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Search results 901 to 1000 out of 1046 for Sema3a

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Type Details Score
Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
25358863 | J:231247
 
First Author: Nakamura F
Year: 2014
Journal: Nat Commun
Title: Amino- and carboxyl-terminal domains of Filamin-A interact with CRMP1 to mediate Sema3A signalling.
Volume: 5
Pages: 5325
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Pathway
R-MMU-399956 | CRMPs in Sema3A signaling
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Pathway
R-MMU-399954 | Sema3A PAK dependent Axon repulsion
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Publication
20298787 | J:164137
First Author: Torre ER
Year: 2010
Journal: Mol Cell Neurosci
Title: Expression by midbrain dopamine neurons of Sema3A and 3F receptors is associated with chemorepulsion in vitro but a mild in vivo phenotype.
Volume: 44
Issue: 2
Pages: 135-53
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Publication
32273484 | J:288246
First Author: Bott CJ
Year: 2020
Journal: J Neurosci
Title: Nestin Selectively Facilitates the Phosphorylation of the Lissencephaly-Linked Protein Doublecortin (DCX) by cdk5/p35 to Regulate Growth Cone Morphology and Sema3a Sensitivity in Developing Neurons.
Volume: 40
Issue: 19
Pages: 3720-3740
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GXD Expression
GXD Expression
Probe: MGI:7522006
Assay Type: Immunohistochemistry
Annotation Date: 2023-08-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3561423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:7522028
Age: embryonic day 15.5
Image: 2B
Note: Expression is in axons that grow rostrally and caudally in regions where Sema3a is absent.
Specimen Label: 2B
Detected: true
Specimen Num: 4
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Allele
Sema3a<em2Smoc> | MGI:7292215
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6476241 | C57BL/6JSmoc-Sema3a<em2Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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DO Term
DOID:0090080 | hypogonadotropic hypogonadism 16 with or without anosmia
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Allele
Sema3a<em1Smoc> | MGI:7292214
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Allele
Sema3a<tm1.1(cre/ERT2)Bzsh> | MGI:7439154
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A; targeted mutation 1.1, Bin Zhou
Allele Type: Targeted
Attribute String: Inducible, Recombinase
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Protein Coding Gene
MGI:1349762 | Dpysl3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1929772 | Dpysl5
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:107793 | Crmp1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1349764 | Dpysl4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P97427
Organism: Mus musculus/domesticus
Length: 572  
Fragment?: false
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Protein
Q62188
Organism: Mus musculus/domesticus
Length: 570  
Fragment?: false
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Protein
Q9EQF6
Organism: Mus musculus/domesticus
Length: 564  
Fragment?: false
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Protein
O35098
Organism: Mus musculus/domesticus
Length: 572  
Fragment?: false
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Protein
O08665
Organism: Mus musculus/domesticus
Length: 772  
Fragment?: false
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Protein Coding Gene
MGI:1349763 | Dpysl2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
O08553
Organism: Mus musculus/domesticus
Length: 572  
Fragment?: false
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Protein Coding Gene
MGI:107684 | Plxna2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2179061 | Plxna4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:95514 | Fes
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:107683 | Plxna3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P70207
Organism: Mus musculus/domesticus
Length: 1894  
Fragment?: false
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Protein
P70208
Organism: Mus musculus/domesticus
Length: 1872  
Fragment?: false
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Protein
Q80UG2
Organism: Mus musculus/domesticus
Length: 1893  
Fragment?: false
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Protein
P16879
Organism: Mus musculus/domesticus
Length: 822  
Fragment?: false
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Strain
MGI:6771141 | C57BL/6JSmoc-Sema3a<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Tg(Sema3a-cre)#Ryba | MGI:7438219
Name: transgene insertion, Nicholas JP Ryba
Allele Type: Transgenic
Attribute String: Recombinase
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Genotype
Genotype
Symbol: Sema3a/Sema3a<+>
Background: Not Specified
Zygosity: ht
Has Mutant Allele: true
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Publication
10781943 | J:62089
First Author: Rohm B
Year: 2000
Journal: Mech Dev
Title: Plexin/neuropilin complexes mediate repulsion by the axonal guidance signal semaphorin 3A.
Volume: 93
Issue: 1-2
Pages: 95-104
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Protein Coding Gene
MGI:101764 | Cdk5r1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P61809
Organism: Mus musculus/domesticus
Length: 307  
Fragment?: false
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Protein
P70206
Organism: Mus musculus/domesticus
Length: 1894  
Fragment?: false
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Sema3a-cre)#Ryba/?
Background: involves: 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Publication
14500350 | -
First Author: Bachelder RE
Year: 2003
Journal: Cancer Res
Title: Competing autocrine pathways involving alternative neuropilin-1 ligands regulate chemotaxis of carcinoma cells.
Volume: 63
Issue: 17
Pages: 5230-3
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Protein Domain
IPR042820 | Sema3A_sema
Type: Domain
Description: This entry represents the sema domain of Semaphorin-3A []. Sema3A has been reported to inhibit the growth of certain experimental tumours and to regulate endothelial cell migration and apoptosis in vitro, as well as arteriogenesis in the muscle, skin vessel permeability, and tumor angiogenesis in vivo []. The function of Sema3A is mediated through receptors neuropilin-1 (NP1) and plexins, although little is known about the requirement of specific plexins in its receptor complex []. It is known however that Plexin-A4 is the receptor for Sema3A in the Toll-like receptor- and sepsis-induced cytokine storm during immune response []. Sema3A is a member of the Class 3 semaphorin family of secreted proteins []. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module [].
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Protein Coding Gene
MGI:101765 | Cdk5
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:104572 | Limk1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:107685 | Plxna1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:106206 | Nrp1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P49615
Organism: Mus musculus/domesticus
Length: 292  
Fragment?: false
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Protein
P97333
Organism: Mus musculus/domesticus
Length: 923  
Fragment?: false
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Protein
P53668
Organism: Mus musculus/domesticus
Length: 647  
Fragment?: false
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Publication
16715077 | J:110786
First Author: Takegahara N
Year: 2006
Journal: Nat Cell Biol
Title: Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis.
Volume: 8
Issue: 6
Pages: 615-22
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Publication
18649144 | -
First Author: O'Connor BP
Year: 2008
Journal: Immunol Res
Title: The evolving role of semaphorins and plexins in the immune system: Plexin-A1 regulation of dendritic cell function.
Volume: 41
Issue: 3
Pages: 217-22
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Protein Domain
IPR042744 | Plexin-A1_Sema
Type: Domain
Description: Plexin A1 is found in both the nervous and immune systems. Its external Sema domain is also shared by semaphorin proteins. In the nervous system, Plexin A1 mediates Sema3A axon guidance function by interacting with the Sema3A coreceptor neuropilin, resulting in actin depolarization and cell repulsion [, ]. In the immune system, Plexin A1 mediates Sema6D signaling by binding to the Sema6D-Trem2-DAP12 complex on immune cells and osteoclasts to promote Rac activation and DAP12 phosphorylation []. In gene profiling experiments, Plexin A1 was identified as a CIITA (class II transactivator) regulated gene in primary dendritic cells (DCs) []. The Sema domain is located at the N terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.
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Publication
15914725 | -
First Author: Potiron V
Year: 2005
Journal: Sci STKE
Title: Class 3 semaphorin signaling: the end of a dogma.
Volume: 2005
Issue: 285
Pages: pe24
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Publication
19887479 | -
First Author: Gaur P
Year: 2009
Journal: Clin Cancer Res
Title: Role of class 3 semaphorins and their receptors in tumor growth and angiogenesis.
Volume: 15
Issue: 22
Pages: 6763-70
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HT Experiment
E-GEOD-46591 | CHD7 regulates gene networks involved in neural crest cell migration and axon guidance
Series Id: GSE46591
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Protein Coding Gene
MGI:1339656 | Pak3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q61036
Organism: Mus musculus/domesticus
Length: 559  
Fragment?: false
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Sema3a/Sema3a<+>
Background: involves: 129S6/SvEvTac * C57BL/6NCrl
Zygosity: cn
Has Mutant Allele: true
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HT Experiment
GSE55054 | Astrocyte-encoded positional cues maintain sensorimotor circuit integrity
Series Id: E-GEOD-55054
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: GEO
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HT Experiment
GSE81683 | Angiogenesis in the skin of SHARPIN-deficient mice with chronic proliferative dermatitis
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
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Protein Coding Gene
MGI:1339984 | Pak2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1861437 | Gsk3b
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:96247 | Hsp90ab1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q8CIN4
Organism: Mus musculus/domesticus
Length: 524  
Fragment?: false
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Protein
Q9WV60
Organism: Mus musculus/domesticus
Length: 420  
Fragment?: false
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Protein
P11499
Organism: Mus musculus/domesticus
Length: 724  
Fragment?: false
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HT Experiment
GSE22034 | Transcriptional profiling of ex vivo isolated mouse blood vascular and lymphatic endothelial cells
Series Id: E-GEOD-22034
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: GEO
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Publication
11956234 | -
First Author: Goshima Y
Year: 2002
Journal: J Clin Invest
Title: Semaphorins as signals for cell repulsion and invasion.
Volume: 109
Issue: 8
Pages: 993-8
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Publication
10934324 | -
First Author: Nakamura F
Year: 2000
Journal: J Neurobiol
Title: Molecular basis of semaphorin-mediated axon guidance.
Volume: 44
Issue: 2
Pages: 219-29
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Publication
12559962 | J:81801
First Author: Usui H
Year: 2003
Journal: Biochem Biophys Res Commun
Title: Plexin-A1 and plexin-B1 specifically interact at their cytoplasmic domains.
Volume: 300
Issue: 4
Pages: 927-31
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Publication
17021275 | J:182385
First Author: Gonthier B
Year: 2007
Journal: Cereb Cortex
Title: Functional interaction between matrix metalloproteinase-3 and semaphorin-3C during cortical axonal growth and guidance.
Volume: 17
Issue: 7
Pages: 1712-21
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Publication
10707971 | J:60158
First Author: Chen H
Year: 2000
Journal: Neuron
Title: Neuropilin-2 regulates the development of selective cranial and sensory nerves and hippocampal mossy fiber projections.
Volume: 25
Issue: 1
Pages: 43-56
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Publication
12732138 | J:83314
First Author: Bagri A
Year: 2003
Journal: Cell
Title: Stereotyped pruning of long hippocampal axon branches triggered by retraction inducers of the semaphorin family.
Volume: 113
Issue: 3
Pages: 285-99
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Publication
22213797 | J:180658
First Author: Zylbersztejn K
Year: 2012
Journal: J Cell Biol
Title: The vesicular SNARE Synaptobrevin is required for Semaphorin 3A axonal repulsion.
Volume: 196
Issue: 1
Pages: 37-46
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Publication
24561343 | J:229507
First Author: Quintá HR
Year: 2014
Journal: Cell Death Differ
Title: Glycan-dependent binding of galectin-1 to neuropilin-1 promotes axonal regeneration after spinal cord injury.
Volume: 21
Issue: 6
Pages: 941-55
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Publication
16677822 | J:111941
First Author: De Winter F
Year: 2006
Journal: Mol Cell Neurosci
Title: The expression of the chemorepellent Semaphorin 3A is selectively induced in terminal Schwann cells of a subset of neuromuscular synapses that display limited anatomical plasticity and enhanced vulnerability in motor neuron disease.
Volume: 32
Issue: 1-2
Pages: 102-17
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Publication
15721238 | J:98440
First Author: Yaron A
Year: 2005
Journal: Neuron
Title: Differential requirement for Plexin-A3 and -A4 in mediating responses of sensory and sympathetic neurons to distinct class 3 Semaphorins.
Volume: 45
Issue: 4
Pages: 513-23
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Publication
31690636 | J:284151
 
First Author: Oleari R
Year: 2019
Journal: Development
Title: PLXNA1 and PLXNA3 cooperate to pattern the nasal axons that guide gonadotropin-releasing hormone neurons.
Volume: 146
Issue: 21
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Publication
26299962 | J:265989
First Author: Barão S
Year: 2015
Journal: Cell Rep
Title: Antagonistic Effects of BACE1 and APH1B-γ-Secretase Control Axonal Guidance by Regulating Growth Cone Collapse.
Volume: 12
Issue: 9
Pages: 1367-76
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Publication
25843720 | J:266014
First Author: Perlini LE
Year: 2015
Journal: Cell Rep
Title: Synapsin III acts downstream of semaphorin 3A/CDK5 signaling to regulate radial migration and orientation of pyramidal neurons in vivo.
Volume: 11
Issue: 2
Pages: 234-48
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Publication
15067019 | J:89300
First Author: Itoh K
Year: 2004
Journal: J Cell Biol
Title: Brain development in mice lacking L1-L1 homophilic adhesion.
Volume: 165
Issue: 1
Pages: 145-54
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Publication
37616346 | J:339457
First Author: Wagner JUG
Year: 2023
Journal: Science
Title: Aging impairs the neurovascular interface in the heart.
Volume: 381
Issue: 6660
Pages: 897-906
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Publication
18059265 | J:130744
First Author: Chen G
Year: 2008
Journal: Nat Neurosci
Title: Semaphorin-3A guides radial migration of cortical neurons during development.
Volume: 11
Issue: 1
Pages: 36-44
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Publication
19652227 | J:155713
First Author: Uchida Y
Year: 2009
Journal: J Biol Chem
Title: Semaphorin3A signaling mediated by Fyn-dependent tyrosine phosphorylation of collapsin response mediator protein 2 at tyrosine 32.
Volume: 284
Issue: 40
Pages: 27393-401
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Publication
27687730 | J:237638
First Author: Ng T
Year: 2016
Journal: J Biol Chem
Title: Neuropilin 2 Signaling Is Involved in Cell Positioning of Adult-born Neurons through Glycogen Synthase Kinase-3β (GSK3β).
Volume: 291
Issue: 48
Pages: 25088-25095
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Publication
30595434 | J:273777
First Author: Cagnetta R
Year: 2019
Journal: Mol Cell
Title: Noncanonical Modulation of the eIF2 Pathway Controls an Increase in Local Translation during Neural Wiring.
Volume: 73
Issue: 3
Pages: 474-489.e5
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Publication
12925274 | -
First Author: Antipenko A
Year: 2003
Journal: Neuron
Title: Structure of the semaphorin-3A receptor binding module.
Volume: 39
Issue: 4
Pages: 589-98
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Publication
15094469 | -
First Author: Lindholm T
Year: 2004
Journal: Neuroreport
Title: Semaphorin and neuropilin expression in motoneurons after intraspinal motoneuron axotomy.
Volume: 15
Issue: 4
Pages: 649-54
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Publication
12213213 | -
First Author: Steinbach K
Year: 2002
Journal: Exp Cell Res
Title: Semaphorin 3E/collapsin-5 inhibits growing retinal axons.
Volume: 279
Issue: 1
Pages: 52-61
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Protein Domain
IPR015512 | Semaphorin_4F
Type: Family
Description: Semaphorins were first cloned as recognised mediators of cellular guidance, and consist of a large family of phylogenetically conserved secreted and transmembrane signalling proteins. Among the best-characterised vertebrate Semaphorins are the five secreted Class 3 members that contain an approximately 500 amino acid N-terminal Semaphorin domain, a C2 type immunoglobulin domain, and a highly basic C-terminal tail []. Two receptor families have been implicated in mediating the actions of class 3 semaphorins: the Neuropilins and Plexins. The nine known vertebrate Plexins are divided into four subfamilies (A through D) based on structure []. Several Plexins have been shown to interact directly with some class 4, 7 and V Semaphorins, but class 3 Semaphorins, however, do not appear to bind Plexins directly. Rather, the functional receptors for these Semaphorins are complexes of Neuropilins and A-type Plexins, with the former serving as the ligand-binding moiety and the latter the signal-transducing component [, ]. There are two Neuropilins (NP-1 and NP-2) that bind the five class 3 Semaphorins preferentially. In particular, Sema3A binds NP-1, whereas Sema3F utilises NP-2, while NP-1 and NP-2 heterodimers are thought to serve as functional receptors for Sema3C [].Semaphorin 4F may be involved in the injury response of intramedullary axotomized motoneurons [].
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Protein Domain
IPR015513 | Semaphorin_3E
Type: Family
Description: Semaphorins were first cloned as recognised mediators of cellular guidance, and consist of a large family of phylogenetically conserved secreted and transmembrane signalling proteins. Among the best-characterised vertebrate Semaphorins are the five secreted Class 3 members that contain an approximately 500 amino acid N-terminal Semaphorin domain, a C2 type immunoglobulin domain, and a highly basic C-terminal tail []. Two receptor families have been implicated in mediating the actions of class 3 semaphorins: the Neuropilins and Plexins. The nine known vertebrate Plexins are divided into four subfamilies (A through D) based on structure []. Several Plexins have been shown to interact directly with some class 4, 7 and V Semaphorins, but class 3 Semaphorins, however, do not appear to bind Plexins directly. Rather, the functional receptors for these Semaphorins are complexes of Neuropilins and A-type Plexins, with the former serving as the ligand-binding moiety and the latter the signal-transducing component [, ]. There are two Neuropilins (NP-1 and NP-2), which bind the five class 3 Semaphorins preferentially. In particular, Sema3A binds NP-1, whereas Sema3F utilises NP-2, while NP-1 and NP-2 heterodimers are thought to serve as functional receptors for Sema3C [].Recent work suggests a possible role of Gallus gallus (Chicken) Sema3E/collapsin-5 in restricting growth of retinal ganglion cell axons to the optic fibre layer [].
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Protein Domain
IPR015514 | Semaphorin_6C
Type: Family
Description: Semaphorins were first cloned as recognised mediators of cellular guidance, and consist of a large family of phylogenetically conserved secreted and transmembrane signalling proteins. Among the best-characterised vertebrate Semaphorins are the five secreted Class 3 members that contain an approximately 500 amino acid N-terminal Semaphorin domain, a C2 type immunoglobulin domain, and a highly basic C-terminal tail []. Two receptor families have been implicated in mediating the actions of class 3 semaphorins: the Neuropilins and Plexins. The nine known vertebrate Plexins are divided into four subfamilies (A through D) based on structure []. Several Plexins have been shown to interact directly with some class 4, 7 and V Semaphorins, but class 3 Semaphorins, however, do not appear to bind Plexins directly. Rather, the functional receptors for these Semaphorins are complexes of Neuropilins and A-type Plexins, with the former serving as the ligand-binding moiety and the latter the signal-transducing component [, ]. There are two Neuropilins (NP-1 and NP-2) that bind the five class 3 Semaphorins preferentially. In particular, Sema3A binds NP-1, whereas Sema3F utilises NP-2, while NP-1 and NP-2 heterodimers are thought to serve as functional receptors for Sema3C [].Recent microarray studies have suggested a role for Sema 6C in dental mesenchyme-induced neurite repulsion [].
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Protein Coding Gene
MGI:95602 | Fyn
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:96250 | Hsp90aa1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1339975 | Pak1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P07901
Organism: Mus musculus/domesticus
Length: 733  
Fragment?: false
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Protein
O88643
Organism: Mus musculus/domesticus
Length: 545  
Fragment?: false
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Protein
P39688
Organism: Mus musculus/domesticus
Length: 537  
Fragment?: false
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Publication
9875845 | -
First Author: Winberg ML
Year: 1998
Journal: Cell
Title: Plexin A is a neuronal semaphorin receptor that controls axon guidance.
Volume: 95
Issue: 7
Pages: 903-16
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Protein
S4R1B4
Organism: Mus musculus/domesticus
Length: 80  
Fragment?: false
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Publication
16584533 | -
First Author: Yazdani U
Year: 2006
Journal: Genome Biol
Title: The semaphorins.
Volume: 7
Issue: 3
Pages: 211
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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