|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 901 to 1000 out of 1099 for Smo

<< First    < Previous  |  Next >    Last >>
0.031s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Protein Coding Gene
MGI:94891 | Dhh
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI:98297 | Shh
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein
P97812
Organism: Mus musculus/domesticus
Length: 411  
Fragment?: false
•
•
•
•
•
Protein
Q61488
Organism: Mus musculus/domesticus
Length: 396  
Fragment?: false
•
•
•
•
•
Protein
Q62226
Organism: Mus musculus/domesticus
Length: 437  
Fragment?: false
•
•
•
•
•
Publication
8706127 | -
First Author: Alcedo J
Year: 1996
Journal: Cell
Title: The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal.
Volume: 86
Issue: 2
Pages: 221-32
•
•
•
•
•
Protein Domain
IPR041771 | SMO_CRD
Type: Domain
Description: The cysteine-rich domain (CRD) is part of the smoothened receptor (Smo), an integral membrane protein and one of the key players in the Hedgehog (Hh) signaling pathway, critical for development, cell growth and migration, as well as stem cell maintenance. The CRD of Smo is conserved in vertebrates and can also be identified in invertebrates. The precise function of the CRD in Smo is unknown []. Mutations in the Drosophila CRD disrupt Smo activity in vivo, while deletion of the CRD in mammalian cells does not seem to affect the activity of overexpressed Smo [].
•
•
•
•
•
HT Experiment
GSE221389 | BMP7 expression in mammalian cortical radial glial cells increases the length of the neurogenic period
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
•
•
•
•
•
Protein
Q8C784
Organism: Mus musculus/domesticus
Length: 167  
Fragment?: false
•
•
•
•
•
Protein
A0A140LII5
Organism: Mus musculus/domesticus
Length: 89  
Fragment?: true
•
•
•
•
•
Protein
A0A140LH99
Organism: Mus musculus/domesticus
Length: 108  
Fragment?: false
•
•
•
•
•
Protein Domain
IPR037663 | Mosmo
Type: Family
Description: MOSMO, also known as Atthog (attenuator of hedgehog) in mouse, acts as a negative regulator of hedgehog (Hh) signaling, probably by promoting internalization and subsequent degradation of Smoothened (SMO). SMO is an oncoprotein that transduces the Hh signal across the membrane. In the absence of Atthog, SMO was stabilized at the cell surface and concentrated in the ciliary membrane [].
•
•
•
•
•
GO Term
GO:1990788 | GLI-SUFU complex
•
•
•
•
•
Publication
14977528 | -
 
First Author: Malbon CC
Year: 2004
Journal: Front Biosci
Title: Frizzleds: new members of the superfamily of G-protein-coupled receptors.
Volume: 9
Pages: 1048-58
•
•
•
•
•
Publication
24148123 | -
First Author: Ruat M
Year: 2013
Journal: Med Sci (Paris)
Title: [Structure of the Smoothened receptor].
Volume: 29
Issue: 10
Pages: 855-60
•
•
•
•
•
Protein Domain
IPR035683 | SMO_7TM
Type: Domain
Description: Smoothened (SMO) is a transmembrane G protein-coupled receptor that acts as the transducer of the hedgehog (HH) signaling pathway []. SMO is activated by the hedgehog (HH) family of proteins acting on the 12-transmembrane domain receptor patched (PTCH), which constitutively inhibits SMO. Thus, in the absence of HH proteins, PTCH inhibits SMO signaling. On the other hand, binding of HH to the PTCH receptor activates its internalization and degradation, thereby releasing the PTCH inhibition of SMO. This allows SMO to trigger intracellular signaling and the subsequent activation of the Gli family of zinc finger transcriptional factors and induction of HH target gene expression (PTCH, Gli1, cyclin, Bcl-2, etc) []. SMO is closely related to the frizzled (FZD) family of seven transmembrane-spanning proteins, which constitute a novel and separate family of G-protein coupled receptors [, ].
•
•
•
•
•
Publication
36438482 | J:331709
First Author: Zhang S
Year: 2022
Journal: Theranostics
Title: The PROTAC selectively degrading Bcl-x(L) represents a novel Hedgehog pathway inhibitor with capacity of combating resistance to Smoothened inhibitors while sparing bone growth.
Volume: 12
Issue: 17
Pages: 7476-7490
•
•
•
•
•
Allele
Tg(KRT5-SMO*W535L)#Fjs | MGI:3525058
Name: transgene insertion #, Frederic J de Sauvage
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
•
•
•
•
•
Allele
Tg(Neurod2-Smo*A1)199Jols | MGI:3830738
Name: transgene insertion 199, James M Olson
Allele Type: Transgenic
Attribute String: Constitutively active, Inserted expressed sequence
•
•
•
•
•
Strain
MGI:6476345 | C57BL/6JSmoc-Smo<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
•
•
•
•
•
Publication
30487124 | J:320766
First Author: Rodriguez-Blanco J
Year: 2019
Journal: Clin Cancer Res
Title: A CK1α Activator Penetrates the Brain and Shows Efficacy Against Drug-resistant Metastatic Medulloblastoma.
Volume: 25
Issue: 4
Pages: 1379-1388
•
•
•
•
•
Protein Coding Gene
MGI:107689 | Kif3a
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI:1934950 | Csnk1a1
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein
Q8BK63
Organism: Mus musculus/domesticus
Length: 337  
Fragment?: false
•
•
•
•
•
Protein
P28741
Organism: Mus musculus/domesticus
Length: 701  
Fragment?: false
•
•
•
•
•
Publication
9811578 | -
First Author: Chen Y
Year: 1998
Journal: Development
Title: In vivo evidence that Patched and Smoothened constitute distinct binding and transducing components of a Hedgehog receptor complex.
Volume: 125
Issue: 24
Pages: 4943-8
•
•
•
•
•
Publication
35857834 | J:327233
First Author: Swiderska-Syn M
Year: 2022
Journal: Sci Adv
Title: Noncanonical activation of GLI signaling in SOX2+ cells drives medulloblastoma relapse.
Volume: 8
Issue: 29
Pages: eabj9138
•
•
•
•
•
Allele
Tg(UAS-Smo*W539L)1Amc | MGI:3584023
Name: transgene insertion 1, Andrew P McMahon
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
•
•
•
•
•
Strain
MGI:3831147 | C57BL/6-Tg(Neurod2-Smo*A1)199Jols/J
Attribute String: coisogenic, targeted mutation
•
•
•
•
•
Strain
MGI:3831128 | C57BL/6-Tg(Neurod2-Smo*A1)199Jols
Attribute String: transgenic, coisogenic
•
•
•
•
•
Publication
18339857 | J:133312
First Author: Hatton BA
Year: 2008
Journal: Cancer Res
Title: The Smo/Smo model: hedgehog-induced medulloblastoma with 90% incidence and leptomeningeal spread.
Volume: 68
Issue: 6
Pages: 1768-76
•
•
•
•
•
Publication
28031228 | J:239740
First Author: Ward SA
Year: 2017
Journal: Cancer Res
Title: Reprogramming Medulloblastoma-Propagating Cells by a Combined Antagonism of Sonic Hedgehog and CXCR4.
Volume: 77
Issue: 6
Pages: 1416-1426
•
•
•
•
•
Publication
32934143 | J:296276
First Author: Kim J
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Engineered biomimetic nanoparticle for dual targeting of the cancer stem-like cell population in sonic hedgehog medulloblastoma.
Volume: 117
Issue: 39
Pages: 24205-24212
•
•
•
•
•
Publication
26446920 | J:237594
First Author: Malhotra A
Year: 2016
Journal: Mol Cancer Res
Title: Sonic Hedgehog Signaling Drives Mitochondrial Fragmentation by Suppressing Mitofusins in Cerebellar Granule Neuron Precursors and Medulloblastoma.
Volume: 14
Issue: 1
Pages: 114-24
•
•
•
•
•
Publication
19351822 | J:147730
First Author: Northcott PA
Year: 2009
Journal: Cancer Res
Title: The miR-17/92 polycistron is up-regulated in sonic hedgehog-driven medulloblastomas and induced by N-myc in sonic hedgehog-treated cerebellar neural precursors.
Volume: 69
Issue: 8
Pages: 3249-55
•
•
•
•
•
Publication
23452854 | J:194038
First Author: Snuderl M
Year: 2013
Journal: Cell
Title: Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma.
Volume: 152
Issue: 5
Pages: 1065-76
•
•
•
•
•
Publication
24469054 | J:218631
First Author: Knight ER
Year: 2015
Journal: Oncogene
Title: ASC deficiency suppresses proliferation and prevents medulloblastoma incidence.
Volume: 34
Issue: 3
Pages: 394-402
•
•
•
•
•
Publication
29229597 | J:257853
First Author: Zhang Y
Year: 2018
Journal: Cancer Res
Title: Nkx2-2as Suppression Contributes to the Pathogenesis of Sonic Hedgehog Medulloblastoma.
Volume: 78
Issue: 4
Pages: 962-973
•
•
•
•
•
Publication
26938241 | J:259817
First Author: Singh AR
Year: 2016
Journal: PLoS One
Title: PI-3K Inhibitors Preferentially Target CD15+ Cancer Stem Cell Population in SHH Driven Medulloblastoma.
Volume: 11
Issue: 3
Pages: e0150836
•
•
•
•
•
Publication
32123231 | J:293139
First Author: Xin Y
Year: 2020
Journal: Sci Rep
Title: PET imaging of medulloblastoma with an 18F-labeled tryptophan analogue in a transgenic mouse model.
Volume: 10
Issue: 1
Pages: 3800
•
•
•
•
•
Publication
19638572 | J:150937
First Author: Veiseh O
Year: 2009
Journal: Cancer Res
Title: Specific targeting of brain tumors with an optical/magnetic resonance imaging nanoprobe across the blood-brain barrier.
Volume: 69
Issue: 15
Pages: 6200-7
•
•
•
•
•
Publication
30224541 | J:272040
First Author: Wei Y
Year: 2019
Journal: Mol Cancer Res
Title: p53 Function Is Compromised by Inhibitor 2 of Phosphatase 2A in Sonic Hedgehog Medulloblastoma.
Volume: 17
Issue: 1
Pages: 186-198
•
•
•
•
•
Allele
Tg(Neurod2-Smo*A2)#Jols | MGI:5447065
Name: transgene insertion, James M Olson
Allele Type: Transgenic
Attribute String: Constitutively active, Inserted expressed sequence
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(Neurod2-Smo*A1)199Jols/?
Background: C57BL/6-Tg(Neurod2-Smo*A1)199Jols
Zygosity: ot
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(Neurod2-Smo*A1)199Jols/Tg(Neurod2-Smo*A1)199Jols
Background: C57BL/6-Tg(Neurod2-Smo*A1)199Jols
Zygosity: hm
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(Neurod2-Smo*A1)199Jols/?
Background: involves: C57BL/6
Zygosity: ot
Has Mutant Allele: true
•
•
•
•
•
Protein Coding Gene
MGI:87940 | Grk2
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein
Q99MK8
Organism: Mus musculus/domesticus
Length: 689  
Fragment?: false
•
•
•
•
•
Publication
20520772 | J:160902
First Author: Castellino RC
Year: 2010
Journal: PLoS One
Title: Heterozygosity for Pten promotes tumorigenesis in a mouse model of medulloblastoma.
Volume: 5
Issue: 5
Pages: e10849
•
•
•
•
•
Strain
MGI:5447647 | C57BL/6-Tg(Neurod2-Smo*A2)#Jols
Attribute String: coisogenic, mutant strain, transgenic
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(Col2a1-GAL4)1Amc/? Tg(UAS-Smo*W539L)1Amc/?
Background: Not Specified
Zygosity: cx
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(Neurod2-Smo*A2)#Jols/?
Background: C57BL/6-Tg(Neurod2-Smo*A2)#Jols
Zygosity: ot
Has Mutant Allele: true
•
•
•
•
•
Publication
28275010 | J:240027
First Author: Monkkonen T
Year: 2017
Journal: Development
Title: Epithelial and non-epithelial Ptch1 play opposing roles to regulate proliferation and morphogenesis of the mouse mammary gland.
Volume: 144
Issue: 7
Pages: 1317-1327
•
•
•
•
•
Protein Coding Gene
MGI:99474 | Arrb2
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI:99473 | Arrb1
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein
Q8BWG8
Organism: Mus musculus/domesticus
Length: 418  
Fragment?: false
•
•
•
•
•
Protein
Q91YI4
Organism: Mus musculus/domesticus
Length: 410  
Fragment?: false
•
•
•
•
•
Publication
15239825 | -
First Author: Huang HC
Year: 2004
Journal: Genome Biol
Title: The Frizzled family: receptors for multiple signal transduction pathways.
Volume: 5
Issue: 7
Pages: 234
•
•
•
•
•
HT Experiment
E-GEOD-17473 | Transcription profiling of mouse embryonic E16.5 temporomandibular joint
Series Id: GSE17473
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
•
•
•
•
•
Publication
20890301 | J:168813
First Author: Bhatia B
Year: 2011
Journal: Oncogene
Title: Mitogenic Sonic hedgehog signaling drives E2F1-dependent lipogenesis in progenitor cells and medulloblastoma.
Volume: 30
Issue: 4
Pages: 410-22
•
•
•
•
•
Publication
24068730 | J:209539
First Author: Abad C
Year: 2014
Journal: J Leukoc Biol
Title: Targeted STAT3 disruption in myeloid cells alters immunosuppressor cell abundance in a murine model of spontaneous medulloblastoma.
Volume: 95
Issue: 2
Pages: 357-67
•
•
•
•
•
Publication
25879388 | J:309638
First Author: Bhatia S
Year: 2015
Journal: Oncotarget
Title: Knockdown of EphB1 receptor decreases medulloblastoma cell growth and migration and increases cellular radiosensitization.
Volume: 6
Issue: 11
Pages: 8929-46
•
•
•
•
•
Publication
30778099 | J:275403
First Author: Paine MRL
Year: 2019
Journal: Sci Rep
Title: Three-Dimensional Mass Spectrometry Imaging Identifies Lipid Markers of Medulloblastoma Metastasis.
Volume: 9
Issue: 1
Pages: 2205
•
•
•
•
•
Publication
19048113 | J:331046
First Author: Michael LE
Year: 2008
Journal: Neoplasia
Title: Bmi1 is required for Hedgehog pathway-driven medulloblastoma expansion.
Volume: 10
Issue: 12
Pages: 1343-9, 5p following 1349
•
•
•
•
•
Genotype
Genotype
Symbol: Mir34a/Mir34a<+> Tg(Neurod2-Smo*A1)199Jols/?
Background: involves: C57BL/6 * C57BL/6N
Zygosity: cx
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Mir34a/Mir34a Tg(Neurod2-Smo*A1)199Jols/?
Background: involves: C57BL/6 * C57BL/6N
Zygosity: cx
Has Mutant Allele: true
•
•
•
•
•
HT Experiment
E-GEOD-11063 | Expression data from E11.5 mouse embryonic forelimbs - various mutant conditions or dissected limb domains
Series Id: GSE11063
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
•
•
•
•
•
Protein
Q8BS35
Organism: Mus musculus/domesticus
Length: 447  
Fragment?: false
•
•
•
•
•
Protein
Q9Z0F5
Organism: Mus musculus/domesticus
Length: 298  
Fragment?: false
•
•
•
•
•
Protein
Q9CRA4
Organism: Mus musculus/domesticus
Length: 293  
Fragment?: false
•
•
•
•
•
Protein
O88822
Organism: Mus musculus/domesticus
Length: 299  
Fragment?: false
•
•
•
•
•
Protein
A0A1W2P846
Organism: Mus musculus/domesticus
Length: 295  
Fragment?: false
•
•
•
•
•
Protein
Q8R1S3
Organism: Mus musculus/domesticus
Length: 299  
Fragment?: false
•
•
•
•
•
Protein
A0A1W2P8B8
Organism: Mus musculus/domesticus
Length: 313  
Fragment?: false
•
•
•
•
•
Protein
A0A1W2P6W1
Organism: Mus musculus/domesticus
Length: 311  
Fragment?: false
•
•
•
•
•
Protein
A0A1L1SSH0
Organism: Mus musculus/domesticus
Length: 215  
Fragment?: true
•
•
•
•
•
Publication
8718622 | -
First Author: Aarts MG
Year: 1995
Journal: Plant Cell
Title: Molecular characterization of the CER1 gene of arabidopsis involved in epicuticular wax biosynthesis and pollen fertility.
Volume: 7
Issue: 12
Pages: 2115-27
•
•
•
•
•
Publication
12880870 | -
First Author: Darnet S
Year: 2003
Journal: Biochim Biophys Acta
Title: Enzymological properties of sterol-C4-methyl-oxidase of yeast sterol biosynthesis.
Volume: 1633
Issue: 2
Pages: 106-17
•
•
•
•
•
Publication
10344195 | -
First Author: Husselstein T
Year: 1999
Journal: Plant Mol Biol
Title: Delta7-sterol-C5-desaturase: molecular characterization and functional expression of wild-type and mutant alleles.
Volume: 39
Issue: 5
Pages: 891-906
•
•
•
•
•
Publication
14653780 | -
First Author: Darnet S
Year: 2004
Journal: Biochem J
Title: Plant sterol biosynthesis: identification of two distinct families of sterol 4alpha-methyl oxidases.
Volume: 378
Issue: Pt 3
Pages: 889-98
•
•
•
•
•
Publication
26515067 | -
First Author: Zhu G
Year: 2015
Journal: J Biol Chem
Title: The Crystal Structure of an Integral Membrane Fatty Acid α-Hydroxylase.
Volume: 290
Issue: 50
Pages: 29820-33
•
•
•
•
•
Protein Domain
IPR006694 | Fatty_acid_hydroxylase
Type: Domain
Description: This entry includes fatty acid and carotene hydroxylases and sterol desaturases. Beta-carotene hydroxylase is involved in zeaxanthin synthesis by hydroxylating beta-carotene, but the enzyme may be involved in other pathways []. This family includes C-5 sterol desaturase []and C-4 sterol methyl oxidase (SMO) [, ]. Members of this family are involved in cholesterol biosynthesis and biosynthesis a plant cuticular wax. These enzymes contain two copies of a HXHH motif, involved in coordination of two iron atoms in the catalytic centre. Members of this family are ER integral membrane proteins with a mushroom-like structure consisting of four transmembrane helices (TM1-TM4) that anchor them to the membrane, capped by a cytosolic domain containing the unique histidine-coordinating di metal centre [].The plant SMO amino acid sequences possess three histidine-rich motifs (HX3H, HX2HH and HX2HH), characteristic of the small family of membrane-bound non-haem iron oxygenases that are involved in lipid oxidation [].
•
•
•
•
•
Publication
21215705 | J:168256
First Author: Wang GY
Year: 2011
Journal: Cancer Cell
Title: Basal cell carcinomas arise from hair follicle stem cells in Ptch1(+/-) mice.
Volume: 19
Issue: 1
Pages: 114-24
•
•
•
•
•
Publication
29168692 | J:254972
   
First Author: Klisch TJ
Year: 2017
Journal: Elife
Title: Jak2-mediated phosphorylation of Atoh1 is critical for medulloblastoma growth.
Volume: 6
•
•
•
•
•
Publication
35680976 | J:325596
First Author: Pokrajac NT
Year: 2022
Journal: Commun Biol
Title: Three dimensional reconstruction of the mouse cerebellum in Hedgehog-driven medulloblastoma models to identify Norrin-dependent effects on preneoplasia.
Volume: 5
Issue: 1
Pages: 569
•
•
•
•
•
Publication
20440271 | J:168168
First Author: Hatton BA
Year: 2010
Journal: Oncogene
Title: Notch signaling is not essential in sonic hedgehog-activated medulloblastoma.
Volume: 29
Issue: 26
Pages: 3865-72
•
•
•
•
•
Publication
30659230 | J:275488
First Author: Lim Y
Year: 2019
Journal: Sci Rep
Title: Arx Expression Suppresses Ventralization of the Developing Dorsal Forebrain.
Volume: 9
Issue: 1
Pages: 226
•
•
•
•
•
Publication
25082897 | J:213930
First Author: Gate D
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: T-cell TGF-β signaling abrogation restricts medulloblastoma progression.
Volume: 111
Issue: 33
Pages: E3458-66
•
•
•
•
•
Publication
19738049 | J:152687
First Author: Bhatia B
Year: 2009
Journal: Cancer Res
Title: Tuberous sclerosis complex suppression in cerebellar development and medulloblastoma: separate regulation of mammalian target of rapamycin activity and p27 Kip1 localization.
Volume: 69
Issue: 18
Pages: 7224-34
•
•
•
•
•
Publication
28515149 | J:242568
First Author: Tech K
Year: 2017
Journal: Cancer Res
Title: Pyruvate Kinase Inhibits Proliferation during Postnatal Cerebellar Neurogenesis and Suppresses Medulloblastoma Formation.
Volume: 77
Issue: 12
Pages: 3217-3230
•
•
•
•
•
Publication
15520185 | J:93861
First Author: Hallahan AR
Year: 2004
Journal: Cancer Res
Title: The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of sonic hedgehog-induced medulloblastomas.
Volume: 64
Issue: 21
Pages: 7794-800
•
•
•
•
•
Publication
33926529 | J:331043
First Author: Kim H
Year: 2021
Journal: Genome Biol
Title: Ten-eleven translocation protein 1 modulates medulloblastoma progression.
Volume: 22
Issue: 1
Pages: 125
•
•
•
•
•
Publication
25348795 | J:221990
First Author: Thor T
Year: 2015
Journal: Int J Cancer
Title: MiR-34a deficiency accelerates medulloblastoma formation in vivo.
Volume: 136
Issue: 10
Pages: 2293-303
•
•
•
•
•
Publication
31851932 | J:298884
First Author: Aiello G
Year: 2019
Journal: Cell Rep
Title: Truncated BRPF1 Cooperates with Smoothened to Promote Adult Shh Medulloblastoma.
Volume: 29
Issue: 12
Pages: 4036-4052.e10
•
•
•
•
•
Publication
25834022 | J:221426
First Author: Liu J
Year: 2015
Journal: Development
Title: The loss of Hh responsiveness by a non-ciliary Gli2 variant.
Volume: 142
Issue: 9
Pages: 1651-60
•
•
•
•
•
Publication
29103956 | J:253967
First Author: Wu CC
Year: 2017
Journal: Dev Cell
Title: mTORC1-Mediated Inhibition of 4EBP1 Is Essential for Hedgehog Signaling-Driven Translation and Medulloblastoma.
Volume: 43
Issue: 6
Pages: 673-688.e5
•
•
•
•
•
Publication
20385363 | J:158946
First Author: Kim J
Year: 2010
Journal: Cancer Cell
Title: Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth.
Volume: 17
Issue: 4
Pages: 388-99
•
•
•
•
•
Publication
21321207 | J:170482
First Author: Wong SY
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Wounding mobilizes hair follicle stem cells to form tumors.
Volume: 108
Issue: 10
Pages: 4093-8
•
•
•
•
•
Publication
34551292 | J:328728
First Author: Wang Y
Year: 2021
Journal: Cell Rep
Title: A long-range, recurrent neuronal network linking the emotion regions with the somatic motor cortex.
Volume: 36
Issue: 12
Pages: 109733
•
•
•
•
•
Publication
32332736 | J:291852
First Author: Kim Y
Year: 2020
Journal: Nat Commun
Title: Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration.
Volume: 11
Issue: 1
Pages: 1994
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom