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Search results 901 to 998 out of 998 for Snca

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0.036s
Type Details Score
Publication
First Author: Kim E
Year: 2016
Journal: Hum Mol Genet
Title: NEDD4-mediated HSF1 degradation underlies α-synucleinopathy.
Volume: 25
Issue: 2
Pages: 211-22
Strain
Attribute String: congenic, mutant strain, targeted mutation
Strain
Attribute String: congenic, mutant strain, targeted mutation
Strain
Attribute String: congenic, mutant strain, targeted mutation
Genotype
Symbol: Snca/Snca
Background: involves: 129
Zygosity: hm
Has Mutant Allele: true
HT Experiment
Series Id: GSE20547
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
HT Experiment
Series Id: GSE60414
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
Strain
Attribute String: inbred strain
Publication  
First Author: Hall K
Year: 2015
Journal: Exp Neurol
Title: Behavioural deficits in transgenic mice expressing human truncated (1-120 amino acid) alpha-synuclein.
Volume: 264
Pages: 8-13
Publication
First Author: Mougenot AL
Year: 2012
Journal: Neurobiol Aging
Title: Prion-like acceleration of a synucleinopathy in a transgenic mouse model.
Volume: 33
Issue: 9
Pages: 2225-8
Publication
First Author: Kisos H
Year: 2012
Journal: PLoS One
Title: Increased neuronal α-synuclein pathology associates with its accumulation in oligodendrocytes in mice modeling α-synucleinopathies.
Volume: 7
Issue: 10
Pages: e46817
Publication
First Author: Kim C
Year: 2015
Journal: Cell Rep
Title: Antagonizing Neuronal Toll-like Receptor 2 Prevents Synucleinopathy by Activating Autophagy.
Volume: 13
Issue: 4
Pages: 771-782
Strain
Attribute String: mutant stock, targeted mutation, transgenic
Strain
Attribute String: mutant stock, transgenic
Publication
First Author: Platt NJ
Year: 2012
Journal: PLoS One
Title: Striatal dopamine transmission is subtly modified in human A53Tα-synuclein overexpressing mice.
Volume: 7
Issue: 5
Pages: e36397
Publication
First Author: Kurz A
Year: 2012
Journal: J Neural Transm (Vienna)
Title: A53T-alpha-synuclein-overexpression in the mouse nigrostriatal pathway leads to early increase of 14-3-3 epsilon and late increase of GFAP.
Volume: 119
Issue: 3
Pages: 297-312
Publication  
First Author: Tian Y
Year: 2023
Journal: Behav Brain Res
Title: SYNJ1 rescues motor functions in hereditary and sporadic Parkinson's disease mice by upregulating TSP-1 expression.
Volume: 452
Pages: 114569
Publication
First Author: Noorian AR
Year: 2012
Journal: Neurobiol Dis
Title: Alpha-synuclein transgenic mice display age-related slowing of gastrointestinal motility associated with transgene expression in the vagal system.
Volume: 48
Issue: 1
Pages: 9-19
Publication
First Author: Jasmin M
Year: 2021
Journal: EMBO J
Title: Netrin-1 and its receptor DCC modulate survival and death of dopamine neurons and Parkinson's disease features.
Volume: 40
Issue: 3
Pages: e105537
Allele
Name: synuclein, alpha; targeted mutation 1, Gregor Eichele
Allele Type: Targeted
Attribute String: Conditional ready, Humanized sequence, Inserted expressed sequence
Allele
Name: synuclein, alpha; targeted mutation 2, Gregor Eichele
Allele Type: Targeted
Attribute String: Conditional ready, Humanized sequence, Inserted expressed sequence
Genotype
Symbol: Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
Background: involves: 129S6/SvEvTac * FVB/N
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
Background: involves: FVB/N
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Prkn/Prkn Tg(CAG-SNCA*)1.1Ccs/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Prkn/Prkn Tg(Th-SNCA*)1.2Ccs/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Tg(SOD1*G93A)1Gur/? Tg(THY1-SNCA)1Sud/?
Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Tg(Camk2a-tTA)1Mmay/? Tg(tetO-SNCA)1Cai/?
Background: involves: C57BL/6
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Tg(Prnp-SNCA*A53T)AAub/?
Background: involves: FVB/N
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Atp13a2/Atp13a2 Snca/Snca
Background: involves: 129 * C57BL/6
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Tg(Camk2a-SNCA*)2Mgsp/? Del(6Snca)1Slab/Del(6Snca)1Slab
Background: B6JOlaHsd.Cg-Tg(Camk2a-SNCA*)2Mgsp
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Abl1/Abl1 Tg(Nes-cre)1Kag/? Tg(tetO/Prnp-SNCA*A53T)4360Tmd/?
Background: involves: 129S4/SvJae * C3H * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Tg(tetO/Prnp-SNCA*A53T)4360Tmd/? Zfp746/Zfp746
Background: involves: 129S4/SvJae * C3H * C57BL/6
Zygosity: cx
Has Mutant Allele: true
Publication
First Author: Lassot I
Year: 2018
Journal: Cell Rep
Title: The E3 Ubiquitin Ligases TRIM17 and TRIM41 Modulate α-Synuclein Expression by Regulating ZSCAN21.
Volume: 25
Issue: 9
Pages: 2484-2496.e9
Publication
First Author: Gui YX
Year: 2012
Journal: Neurobiol Aging
Title: Extracellular signal-regulated kinase is involved in alpha-synuclein-induced mitochondrial dynamic disorders by regulating dynamin-like protein 1.
Volume: 33
Issue: 12
Pages: 2841-54
Publication
First Author: LaPierre MP
Year: 2022
Journal: Nat Commun
Title: MicroRNA-7 regulates melanocortin circuits involved in mammalian energy homeostasis.
Volume: 13
Issue: 1
Pages: 5733
Publication
First Author: Mittal S
Year: 2017
Journal: Science
Title: β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson's disease.
Volume: 357
Issue: 6354
Pages: 891-898
Publication
First Author: Oh SH
Year: 2017
Journal: Stem Cells
Title: Mesenchymal Stem Cells Stabilize Axonal Transports for Autophagic Clearance of α-Synuclein in Parkinsonian Models.
Volume: 35
Issue: 8
Pages: 1934-1947
Strain
Attribute String: transgenic, targeted mutation, mutant strain, congenic
Strain
Attribute String: congenic, mutant strain, targeted mutation, transgenic
Strain
Attribute String: mutant strain, congenic, targeted mutation, transgenic
Publication
First Author: Ben-Moshe H
Year: 2020
Journal: J Mol Neurosci
Title: ApoE4 Exacerbates Hippocampal Pathology Following Acute Brain Penetration Injury in Female Mice.
Volume: 70
Issue: 1
Pages: 32-44
Publication  
First Author: Bar R
Year: 2018
Journal: Alzheimers Dement (Amst)
Title: The effects of apolipoprotein E genotype, α-synuclein deficiency, and sex on brain synaptic and Alzheimer's disease-related pathology.
Volume: 10
Pages: 1-11
Publication
First Author: Simonovitch S
Year: 2019
Journal: J Alzheimers Dis
Title: The Effects of APOE4 on Mitochondrial Dynamics and Proteins in vivo.
Volume: 70
Issue: 3
Pages: 861-875
Publication  
First Author: Faustini G
Year: 2020
Journal: Neurobiol Dis
Title: Alpha-synuclein/synapsin III pathological interplay boosts the motor response to methylphenidate.
Volume: 138
Pages: 104789
Publication
First Author: Lasser-Katz E
Year: 2017
Journal: J Neurosci
Title: Mutant α-Synuclein Overexpression Induces Stressless Pacemaking in Vagal Motoneurons at Risk in Parkinson's Disease.
Volume: 37
Issue: 1
Pages: 47-57
Publication
First Author: Stichel CC
Year: 2007
Journal: Hum Mol Genet
Title: Mono- and double-mutant mouse models of Parkinson's disease display severe mitochondrial damage.
Volume: 16
Issue: 20
Pages: 2377-93
Publication
First Author: Schmidt S
Year: 2011
Journal: Hum Mol Genet
Title: Genetic mouse models for Parkinson's disease display severe pathology in glial cell mitochondria.
Volume: 20
Issue: 6
Pages: 1197-211
Publication
First Author: Maskri L
Year: 2004
Journal: Neurodegener Dis
Title: Influence of different promoters on the expression pattern of mutated human alpha-synuclein in transgenic mice.
Volume: 1
Issue: 6
Pages: 255-65
Genotype
Symbol: Snca/Snca Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
Background: involves: 129S6/SvEvTac * FVB/N
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Del(6Snca)1Slab/Del(6Snca)1Slab Tg(Th-SNCA*)1Mgsp/?
Background: involves: C57BL/6J * C57BL/6JOlaHsd * CBA/Ca
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Tg(Camk2a-tTA)1Mmay/? Tg(tetO-LRRK2*G2019S)E3Cai/? Tg(tetO-SNCA)1Cai/?
Background: involves: C57BL/6
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Snca/Snca Tg(SNCA)OVX37Rwm/?
Background: B6.Cg-Tg(SNCA)OVX37Rwm Snca
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Snca/Snca Tg(SNCA*A30P)192Rwm/?
Background: B6.Cg-Snca Tg(SNCA*A30P)#Rwm
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Tg(Slc6a5-EGFP)1Uze/? Tg(THY1-SNCA*A53T)M53Sud/?
Background: involves: C57BL/6 * FVB/N
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Pink1/Pink1 Tg(Prnp-SNCA*A53T)AAub/?
Background: involves: 129S2/SvPas * C57BL/6J * FVB/N
Zygosity: cx
Has Mutant Allele: true
Publication
First Author: Tayebi N
Year: 2017
Journal: Mol Genet Metab
Title: Glucocerebrosidase haploinsufficiency in A53T α-synuclein mice impacts disease onset and course.
Volume: 122
Issue: 4
Pages: 198-208
Publication
First Author: Ochi S
Year: 2020
Journal: Mol Neurobiol
Title: Identifying Blood Transcriptome Biomarkers of Alzheimer's Disease Using Transgenic Mice.
Volume: 57
Issue: 12
Pages: 4941-4951
Publication
First Author: Argyrofthalmidou M
Year: 2021
Journal: Hum Mol Genet
Title: Nurr1 repression mediates cardinal features of Parkinson's disease in α-synuclein transgenic mice.
Volume: 30
Issue: 16
Pages: 1469-1483
Publication
First Author: Rotermund C
Year: 2017
Journal: J Neurochem
Title: Enhanced motivation to alcohol in transgenic mice expressing human α-synuclein.
Volume: 143
Issue: 3
Pages: 294-305
Publication
First Author: Lahut S
Year: 2017
Journal: Dis Model Mech
Title: Blood RNA biomarkers in prodromal PARK4 and rapid eye movement sleep behavior disorder show role of complexin 1 loss for risk of Parkinson's disease.
Volume: 10
Issue: 5
Pages: 619-631
Publication  
First Author: Cao YL
Year: 2017
Journal: Neurobiol Aging
Title: A role of BAG3 in regulating SNCA/α-synuclein clearance via selective macroautophagy.
Volume: 60
Pages: 104-115
Publication
First Author: Song S
Year: 2020
Journal: Sci Rep
Title: Norepinephrine depleting toxin DSP-4 and LPS alter gut microbiota and induce neurotoxicity in α-synuclein mutant mice.
Volume: 10
Issue: 1
Pages: 15054
Publication  
First Author: Sheng YL
Year: 2017
Journal: Exp Neurol
Title: Urate promotes SNCA/α-synuclein clearance via regulating mTOR-dependent macroautophagy.
Volume: 297
Pages: 138-147
Publication  
First Author: Giraldo G
Year: 2018
Journal: Neurobiol Aging
Title: Locomotor differences in mice expressing wild-type human α-synuclein.
Volume: 65
Pages: 140-148
Publication
First Author: Kilpeläinen T
Year: 2019
Journal: Sci Rep
Title: Behavioural and dopaminergic changes in double mutated human A30P*A53T alpha-synuclein transgenic mouse model of Parkinson´s disease.
Volume: 9
Issue: 1
Pages: 17382
Publication
First Author: Uehara T
Year: 2019
Journal: Sci Rep
Title: Amido-bridged nucleic acid (AmNA)-modified antisense oligonucleotides targeting α-synuclein as a novel therapy for Parkinson's disease.
Volume: 9
Issue: 1
Pages: 7567
Publication  
First Author: Moceri S
Year: 2024
Journal: Behav Brain Res
Title: Young human alpha synuclein transgenic (BAC-SNCA) mice display sex- and gene-dose-dependent phenotypic disturbances.
Volume: 460
Pages: 114781
Publication
First Author: Clark J
Year: 2010
Journal: PLoS One
Title: Oral N-acetyl-cysteine attenuates loss of dopaminergic terminals in alpha-synuclein overexpressing mice.
Volume: 5
Issue: 8
Pages: e12333
Publication  
First Author: Hong CT
Year: 2020
Journal: Cells
Title: Insulin Resistance Promotes Parkinson's Disease through Aberrant Expression of α-Synuclein, Mitochondrial Dysfunction, and Deregulation of the Polo-Like Kinase 2 Signaling.
Volume: 9
Issue: 3
Publication
First Author: Valente T
Year: 2020
Journal: Cell Death Differ
Title: CCAAT/enhancer binding protein δ is a transcriptional repressor of α-synuclein.
Volume: 27
Issue: 2
Pages: 509-524
Publication
First Author: Rutherford NJ
Year: 2017
Journal: Hum Mol Genet
Title: Comparison of the in vivo induction and transmission of α-synuclein pathology by mutant α-synuclein fibril seeds in transgenic mice.
Volume: 26
Issue: 24
Pages: 4906-4915
Publication
First Author: Li R
Year: 2022
Journal: Autophagy
Title: Piperine promotes autophagy flux by P2RX4 activation in SNCA/α-synuclein-induced Parkinson disease model.
Volume: 18
Issue: 3
Pages: 559-575
Publication  
First Author: Wassouf Z
Year: 2018
Journal: Front Neurosci
Title: Distinct Stress Response and Altered Striatal Transcriptome in Alpha-Synuclein Overexpressing Mice.
Volume: 12
Pages: 1033
Publication
First Author: Levi O
Year: 2003
Journal: Neurobiol Dis
Title: ApoE4 impairs hippocampal plasticity isoform-specifically and blocks the environmental stimulation of synaptogenesis and memory.
Volume: 13
Issue: 3
Pages: 273-82
Publication
First Author: Kurtenbach S
Year: 2013
Journal: PLoS One
Title: Olfaction in three genetic and two MPTP-induced Parkinson's disease mouse models.
Volume: 8
Issue: 10
Pages: e77509
Publication  
First Author: Aranburu A
Year: 2023
Journal: Front Immunol
Title: Clonal relationships of memory B cell subsets in autoimmune mice.
Volume: 14
Pages: 1129234
Publication
First Author: Brahmachari S
Year: 2019
Journal: Brain
Title: Parkin interacting substrate zinc finger protein 746 is a pathological mediator in Parkinson's disease.
Volume: 142
Issue: 8
Pages: 2380-2401
Publication
First Author: Yin S
Year: 2023
Journal: J Neuroinflammation
Title: RGS5 augments astrocyte activation and facilitates neuroinflammation via TNF signaling.
Volume: 20
Issue: 1
Pages: 203
Strain
Attribute String: mutant stock, targeted mutation, transgenic
Strain
Attribute String: mutant stock, targeted mutation, transgenic
Strain
Attribute String: transgenic, targeted mutation, mutant stock
Strain
Attribute String: mutant stock, targeted mutation, transgenic
Publication  
First Author: Auburger G
Year: 2016
Journal: Parkinsons Dis
Title: Methyl-Arginine Profile of Brain from Aged PINK1-KO+A53T-SNCA Mice Suggests Altered Mitochondrial Biogenesis.
Volume: 2016
Pages: 4686185
Publication  
First Author: Maki RA
Year: 2019
Journal: Free Radic Biol Med
Title: Human myeloperoxidase (hMPO) is expressed in neurons in the substantia nigra in Parkinson's disease and in the hMPO-α-synuclein-A53T mouse model, correlating with increased nitration and aggregation of α-synuclein and exacerbation of motor impairment.
Volume: 141
Pages: 115-140
Genotype
Symbol: Snca/Snca Tg(SNCA*A30P)1Nbm/Tg(SNCA*A30P)1Nbm Tg(SNCA*A30P)2Nbm/Tg(SNCA*A30P)2Nbm
Background: involves: 129S6/SvEvTac * FVB/N
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Snca/Snca Tg(SNCA*A53T)1Nbm/Tg(SNCA*A53T)1Nbm Tg(SNCA*A53T)2Nbm/Tg(SNCA*A53T)2Nbm
Background: involves: 129S6/SvEvTac * FVB/N
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Pink1/Pink1 Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
Background: involves: 129S/SvEv * FVB/N
Zygosity: cx
Has Mutant Allele: true
Publication
First Author: Prieto Huarcaya S
Year: 2022
Journal: Autophagy
Title: Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-Synuclein degradation in α-Synucleinopathy models.
Volume: 18
Issue: 5
Pages: 1127-1151
Publication
First Author: Taguchi T
Year: 2020
Journal: Brain
Title: α-Synuclein BAC transgenic mice exhibit RBD-like behaviour and hyposmia: a prodromal Parkinson's disease model.
Volume: 143
Issue: 1
Pages: 249-265
Publication
First Author: Israeli E
Year: 2011
Journal: PLoS One
Title: α-Synuclein expression selectively affects tumorigenesis in mice modeling Parkinson's disease.
Volume: 6
Issue: 5
Pages: e19622
Publication  
First Author: Martin LJ
Year: 2019
Journal: Front Neurol
Title: Neonatal Brain Injury and Genetic Causes of Adult-Onset Neurodegenerative Disease in Mice Interact With Effects on Acute and Late Outcomes.
Volume: 10
Pages: 635
Strain
Attribute String: mutant stock, targeted mutation, transgenic
Publication
First Author: Evsyukov V
Year: 2017
Journal: Dis Model Mech
Title: Genetic mutations linked to Parkinson's disease differentially control nucleolar activity in pre-symptomatic mouse models.
Volume: 10
Issue: 5
Pages: 633-643
Strain
Attribute String: mutant stock, targeted mutation, transgenic
Publication
First Author: Fourgeaud L
Year: 2016
Journal: Nature
Title: TAM receptors regulate multiple features of microglial physiology.
Volume: 532
Issue: 7598
Pages: 240-244
Publication
First Author: Liu YJ
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: Cspg4(high) microglia contribute to microgliosis during neurodegeneration.
Volume: 120
Issue: 8
Pages: e2210643120
Publication      
First Author: European Mouse Mutant Archive
Year: 2003
Journal: Unpublished
Title: Information obtained from the European Mouse Mutant Archive (EMMA)
Publication      
First Author: The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY)
Year: 2005
Journal: Database Download
Title: MGI download of GENSAT transgene data