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Search results 901 to 1000 out of 1340 for Tlr9

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Type Details Score
Publication
31546246 | J:287430
First Author: Majer O
Year: 2019
Journal: Nature
Title: UNC93B1 recruits syntenin-1 to dampen TLR7 signalling and prevent autoimmunity.
Volume: 575
Issue: 7782
Pages: 366-370
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Publication
31546247 | J:287503
First Author: Majer O
Year: 2019
Journal: Nature
Title: Release from UNC93B1 reinforces the compartmentalized activation of select TLRs.
Volume: 575
Issue: 7782
Pages: 371-374
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Heritable Phenotypic Marker
MGI:5445550 | spcy
Type: heritable_phenotypic_marker
Organism: mouse, laboratory
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Allele
Tlr9<M8Btlr> | MGI:4887254
 
Name: toll-like receptor 9; mutation 8, Bruce Beutler
Allele Type: Chemically induced (ENU)
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Strain
MGI:6475588 | C57BL/6JSmoc-Il5<tm3(IL5)Smoc> Il5ra<tm1(IL5RA)Smoc>/Smoc
Attribute String: coisogenic, targeted mutation, mutant strain
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Strain
MGI:6354930 | C57BL/6JSmoc-Il5<tm3(IL5)Smoc>/Smoc
Attribute String: coisogenic, mutant strain, targeted mutation
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Strain
MGI:6354514 | C57BL/6JSmoc-Tlr9 <tm1(TLR9)Smoc>/Smoc
Attribute String: coisogenic, mutant strain, targeted mutation
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Publication
26548852 | -
First Author: Liu N
Year: 2015
Journal: Mol Immunol
Title: TRAF6-mediated degradation of DOK3 is required for production of IL-6 and TNFα in TLR9 signaling.
Volume: 68
Issue: 2 Pt C
Pages: 699-705
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Protein
A0A494B9X0
Organism: Mus musculus/domesticus
Length: 138  
Fragment?: true
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Protein
A0A494BBK7
Organism: Mus musculus/domesticus
Length: 262  
Fragment?: true
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Publication
23166319 | -
First Author: Pohar J
Year: 2013
Journal: J Biol Chem
Title: The role of UNC93B1 protein in surface localization of TLR3 receptor and in cell priming to nucleic acid agonists.
Volume: 288
Issue: 1
Pages: 442-54
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Protein Domain
IPR043268 | UNC93B1
Type: Family
Description: UNC93B1 is a multi-transmembrane domain-containing protein that plays an essential role in signalling by the nucleotide-sensing Toll-like receptors (TLRs), including TLR3, TLR7 and TLR9 [, ]. UNC93B1 delivers the nucleotide-sensing receptors TLR7 and TLR9 from the ER to endolysosomes []. It has been shown to recruit Syntenin-1 and dampen TLR7 signalling and prevent autoimmunity []. It also binds TLR9, and the release of TLR9 from UNC93B1 is required for TLR9 to function []. Mutations in the UNC93B1 gene that result in aberrant TLR trafficking can lead to autoimmune disease [].
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Publication
- | J:94077
     
First Author: Mutant Mouse Regional Resource Centers
Year: 2004
Journal: Unpublished
Title: Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC)
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Publication
17878374 | -
First Author: Hoarau C
Year: 2007
Journal: J Immunol
Title: TLR9 activation induces normal neutrophil responses in a child with IRAK-4 deficiency: involvement of the direct PI3K pathway.
Volume: 179
Issue: 7
Pages: 4754-65
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Strain
MGI:4949130 | C57BL/6J-Tlr9<M8Btlr>/Mmucd
Attribute String: coisogenic, mutant strain, chemically induced mutation
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Strain
MGI:6355097 | C57BL/6JSmoc-Pdcd1<em1(PDCD1)Smoc> Tlr9<tm1(TLR9)Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Strain
MGI:7788725 | C57BL/6JSmoc-Il5<tm3(IL5)> Il5ra<em2(IL5RA)Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain, targeted mutation
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Strain
MGI:7788726 | C57BL/6JSmoc-Il5ra<em3(IL5RA)Smoc> Il5<tm3(IL5)>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain, targeted mutation
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Genotype
Genotype
Symbol: Tlr9/Tlr9
Background: involves: C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Strain
MGI:7751771 | STOCK Il5ra<tm1(IL5RA)Smoc> Il5<tm3(IL5)Smoc> Prkdc<scid> Il2rg<em1Smoc>/Smoc
Attribute String: endonuclease-mediated mutation, mutant stock, spontaneous mutation, targeted mutation
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Strain
MGI:6354515 | C57BL/6JSmoc-Tnfrsf4<em3(TNFRSF4)Smoc> Tlr9<tm1(TLR9)Smoc>/Smoc
Attribute String: coisogenic, mutant strain, targeted mutation, endonuclease-mediated mutation
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Protein
Q8VCW4
Organism: Mus musculus/domesticus
Length: 598  
Fragment?: false
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Protein
E9Q8P6
Organism: Mus musculus/domesticus
Length: 422  
Fragment?: false
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Protein
E9PYK0
Organism: Mus musculus/domesticus
Length: 619  
Fragment?: false
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Publication
11286707 | J:67571
First Author: Kaisho T
Year: 2001
Journal: Trends Immunol
Title: Dendritic-cell function in Toll-like receptor- and MyD88-knockout mice.
Volume: 22
Issue: 2
Pages: 78-83
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Publication
18490904 | -
First Author: Meylan E
Year: 2008
Journal: Nat Immunol
Title: IRAK2 takes its place in TLR signaling.
Volume: 9
Issue: 6
Pages: 581-2
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Publication
23166766 | -
First Author: Gosu V
Year: 2012
Journal: PLoS One
Title: Molecular evolution and structural features of IRAK family members.
Volume: 7
Issue: 11
Pages: e49771
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Protein Domain
IPR042151 | Death_IRAK2
Type: Domain
Description: This entry represents the death domain found in interleukin-1 receptor-associated kinase-like 2 (IRAK2) []. IRAK2 is an essential component of several signaling pathways, including NF-kappaB and the IL-1 signaling pathways. It is an inactive kinase that participates in septic shock mediated by TLR4 and TLR9 []. It plays a redundant role with IRAK1 in early NF-kB and MAPK responses, and remains present at later stages whereas IRAK1 disappears [, ].Interleukin-1 receptor-associated kinases (IRAKs) are essential components of innate immunity and inflammation in mammals and other vertebrates []. They are involved in signal transduction pathways involving IL-1 and IL-18 receptors, Toll-like receptors, nuclear factor-kappaB (NF-kB), and mitogen-activated protein kinases (MAPKs). IRAKs contain an N-terminal death domain (DD) and a C-terminal kinase domain [, , , ].Death domains (DDs) are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including CARD (Caspase activation and recruitment domain), DED (Death Effector Domain), and PYRIN. They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes [].
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Publication
12682240 | J:128788
First Author: Datta SK
Year: 2003
Journal: J Immunol
Title: A subset of Toll-like receptor ligands induces cross-presentation by bone marrow-derived dendritic cells.
Volume: 170
Issue: 8
Pages: 4102-10
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Publication
21743479 | J:174420
First Author: Tun-Kyi A
Year: 2011
Journal: Nat Immunol
Title: Essential role for the prolyl isomerase Pin1 in Toll-like receptor signaling and type I interferon-mediated immunity.
Volume: 12
Issue: 8
Pages: 733-41
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Publication
20485341 | -
First Author: Lin SC
Year: 2010
Journal: Nature
Title: Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling.
Volume: 465
Issue: 7300
Pages: 885-90
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Publication
18438411 | J:136290
First Author: Kawagoe T
Year: 2008
Journal: Nat Immunol
Title: Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2.
Volume: 9
Issue: 6
Pages: 684-91
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Publication
15322147 | J:92728
First Author: Gohda J
Year: 2004
Journal: J Immunol
Title: Cutting edge: TNFR-associated factor (TRAF) 6 is essential for MyD88-dependent pathway but not toll/IL-1 receptor domain-containing adaptor-inducing IFN-beta (TRIF)-dependent pathway in TLR signaling.
Volume: 173
Issue: 5
Pages: 2913-7
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Publication
17997333 | J:127600
First Author: Deane JA
Year: 2007
Journal: Immunity
Title: Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation.
Volume: 27
Issue: 5
Pages: 801-10
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Publication
29760532 | J:282428
First Author: Shinde R
Year: 2018
Journal: Nat Immunol
Title: Apoptotic cell-induced AhR activity is required for immunological tolerance and suppression of systemic lupus erythematosus in mice and humans.
Volume: 19
Issue: 6
Pages: 571-582
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Publication
21353603 | J:170704
First Author: Hou B
Year: 2011
Journal: Immunity
Title: Selective utilization of Toll-like receptor and MyD88 signaling in B cells for enhancement of the antiviral germinal center response.
Volume: 34
Issue: 3
Pages: 375-84
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Publication
20498068 | J:161289
First Author: Johnson BA 3rd
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: B-lymphoid cells with attributes of dendritic cells regulate T cells via indoleamine 2,3-dioxygenase.
Volume: 107
Issue: 23
Pages: 10644-8
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Publication
39092178 | J:353087
First Author: Tsai PJ
Year: 2024
Journal: iScience
Title: PTEN acts as a crucial inflammatory checkpoint controlling TLR9/IL-6 axis in B cells.
Volume: 27
Issue: 7
Pages: 110388
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Publication
18656388 | J:139001
First Author: Hou B
Year: 2008
Journal: Immunity
Title: Toll-like receptors activate innate and adaptive immunity by using dendritic cell-intrinsic and -extrinsic mechanisms.
Volume: 29
Issue: 2
Pages: 272-82
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Publication
28729715 | J:288135
First Author: De Koker S
Year: 2017
Journal: Sci Rep
Title: Inflammatory monocytes regulate Th1 oriented immunity to CpG adjuvanted protein vaccines through production of IL-12.
Volume: 7
Issue: 1
Pages: 5986
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Publication
21480215 | J:177313
First Author: Biondo C
Year: 2011
Journal: Eur J Immunol
Title: Recognition of yeast nucleic acids triggers a host-protective type I interferon response.
Volume: 41
Issue: 7
Pages: 1969-79
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Publication
16771860 | J:111956
First Author: Piercy J
Year: 2006
Journal: Immunology
Title: CD45 negatively regulates tumour necrosis factor and interleukin-6 production in dendritic cells.
Volume: 118
Issue: 2
Pages: 250-6
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Publication
17275357 | J:118427
First Author: Yang Y
Year: 2007
Journal: Immunity
Title: Heat shock protein gp96 is a master chaperone for toll-like receptors and is important in the innate function of macrophages.
Volume: 26
Issue: 2
Pages: 215-26
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Publication
16611887 | J:144127
First Author: Szomolanyi-Tsuda E
Year: 2006
Journal: J Virol
Title: Role for TLR2 in NK cell-mediated control of murine cytomegalovirus in vivo.
Volume: 80
Issue: 9
Pages: 4286-91
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Publication
21270393 | J:169397
First Author: Wan Y
Year: 2011
Journal: J Immunol
Title: The dual functions of IL-1 receptor-associated kinase 2 in TLR9-mediated IFN and proinflammatory cytokine production.
Volume: 186
Issue: 5
Pages: 3006-14
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Publication
28539427 | J:254775
First Author: Sheen JH
Year: 2017
Journal: J Immunol
Title: TLR-Induced Murine Dendritic Cell (DC) Activation Requires DC-Intrinsic Complement.
Volume: 199
Issue: 1
Pages: 278-291
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Publication
16237046 | J:119367
First Author: Mellor AL
Year: 2005
Journal: J Immunol
Title: Cutting edge: CpG oligonucleotides induce splenic CD19+ dendritic cells to acquire potent indoleamine 2,3-dioxygenase-dependent T cell regulatory functions via IFN Type 1 signaling.
Volume: 175
Issue: 9
Pages: 5601-5
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Publication
21115688 | J:176867
First Author: Gregorio J
Year: 2010
Journal: J Exp Med
Title: Plasmacytoid dendritic cells sense skin injury and promote wound healing through type I interferons.
Volume: 207
Issue: 13
Pages: 2921-30
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Publication
16148088 | J:116713
First Author: Beisner DR
Year: 2005
Journal: J Immunol
Title: Cutting edge: innate immunity conferred by B cells is regulated by caspase-8.
Volume: 175
Issue: 6
Pages: 3469-73
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Publication
28928016 | J:303438
 
First Author: Tanegashima K
Year: 2017
Journal: EBioMedicine
Title: CXCL14 Acts as a Specific Carrier of CpG DNA into Dendritic Cells and Activates Toll-like Receptor 9-mediated Adaptive Immunity.
Volume: 24
Pages: 247-256
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Publication
24388751 | J:206874
First Author: Kalantari P
Year: 2014
Journal: Cell Rep
Title: Dual engagement of the NLRP3 and AIM2 inflammasomes by plasmodium-derived hemozoin and DNA during malaria.
Volume: 6
Issue: 1
Pages: 196-210
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Publication
38697117 | J:348311
First Author: Gitlin AD
Year: 2024
Journal: Immunity
Title: N4BP1 coordinates ubiquitin-dependent crosstalk within the IκB kinase family to limit Toll-like receptor signaling and inflammation.
Volume: 57
Issue: 5
Pages: 973-986.e7
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Publication
22422879 | J:184068
First Author: O'Keeffe M
Year: 2012
Journal: J Immunol
Title: Nonplasmacytoid, high IFN-α-producing, bone marrow dendritic cells.
Volume: 188
Issue: 8
Pages: 3774-83
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Publication
32294437 | J:323545
First Author: Berry CT
Year: 2020
Journal: Cell Rep
Title: BCR-Induced Ca2+ Signals Dynamically Tune Survival, Metabolic Reprogramming, and Proliferation of Naive B Cells.
Volume: 31
Issue: 2
Pages: 107474
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Publication
23349877 | J:195842
First Author: Kamran N
Year: 2013
Journal: PLoS One
Title: Toll-like receptor ligands induce expression of the costimulatory molecule CD155 on antigen-presenting cells.
Volume: 8
Issue: 1
Pages: e54406
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Publication
16473830 | J:113329
First Author: Veldhoen M
Year: 2006
Journal: Immunity
Title: TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells.
Volume: 24
Issue: 2
Pages: 179-89
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Publication
18758466 | J:140990
First Author: Cao W
Year: 2008
Journal: Nat Immunol
Title: Toll-like receptor-mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway.
Volume: 9
Issue: 10
Pages: 1157-64
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Publication
16709806 | J:131775
First Author: Fields ML
Year: 2006
Journal: J Immunol
Title: Exogenous and endogenous TLR ligands activate anti-chromatin and polyreactive B cells.
Volume: 176
Issue: 11
Pages: 6491-502
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Publication
31747600 | J:287272
First Author: Castillo-Dela Cruz P
Year: 2019
Journal: Cell Rep
Title: Intestinal IL-17R Signaling Constrains IL-18-Driven Liver Inflammation by the Regulation of Microbiome-Derived Products.
Volume: 29
Issue: 8
Pages: 2270-2283.e7
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Publication
21130004 | J:166504
First Author: Swiecki M
Year: 2010
Journal: Immunity
Title: Plasmacytoid dendritic cell ablation impacts early interferon responses and antiviral NK and CD8(+) T cell accrual.
Volume: 33
Issue: 6
Pages: 955-66
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Publication
23426999 | J:198001
 
First Author: Lee BL
Year: 2013
Journal: Elife
Title: UNC93B1 mediates differential trafficking of endosomal TLRs.
Volume: 2
Pages: e00291
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Publication
24270517 | J:209085
First Author: Agudo J
Year: 2014
Journal: Nat Immunol
Title: The miR-126-VEGFR2 axis controls the innate response to pathogen-associated nucleic acids.
Volume: 15
Issue: 1
Pages: 54-62
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Publication
36609505 | J:337511
First Author: Irazoki A
Year: 2023
Journal: Nat Commun
Title: Disruption of mitochondrial dynamics triggers muscle inflammation through interorganellar contacts and mitochondrial DNA mislocation.
Volume: 14
Issue: 1
Pages: 108
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Publication
35420160 | J:340073
First Author: Wang B
Year: 2022
Journal: Immunology
Title: cGAS modulates cytokine secretion and bacterial burdens by altering the release of mitochondrial DNA in pseudomonas pulmonary infection.
Volume: 166
Issue: 3
Pages: 408-423
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Publication
33318509 | J:321020
First Author: Kapoor T
Year: 2020
Journal: Sci Rep
Title: MZB1 enables efficient interferon α secretion in stimulated plasmacytoid dendritic cells.
Volume: 10
Issue: 1
Pages: 21626
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Publication
15723075 | J:97110
First Author: Hornung V
Year: 2005
Journal: Nat Med
Title: Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7.
Volume: 11
Issue: 3
Pages: 263-70
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Publication
15492225 | J:93531
First Author: Honda K
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling.
Volume: 101
Issue: 43
Pages: 15416-21
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Publication
16887997 | J:138390
First Author: Logue EC
Year: 2006
Journal: J Immunol
Title: ICOS-induced B7h shedding on B cells is inhibited by TLR7/8 and TLR9.
Volume: 177
Issue: 4
Pages: 2356-64
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Publication
19454672 | J:148867
First Author: Wu QL
Year: 2009
Journal: J Immunol
Title: Tumoricidal effects of activated macrophages in a mouse model of chronic lymphocytic leukemia.
Volume: 182
Issue: 11
Pages: 6771-8
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Publication
19883904 | J:155337
First Author: Ravindran C
Year: 2010
Journal: Cell Immunol
Title: CpG-ODNs induces up-regulated expression of chemokine CCL9 in mouse macrophages and microglia.
Volume: 260
Issue: 2
Pages: 113-8
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Publication
20028774 | J:158853
First Author: Ripoll VM
Year: 2010
Journal: J Leukoc Biol
Title: Macrophages from BALB/c and CBA/Ca mice differ in their cellular responses to Streptococcus pneumoniae.
Volume: 87
Issue: 4
Pages: 735-41
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Publication
25074615 | J:214610
First Author: Viaud S
Year: 2014
Journal: Cancer Res
Title: Harnessing the intestinal microbiome for optimal therapeutic immunomodulation.
Volume: 74
Issue: 16
Pages: 4217-21
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Protein Coding Gene
MGI:1330838 | Lgmn
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CAROLIEiJ_G0018035 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0020031 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0019987 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0019963 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0019973 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0019775 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1330838 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0020422 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0019321 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0019747 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0019858 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0019847 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0019934 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0019887 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0020451 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0019084 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0019375 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0029794 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0018880 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
9742219 | J:50324
 
First Author: Chen JM
Year: 1998
Journal: Biochem J
Title: Cloning and expression of mouse legumain, a lysosomal endopeptidase.
Volume: 335 ( Pt 1)
Pages: 111-7
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Publication
9821970 | J:50855
First Author: Halfon S
Year: 1998
Journal: FEBS Lett
Title: Autocatalytic activation of human legumain at aspartic acid residues.
Volume: 438
Issue: 1-2
Pages: 114-8
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Publication
17350006 | J:121440
First Author: Morita Y
Year: 2007
Journal: FEBS Lett
Title: Legumain/asparaginyl endopeptidase controls extracellular matrix remodeling through the degradation of fibronectin in mouse renal proximal tubular cells.
Volume: 581
Issue: 7
Pages: 1417-24
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Publication
33677035 | J:306943
 
First Author: Zou L
Year: 2021
Journal: Neurobiol Dis
Title: Asparagine endopeptidase cleaves synaptojanin 1 and triggers synaptic dysfunction in Parkinson's disease.
Volume: 154
Pages: 105326
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Publication
19106291 | J:143886
First Author: Chan CB
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Mice lacking asparaginyl endopeptidase develop disorders resembling hemophagocytic syndrome.
Volume: 106
Issue: 2
Pages: 468-73
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Publication
35443102 | J:355367
First Author: Meng L
Year: 2022
Journal: Aging Cell
Title: A synapsin Ⅰ cleavage fragment contributes to synaptic dysfunction in Alzheimer's disease.
Volume: 21
Issue: 5
Pages: e13619
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Publication
26549211 | J:228032
 
First Author: Zhang Z
Year: 2015
Journal: Nat Commun
Title: Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease.
Volume: 6
Pages: 8762
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Publication
35217650 | J:321918
First Author: Lei C
Year: 2022
Journal: Cell Death Dis
Title: Asparaginyl endopeptidase protects against podocyte injury in diabetic nephropathy through cleaving cofilin-1.
Volume: 13
Issue: 2
Pages: 184
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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