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Search results 901 to 1000 out of 1177 for Stat6

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0.037s

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Type Details Score
Protein
A0A087WQD8
Organism: Mus musculus/domesticus
Length: 654  
Fragment?: false
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Publication
10791955 | -
First Author: Ling L
Year: 2000
Journal: J Biol Chem
Title: MIP-T3, a novel protein linking tumor necrosis factor receptor-associated factor 3 to the microtubule network.
Volume: 275
Issue: 31
Pages: 23852-60
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Publication
12812986 | -
First Author: Morris JA
Year: 2003
Journal: Hum Mol Genet
Title: DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation.
Volume: 12
Issue: 13
Pages: 1591-608
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Protein Domain
IPR028819 | NCOA1
Type: Family
Description: Nuclear receptor coactivator 1 (NCOA1, also known as SRC-1) belongs to the SRC/p160 nuclear receptor coactivator family, which contains proteins that are ligand-dependent transcription factors []. These receptors can function as molecular switches [].NCOA1 directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion []. It is involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs) []. It is also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors [, , ]. It plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors []. It can be regulated by sumoylation and ubiquitination [].
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Protein Domain
IPR042576 | TRAF3IP1_N_sf
Type: Homologous_superfamily
Description: TRAF3-interacting protein 1 (TRAF3IP1) recruits TRAF3 (tumour necrosis factor receptor-associated factor 3) and DISC1 (Disrupted-In-Schizophrenia 1) to the microtubules and is conserved from worms to humans []. The N-terminal region is the microtubule binding domain and is well-conserved; the C-terminal 100 residues, also well-conserved, constitute the coiled-coil region which binds to TRAF3. The central region of the protein is rich in lysine and glutamic acid and carries KKE motifs which may also be necessary for tubulin-binding, but this region is the least well-conserved []. In humans, it plays an inhibitory role on IL13 signaling by binding to IL13RA1. It is involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding [, ].This superfamily represents the N-terminal domain of TRAF3-interacting protein 1.
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Protein Domain
IPR040468 | TRAF3IP1_N
Type: Domain
Description: TRAF3-interacting protein 1 (TRAF3IP1) recruits TRAF3 (tumour necrosis factor receptor-associated factor 3) and DISC1 (Disrupted-In-Schizophrenia 1) to the microtubules and is conserved from worms to humans []. The N-terminal region is the microtubule binding domain and is well-conserved; the C-terminal 100 residues, also well-conserved, constitute the coiled-coil region which binds to TRAF3. The central region of the protein is rich in lysine and glutamic acid and carries KKE motifs which may also be necessary for tubulin-binding, but this region is the least well-conserved []. In humans, it plays an inhibitory role on IL13 signaling by binding to IL13RA1. It is involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding [, ].This entry represents the N-terminal domain of TRAF3-interacting protein 1.
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Publication
16698929 | J:110219
First Author: Chen Z
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells.
Volume: 103
Issue: 21
Pages: 8137-42
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Publication
10817963 | J:62426
First Author: Takeda K
Year: 2000
Journal: Cytokine Growth Factor Rev
Title: STAT family of transcription factors in cytokine-mediated biological responses.
Volume: 11
Issue: 3
Pages: 199-207
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Publication
11120785 | J:66158
First Author: Takemoto N
Year: 2000
Journal: J Immunol
Title: Cutting edge: chromatin remodeling at the IL-4/IL-13 intergenic regulatory region for Th2-specific cytokine gene cluster.
Volume: 165
Issue: 12
Pages: 6687-91
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GO Term
GO:0042531 | positive regulation of tyrosine phosphorylation of STAT protein
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Protein
A0A1W2P7S6
Organism: Mus musculus/domesticus
Length: 430  
Fragment?: true
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Publication
9427757 | -
First Author: Kalkhoven E
Year: 1998
Journal: EMBO J
Title: Isoforms of steroid receptor co-activator 1 differ in their ability to potentiate transcription by the oestrogen receptor.
Volume: 17
Issue: 1
Pages: 232-43
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Publication
12954634 | -
First Author: Litterst CM
Year: 2003
Journal: J Biol Chem
Title: NCoA-1/SRC-1 is an essential coactivator of STAT5 that binds to the FDL motif in the alpha-helical region of the STAT5 transactivation domain.
Volume: 278
Issue: 46
Pages: 45340-51
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Publication
11773079 | -
First Author: Giraud S
Year: 2002
Journal: J Biol Chem
Title: Functional interaction of STAT3 transcription factor with the coactivator NcoA/SRC1a.
Volume: 277
Issue: 10
Pages: 8004-11
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Publication
10449719 | -
First Author: Liu Z
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: Steroid receptor coactivator-1 (SRC-1) enhances ligand-dependent and receptor-dependent cell-free transcription of chromatin.
Volume: 96
Issue: 17
Pages: 9485-90
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Publication
12529333 | -
First Author: Chauchereau A
Year: 2003
Journal: J Biol Chem
Title: Sumoylation of the progesterone receptor and of the steroid receptor coactivator SRC-1.
Volume: 278
Issue: 14
Pages: 12335-43
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Publication
16192273 | -
First Author: Neculai D
Year: 2005
Journal: J Biol Chem
Title: Structure of the unphosphorylated STAT5a dimer.
Volume: 280
Issue: 49
Pages: 40782-7
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Protein
A0A1W2P7D7
Organism: Mus musculus/domesticus
Length: 154  
Fragment?: true
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Protein
Q3U3A3
Organism: Mus musculus/domesticus
Length: 55  
Fragment?: true
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Publication
24920804 | J:214442
First Author: Dulek DE
Year: 2014
Journal: J Virol
Title: STAT4 deficiency fails to induce lung Th2 or Th17 immunity following primary or secondary respiratory syncytial virus (RSV) challenge but enhances the lung RSV-specific CD8+ T cell immune response to secondary challenge.
Volume: 88
Issue: 17
Pages: 9655-72
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Publication
19109131 | -
First Author: Kariuki SN
Year: 2009
Journal: J Immunol
Title: Cutting edge: autoimmune disease risk variant of STAT4 confers increased sensitivity to IFN-alpha in lupus patients in vivo.
Volume: 182
Issue: 1
Pages: 34-8
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Publication
17804842 | -
First Author: Remmers EF
Year: 2007
Journal: N Engl J Med
Title: STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus.
Volume: 357
Issue: 10
Pages: 977-86
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Publication
15546391 | -
 
First Author: Watford WT
Year: 2004
Journal: Immunol Rev
Title: Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4.
Volume: 202
Pages: 139-56
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Publication
18682104 | -
First Author: Korman BD
Year: 2008
Journal: Curr Allergy Asthma Rep
Title: STAT4: genetics, mechanisms, and implications for autoimmunity.
Volume: 8
Issue: 5
Pages: 398-403
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Publication
12213961 | J:79231
First Author: Morinobu A
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: STAT4 serine phosphorylation is critical for IL-12-induced IFN-gamma production but not for cell proliferation.
Volume: 99
Issue: 19
Pages: 12281-6
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Publication
21276004 | -
 
First Author: Heltemes-Harris LM
Year: 2011
Journal: Ann N Y Acad Sci
Title: The role of STAT5 in the development, function, and transformation of B and T lymphocytes.
Volume: 1217
Pages: 18-31
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Publication
27796300 | J:242633
 
First Author: Iwata H
Year: 2016
Journal: Nat Commun
Title: PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation.
Volume: 7
Pages: 12849
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Publication
15987782 | J:99860
First Author: Martin P
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Control of T helper 2 cell function and allergic airway inflammation by PKCzeta.
Volume: 102
Issue: 28
Pages: 9866-71
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Publication
17339609 | J:122340
First Author: Voehringer D
Year: 2007
Journal: J Leukoc Biol
Title: Eosinophils develop in distinct stages and are recruited to peripheral sites by alternatively activated macrophages.
Volume: 81
Issue: 6
Pages: 1434-44
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Publication
23954132 | J:208227
First Author: McHedlidze T
Year: 2013
Journal: Immunity
Title: Interleukin-33-dependent innate lymphoid cells mediate hepatic fibrosis.
Volume: 39
Issue: 2
Pages: 357-71
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Publication
15497457 | J:102002
First Author: Welner R
Year: 2004
Journal: Autoimmunity
Title: Hyperactivation and proliferation of lymphocytes from the spleens of flaky skin (fsn) mutant mice.
Volume: 37
Issue: 3
Pages: 227-35
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Publication
22806101 | J:325787
First Author: Mishra PK
Year: 2013
Journal: Mucosal Immunol
Title: Prevention of type 1 diabetes through infection with an intestinal nematode parasite requires IL-10 in the absence of a Th2-type response.
Volume: 6
Issue: 2
Pages: 297-308
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Publication
27117406 | J:235391
First Author: Schleicher U
Year: 2016
Journal: Cell Rep
Title: TNF-Mediated Restriction of Arginase 1 Expression in Myeloid Cells Triggers Type 2 NO Synthase Activity at the Site of Infection.
Volume: 15
Issue: 5
Pages: 1062-1075
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Publication
23177319 | J:192314
First Author: Spence S
Year: 2013
Journal: Immunity
Title: Suppressors of cytokine signaling 2 and 3 diametrically control macrophage polarization.
Volume: 38
Issue: 1
Pages: 66-78
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Publication
33617447 | J:302531
   
First Author: Zhou JY
Year: 2021
Journal: Elife
Title: Integration of IL-2 and IL-4 signals coordinates divergent regulatory T cell responses and drives therapeutic efficacy.
Volume: 10
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Publication
26365427 | J:227004
 
First Author: Xiao X
Year: 2015
Journal: Nat Commun
Title: GITR subverts Foxp3(+) Tregs to boost Th9 immunity through regulation of histone acetylation.
Volume: 6
Pages: 8266
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Publication
12488562 | J:106129
First Author: Sugawara I
Year: 2003
Journal: J Med Microbiol
Title: Relative importance of STAT4 in murine tuberculosis.
Volume: 52
Issue: Pt 1
Pages: 29-34
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Publication
30996000 | J:276217
First Author: Miller MM
Year: 2019
Journal: J Immunol
Title: A New IRF-1-Driven Apoptotic Pathway Triggered by IL-4/IL-13 Kills Neonatal Th1 Cells and Weakens Protection against Viral Infection.
Volume: 202
Issue: 11
Pages: 3173-3186
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Publication
19770271 | J:152376
First Author: Tachdjian R
Year: 2009
Journal: J Exp Med
Title: Pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma.
Volume: 206
Issue: 10
Pages: 2191-204
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Publication
30463015 | J:270675
First Author: Wehde BL
Year: 2018
Journal: Cell Rep
Title: Janus Kinase 1 Plays a Critical Role in Mammary Cancer Progression.
Volume: 25
Issue: 8
Pages: 2192-2207.e5
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Publication
37080971 | J:335723
First Author: Caratti G
Year: 2023
Journal: Nat Commun
Title: Glucocorticoid activation of anti-inflammatory macrophages protects against insulin resistance.
Volume: 14
Issue: 1
Pages: 2271
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Publication
17934471 | J:130074
First Author: Weckmann M
Year: 2007
Journal: Nat Med
Title: Critical link between TRAIL and CCL20 for the activation of TH2 cells and the expression of allergic airway disease.
Volume: 13
Issue: 11
Pages: 1308-15
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Publication
18522830 | J:137033
First Author: Kang K
Year: 2008
Journal: Cell Metab
Title: Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity.
Volume: 7
Issue: 6
Pages: 485-95
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Publication
37963021 | J:355335
First Author: Zhu Y
Year: 2023
Journal: Cell Rep
Title: Macrophage autophagy deficiency-induced CEBPB accumulation alleviates atopic dermatitis via impairing M2 polarization.
Volume: 42
Issue: 11
Pages: 113430
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Publication
18978793 | J:143229
First Author: El Kasmi KC
Year: 2008
Journal: Nat Immunol
Title: Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens.
Volume: 9
Issue: 12
Pages: 1399-406
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Publication
33462408 | J:359870
First Author: Chen L
Year: 2021
Journal: Cell Death Differ
Title: Kdm2a deficiency in macrophages enhances thermogenesis to protect mice against HFD-induced obesity by enhancing H3K36me2 at the Pparg locus.
Volume: 28
Issue: 6
Pages: 1880-1899
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Publication
19561615 | J:151652
First Author: Okamoto M
Year: 2009
Journal: Nat Immunol
Title: Mina, an Il4 repressor, controls T helper type 2 bias.
Volume: 10
Issue: 8
Pages: 872-9
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Publication
26436920 | J:227202
 
First Author: Su S
Year: 2015
Journal: Nat Commun
Title: miR-142-5p and miR-130a-3p are regulated by IL-4 and IL-13 and control profibrogenic macrophage program.
Volume: 6
Pages: 8523
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Publication
15526032 | J:115464
First Author: Durán A
Year: 2004
Journal: EMBO J
Title: Crosstalk between PKCzeta and the IL4/Stat6 pathway during T-cell-mediated hepatitis.
Volume: 23
Issue: 23
Pages: 4595-605
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Publication
37193606 | J:359291
 
First Author: Nomura A
Year: 2023
Journal: Life Sci Alliance
Title: Identification of a novel enhancer essential for Satb1 expression in T(H)2 cells and activated ILC2s.
Volume: 6
Issue: 8
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Publication
38264642 | J:349510
 
First Author: Yu C
Year: 2023
Journal: Front Immunol
Title: Major vault protein regulates tumor-associated macrophage polarization through interaction with signal transducer and activator of transcription 6.
Volume: 14
Pages: 1289795
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Publication
14557412 | J:86215
First Author: Blaeser F
Year: 2003
Journal: J Exp Med
Title: Targeted inactivation of the IL-4 receptor alpha chain I4R motif promotes allergic airway inflammation.
Volume: 198
Issue: 8
Pages: 1189-200
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Publication
10549628 | J:96857
First Author: Homann D
Year: 1999
Journal: Immunity
Title: Autoreactive CD4+ T cells protect from autoimmune diabetes via bystander suppression using the IL-4/Stat6 pathway.
Volume: 11
Issue: 4
Pages: 463-72
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Publication
33147467 | J:346845
First Author: Haniuda K
Year: 2020
Journal: Cell Rep
Title: Metabolic Reprogramming Induces Germinal Center B Cell Differentiation through Bcl6 Locus Remodeling.
Volume: 33
Issue: 5
Pages: 108333
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Publication
34816101 | J:328768
First Author: Nascimento Da Conceicao V
Year: 2021
Journal: iScience
Title: Resolving macrophage polarization through distinct Ca2+ entry channel that maintains intracellular signaling and mitochondrial bioenergetics.
Volume: 24
Issue: 11
Pages: 103339
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Publication
37827122 | J:353110
First Author: Butterworth S
Year: 2023
Journal: Cell Host Microbe
Title: High-throughput identification of Toxoplasma gondii effector proteins that target host cell transcription.
Volume: 31
Issue: 10
Pages: 1748-1762.e8
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Publication
23315963 | J:194068
First Author: Oliver CH
Year: 2013
Journal: Genesis
Title: The KRAB domain zinc finger protein, Zfp157, is expressed in multiple tissues during mouse embryogenesis and in specific cells in adult mammary gland and skin.
Volume: 51
Issue: 3
Pages: 179-86
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Publication
20080759 | J:156521
First Author: Kashiwada M
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: IL-4-induced transcription factor NFIL3/E4BP4 controls IgE class switching.
Volume: 107
Issue: 2
Pages: 821-6
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Publication
11854514 | J:74765
First Author: Chen XP
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Pim serine/threonine kinases regulate the stability of Socs-1 protein.
Volume: 99
Issue: 4
Pages: 2175-80
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Publication
10878334 | J:65151
First Author: Venkataraman C
Year: 2000
Journal: J Immunol
Title: Cutting edge: Chandra, a novel four-transmembrane domain protein differentially expressed in helper type 1 lymphocytes.
Volume: 165
Issue: 2
Pages: 632-6
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Publication
8999817 | J:38457
First Author: Grunewald SM
Year: 1997
Journal: J Biol Chem
Title: A murine interleukin-4 antagonistic mutant protein completely inhibits interleukin-4-induced cell proliferation, differentiation, and signal transduction.
Volume: 272
Issue: 3
Pages: 1480-3
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Publication
9013879 | J:38133
First Author: Miloux B
Year: 1997
Journal: FEBS Lett
Title: Cloning of the human IL-13R alpha1 chain and reconstitution with the IL4R alpha of a functional IL-4/IL-13 receptor complex.
Volume: 401
Issue: 2-3
Pages: 163-6
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Publication
15728454 | J:97743
First Author: Canfield S
Year: 2005
Journal: J Immunol
Title: Cutting edge: IL-4 induces suppressor of cytokine signaling-3 expression in B cells by a mechanism dependent on activation of p38 MAPK.
Volume: 174
Issue: 5
Pages: 2494-8
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Publication
15975924 | J:101052
First Author: Yamashita M
Year: 2005
Journal: J Biol Chem
Title: Ras-ERK MAPK cascade regulates GATA3 stability and Th2 differentiation through ubiquitin-proteasome pathway.
Volume: 280
Issue: 33
Pages: 29409-19
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Publication
16598817 | J:114779
First Author: Hu ZQ
Year: 2006
Journal: Eur J Immunol
Title: Interleukin-4-triggered, STAT6-dependent production of a factor that induces mouse mast cell apoptosis.
Volume: 36
Issue: 5
Pages: 1275-84
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Publication
18852284 | J:143289
First Author: Wurster AL
Year: 2008
Journal: Mol Cell Biol
Title: BRG1-mediated chromatin remodeling regulates differentiation and gene expression of T helper cells.
Volume: 28
Issue: 24
Pages: 7274-85
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Publication
18971287 | J:145193
First Author: Stevenson NJ
Year: 2009
Journal: J Leukoc Biol
Title: CCL11 blocks IL-4 and GM-CSF signaling in hematopoietic cells and hinders dendritic cell differentiation via suppressor of cytokine signaling expression.
Volume: 85
Issue: 2
Pages: 289-97
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Publication
27166374 | J:246822
First Author: Lee B
Year: 2016
Journal: Nucleic Acids Res
Title: Synergistic activation of Arg1 gene by retinoic acid and IL-4 involves chromatin remodeling for transcription initiation and elongation coupling.
Volume: 44
Issue: 16
Pages: 7568-79
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Publication
29757188 | J:277878
First Author: Wu R
Year: 2018
Journal: J Clin Invest
Title: MicroRNA-210 overexpression promotes psoriasis-like inflammation by inducing Th1 and Th17 cell differentiation.
Volume: 128
Issue: 6
Pages: 2551-2568
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Publication
29273506 | J:270345
First Author: Yan A
Year: 2018
Journal: Biochem Biophys Res Commun
Title: Bromodomain-containing protein 7 deficiency augments atherosclerotic lesions in ApoE-/- mice.
Volume: 495
Issue: 3
Pages: 2202-2208
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Publication
30332629 | J:305322
First Author: Daniel B
Year: 2018
Journal: Immunity
Title: The Nuclear Receptor PPARγ Controls Progressive Macrophage Polarization as a Ligand-Insensitive Epigenomic Ratchet of Transcriptional Memory.
Volume: 49
Issue: 4
Pages: 615-626.e6
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Publication
34006836 | J:328625
First Author: Cui J
Year: 2021
Journal: Cell Death Dis
Title: IL-4 inhibits regulatory T cells differentiation by HDAC9-mediated epigenetic regulation.
Volume: 12
Issue: 6
Pages: 501
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Publication
21854393 | -
First Author: Niessen NA
Year: 2011
Journal: J Neurochem
Title: Steroid receptor coactivator 2 modulates steroid-dependent male sexual behavior and neuroplasticity in Japanese quail (Coturnix japonica).
Volume: 119
Issue: 3
Pages: 579-93
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Publication
21081493 | -
First Author: Mehrotra P
Year: 2011
Journal: J Biol Chem
Title: PARP-14 functions as a transcriptional switch for Stat6-dependent gene activation.
Volume: 286
Issue: 3
Pages: 1767-76
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Publication
17875708 | J:124844
First Author: Yanagawa T
Year: 2007
Journal: Cancer Res
Title: Regulation of phosphoglucose isomerase/autocrine motility factor activities by the poly(ADP-ribose) polymerase family-14.
Volume: 67
Issue: 18
Pages: 8682-9
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Publication
9020188 | -
First Author: Bluyssen HA
Year: 1997
Journal: J Biol Chem
Title: Stat2 is a transcriptional activator that requires sequence-specific contacts provided by stat1 and p48 for stable interaction with DNA.
Volume: 272
Issue: 7
Pages: 4600-5
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Publication
8848048 | -
First Author: Bhattacharya S
Year: 1996
Journal: Nature
Title: Cooperation of Stat2 and p300/CBP in signalling induced by interferon-alpha.
Volume: 383
Issue: 6598
Pages: 344-7
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Publication
27103560 | -
First Author: Michaud C
Year: 2016
Journal: Allergy Rhinol (Providence)
Title: Idiopathic pancreatitis in a patient with a STAT3 mutation.
Volume: 7
Issue: 1
Pages: 42-4
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Publication
23404867 | -
First Author: Przybyla LM
Year: 2013
Journal: Stem Cells
Title: Matrix remodeling maintains embryonic stem cell self-renewal by activating Stat3.
Volume: 31
Issue: 6
Pages: 1097-106
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Publication
28564606 | -
First Author: Tripathi SK
Year: 2017
Journal: Cell Rep
Title: Genome-wide Analysis of STAT3-Mediated Transcription during Early Human Th17 Cell Differentiation.
Volume: 19
Issue: 9
Pages: 1888-1901
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Publication
15705584 | -
First Author: Debidda M
Year: 2005
Journal: J Biol Chem
Title: A role of STAT3 in Rho GTPase-regulated cell migration and proliferation.
Volume: 280
Issue: 17
Pages: 17275-85
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Publication
8621447 | -
First Author: Li X
Year: 1996
Journal: J Biol Chem
Title: Formation of STAT1-STAT2 heterodimers and their role in the activation of IRF-1 gene transcription by interferon-alpha.
Volume: 271
Issue: 10
Pages: 5790-4
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Publication
11909852 | -
First Author: Wong LH
Year: 2002
Journal: J Biol Chem
Title: Isolation and characterization of a human STAT1 gene regulatory element. Inducibility by interferon (IFN) types I and II and role of IFN regulatory factor-1.
Volume: 277
Issue: 22
Pages: 19408-17
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Protein Domain
IPR017426 | Nuclear_rcpt_coactivator
Type: Family
Description: This group represents the nuclear receptor coactivator family, also known as the SRC/p160 nuclear receptor coactivator family, which contains proteins that are ligand-dependent transcription factors []. These receptors can function as molecular switches [].NCOA1 directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion []. It is involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs) []. It is also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors [, , ]. It plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors []. It can be regulated by sumoylation and ubiquitination []. NCOA2 is a transcriptional coactivator for steroid receptors and nuclear receptors. It functions as a coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) []. Together with NCOA1, it is required to control energy balance between white and brown adipose tissues []. NCOA3 is overexpressed in a fraction of breast cancers and has been linked to prognosis and tamoxifen resistance [, ].
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Protein Domain
IPR010011 | NCO_DUF1518
Type: Domain
Description: This conserved domain of unknown function is usually found tandemly repeated in the nuclear receptor coactivator family (NCOA1/2/3), also known as the SRC/p160 nuclear receptor coactivator family, which are ligand-dependent transcription factors [, ].NCOA1 directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion []. It is involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs) []. It is also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors [, , ]. It plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors []. It can be regulated by sumoylation and ubiquitination []. NCOA2 is a transcriptional coactivator for steroid receptors and nuclear receptors. It functions as a coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) []. Together with NCOA1, it is required to control energy balance between white and brown adipose tissues []. NCOA3 is overexpressed in a fraction of breast cancers and has been linked to prognosis and tamoxifen resistance [, ].
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Protein Domain
IPR035886 | STAT5b_SH2
Type: Domain
Description: This entry represents the SH2 domain of STAT5b.STAT5 is a member of the STAT family of transcription factors. Two highly related proteins, STAT5a and STAT5b are encoded by separate genes, but are 90% identical at the amino acid level. Both STAT5a and STAT5b are ubiquitously expressed and functionally interchangeable. They regulate B and T cell development [, ].STAT proteins have a dual function: signal transduction and activation of transcription. When cytokines are bound to cell surface receptors, the associated Janus kinases (JAKs) are activated, leading to tyrosine phosphorylation of the given STAT proteins []. Phosphorylated STATs form dimers, translocate to the nucleus, and bind specific response elements to activate transcription of target genes []. STAT proteins contain an N-terminal domain (NTD), a coiled-coil domain (CCD), a DNA-binding domain (DBD), an α-helical linker domain (LD), an SH2 domain, and a transactivation domain (TAD). The SH2 domain is necessary for receptor association and tyrosine phosphodimer formation. There are seven mammalian STAT family members which have been identified: STAT1, STAT2, STAT3, STAT4, STAT5 (STAT5A and STAT5B), and STAT6 [].
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Protein Domain
IPR035854 | STAT2_SH2
Type: Domain
Description: STAT2 is a member of the STAT protein family. In response to interferon, STAT2 forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly []. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with STAT2, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus []. This entry represents the SH2 domain of STAT2.STAT proteins have a dual function: signal transduction and activation of transcription. When cytokines are bound to cell surface receptors, the associated Janus kinases (JAKs) are activated, leading to tyrosine phosphorylation of the given STAT proteins []. Phosphorylated STATs form dimers, translocate to the nucleus, and bind specific response elements to activate transcription of target genes []. STAT proteins contain an N-terminal domain (NTD), a coiled-coil domain (CCD), a DNA-binding domain (DBD), an α-helical linker domain (LD), an SH2 domain, and a transactivation domain (TAD). The SH2 domain is necessary for receptor association and tyrosine phosphodimer formation. There are seven mammalian STAT family members which have been identified: STAT1, STAT2, STAT3, STAT4, STAT5 (STAT5A and STAT5B), and STAT6 [].
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Protein Domain
IPR035855 | STAT3_SH2
Type: Domain
Description: STAT3 is a member of the STAT protein family. STAT3 mediates the expression of a variety of genes in response to cell stimuli, and plays a key role in many cellular processes such as cell growth and apoptosis. STAT3 has been shown to interact with Rho GTPases []Three alternatively spliced transcript variants encoding distinct isoforms have been described. STAT3 activation is required for self-renewal of embryonic stem cells (ESCs) []and is essential for the differentiation of the TH17 helper T cells []. Mutations in the STAT3 gene result in hyperimmunoglobulin E syndrome and human cancers []. This entry represents the SH2 domain of STAT3.STAT proteins have a dual function: signal transduction and activation of transcription. When cytokines are bound to cell surface receptors, the associated Janus kinases (JAKs) are activated, leading to tyrosine phosphorylation of the given STAT proteins []. Phosphorylated STATs form dimers, translocate to the nucleus, and bind specific response elements to activate transcription of target genes []. STAT proteins contain an N-terminal domain (NTD), a coiled-coil domain (CCD), a DNA-binding domain (DBD), an α-helical linker domain (LD), an SH2 domain, and a transactivation domain (TAD). The SH2 domain is necessary for receptor association and tyrosine phosphodimer formation. There are seven mammalian STAT family members which have been identified: STAT1, STAT2, STAT3, STAT4, STAT5 (STAT5A and STAT5B), and STAT6 [].
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Protein Domain
IPR035856 | STAT4_SH2
Type: Domain
Description: Signal transducer and activator of transcription 4 (STAT4) transduces interleukin-12, interleukin-23, and type I interferon cytokine signals in T cells and monocytes [, ]. It plays an important role in CD4+ Th1 lineage differentiation and IFN-gamma protein expression by CD4+ T cells []. It is crucial for both innate and adaptive immune responses to viral infection []. Variations of the STAT4 gene affect the susceptibility to autoimmune diseases [], such as systemic lupus erythematosus 11 (SLEB11) []and rheumatoid arthritis (RA) []. STAT proteins have a dual function: signal transduction and activation of transcription. When cytokines are boundto cell surface receptors, the associated Janus kinases (JAKs) are activated, leading to tyrosine phosphorylation of the given STAT proteins []. Phosphorylated STATs form dimers, translocate to the nucleus, and bind specific response elements to activate transcription of target genes []. STAT proteins contain an N-terminal domain (NTD), a coiled-coil domain (CCD), a DNA-binding domain (DBD), an α-helical linker domain (LD), an SH2 domain, and a transactivation domain (TAD). The SH2 domain is necessary for receptor association and tyrosine phosphodimer formation. There are seven mammalian STAT family members which have been identified: STAT1, STAT2, STAT3, STAT4, STAT5 (STAT5A and STAT5B), and STAT6 []. This entry represents the SH2 domain of STAT4.
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Protein Domain
IPR035859 | STAT1_SH2
Type: Domain
Description: STAT1 is a member of the STAT family of transcription factors. STAT1 is involved in upregulating genes due to a signal by interferons []. STAT1 forms a heterodimer with STAT2 that can bind Interferon Stimulated Response Element (ISRE) promoter element in response to either IFN-alpha or IFN-beta stimulation [].STAT proteins have a dual function: signal transduction and activation of transcription. When cytokines are bound to cell surface receptors, the associated Janus kinases (JAKs) are activated, leading to tyrosine phosphorylation of the given STAT proteins []. Phosphorylated STATs form dimers, translocate to the nucleus, and bind specific response elements to activate transcription of target genes []. STAT proteins contain an N-terminal domain (NTD), a coiled-coil domain (CCD), a DNA-binding domain (DBD), an α-helical linker domain (LD), an SH2 domain, and a transactivation domain (TAD). The SH2 domain is necessary for receptor association and tyrosine phosphodimer formation. There are seven mammalian STAT family members which have been identified: STAT1, STAT2, STAT3, STAT4, STAT5 (STAT5A and STAT5B), and STAT6 [].
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Protein Domain
IPR034517 | PAR14_RRM2
Type: Domain
Description: This entry represents the RNA recognition motif 2 (RRM2) of poly [ADP-ribose]polymerase 14 (PARP-14), also termed aggressive lymphoma protein 2, a member of the B aggressive lymphoma (BAL) family of macrodomain-containing PARPs []. It is expressed in B lymphocytes and interacts with the IL-4-induced transcription factor Stat6. It plays a fundamental role in the regulation of IL-4-induced B-cell protection against apoptosis after irradiation or growth factor withdrawal. It mediates IL-4 effects on the levels of gene products that regulate cell survival, proliferation, and lymphomagenesis. PARP-14 acts as a transcriptional switch for Stat6-dependent gene activation. In the presence of IL-4, PARP-14 activates transcription by facilitating the binding of Stat6 to the promoter and release of HDACs from the promoter with an IL-4 signal. In contrast, in the absence of a signal, PARP-14 acts as a transcriptional repressor by recruiting HDACs []. Absence of PARP-14 protects against Myc-induced developmental block and lymphoma. Thus, PARP-14 may play an important role in Myc-induced oncogenesis []. Additional research indicates that PARP-14 is also a binding partner with phosphoglucose isomerase (PGI)/autocrine motility factor (AMF). It can inhibit PGI/AMF ubiquitination, thus contributing to its stabilization and secretion [].PARP-14 contains two N-terminal RNA recognition motifs (RRMs), three tandem macro domains, and C-terminal region with sequence homology to PARP catalytic domain.
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Protein Domain
IPR029839 | STAT4
Type: Family
Description: Signal transducer and activator of transcription 4 (STAT4) transduces interleukin-12, interleukin-23, and type I interferon cytokine signals in T cells and monocytes [, ]. It plays an important role in CD4+ Th1 lineage differentiation and IFN-gamma protein expression by CD4+ T cells []. It is crucial for both innate and adaptive immune responses to viral infection []. Variations of the STAT4 gene affect the susceptibility to autoimmune diseases [], such as systemic lupus erythematosus 11 (SLEB11) []and rheumatoid arthritis (RA) []. STAT proteins have a dual function: signal transduction and activation of transcription. When cytokines are bound to cell surface receptors, the associated Janus kinases (JAKs) are activated, leading to tyrosine phosphorylation of the given STAT proteins []. Phosphorylated STATs form dimers, translocate to the nucleus, and bind specific response elements to activate transcription of target genes []. STAT proteins contain an N-terminal domain (NTD), a coiled-coil domain (CCD), a DNA-binding domain (DBD), an α-helical linker domain (LD), an SH2 domain, and a transactivation domain (TAD). The SH2 domain is necessary for receptor association and tyrosine phosphodimer formation. There are seven mammalian STAT family members which have been identified: STAT1, STAT2, STAT3, STAT4, STAT5 (STAT5A and STAT5B), and STAT6 [].
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Protein Domain
IPR035858 | STAT5a/5b
Type: Family
Description: STAT5 is a member of the STAT family of transcription factors. Two highly related proteins, STAT5a and STAT5b are encoded by separate genes, but are 90% identical at the amino acid level. Both STAT5a and STAT5b are ubiquitously expressed and functionally interchangeable. They regulate B and T cell development [, ].STAT proteins have a dual function: signal transduction and activation of transcription. When cytokines are bound to cell surface receptors, the associated Janus kinases (JAKs) are activated, leading to tyrosine phosphorylation of the given STAT proteins []. Phosphorylated STATs form dimers, translocate to the nucleus, and bind specific response elements to activate transcription of target genes []. STAT proteins contain an N-terminal domain (NTD), a coiled-coil domain (CCD), a DNA-binding domain (DBD), an α-helical linker domain (LD), an SH2 domain, and a transactivation domain (TAD). The SH2 domain is necessary for receptor association and tyrosine phosphodimer formation. There are seven mammalian STAT family members which have been identified: STAT1, STAT2, STAT3, STAT4, STAT5 (STAT5A and STAT5B), and STAT6 [].
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Publication
27021404 | J:233602
First Author: Sehra S
Year: 2016
Journal: J Invest Dermatol
Title: Mast Cells Regulate Epidermal Barrier Function and the Development of Allergic Skin Inflammation.
Volume: 136
Issue: 7
Pages: 1429-1437
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Publication
12507421 | J:80975
First Author: Picard F
Year: 2002
Journal: Cell
Title: SRC-1 and TIF2 control energy balance between white and brown adipose tissues.
Volume: 111
Issue: 7
Pages: 931-41
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Publication
10823921 | J:62724
First Author: Xu J
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: The steroid receptor coactivator SRC-3 (p/CIP/RAC3/AIB1/ACTR/TRAM-1) is required for normal growth, puberty, female reproductive function, and mammary gland development.
Volume: 97
Issue: 12
Pages: 6379-84
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Protein
A0A1W2P881
Organism: Mus musculus/domesticus
Length: 99  
Fragment?: true
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Publication
9430642 | J:45674
First Author: Voegel JJ
Year: 1998
Journal: EMBO J
Title: The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways.
Volume: 17
Issue: 2
Pages: 507-19
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Publication
23226788 | -
First Author: Chang AK
Year: 2012
Journal: Oncol Lett
Title: The role of AIB1 in breast cancer.
Volume: 4
Issue: 4
Pages: 588-594
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Protein
Q8C961
Organism: Mus musculus/domesticus
Length: 115  
Fragment?: true
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