesticus
Length: 567  
Fragment?: false
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Protein
Q6R5N8
Organism: Mus musculus/domesticus
Length: 991  
Fragment?: false
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Protein
Q99MB1
Organism: Mus musculus/domesticus
Length: 905  
Fragment?: false
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Protein
Q6R5P0
Organism: Mus musculus/domesticus
Length: 926  
Fragment?: false
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Protein
Q9EPW9
Organism: Mus musculus/domesticus
Length: 795  
Fragment?: false
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Protein
Q9EPQ1
Organism: Mus musculus/domesticus
Length: 795  
Fragment?: false
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Protein
Q9QUK6
Organism: Mus musculus/domesticus
Length: 835  
Fragment?: false
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Protein
Q9QUN7
Organism: Mus musculus/domesticus
Length: 784  
Fragment?: false
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Protein
Q6QNU9
Organism: Mus musculus/domesticus
Length: 906  
Fragment?: false
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Protein
Q9JLF7
Organism: Mus musculus/domesticus
Length: 859  
Fragment?: false
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Protein
Q61730
Organism: Mus musculus/domesticus
Length: 570  
Fragment?: false
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Protein
U5LHT3
Organism: Mus musculus/domesticus
Length: 749  
Fragment?: true
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Protein
V9PC74
Organism: Mus musculus/domesticus
Length: 748  
Fragment?: true
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Protein
U5LIX2
Organism: Mus musculus/domesticus
Length: 749  
Fragment?: true
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Protein
V9PCB9
Organism: Mus musculus/domesticus
Length: 748  
Fragment?: true
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Protein
U5LIT5
Organism: Mus musculus/domesticus
Length: 749  
Fragment?: true
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Protein
U5LL62
Organism: Mus musculus/domesticus
Length: 749  
Fragment?: true
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Protein
V9PC79
Organism: Mus musculus/domesticus
Length: 748  
Fragment?: true
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Protein
V9PCD3
Organism: Mus musculus/domesticus
Length: 748  
Fragment?: true
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Protein
V9PC30
Organism: Mus musculus/domesticus
Length: 748  
Fragment?: true
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Protein
V9PC06
Organism: Mus musculus/domesticus
Length: 748  
Fragment?: true
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Protein
B1ASU0
Organism: Mus musculus/domesticus
Length: 696  
Fragment?: false
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Protein
Q3UV88
Organism: Mus musculus/domesticus
Length: 806  
Fragment?: false
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Protein
V9PCB6
Organism: Mus musculus/domesticus
Length: 748  
Fragment?: true
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Protein
V9PC22
Organism: Mus musculus/domesticus
Length: 748  
Fragment?: true
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Protein
V9PC08
Organism: Mus musculus/domesticus
Length: 748  
Fragment?: true
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Protein
Q05AH3
Organism: Mus musculus/domesticus
Length: 859  
Fragment?: false
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Protein
Q3U4D4
Organism: Mus musculus/domesticus
Length: 835  
Fragment?: false
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Protein
U5LIT9
Organism: Mus musculus/domesticus
Length: 749  
Fragment?: true
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Protein
V9PBW6
Organism: Mus musculus/domesticus
Length: 748  
Fragment?: true
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Protein
Q811T5
Organism: Mus musculus/domesticus
Length: 784  
Fragment?: false
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Protein
Q3TM31
Organism: Mus musculus/domesticus
Length: 905  
Fragment?: false
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Protein
V9PBV4
Organism: Mus musculus/domesticus
Length: 748  
Fragment?: true
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Protein
U5LL15
Organism: Mus musculus/domesticus
Length: 749  
Fragment?: true
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Protein
Q0PM14
Organism: Mus musculus/domesticus
Length: 806  
Fragment?: false
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Protein
A0A0A6YVY4
Organism: Mus musculus/domesticus
Length: 873  
Fragment?: false
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Protein
Q499F3
Organism: Mus musculus/domesticus
Length: 905  
Fragment?: false
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Protein
L0CL36
Organism: Mus musculus/domesticus
Length: 835  
Fragment?: false
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Protein
Q3V2X3
Organism: Mus musculus/domesticus
Length: 685  
Fragment?: false
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Protein
V9PC21
Organism: Mus musculus/domesticus
Length: 748  
Fragment?: true
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Protein
Q8K3D9
Organism: Mus musculus/domesticus
Length: 784  
Fragment?: false
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Protein
Q0VBK3
Organism: Mus musculus/domesticus
Length: 614  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom