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Search results 1 to 100 out of 275 for Abcc6

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Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
368 | ABCC6
Type: gene
Organism: human
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Gene
717875 | ABCC6
Type: gene
Organism: macaque, rhesus
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Gene
100493037 | abcc6
Type: gene
Organism: frog, western clawed
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Gene
81642 | Abcc6
Type: gene
Organism: rat
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Gene
489993 | ABCC6
Type: gene
Organism: dog, domestic
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Gene
100337270 | ABCC6
Type: gene
Organism: cattle
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Gene
416600 | ABCC6
Type: gene
Organism: chicken
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Protein Domain
IPR030239 | ABCC6
Type: Family
Description: This entry represents ATP-binding cassette sub-family C member 6 (MRP6 or ABCC6) from animals. It belongs to the MRP (multidrug resistance protein) subfamily of the ATP-binding cassette (ABC) transporter family []. It is a multispecific organic anion transporter able to export glutathione conjugates including lencotriene C4, DNP, and N-ethylmaleimide S-glutathione; it also exports anthracyclines, epipodophyllotoxins, cisplatin, and probably exports probenecid, benzbromarone and indomethacin []. ABCC6 deficiency causes the ectopic mineralisation disorder pseudoxanthoma elasticum (PXE), characterised by calcification and fragmentation of elastic fibres, resulting in oculocutaneous and cardiovascular symptoms [].The ABC transporter family is a group of membrane proteins that use the hydrolysis of ATP to power the translocation of a wide variety of substrates across cellular membranes. ABC transporters minimally consist of two conserved regions: a highly conserved nucleotide-binding domain (NBD) and a less conserved transmembrane domain (TMD). Eukaryotic ABC proteins are usually organised either as full transporters (containing two NBDs and two TMDs), or as half transporters (containing one NBD and one TMD), that have to form homo- or heterodimers in order to constitute a functional protein [].
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Protein Coding Gene
MGI:1351634 | Abcc6
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
24137173 | -
 
First Author: Vanakker OM
Year: 2013
Journal: Front Genet
Title: The ABCC6 transporter: what lessons can be learnt from other ATP-binding cassette transporters?
Volume: 4
Pages: 203
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Publication
22811557 | J:212643
First Author: Martin LJ
Year: 2012
Journal: Circ Res
Title: ABCC6 localizes to the mitochondria-associated membrane.
Volume: 111
Issue: 5
Pages: 516-20
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Publication
38057332 | J:343494
First Author: Casemayou A
Year: 2023
Journal: Sci Rep
Title: Abcc6 deficiency prevents rhabdomyolysis-induced acute kidney injury.
Volume: 13
Issue: 1
Pages: 21513
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Publication
23625951 | J:213284
First Author: Pomozi V
Year: 2013
Journal: Circ Res
Title: ABCC6 is a basolateral plasma membrane protein.
Volume: 112
Issue: 11
Pages: e148-51
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Publication
33594095 | J:303746
First Author: Brampton C
Year: 2021
Journal: Sci Rep
Title: ABCC6 deficiency promotes dyslipidemia and atherosclerosis.
Volume: 11
Issue: 1
Pages: 3881
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Publication
29991491 | J:291938
First Author: Letavernier E
Year: 2018
Journal: J Am Soc Nephrol
Title: ABCC6 Deficiency Promotes Development of Randall Plaque.
Volume: 29
Issue: 9
Pages: 2337-2347
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Publication
33483533 | J:300433
First Author: Ibold B
Year: 2021
Journal: Sci Rep
Title: Genetic deletion of Abcc6 disturbs cholesterol homeostasis in mice.
Volume: 11
Issue: 1
Pages: 2137
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Publication
15888484 | J:105062
First Author: Gorgels TG
Year: 2005
Journal: Hum Mol Genet
Title: Disruption of Abcc6 in the mouse: novel insight in the pathogenesis of pseudoxanthoma elasticum.
Volume: 14
Issue: 13
Pages: 1763-73
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Publication
27826008 | J:240046
First Author: Pomozi V
Year: 2017
Journal: J Invest Dermatol
Title: Functional Rescue of ABCC6 Deficiency by 4-Phenylbutyrate Therapy Reduces Dystrophic Calcification in Abcc6-/- Mice.
Volume: 137
Issue: 3
Pages: 595-602
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Publication
24479134 | J:206726
First Author: Brampton C
Year: 2014
Journal: Am J Pathol
Title: The level of hepatic ABCC6 expression determines the severity of calcification after cardiac injury.
Volume: 184
Issue: 1
Pages: 159-70
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Publication
30611276 | J:295676
First Author: Ibold B
Year: 2019
Journal: Lipids Health Dis
Title: Abcc6 deficiency in mice leads to altered ABC transporter gene expression in metabolic active tissues.
Volume: 18
Issue: 1
Pages: 2
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Publication
23041262 | J:203667
 
First Author: Gorgels TG
Year: 2012
Journal: Exp Eye Res
Title: Abcc6 deficiency in the mouse leads to calcification of collagen fibers in Bruch's membrane.
Volume: 104
Pages: 59-64
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Publication
21979437 | J:191450
First Author: Mungrue IN
Year: 2011
Journal: Arterioscler Thromb Vasc Biol
Title: Abcc6 deficiency causes increased infarct size and apoptosis in a mouse cardiac ischemia-reperfusion model.
Volume: 31
Issue: 12
Pages: 2806-12
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Publication
16135817 | J:101372
First Author: Klement JF
Year: 2005
Journal: Mol Cell Biol
Title: Targeted ablation of the abcc6 gene results in ectopic mineralization of connective tissues.
Volume: 25
Issue: 18
Pages: 8299-310
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Publication
22056557 | J:178632
First Author: Fülöp K
Year: 2011
Journal: Biochem Biophys Res Commun
Title: ABCC6 does not transport vitamin K3-glutathione conjugate from the liver: relevance to pathomechanisms of pseudoxanthoma elasticum.
Volume: 415
Issue: 3
Pages: 468-71
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Publication
24352041 | J:207319
First Author: Pomozi V
Year: 2014
Journal: J Invest Dermatol
Title: Analysis of pseudoxanthoma elasticum-causing missense mutants of ABCC6 in vivo; pharmacological correction of the mislocalized proteins.
Volume: 134
Issue: 4
Pages: 946-953
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Publication
24277820 | J:205185
First Author: Jansen RS
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: ABCC6 prevents ectopic mineralization seen in pseudoxanthoma elasticum by inducing cellular nucleotide release.
Volume: 110
Issue: 50
Pages: 20206-11
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Publication
17214963 | J:117853
First Author: Douet V
Year: 2007
Journal: Biochem Biophys Res Commun
Title: DNA methylation and Sp1 binding determine the tissue-specific transcriptional activity of the mouse Abcc6 promoter.
Volume: 354
Issue: 1
Pages: 66-71
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Publication
21281810 | J:169076
First Author: Martin L
Year: 2011
Journal: Am J Pathol
Title: A mouse model of β-thalassemia shows a liver-specific down-regulation of Abcc6 expression.
Volume: 178
Issue: 2
Pages: 774-83
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Publication
15900406 | J:101483
First Author: Beck K
Year: 2005
Journal: J Mol Histol
Title: The tissue distribution of murine Abcc6 (Mrp6) during embryogenesis indicates that the presence of Abcc6 in elastic tissues is not required for elastic fiber assembly.
Volume: 36
Issue: 3
Pages: 167-70
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Protein
A0A1B0GRV2
Organism: Mus musculus/domesticus
Length: 182  
Fragment?: true
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Publication
21103974 | -
 
First Author: Keppler D
Year: 2011
Journal: Handb Exp Pharmacol
Title: Multidrug resistance proteins (MRPs, ABCCs): importance for pathophysiology and drug therapy.
Issue: 201
Pages: 299-323
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Publication
21740521 | J:190790
First Author: Chen ZS
Year: 2011
Journal: FEBS J
Title: Multidrug resistance proteins (MRPs/ABCCs) in cancer chemotherapy and genetic diseases.
Volume: 278
Issue: 18
Pages: 3226-45
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Publication
34597610 | J:314177
     
First Author: Kowal L
Year: 2021
Journal: J Invest Dermatol
Title: Functional Assessment of Missense Variants in the ABCC6 Gene Implicated in Pseudoxanthoma Elasticum, a Heritable Ectopic Mineralization Disorder.
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Publication
17360558 | J:120144
First Author: Meng H
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Identification of Abcc6 as the major causal gene for dystrophic cardiac calcification in mice through integrative genomics.
Volume: 104
Issue: 11
Pages: 4530-5
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Protein
Q9R1S7
Organism: Mus musculus/domesticus
Length: 1498  
Fragment?: false
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Publication
11441126 | -
First Author: Dean M
Year: 2001
Journal: J Lipid Res
Title: The human ATP-binding cassette (ABC) transporter superfamily.
Volume: 42
Issue: 7
Pages: 1007-17
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Publication
24675664 | J:222902
First Author: Kauffenstein G
Year: 2014
Journal: Arterioscler Thromb Vasc Biol
Title: Disseminated arterial calcification and enhanced myogenic response are associated with abcc6 deficiency in a mouse model of pseudoxanthoma elasticum.
Volume: 34
Issue: 5
Pages: 1045-56
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Publication
23014343 | J:196478
First Author: Berndt A
Year: 2013
Journal: J Invest Dermatol
Title: A single-nucleotide polymorphism in the Abcc6 gene associates with connective tissue mineralization in mice similar to targeted models for pseudoxanthoma elasticum.
Volume: 133
Issue: 3
Pages: 833-6
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Publication
20031637 | J:182797
First Author: Wang SS
Year: 2009
Journal: Circ Cardiovasc Genet
Title: Disruption of the aortic elastic lamina and medial calcification share genetic determinants in mice.
Volume: 2
Issue: 6
Pages: 573-82
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Publication
31207231 | J:284683
First Author: Li Q
Year: 2019
Journal: J Invest Dermatol
Title: Quantitative Trait Locus and Integrative Genomics Revealed Candidate Modifier Genes for Ectopic Mineralization in Mouse Models of Pseudoxanthoma Elasticum.
Volume: 139
Issue: 12
Pages: 2447-2457.e7
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Publication
18049453 | J:135500
First Author: Li Q
Year: 2008
Journal: J Invest Dermatol
Title: Pseudoxanthoma elasticum: oxidative stress and antioxidant diet in a mouse model (Abcc6-/-).
Volume: 128
Issue: 5
Pages: 1160-4
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Publication
21435020 | J:331783
First Author: Li Q
Year: 2011
Journal: Exp Dermatol
Title: Expression of the Abca-subfamily of genes in Abcc6-/- mice--upregulation of Abca4.
Volume: 20
Issue: 5
Pages: 452-4
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Publication
22846719 | J:188698
First Author: Li Q
Year: 2012
Journal: Am J Pathol
Title: A novel animal model for pseudoxanthoma elasticum: the KK/HlJ mouse.
Volume: 181
Issue: 4
Pages: 1190-6
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Publication
18201967 | J:133936
First Author: Aherrahrou Z
Year: 2008
Journal: J Biol Chem
Title: An alternative splice variant in Abcc6, the gene causing dystrophic calcification, leads to protein deficiency in C3H/He mice.
Volume: 283
Issue: 12
Pages: 7608-15
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Publication
28416300 | J:243347
First Author: Pomozi V
Year: 2017
Journal: Am J Pathol
Title: Pyrophosphate Supplementation Prevents Chronic and Acute Calcification in ABCC6-Deficient Mice.
Volume: 187
Issue: 6
Pages: 1258-1272
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Publication
35216422 | J:337077
 
First Author: Bouderlique E
Year: 2022
Journal: Int J Mol Sci
Title: Vitamin D and Calcium Supplementation Accelerate Vascular Calcification in a Model of Pseudoxanthoma Elasticum.
Volume: 23
Issue: 4
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Publication
24969777 | J:227093
First Author: Jansen RS
Year: 2014
Journal: Arterioscler Thromb Vasc Biol
Title: ABCC6-mediated ATP secretion by the liver is the main source of the mineralization inhibitor inorganic pyrophosphate in the systemic circulation-brief report.
Volume: 34
Issue: 9
Pages: 1985-9
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Publication
29501384 | J:265687
First Author: Kauffenstein G
Year: 2018
Journal: J Invest Dermatol
Title: Alteration of Extracellular Nucleotide Metabolism in Pseudoxanthoma Elasticum.
Volume: 138
Issue: 8
Pages: 1862-1870
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Publication
23935882 | J:204356
First Author: Prunier F
Year: 2013
Journal: PLoS One
Title: Pseudoxanthoma elasticum: cardiac findings in patients and Abcc6-deficient mouse model.
Volume: 8
Issue: 7
Pages: e68700
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Publication
22469843 | J:184705
First Author: Le Corre Y
Year: 2012
Journal: Am J Pathol
Title: Quantification of the calcification phenotype of Abcc6-deficient mice with microcomputed tomography.
Volume: 180
Issue: 6
Pages: 2208-13
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Publication
31704980 | J:287169
First Author: Omarjee L
Year: 2019
Journal: Sci Rep
Title: Evidence of Cardiovascular Calcification and Fibrosis in Pseudoxanthoma Elasticum Mouse Models Subjected to DOCA-Salt Hypertension.
Volume: 9
Issue: 1
Pages: 16327
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Publication
17273159 | J:121552
First Author: Jiang Q
Year: 2007
Journal: J Invest Dermatol
Title: Aberrant mineralization of connective tissues in a mouse model of pseudoxanthoma elasticum: systemic and local regulatory factors.
Volume: 127
Issue: 6
Pages: 1392-402
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Publication
23415960 | J:195990
First Author: Li Q
Year: 2013
Journal: Am J Pathol
Title: Warfarin accelerates ectopic mineralization in Abcc6(-/-) mice: clinical relevance to pseudoxanthoma elasticum.
Volume: 182
Issue: 4
Pages: 1139-50
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Publication
24586646 | J:213757
First Author: Li Q
Year: 2014
Journal: PLoS One
Title: Mouse models for pseudoxanthoma elasticum: genetic and dietary modulation of the ectopic mineralization phenotypes.
Volume: 9
Issue: 2
Pages: e89268
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Publication
24670382 | J:210970
First Author: Boraldi F
Year: 2014
Journal: J Invest Dermatol
Title: Changes in dermal fibroblasts from Abcc6(-/-) mice are present before and after the onset of ectopic tissue mineralization.
Volume: 134
Issue: 7
Pages: 1855-1861
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Publication
30112102 | J:278670
First Author: Li Q
Year: 2018
Journal: Oncotarget
Title: Etidronate prevents, but does not reverse, ectopic mineralization in a mouse model of pseudoxanthoma elasticum (Abcc6-/- ).
Volume: 9
Issue: 56
Pages: 30721-30730
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Publication
17979973 | J:148053
First Author: LaRusso J
Year: 2008
Journal: Exp Dermatol
Title: Ectopic mineralization of connective tissue in Abcc6-/- mice: effects of dietary modifications and a phosphate binder--a preliminary study.
Volume: 17
Issue: 3
Pages: 203-7
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Publication
27758107 | J:329839
First Author: Rasmussen MR
Year: 2016
Journal: J Proteome Res
Title: Untargeted Metabolomics Analysis of ABCC6-Deficient Mice Discloses an Altered Metabolic Liver Profile.
Volume: 15
Issue: 12
Pages: 4591-4600
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Publication
16926270 | J:119222
First Author: Aherrahrou Z
Year: 2007
Journal: Physiol Genomics
Title: Ultrafine mapping of Dyscalc1 to an 80-kb chromosomal segment on chromosome 7 in mice susceptible for dystrophic calcification.
Volume: 28
Issue: 2
Pages: 203-12
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Publication
26375467 | J:244242
First Author: Marton J
Year: 2015
Journal: PLoS One
Title: Cyclosporine A Treatment Inhibits Abcc6-Dependent Cardiac Necrosis and Calcification following Coxsackievirus B3 Infection in Mice.
Volume: 10
Issue: 9
Pages: e0138222
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Publication
18685618 | J:150235
First Author: Jiang Q
Year: 2009
Journal: J Invest Dermatol
Title: Pseudoxanthoma elasticum is a metabolic disease.
Volume: 129
Issue: 2
Pages: 348-54
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Publication
20185580 | J:158759
First Author: Jiang Q
Year: 2010
Journal: Am J Pathol
Title: Parabiotic heterogenetic pairing of Abcc6-/-/Rag1-/- mice and their wild-type counterparts halts ectopic mineralization in a murine model of pseudoxanthoma elasticum.
Volume: 176
Issue: 4
Pages: 1855-62
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Publication
17942075 | J:127430
First Author: Li Q
Year: 2007
Journal: Biochem Biophys Res Commun
Title: Pseudoxanthoma elasticum: reduced gamma-glutamyl carboxylation of matrix gla protein in a mouse model (Abcc6-/-).
Volume: 364
Issue: 2
Pages: 208-13
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Publication
28652107 | J:252205
First Author: Zhao J
Year: 2017
Journal: J Invest Dermatol
Title: Plasma PPi Deficiency Is the Major, but Not the Exclusive, Cause of Ectopic Mineralization in an Abcc6-/- Mouse Model of PXE.
Volume: 137
Issue: 11
Pages: 2336-2343
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Publication
17845218 | J:148147
First Author: Li Q
Year: 2007
Journal: Exp Dermatol
Title: Targeted ablation of Abcc1 or Abcc3 in Abcc6(-/-) mice does not modify the ectopic mineralization process.
Volume: 16
Issue: 10
Pages: 853-9
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Publication
28701330 | J:266816
First Author: Dedinszki D
Year: 2017
Journal: EMBO Mol Med
Title: Oral administration of pyrophosphate inhibits connective tissue calcification.
Volume: 9
Issue: 11
Pages: 1463-1470
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Publication
24732453 | J:211672
First Author: Li Q
Year: 2014
Journal: Lab Invest
Title: Genetic modulation of nephrocalcinosis in mouse models of ectopic mineralization: the Abcc6(tm1Jfk) and Enpp1(asj) mutant mice.
Volume: 94
Issue: 6
Pages: 623-32
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Publication
23644099 | J:197320
First Author: Sowa AK
Year: 2013
Journal: Am J Pathol
Title: Functional interaction of osteogenic transcription factors Runx2 and Vdr in transcriptional regulation of Opn during soft tissue calcification.
Volume: 183
Issue: 1
Pages: 60-8
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Publication
16705021 | J:109580
First Author: Korff S
Year: 2006
Journal: Physiol Genomics
Title: Fine mapping of Dyscalc1, the major genetic determinant of dystrophic cardiac calcification in mice.
Volume: 25
Issue: 3
Pages: 387-92
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Publication
28592560 | J:252837
 
First Author: Ziegler SG
Year: 2017
Journal: Sci Transl Med
Title: Ectopic calcification in pseudoxanthoma elasticum responds to inhibition of tissue-nonspecific alkaline phosphatase.
Volume: 9
Issue: 393
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Protein Coding Gene
MGP_CAROLIEiJ_G0029754 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0032257 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0032236 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0032172 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0032248 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0031963 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1351634 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0032740 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0031291 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0031928 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0032085 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0032037 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0032164 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0032074 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0032755 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0031014 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0031409 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0012979 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0030852 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
10395807 | J:56263
First Author: Brunnert SR
Year: 1999
Journal: Genomics
Title: Chromosomal localization of the loci responsible for dystrophic cardiac calcinosis in DBA/2 mice.
Volume: 59
Issue: 1
Pages: 105-7
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Publication
31449775 | J:282257
First Author: Bouderlique E
Year: 2019
Journal: Am J Pathol
Title: Vitamin D and Calcium Supplementation Accelerates Randall's Plaque Formation in a Murine Model.
Volume: 189
Issue: 11
Pages: 2171-2180
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Publication
37189419 | J:335657
 
First Author: Plümers R
Year: 2023
Journal: Biomolecules
Title: Matrix Metalloproteinases Contribute to the Calcification Phenotype in Pseudoxanthoma Elasticum.
Volume: 13
Issue: 4
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Publication
29643466 | J:262729
First Author: Bauer C
Year: 2018
Journal: Sci Rep
Title: Etidronate prevents dystrophic cardiac calcification by inhibiting macrophage aggregation.
Volume: 8
Issue: 1
Pages: 5812
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Publication
20090764 | J:159928
First Author: Jiang Q
Year: 2010
Journal: J Invest Dermatol
Title: Overexpression of fetuin-a counteracts ectopic mineralization in a mouse model of pseudoxanthoma elasticum (abcc6(-/-)).
Volume: 130
Issue: 5
Pages: 1288-96
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Publication
22421595 | J:188304
First Author: Kavukcuoglu NB
Year: 2012
Journal: Matrix Biol
Title: Connective tissue mineralization in Abcc6-/- mice, a model for pseudoxanthoma elasticum.
Volume: 31
Issue: 4
Pages: 246-52
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Publication
19122649 | J:151047
First Author: LaRusso J
Year: 2009
Journal: J Invest Dermatol
Title: Elevated dietary magnesium prevents connective tissue mineralization in a mouse model of pseudoxanthoma elasticum (Abcc6(-/-)).
Volume: 129
Issue: 6
Pages: 1388-94
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Publication
35143822 | J:337149
First Author: Huang J
Year: 2022
Journal: J Invest Dermatol
Title: Inhibition of the DNA Damage Response Attenuates Ectopic Calcification in Pseudoxanthoma Elasticum.
Volume: 142
Issue: 8
Pages: 2140-2148.e1
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Publication
37894722 | J:342238
 
First Author: Jacobs IJ
Year: 2023
Journal: Int J Mol Sci
Title: Novel Treatments for PXE: Targeting the Systemic and Local Drivers of Ectopic Calcification.
Volume: 24
Issue: 20
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Publication
23774530 | J:203968
First Author: Sundberg JP
Year: 2014
Journal: J Invest Dermatol
Title: Mouse alopecia areata and heart disease: know your mouse!
Volume: 134
Issue: 1
Pages: 279-281
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Publication
23746654 | J:199088
First Author: Kirsch AH
Year: 2013
Journal: Am J Pathol
Title: Regulatory T cells improve nephrocalcinosis but not dystrophic cardiac calcinosis in DBA/2 mice.
Volume: 183
Issue: 2
Pages: 382-90
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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