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Search results 901 to 1000 out of 1116 for Vangl2

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Type Details Score
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication      
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication        
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
First Author: Sittaramane V
Year: 2013
Journal: Dev Biol
Title: The PCP protein Vangl2 regulates migration of hindbrain motor neurons by acting in floor plate cells, and independently of cilia function.
Volume: 382
Issue: 2
Pages: 400-12
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Publication
First Author: Lei YP
Year: 2010
Journal: N Engl J Med
Title: VANGL2 mutations in human cranial neural-tube defects.
Volume: 362
Issue: 23
Pages: 2232-5
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Interaction Experiment
Description: Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals.
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Interaction Experiment
Description: VANGL2 inhibits antiviral IFN-I signaling by targeting TBK1 for autophagic degradation.
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Interaction Experiment
Description: VANGL2 alleviates inflammatory bowel disease by recruiting the ubiquitin ligase MARCH8 to limit NLRP3 inflammasome activation through OPTN-mediated selective autophagy.
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Allele
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Yingzi Yang
Allele Type: Targeted
Attribute String: Conditional ready, Epitope tag, Inserted expressed sequence
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Interaction Experiment
Description: Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family.
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Allele
Name: intergenic site 1; targeted mutation 4, Jeremy Nathans
Allele Type: Targeted
Attribute String: Conditional ready, Inserted expressed sequence, No functional change, Reporter
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Strain
Attribute String: mutant stock, targeted mutation
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Allele
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Yingzi Yang
Allele Type: Targeted
Attribute String: Conditional ready, Epitope tag, Inserted expressed sequence
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Allele
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 3, Yingzi Yang
Allele Type: Targeted
Attribute String: Conditional ready, Epitope tag, Inserted expressed sequence
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Genotype
Symbol: Igs1/Igs1
Background: involves: 129 * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Protein
Organism: Mus musculus/domesticus
Length: 521  
Fragment?: false
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Protein
Organism: Mus musculus/domesticus
Length: 526  
Fragment?: false
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Protein
Organism: Mus musculus/domesticus
Length: 569  
Fragment?: false
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Protein
Organism: Mus musculus/domesticus
Length: 561  
Fragment?: false
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Protein
Organism: Mus musculus/domesticus
Length: 476  
Fragment?: false
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Protein
Organism: Mus musculus/domesticus
Length: 575  
Fragment?: true
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Protein
Organism: Mus musculus/domesticus
Length: 393  
Fragment?: false
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Protein
Organism: Mus musculus/domesticus
Length: 102  
Fragment?: true
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Protein
Organism: Mus musculus/domesticus
Length: 130  
Fragment?: true
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Protein
Organism: Mus musculus/domesticus
Length: 137  
Fragment?: true
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Protein
Organism: Mus musculus/domesticus
Length: 253  
Fragment?: true
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Publication
First Author: Hatakeyama J
Year: 2014
Journal: Endocr Relat Cancer
Title: Vangl1 and Vangl2: planar cell polarity components with a developing role in cancer.
Volume: 21
Issue: 5
Pages: R345-56
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Protein Domain
Type: Family
Description: VANGL proteins play important roles in the establishment of planar cell polarity (PCP) []. Vangl2 is required for retinal axon guidance [], kidney-branching morphogenesis and glomerular maturation []. It also plays a role in the orientation of stereociliary bundles in the cochlea and is required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process []. It is required for cell surface localization of FZD3 and FZD6 in the inner ear [].
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HT Experiment
Series Id: GSE24276
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
First Author: Ban Y
Year: 2021
Journal: Sci Adv
Title: Prickle promotes the formation and maintenance of glutamatergic synapses by stabilizing the intercellular planar cell polarity complex.
Volume: 7
Issue: 41
Pages: eabh2974
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Publication  
First Author: Cheong SS
Year: 2023
Journal: Dis Model Mech
Title: A method for TAT-Cre recombinase-mediated floxed allele modification in ex vivo tissue slices.
Volume: 16
Issue: 11
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Publication
First Author: Yang T
Year: 2014
Journal: Cell Tissue Res
Title: Prickle1 is necessary for the caudal migration of murine facial branchiomotor neurons.
Volume: 357
Issue: 3
Pages: 549-61
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Publication
First Author: Treat AC
Year: 2016
Journal: PLoS One
Title: The PDZ Protein Na+/H+ Exchanger Regulatory Factor-1 (NHERF1) Regulates Planar Cell Polarity and Motile Cilia Organization.
Volume: 11
Issue: 4
Pages: e0153144
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Publication
First Author: Chen Y
Year: 2024
Journal: Sci Rep
Title: DPP an extracellular matrix molecule induces Wnt5a mediated signaling to promote the differentiation of adult stem cells into odontogenic lineage.
Volume: 14
Issue: 1
Pages: 26187
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Publication
First Author: Richards T
Year: 2019
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Atmin modulates Pkhd1 expression and may mediate Autosomal Recessive Polycystic Kidney Disease (ARPKD) through altered non-canonical Wnt/Planar Cell Polarity (PCP) signalling.
Volume: 1865
Issue: 2
Pages: 378-390
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Publication
First Author: Seo JH
Year: 2011
Journal: Hum Mol Genet
Title: Mutations in the planar cell polarity gene, Fuzzy, are associated with neural tube defects in humans.
Volume: 20
Issue: 22
Pages: 4324-33
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Publication
First Author: Goodyear RJ
Year: 2017
Journal: Development
Title: A tectorin-based matrix and planar cell polarity genes are required for normal collagen-fibril orientation in the developing tectorial membrane.
Volume: 144
Issue: 21
Pages: 3978-3989
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Publication
First Author: Moreno-Fortuny A
Year: 2017
Journal: Biol Open
Title: MCAM contributes to the establishment of cell autonomous polarity in myogenic and chondrogenic differentiation.
Volume: 6
Issue: 11
Pages: 1592-1601
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Publication  
First Author: Fern?ndez-Santos B
Year: 2023
Journal: Dis Model Mech
Title: The loop-tail mouse model displays open and closed caudal neural tube defects.
Volume: 16
Issue: 8
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression    
Probe: MGI:5641378
Assay Type: RT-PCR
Annotation Date: 2015-06-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2576528
Stage: TS28
Assay Id: MGI:5641379
Age: postnatal
Image: 1
Specimen Label: +/+
Detected: true
Specimen Num: 1
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GXD Expression    
Probe: MGI:5641378
Assay Type: RT-PCR
Annotation Date: 2015-06-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2576528
Stage: TS28
Assay Id: MGI:5641379
Age: postnatal
Image: 1
Specimen Label: +/-
Detected: true
Specimen Num: 3
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GXD Expression    
Probe: MGI:5641378
Assay Type: RT-PCR
Annotation Date: 2015-06-20
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2576528
Stage: TS28
Assay Id: MGI:5641379
Age: postnatal
Image: 1
Specimen Label: -/-
Detected: false
Specimen Num: 5
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GXD Expression      
Probe: MGI:6760680
Assay Type: RT-PCR
Annotation Date: 2021-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:6760686
Age: embryonic day 13.5
Specimen Label: brain
Detected: true
Specimen Num: 2
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GXD Expression  
Probe: MGI:4946657
Assay Type: RNA in situ
Annotation Date: 2011-04-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3538627
Pattern: Regionally restricted
Stage: TS27
Assay Id: MGI:4946666
Age: postnatal day 0
Note: Expression was detected in habenular nuclei.
Specimen Label: 5I
Detected: true
Specimen Num: 6
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GXD Expression
Probe: MGI:6403714
Assay Type: RNA in situ
Annotation Date: 2020-04-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1616213
Pattern: Regionally restricted
Stage: TS13
Assay Id: MGI:6403721
Age: embryonic day 8.5
Image: 2C
Note: Expression is ventral and is absent at the edges.
Specimen Label: 2C
Detected: true
Specimen Num: 4
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GXD Expression
Probe: MGI:6403714
Assay Type: RNA in situ
Annotation Date: 2020-04-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1616213
Pattern: Regionally restricted
Stage: TS13
Assay Id: MGI:6403721
Age: embryonic day 8.5
Image: 2D
Note: Expression is ventral from the level of the hindbrain to the low spine.
Specimen Label: 2D
Detected: true
Specimen Num: 5
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GXD Expression
Probe: MGI:6403714
Assay Type: RNA in situ
Annotation Date: 2020-04-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1616213
Pattern: Regionally restricted
Stage: TS13
Assay Id: MGI:6403721
Age: embryonic day 8.5
Image: 2A
Note: Expression is ventral from the level of the hindbrain to the low spine.
Specimen Label: 2A
Detected: true
Specimen Num: 1
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GXD Expression
Probe: MGI:6403714
Assay Type: RNA in situ
Annotation Date: 2020-04-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1616213
Pattern: Regionally restricted
Stage: TS13
Assay Id: MGI:6403721
Age: embryonic day 8.5
Image: 2A'
Note: Expression is ventral from the level of the hindbrain to the low spine.
Specimen Label: 2A'
Detected: true
Specimen Num: 2
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GXD Expression
Probe: MGI:6403714
Assay Type: RNA in situ
Annotation Date: 2020-04-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1616213
Pattern: Regionally restricted
Stage: TS13
Assay Id: MGI:6403721
Age: embryonic day 8.5
Image: 2E
Note: Expression in this mutant is the same as in wild-type.
Specimen Label: 2E
Detected: true
Specimen Num: 6
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GXD Expression
Probe: MGI:6403714
Assay Type: RNA in situ
Annotation Date: 2020-04-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1616213
Pattern: Regionally restricted
Stage: TS13
Assay Id: MGI:6403721
Age: embryonic day 8.5
Image: 2E'
Note: Expression in this mutant is the same as in wild-type.
Specimen Label: 2E'
Detected: true
Specimen Num: 7
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GXD Expression
Probe: MGI:6403714
Assay Type: RNA in situ
Annotation Date: 2020-04-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1616213
Pattern: Regionally restricted
Stage: TS13
Assay Id: MGI:6403721
Age: embryonic day 8.5
Image: 2G
Note: Expression in this mutant is the same as in wild-type.
Specimen Label: 2G
Detected: true
Specimen Num: 9
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GXD Expression
Probe: MGI:6403714
Assay Type: RNA in situ
Annotation Date: 2020-04-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1616213
Pattern: Regionally restricted
Stage: TS13
Assay Id: MGI:6403721
Age: embryonic day 8.5
Image: 2H
Note: Expression in this mutant is the same as in wild-type.
Specimen Label: 2H
Detected: true
Specimen Num: 10
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GXD Expression  
Probe: MGI:5641647
Assay Type: Immunohistochemistry
Annotation Date: 2015-06-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1616513
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:5641650
Age: embryonic day 8.5
Image: 2A
Specimen Label: 2A
Detected: true
Specimen Num: 1
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GXD Expression  
Probe: MGI:5641647
Assay Type: Immunohistochemistry
Annotation Date: 2015-06-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1616513
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:5641650
Age: embryonic day 8.5
Image: 2I
Specimen Label: 2I
Detected: true
Specimen Num: 2
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GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2015-06-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1616513
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:5641651
Age: embryonic day 8.5
Image: 2B
Specimen Label: 2B
Detected: true
Specimen Num: 1
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GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2015-06-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1616513
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:5641651
Age: embryonic day 8.5
Image: 2C
Specimen Label: 2C
Detected: true
Specimen Num: 2
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GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2015-06-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1616513
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:5641651
Age: embryonic day 8.5
Image: 2D
Specimen Label: 2D
Detected: true
Specimen Num: 3
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GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2015-06-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1616513
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:5641651
Age: embryonic day 8.5
Image: 2E
Specimen Label: 2E
Detected: true
Specimen Num: 4
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GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2015-06-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1616513
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:5641651
Age: embryonic day 8.5
Image: 2F
Specimen Label: 2F
Detected: true
Specimen Num: 5
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GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2015-06-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1616513
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:5641651
Age: embryonic day 8.5
Image: 2G
Specimen Label: 2G
Detected: true
Specimen Num: 6
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GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2015-06-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1616513
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:5641651
Age: embryonic day 8.5
Image: 2H
Specimen Label: 2H
Detected: true
Specimen Num: 7
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GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2015-06-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1616513
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:5641651
Age: embryonic day 8.5
Image: 2L
Specimen Label: 2L
Detected: true
Specimen Num: 10
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GXD Expression
Probe: MGI:5641647
Assay Type: Immunohistochemistry
Annotation Date: 2015-06-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1616513
Pattern: Regionally restricted
Stage: TS13
Assay Id: MGI:5641650
Age: embryonic day 8.5
Image: 3A
Note: Expression is at the midline floor plate cells.
Specimen Label: 3A
Detected: true
Specimen Num: 3
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GXD Expression
Probe: MGI:5641647
Assay Type: Immunohistochemistry
Annotation Date: 2015-06-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1616513
Pattern: Regionally restricted
Stage: TS13
Assay Id: MGI:5641650
Age: embryonic day 8.5
Image: 3D
Note: Expression is at the midline floor plate cells.
Specimen Label: 3D
Detected: true
Specimen Num: 4
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GXD Expression  
Assay Type: In situ reporter (knock in)
Annotation Date: 2015-06-23
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1614813
Pattern: Regionally restricted
Stage: TS13
Assay Id: MGI:5641651
Age: embryonic day 8.5
Image: 2E
Note: Expression in the rostral hindbrain is in the ventral ventricular zone.
Specimen Label: 2E
Detected: true
Specimen Num: 4
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GXD Expression
Probe: MGI:6403714
Assay Type: RNA in situ
Annotation Date: 2020-04-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1614813
Pattern: Regionally restricted
Stage: TS13
Assay Id: MGI:6403721
Age: embryonic day 8.5
Image: 2A
Note: Expression is ventral.
Specimen Label: 2A
Detected: true
Specimen Num: 1
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GXD Expression
Probe: MGI:6403714
Assay Type: RNA in situ
Annotation Date: 2020-04-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1614813
Pattern: Regionally restricted
Stage: TS13
Assay Id: MGI:6403721
Age: embryonic day 8.5
Image: 2A'
Note: Expression is ventral.
Specimen Label: 2A'
Detected: true
Specimen Num: 2
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GXD Expression
Probe: MGI:6403714
Assay Type: RNA in situ
Annotation Date: 2020-04-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1614813
Pattern: Regionally restricted
Stage: TS13
Assay Id: MGI:6403721
Age: embryonic day 8.5
Image: 2C
Note: Expression is ventral.
Specimen Label: 2C
Detected: true
Specimen Num: 4
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GXD Expression
Probe: MGI:6403714
Assay Type: RNA in situ
Annotation Date: 2020-04-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1614813
Pattern: Regionally restricted
Stage: TS13
Assay Id: MGI:6403721
Age: embryonic day 8.5
Image: 2E
Note: Expression in this mutant is the same as in wild-type.
Specimen Label: 2E
Detected: true
Specimen Num: 6
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GXD Expression
Probe: MGI:6403714
Assay Type: RNA in situ
Annotation Date: 2020-04-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1614813
Pattern: Regionally restricted
Stage: TS13
Assay Id: MGI:6403721
Age: embryonic day 8.5
Image: 2E'
Note: Expression in this mutant is the same as in wild-type.
Specimen Label: 2E'
Detected: true
Specimen Num: 7
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GXD Expression
Probe: MGI:6403714
Assay Type: RNA in situ
Annotation Date: 2020-04-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1614813
Pattern: Regionally restricted
Stage: TS13
Assay Id: MGI:6403721
Age: embryonic day 8.5
Image: 2G
Note: Expression in this mutant is the same as in wild-type.
Specimen Label: 2G
Detected: true
Specimen Num: 9
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GXD Expression  
Probe: MGI:4946657
Assay Type: RNA in situ
Annotation Date: 2011-04-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267822
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:4946666
Age: embryonic day 14.5
Note: No signal was seen in the brain, except in the raphe in the brainstem.
Specimen Label: not shown
Detected: true
Specimen Num: 3
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GXD Expression  
Probe: MGI:4946657
Assay Type: RNA in situ
Annotation Date: 2011-04-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267825
Pattern: Regionally restricted
Stage: TS25
Assay Id: MGI:4946666
Age: embryonic day 17.5
Note: Expression was present in the reticular formation and the cochleovestibular nuclei.
Specimen Label: Table 2
Detected: true
Specimen Num: 4
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