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Search results 901 to 1000 out of 1005 for Ripk1

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Type Details Score
Publication
First Author: Casellas J
Year: 2010
Journal: J Hered
Title: Segregation analysis of a sex ratio distortion locus in congenic mice.
Volume: 101
Issue: 3
Pages: 351-9
Publication
First Author: Bradford GE
Year: 1984
Journal: Genet Res
Title: Evidence for a major gene for rapid postweaning growth in mice.
Volume: 44
Issue: 3
Pages: 293-308
Publication
First Author: Calvert CC
Year: 1986
Journal: J Anim Sci
Title: Efficiency of growth in mice with a major gene for rapid postweaning gain.
Volume: 62
Issue: 1
Pages: 77-85
Publication
First Author: Reiser K
Year: 1996
Journal: Am J Physiol
Title: Effects of elevated circulating IGF-1 on the extracellular matrix in "high-growth" C57BL/6J mice.
Volume: 271
Issue: 3 Pt 2
Pages: R696-703
Genotype
Symbol: Mohg1/Mohg1 Socs2/Socs2
Background: involves: C57BL/6J * CAST/EiJ
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Mohg3/Mohg3 Socs2/Socs2
Background: involves: C57BL/6J * CAST/EiJ
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Mohg3/Mohg3 Socs2/Socs2
Background: involves: C57BL/6J * CAST/EiJ
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Socs2/Socs2
Background: involves: AKR/J * C3H/HeJ * C57BL/6J * DBA/2J
Zygosity: hm
Has Mutant Allele: true
Publication  
First Author: Pearson JS
Year: 2017
Journal: Nat Microbiol
Title: EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation.
Volume: 2
Pages: 16258
Protein Domain
Type: Domain
Description: This domain is present in the N-terminal region of the ShET2 enterotoxin produced by Shigella flexneri () and Escherichia coli (). This protein was found to confer toxigenicity in Ussing chamber assays, and the N-terminal region was found to be important for its enterotoxic effect. The N-terminal domain is a cysteine-type peptidase with a Cys/His/Asp catalytic triad that cleaves within the receptor-interacting protein homotypic interaction motifs found within host adaptor proteins such as receptor-interacting serine/threonine protein kinases RIPK1 and RIPK3, TIR-domain-containing adapter-inducing interferon beta and Z-DNA-binding protein 1, inactivating them and thus inhibiting necroptosis and inflammatory signalling []. The toxin is injected into the host cell by the type III secretion system [].Most proteins containing this domain are annotated as putative enterotoxins, but one member () is a regulator of acetyl CoA synthetase, and another two members (and ) are annotated as ankyrin-like regulatory proteins and contain Ank repeats ().
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
Strain
Attribute String: congenic, mutant strain, spontaneous mutation, deletion
Strain
Attribute String: congenic, mutant strain, spontaneous mutation, deletion, QTL
Strain
Attribute String: congenic, mutant strain, deletion, spontaneous mutation
Publication
First Author: Wu R
Year: 2005
Journal: Genetics
Title: Functional mapping of quantitative trait loci that interact with the hg mutation to regulate growth trajectories in mice.
Volume: 171
Issue: 1
Pages: 239-49
Publication  
First Author: Farber CR
Year: 2008
Journal: BMC Genet
Title: Overexpression of Scg5 increases enzymatic activity of PCSK2 and is inversely correlated with body weight in congenic mice.
Volume: 9
Pages: 34
Genotype
Symbol: Mohg1/Mohg1 Socs2/Socs2
Background: involves: C57BL/6J * CAST/EiJ
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Mohg2/Mohg2 Socs2/Socs2
Background: involves: C57BL/6J * CAST/EiJ
Zygosity: cx
Has Mutant Allele: true
Publication  
First Author: Stennicke HR
Year: 2000
Journal: Biochem J
Title: Internally quenched fluorescent peptide substrates disclose the subsite preferences of human caspases 1, 3, 6, 7 and 8.
Volume: 350 Pt 2
Pages: 563-8
Publication
First Author: Nogusa S
Year: 2016
Journal: Cell Host Microbe
Title: RIPK3 Activates Parallel Pathways of MLKL-Driven Necroptosis and FADD-Mediated Apoptosis to Protect against Influenza A Virus.
Volume: 20
Issue: 1
Pages: 13-24
Publication
First Author: Thapa RJ
Year: 2016
Journal: Cell Host Microbe
Title: DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death.
Volume: 20
Issue: 5
Pages: 674-681
Publication
First Author: Rodrigue-Gervais IG
Year: 2014
Journal: Cell Host Microbe
Title: Cellular inhibitor of apoptosis protein cIAP2 protects against pulmonary tissue necrosis during influenza virus infection to promote host survival.
Volume: 15
Issue: 1
Pages: 23-35
Publication
First Author: Morioka S
Year: 2014
Journal: J Cell Biol
Title: TAK1 kinase switches cell fate from apoptosis to necrosis following TNF stimulation.
Volume: 204
Issue: 4
Pages: 607-23
Publication
First Author: Ito-Kureha T
Year: 2022
Journal: Nat Immunol
Title: The function of Wtap in N6-adenosine methylation of mRNAs controls T cell receptor signaling and survival of T cells.
Volume: 23
Issue: 8
Pages: 1208-1221
Publication
First Author: Yow SJ
Year: 2024
Journal: Cell Death Dis
Title: Differential signalling requirements for RIPK1-dependent pyroptosis in neutrophils and macrophages.
Volume: 15
Issue: 7
Pages: 479
Publication
First Author: Wu YH
Year: 2022
Journal: Sci Adv
Title: Caspase-8 inactivation drives autophagy-dependent inflammasome activation in myeloid cells.
Volume: 8
Issue: 45
Pages: eabn9912
Publication
First Author: Naito MG
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Sequential activation of necroptosis and apoptosis cooperates to mediate vascular and neural pathology in stroke.
Volume: 117
Issue: 9
Pages: 4959-4970
Publication
First Author: Kang TB
Year: 2013
Journal: Immunity
Title: Caspase-8 blocks kinase RIPK3-mediated activation of the NLRP3 inflammasome.
Volume: 38
Issue: 1
Pages: 27-40
Publication
First Author: Kattah MG
Year: 2018
Journal: J Exp Med
Title: A20 and ABIN-1 synergistically preserve intestinal epithelial cell survival.
Volume: 215
Issue: 7
Pages: 1839-1852
Publication
First Author: Pajuelo D
Year: 2018
Journal: Cell Rep
Title: NAD+ Depletion Triggers Macrophage Necroptosis, a Cell Death Pathway Exploited by Mycobacterium tuberculosis.
Volume: 24
Issue: 2
Pages: 429-440
Publication
First Author: Kitur K
Year: 2016
Journal: Cell Rep
Title: Necroptosis Promotes Staphylococcus aureus Clearance by Inhibiting Excessive Inflammatory Signaling.
Volume: 16
Issue: 8
Pages: 2219-2230
Publication
First Author: Alvarez-Diaz S
Year: 2016
Journal: Immunity
Title: The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis.
Volume: 45
Issue: 3
Pages: 513-526
Publication
First Author: Duprez L
Year: 2011
Journal: Immunity
Title: RIP kinase-dependent necrosis drives lethal systemic inflammatory response syndrome.
Volume: 35
Issue: 6
Pages: 908-18
Publication
First Author: Wang JJ
Year: 2020
Journal: Nat Commun
Title: Disruption of auto-inhibition underlies conformational signaling of ASIC1a to induce neuronal necroptosis.
Volume: 11
Issue: 1
Pages: 475
Publication
First Author: Matsuzawa-Ishimoto Y
Year: 2017
Journal: J Exp Med
Title: Autophagy protein ATG16L1 prevents necroptosis in the intestinal epithelium.
Volume: 214
Issue: 12
Pages: 3687-3705
Publication
First Author: Lee SB
Year: 2019
Journal: Nat Cell Biol
Title: The AMPK-Parkin axis negatively regulates necroptosis and tumorigenesis by inhibiting the necrosome.
Volume: 21
Issue: 8
Pages: 940-951
Publication
First Author: Ofengeim D
Year: 2015
Journal: Cell Rep
Title: Activation of necroptosis in multiple sclerosis.
Volume: 10
Issue: 11
Pages: 1836-49
Publication
First Author: Dagenais M
Year: 2016
Journal: Mucosal Immunol
Title: A critical role for cellular inhibitor of protein 2 (cIAP2) in colitis-associated colorectal cancer and intestinal homeostasis mediated by the inflammasome and survival pathways.
Volume: 9
Issue: 1
Pages: 146-58
Publication
First Author: Caccamo A
Year: 2017
Journal: Nat Neurosci
Title: Necroptosis activation in Alzheimer's disease.
Volume: 20
Issue: 9
Pages: 1236-1246
Publication
First Author: He S
Year: 2009
Journal: Cell
Title: Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha.
Volume: 137
Issue: 6
Pages: 1100-11
Publication    
First Author: Li D
Year: 2020
Journal: Elife
Title: Casein kinase 1G2 suppresses necroptosis-promoted testis aging by inhibiting receptor-interacting kinase 3.
Volume: 9
Publication
First Author: Tanzer MC
Year: 2017
Journal: Cell Death Differ
Title: Combination of IAP antagonist and IFNγ activates novel caspase-10- and RIPK1-dependent cell death pathways.
Volume: 24
Issue: 3
Pages: 481-491
Publication    
First Author: Lim J
Year: 2019
Journal: Elife
Title: Autophagy regulates inflammatory programmed cell death via turnover of RHIM-domain proteins.
Volume: 8
Publication
First Author: Zhang H
Year: 2020
Journal: Cell Rep
Title: Crucial Roles of the RIP Homotypic Interaction Motifs of RIPK3 in RIPK1-Dependent Cell Death and Lymphoproliferative Disease.
Volume: 31
Issue: 7
Pages: 107650
Publication  
First Author: Kumari S
Year: 2021
Journal: Life Sci Alliance
Title: NF-κB inhibition in keratinocytes causes RIPK1-mediated necroptosis and skin inflammation.
Volume: 4
Issue: 6
Publication
First Author: Zou Y
Year: 2022
Journal: Cell Death Dis
Title: Deficiency of PPP6C protects TNF-induced necroptosis through activation of TAK1.
Volume: 13
Issue: 7
Pages: 618
Publication
First Author: Li M
Year: 2022
Journal: Dev Cell
Title: Gasdermin D maintains bone mass by rewiring the endo-lysosomal pathway of osteoclastic bone resorption.
Volume: 57
Issue: 20
Pages: 2365-2380.e8
Publication  
First Author: Farber CR
Year: 2006
Journal: BMC Genomics
Title: Genome-wide isolation of growth and obesity QTL using mouse speed congenic strains.
Volume: 7
Pages: 102
Publication
First Author: Farber CR
Year: 2007
Journal: Genetics
Title: Fine mapping reveals sex bias in quantitative trait loci affecting growth, skeletal size and obesity-related traits on mouse chromosomes 2 and 11.
Volume: 175
Issue: 1
Pages: 349-60
Publication
First Author: Lee S
Year: 2021
Journal: Nature
Title: AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence.
Volume: 597
Issue: 7876
Pages: 415-419
Publication
First Author: Vince JE
Year: 2009
Journal: J Biol Chem
Title: TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (tnf) to efficiently activate nf-{kappa}b and to prevent tnf-induced apoptosis.
Volume: 284
Issue: 51
Pages: 35906-15
Publication  
First Author: Ang RL
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Immune dysregulation in SHARPIN-deficient mice is dependent on CYLD-mediated cell death.
Volume: 118
Issue: 50
Publication
First Author: Orvedahl A
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Autophagy genes in myeloid cells counteract IFNγ-induced TNF-mediated cell death and fatal TNF-induced shock.
Volume: 116
Issue: 33
Pages: 16497-16506
Publication
First Author: Anderton H
Year: 2017
Journal: J Invest Dermatol
Title: Inhibitor of Apoptosis Proteins (IAPs) Limit RIPK1-Mediated Skin Inflammation.
Volume: 137
Issue: 11
Pages: 2371-2379
Publication
First Author: Wei J
Year: 2023
Journal: Signal Transduct Target Ther
Title: Elevated peripheral levels of receptor-interacting protein kinase 1 (RIPK1) and IL-8 as biomarkers of human amyotrophic lateral sclerosis.
Volume: 8
Issue: 1
Pages: 451
Publication
First Author: Wang T
Year: 2020
Journal: Cell Death Differ
Title: Necroptosis is dispensable for motor neuron degeneration in a mouse model of ALS.
Volume: 27
Issue: 5
Pages: 1728-1739
Publication  
First Author: Dermentzaki G
Year: 2019
Journal: eNeuro
Title: Deletion of Ripk3 Prevents Motor Neuron Death In Vitro but not In Vivo.
Volume: 6
Issue: 1
Publication
First Author: Lu C
Year: 2022
Journal: Invest Ophthalmol Vis Sci
Title: Rapamycin Inhibits Light-Induced Necrosome Activation Occurring in Wild-Type, but not RPE65-Null, Mouse Retina.
Volume: 63
Issue: 13
Pages: 19
Publication
First Author: Downey J
Year: 2017
Journal: PLoS Pathog
Title: RIPK3 interacts with MAVS to regulate type I IFN-mediated immunity to Influenza A virus infection.
Volume: 13
Issue: 4
Pages: e1006326
Publication
First Author: Linkermann A
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Two independent pathways of regulated necrosis mediate ischemia-reperfusion injury.
Volume: 110
Issue: 29
Pages: 12024-9
Publication
First Author: Petersen SL
Year: 2015
Journal: Cell Death Differ
Title: TRAF2 is a biologically important necroptosis suppressor.
Volume: 22
Issue: 11
Pages: 1846-57
Publication
First Author: Schreiber A
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Necroptosis controls NET generation and mediates complement activation, endothelial damage, and autoimmune vasculitis.
Volume: 114
Issue: 45
Pages: E9618-E9625
Publication
First Author: Seo J
Year: 2016
Journal: Nat Cell Biol
Title: CHIP controls necroptosis through ubiquitylation- and lysosome-dependent degradation of RIPK3.
Volume: 18
Issue: 3
Pages: 291-302
Publication
First Author: Pavlosky A
Year: 2014
Journal: Am J Transplant
Title: RIPK3-mediated necroptosis regulates cardiac allograft rejection.
Volume: 14
Issue: 8
Pages: 1778-90
Publication
First Author: Jouan-Lanhouet S
Year: 2012
Journal: Cell Death Differ
Title: TRAIL induces necroptosis involving RIPK1/RIPK3-dependent PARP-1 activation.
Volume: 19
Issue: 12
Pages: 2003-14
Publication
First Author: Xu C
Year: 2021
Journal: Theranostics
Title: TNF-α-dependent neuronal necroptosis regulated in Alzheimer's disease by coordination of RIPK1-p62 complex with autophagic UVRAG.
Volume: 11
Issue: 19
Pages: 9452-9469
Publication  
First Author: Zhang X
Year: 2018
Journal: Front Physiol
Title: Mechanisms of Pancreatic Injury Induced by Basic Amino Acids Differ Between L-Arginine, L-Ornithine, and L-Histidine.
Volume: 9
Pages: 1922
Publication
First Author: Pawar M
Year: 2017
Journal: Cell Death Differ
Title: FAS apoptotic inhibitory molecule 2 is a stress-induced intrinsic neuroprotective factor in the retina.
Volume: 24
Issue: 10
Pages: 1799-1810
Publication
First Author: Tonnus W
Year: 2021
Journal: Nat Commun
Title: Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury.
Volume: 12
Issue: 1
Pages: 4402
Publication
First Author: Xu D
Year: 2020
Journal: Nature
Title: Modulating TRADD to restore cellular homeostasis and inhibit apoptosis.
Volume: 587
Issue: 7832
Pages: 133-138
Publication
First Author: Bynigeri RR
Year: 2024
Journal: BMC Biol
Title: The protein phosphatase PP6 promotes RIPK1-dependent PANoptosis.
Volume: 22
Issue: 1
Pages: 122
Publication
First Author: Hu YB
Year: 2019
Journal: Cell Death Dis
Title: miR-425 deficiency promotes necroptosis and dopaminergic neurodegeneration in Parkinson's disease.
Volume: 10
Issue: 8
Pages: 589
Publication
First Author: Londoño D
Year: 2011
Journal: J Immunol
Title: IL-10 Prevents apoptosis of brain endothelium during bacteremia.
Volume: 186
Issue: 12
Pages: 7176-86
Publication
First Author: Zhang C
Year: 2019
Journal: Cell Death Dis
Title: Inhibition of HtrA2 alleviated dextran sulfate sodium (DSS)-induced colitis by preventing necroptosis of intestinal epithelial cells.
Volume: 10
Issue: 5
Pages: 344
Publication
First Author: Jean-Charles PY
Year: 2018
Journal: Arterioscler Thromb Vasc Biol
Title: USP20 (Ubiquitin-Specific Protease 20) Inhibits TNF (Tumor Necrosis Factor)-Triggered Smooth Muscle Cell Inflammation and Attenuates Atherosclerosis.
Volume: 38
Issue: 10
Pages: 2295-2305
Publication
First Author: Molnár T
Year: 2021
Journal: FEBS J
Title: Caspase-9 acts as a regulator of necroptotic cell death.
Volume: 288
Issue: 22
Pages: 6476-6491
Publication  
First Author: Lin S
Year: 2024
Journal: Cancer Lett
Title: Exosomal lncCRLA is predictive for the evolvement and development of lung adenocarcinoma.
Volume: 582
Pages: 216588
Publication
First Author: Reed JC
Year: 2003
Journal: Genome Res
Title: Comparative analysis of apoptosis and inflammation genes of mice and humans.
Volume: 13
Issue: 6B
Pages: 1376-88
Publication
First Author: Corva PM
Year: 2001
Journal: Mamm Genome
Title: Quantitative trait loci affecting growth in high growth (hg) mice.
Volume: 12
Issue: 4
Pages: 284-90
Publication
First Author: Lin Q
Year: 2006
Journal: Nucleic Acids Res
Title: Mutagenesis of diploid mammalian genes by gene entrapment.
Volume: 34
Issue: 20
Pages: e139
Publication
First Author: Zoubek ME
Year: 2019
Journal: J Pathol
Title: Protective role of c-Jun N-terminal kinase-2 (JNK2) in ibuprofen-induced acute liver injury.
Volume: 247
Issue: 1
Pages: 110-122
Publication
First Author: Cao LL
Year: 2021
Journal: J Neuroinflammation
Title: Downregulating expression of OPTN elevates neuroinflammation via AIM2 inflammasome- and RIPK1-activating mechanisms in APP/PS1 transgenic mice.
Volume: 18
Issue: 1
Pages: 281
Publication  
First Author: Canet-Pons J
Year: 2021
Journal: Neurobiol Dis
Title: Atxn2-CAG100-KnockIn mouse spinal cord shows progressive TDP43 pathology associated with cholesterol biosynthesis suppression.
Volume: 152
Pages: 105289
Publication  
First Author: Song YF
Year: 2020
Journal: Free Radic Biol Med
Title: The circular RNA TLK1 exacerbates myocardial ischemia/reperfusion injury via targeting miR-214/RIPK1 through TNF signaling pathway.
Volume: 155
Pages: 69-80
Publication
First Author: Arrázola MS
Year: 2019
Journal: J Neurosci
Title: Axonal Degeneration Is Mediated by Necroptosis Activation.
Volume: 39
Issue: 20
Pages: 3832-3844
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 480  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 480  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 480  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 500  
Fragment?: false
Publication      
First Author: NIH Mouse Knockout Inventory
Year: 2004
Journal: MGI Direct Data Submission
Title: Information obtained from the NIH Mouse Knockout Inventory
Publication
First Author: Tang F
Year: 2011
Journal: PLoS One
Title: Deterministic and stochastic allele specific gene expression in single mouse blastomeres.
Volume: 6
Issue: 6
Pages: e21208
Publication      
First Author: University of California, Davis
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the University of California, Davis
Publication        
First Author: Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom
Year: 2023
Title: Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity
Publication
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
Publication
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
Publication
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81