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Search results 901 to 963 out of 963 for Rptor

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Type Details Score
Publication
20876733 | J:164880
First Author: Lee DY
Year: 2010
Journal: Genes Dev
Title: Neurofibromatosis-1 regulates neuroglial progenitor proliferation and glial differentiation in a brain region-specific manner.
Volume: 24
Issue: 20
Pages: 2317-29
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Publication
24939733 | J:215498
First Author: Zhang C
Year: 2014
Journal: Am J Physiol Endocrinol Metab
Title: Glycerol-3-phosphate acyltransferase-4-deficient mice are protected from diet-induced insulin resistance by the enhanced association of mTOR and rictor.
Volume: 307
Issue: 3
Pages: E305-15
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Publication
22307628 | J:182033
First Author: Zhang C
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling.
Volume: 109
Issue: 5
Pages: 1667-72
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Publication
26923591 | J:234363
First Author: Micevic G
Year: 2016
Journal: Cell Rep
Title: DNMT3b Modulates Melanoma Growth by Controlling Levels of mTORC2 Component RICTOR.
Volume: 14
Issue: 9
Pages: 2180-2192
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Publication
32707034 | J:305278
First Author: Kim D
Year: 2020
Journal: Immunity
Title: Anti-inflammatory Roles of Glucocorticoids Are Mediated by Foxp3(+) Regulatory T Cells via a miR-342-Dependent Mechanism.
Volume: 53
Issue: 3
Pages: 581-596.e5
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Publication
22045807 | J:323794
First Author: Brown J
Year: 2011
Journal: J Biol Chem
Title: Mammalian target of rapamycin complex 2 (mTORC2) negatively regulates Toll-like receptor 4-mediated inflammatory response via FoxO1.
Volume: 286
Issue: 52
Pages: 44295-305
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Publication
20832730 | J:163988
First Author: Gao D
Year: 2010
Journal: Mol Cell
Title: Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction.
Volume: 39
Issue: 5
Pages: 797-808
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Publication
23099444 | J:191225
First Author: Tripathy S
Year: 2013
Journal: J Lipid Res
Title: Elovl5 regulates the mTORC2-Akt-FOXO1 pathway by controlling hepatic cis-vaccenic acid synthesis in diet-induced obese mice.
Volume: 54
Issue: 1
Pages: 71-84
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Publication
26936863 | J:243856
First Author: B?nard L
Year: 2016
Journal: Circulation
Title: Cardiac Stim1 Silencing Impairs Adaptive Hypertrophy and Promotes Heart Failure Through Inactivation of mTORC2/Akt Signaling.
Volume: 133
Issue: 15
Pages: 1458-71; discussion 1471
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Publication
31138772 | J:278441
First Author: Manning JR
Year: 2019
Journal: Biochem J
Title: Loss of GCN5L1 in cardiac cells disrupts glucose metabolism and promotes cell death via reduced Akt/mTORC2 signaling.
Volume: 476
Issue: 12
Pages: 1713-1724
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Strain
MGI:5448840 | STOCK Ptprc<b> Thy1<a> Rictor<tm1.1Klg>/SjmJ
Attribute String: mutant stock, targeted mutation, variant allele
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Strain
MGI:6332710 | B6.Cg-Rictor<tm1.1Klg> Ndor1<Tg(UBC-cre/ERT2)1Ejb>/Anu
Attribute String: mutant strain, congenic, targeted mutation, transgenic
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Genotype
Genotype
Symbol: Rictor/Rictor
Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pten/Pten Rictor/Rictor
Background: involves: 129S4/SvJae * 129S6/SvEvTac
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pten/Pten Rictor/Rictor Tg(Ins2-cre)25Mgn/?
Background: involves: 129S4/SvJae * 129S6/SvEvTac * BALB/c * C57BL/6 * DBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rictor/Rictor Tg(Vil1-cre)DNju/?
Background: involves: C57BL/6JGpt
Zygosity: cn
Has Mutant Allele: true
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Publication
24670654 | J:210466
First Author: Liu P
Year: 2014
Journal: Nature
Title: Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus.
Volume: 508
Issue: 7497
Pages: 541-5
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Publication
19064993 | J:147598
First Author: Zong H
Year: 2009
Journal: J Biol Chem
Title: Insulin resistance in striated muscle-specific integrin receptor beta1-deficient mice.
Volume: 284
Issue: 7
Pages: 4679-88
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Publication
26453307 | J:228576
First Author: Singh BK
Year: 2016
Journal: J Biol Chem
Title: Hepatic FOXO1 Target Genes Are Co-regulated by Thyroid Hormone via RICTOR Protein Deacetylation and MTORC2-AKT Protein Inhibition.
Volume: 291
Issue: 1
Pages: 198-214
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Publication
28319045 | J:243606
First Author: Li N
Year: 2017
Journal: J Clin Invest
Title: AKT-mediated stabilization of histone methyltransferase WHSC1 promotes prostate cancer metastasis.
Volume: 127
Issue: 4
Pages: 1284-1302
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Publication
18925875 | J:144578
First Author: Garc?a-Mart?nez JM
Year: 2008
Journal: Biochem J
Title: mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1).
Volume: 416
Issue: 3
Pages: 375-85
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Publication
21135133 | J:170423
First Author: Dunaway CM
Year: 2011
Journal: Mol Cell Biol
Title: Cooperative signaling between Slit2 and Ephrin-A1 regulates a balance between angiogenesis and angiostasis.
Volume: 31
Issue: 3
Pages: 404-16
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Publication
22550181 | J:184787
First Author: Kaur S
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Regulatory effects of mTORC2 complexes in type I IFN signaling and in the generation of IFN responses.
Volume: 109
Issue: 20
Pages: 7723-8
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HT Experiment
GSE150166 | Single-cell transcriptome reveals the novel role of T-bet in suppressing the immature NK gene signature the immature NK gene signature
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Genotype
Genotype
Symbol: Rictor/Rictor Meox2/Meox2<+>
Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rictor/Rictor Rptor/Rptor Tg(ACTA1-cre)1Mll/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pten/Pten<+> Rictor/Rictor<+>
Background: involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rictor/Rictor Speer6-ps1/Speer6-ps1<+>
Background: involves: 129S6/SvEvTac * C57BL/6 * DBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ncr1/Ncr1<+> Rictor/Rictor
Background: involves: C57BL/6J
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Foxo1/Foxo1 Ncr1/Ncr1<+> Rictor/Rictor
Background: involves: 129S6/SvEvTac * C57BL/6J
Zygosity: cn
Has Mutant Allele: true
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Publication
18566586 | J:137614
First Author: Facchinetti V
Year: 2008
Journal: EMBO J
Title: The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C.
Volume: 27
Issue: 14
Pages: 1932-43
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Publication
15268862 | J:320275
First Author: Sarbassov DD
Year: 2004
Journal: Curr Biol
Title: Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton.
Volume: 14
Issue: 14
Pages: 1296-302
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Publication
23444404 | J:197572
First Author: Rosborough BR
Year: 2013
Journal: Blood
Title: Murine dendritic cell rapamycin-resistant and rictor-independent mTOR controls IL-10, B7-H1, and regulatory T-cell induction.
Volume: 121
Issue: 18
Pages: 3619-30
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Publication
22399812 | J:197817
First Author: Lamouille S
Year: 2012
Journal: J Cell Sci
Title: TGF-?-induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion.
Volume: 125
Issue: Pt 5
Pages: 1259-73
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Publication
26645692 | J:230930
First Author: Kroczynska B
Year: 2016
Journal: J Biol Chem
Title: Interferon ? (IFN?) Signaling via Mechanistic Target of Rapamycin Complex 2 (mTORC2) and Regulatory Effects in the Generation of Type II Interferon Biological Responses.
Volume: 291
Issue: 5
Pages: 2389-96
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Genotype
Genotype
Symbol: Foxo1/Foxo1<+> Ncr1/Ncr1<+> Rictor/Rictor
Background: involves: 129S6/SvEvTac * C57BL/6J
Zygosity: cn
Has Mutant Allele: true
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Publication
22609986 | J:190487
First Author: Gan X
Year: 2012
Journal: Nat Cell Biol
Title: PRR5L degradation promotes mTORC2-mediated PKC-? phosphorylation and cell migration downstream of G?12.
Volume: 14
Issue: 7
Pages: 686-96
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Publication
29213092 | J:259795
First Author: Green RM
Year: 2017
Journal: Nat Commun
Title: Developmental nonlinearity drives phenotypic robustness.
Volume: 8
Issue: 1
Pages: 1970
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Publication
21413931 | J:172256
First Author: Pearce LR
Year: 2011
Journal: Biochem J
Title: Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney.
Volume: 436
Issue: 1
Pages: 169-79
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Publication
27572106 | J:287368
 
First Author: Kim-Muller JY
Year: 2016
Journal: Nat Commun
Title: Aldehyde dehydrogenase 1a3 defines a subset of failing pancreatic ? cells in diabetic mice.
Volume: 7
Pages: 12631
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Publication
39932433 | J:363937
   
First Author: Mu Y
Year: 2025
Journal: Elife
Title: Mechanical forces pattern endocardial Notch activation via mTORC2-PKC pathway.
Volume: 13
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HT Experiment
GSE287676 | mTORC1 promotes adipose tissue ILC2 homeostasis through upregulation of PPAR
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
36220823 | J:329956
First Author: Wan S
Year: 2022
Journal: Cell Death Dis
Title: mTORC1 signaling pathway integrates estrogen and growth factor to coordinate vaginal epithelial cells proliferation and differentiation.
Volume: 13
Issue: 10
Pages: 862
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Publication
14661020 | -
First Author: Soares L
Year: 2004
Journal: Nat Immunol
Title: Two isoforms of otubain 1 regulate T cell anergy via GRAIL.
Volume: 5
Issue: 1
Pages: 45-54
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Publication
18954305 | -
First Author: Edelmann MJ
Year: 2009
Journal: Biochem J
Title: Structural basis and specificity of human otubain 1-mediated deubiquitination.
Volume: 418
Issue: 2
Pages: 379-90
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Publication
20725033 | -
First Author: Nakada S
Year: 2010
Journal: Nature
Title: Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1.
Volume: 466
Issue: 7309
Pages: 941-6
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Publication
22325355 | -
First Author: Juang YC
Year: 2012
Journal: Mol Cell
Title: OTUB1 co-opts Lys48-linked ubiquitin recognition to suppress E2 enzyme function.
Volume: 45
Issue: 3
Pages: 384-97
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Publication
19383985 | -
First Author: Stani??i?? V
Year: 2009
Journal: J Biol Chem
Title: OTU Domain-containing ubiquitin aldehyde-binding protein 1 (OTUB1) deubiquitinates estrogen receptor (ER) alpha and affects ERalpha transcriptional activity.
Volume: 284
Issue: 24
Pages: 16135-16145
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Publication
29382726 | -
First Author: Zhao L
Year: 2018
Journal: J Biol Chem
Title: OTUB1 protein suppresses mTOR complex 1 (mTORC1) activity by deubiquitinating the mTORC1 inhibitor DEPTOR.
Volume: 293
Issue: 13
Pages: 4883-4892
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Publication
35927303 | -
First Author: Seo SU
Year: 2023
Journal: Cell Death Differ
Title: Phosphorylation of OTUB1 at Tyr 26 stabilizes the mTORC1 component, Raptor.
Volume: 30
Issue: 1
Pages: 82-93
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Protein Domain
IPR019400 | Peptidase_C65_otubain
Type: Family
Description: This family comprises highly specific ubiquitin isopeptidases (otubains) that remove 'Lys-48'-linked, but not 'Lys-63'-linked, polyubiquitin chains from substrate proteins, regulating protein turnover by preventing degradation [, ]. Family members cannot cleave di-ubiquitin directly and can also remove NEDD8 from NEDD8 conjugates, albeit with lower efficiency than ubiquitin [, ]. The catalytic OTU (ovarian tumour) domain contains a cysteine protease triad and is accompanied by a nuclear localisation signal, a ubiquitin-interaction motif (UIM)-like motif (phi-xx-A-xxxs-xx-Ac, where phi is an aromatic residue, x is any residue and Ac is an acidic residue), a ubiquitin-associated (UBA)-like domain and an LxxLL motif [].Beyond its catalytic activity, the best-characterised member, OTUB1, also acts non-catalytically: it binds and inhibits the E2 enzyme UBE2N/UBC13, blocking RNF168-mediated spreading of 'Lys-63'-linked histone H2A/H2AX ubiquitination at DNA damage sites [, ], and regulates mTORC1/mTORC2 signalling by controlling ubiquitination of RPTOR and DEPTOR [, ]. It further regulates T-cell anergy through isoform-specific interaction with the E3 ligase RNF128/GRAIL []and deubiquitinates substrates such as estrogen receptor alpha []. OTU domain activity is allosterically enhanced by binding of free ubiquitin [, ].
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Publication
26633882 | J:269511
   
First Author: Roy A
Year: 2015
Journal: Elife
Title: Mouse models of human PIK3CA-related brain overgrowth have acutely treatable epilepsy.
Volume: 4
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Publication
12704427 | -
First Author: Balakirev MY
Year: 2003
Journal: EMBO Rep
Title: Otubains: a new family of cysteine proteases in the ubiquitin pathway.
Volume: 4
Issue: 5
Pages: 517-22
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Protein
D3Z0Y8
Organism: Mus musculus/domesticus
Length: 323  
Fragment?: false
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Protein
D3Z7K0
Organism: Mus musculus/domesticus
Length: 95  
Fragment?: true
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Protein
F6SXD2
Organism: Mus musculus/domesticus
Length: 142  
Fragment?: true
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Protein
Q7TQI3
Organism: Mus musculus/domesticus
Length: 271  
Fragment?: false
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Protein
Q9CQX0
Organism: Mus musculus/domesticus
Length: 234  
Fragment?: false
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Protein
D3YWF6
Organism: Mus musculus/domesticus
Length: 241  
Fragment?: false
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Publication
23827681 | -
First Author: Mevissen TE
Year: 2013
Journal: Cell
Title: OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis.
Volume: 154
Issue: 1
Pages: 169-84
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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