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Search results 1 to 100 out of 617 for Acan

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0.047s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication  
First Author: Rashid H
Year: 2017
Journal: Genesis
Title: Dwarfism in homozygous Agc1CreERT mice is associated with decreased expression of aggrecan.
Volume: 55
Issue: 10
Publication
First Author: Henry SP
Year: 2009
Journal: Genesis
Title: Generation of aggrecan-CreERT2 knockin mice for inducible Cre activity in adult cartilage.
Volume: 47
Issue: 12
Pages: 805-14
Publication
First Author: Mailhiot SE
Year: 2015
Journal: PLoS One
Title: Non-Invasive Quantification of Cartilage Using a Novel In Vivo Bioluminescent Reporter Mouse.
Volume: 10
Issue: 7
Pages: e0130564
Publication    
First Author: Jing Y
Year: 2016
Journal: J Vis Exp
Title: Co-localization of Cell Lineage Markers and the Tomato Signal.
Issue: 118
Publication  
First Author: Alberton P
Year: 2019
Journal: Int J Mol Sci
Title: Aggrecan Hypomorphism Compromises Articular Cartilage Biomechanical Properties and Is Associated with Increased Incidence of Spontaneous Osteoarthritis.
Volume: 20
Issue: 5
Publication
First Author: Kitami M
Year: 2019
Journal: Biochem Biophys Res Commun
Title: IFT20 is required for the maintenance of cartilaginous matrix in condylar cartilage.
Volume: 509
Issue: 1
Pages: 222-226
Publication  
First Author: Hu Y
Year: 2017
Journal: Front Cell Neurosci
Title: Increased Susceptibility to Ischemic Brain Injury in Neuroplastin 65-Deficient Mice Likely via Glutamate Excitotoxicity.
Volume: 11
Pages: 110
Publication
First Author: Jing Y
Year: 2017
Journal: Sci Rep
Title: Chondrogenesis and osteogenesis are one continuous developmental and lineage defined biological process.
Volume: 7
Issue: 1
Pages: 10020
Publication
First Author: Jing J
Year: 2014
Journal: J Dent Res
Title: Osterix couples chondrogenesis and osteogenesis in post-natal condylar growth.
Volume: 93
Issue: 10
Pages: 1014-21
Publication  
First Author: Tsingas M
Year: 2020
Journal: Matrix Biol
Title: Sox9 deletion causes severe intervertebral disc degeneration characterized by apoptosis, matrix remodeling, and compartment-specific transcriptomic changes.
Volume: 94
Pages: 110-133
Publication  
First Author: Kurio N
Year: 2018
Journal: Matrix Biol
Title: Roles of Ihh signaling in chondroprogenitor function in postnatal condylar cartilage.
Volume: 67
Pages: 15-31
Publication
First Author: Wang C
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: FoxO1 is a crucial mediator of TGF-β/TAK1 signaling and protects against osteoarthritis by maintaining articular cartilage homeostasis.
Volume: 117
Issue: 48
Pages: 30488-30497
Publication
First Author: Culley KL
Year: 2019
Journal: Sci Rep
Title: Inducible knockout of CHUK/IKKα in adult chondrocytes reduces progression of cartilage degradation in a surgical model of osteoarthritis.
Volume: 9
Issue: 1
Pages: 8905
Publication
First Author: Zhou X
Year: 2014
Journal: PLoS Genet
Title: Chondrocytes transdifferentiate into osteoblasts in endochondral bone during development, postnatal growth and fracture healing in mice.
Volume: 10
Issue: 12
Pages: e1004820
Publication
First Author: Jing J
Year: 2013
Journal: Int J Biol Sci
Title: BMP receptor 1A determines the cell fate of the postnatal growth plate.
Volume: 9
Issue: 9
Pages: 895-906
Publication
First Author: Henry SP
Year: 2012
Journal: J Bone Miner Res
Title: The postnatal role of Sox9 in cartilage.
Volume: 27
Issue: 12
Pages: 2511-25
Publication
First Author: Sinha S
Year: 2017
Journal: PLoS Genet
Title: Unsuspected osteochondroma-like outgrowths in the cranial base of Hereditary Multiple Exostoses patients and modeling and treatment with a BMP antagonist in mice.
Volume: 13
Issue: 4
Pages: e1006742
Publication  
First Author: Dai C
Year: 2020
Journal: Bone
Title: Selective inhibition of progesterone receptor in osteochondral progenitor cells, but not in mature chondrocytes, modulated subchondral bone structures.
Volume: 132
Pages: 115196
Publication
First Author: Liu Z
Year: 2015
Journal: Sci Signal
Title: A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis.
Volume: 8
Issue: 386
Pages: ra71
Publication
First Author: Catheline SE
Year: 2019
Journal: J Bone Miner Res
Title: Chondrocyte-Specific RUNX2 Overexpression Accelerates Post-traumatic Osteoarthritis Progression in Adult Mice.
Volume: 34
Issue: 9
Pages: 1676-1689
Publication
First Author: Liao L
Year: 2019
Journal: J Cell Physiol
Title: Deletion of Runx2 in condylar chondrocytes disrupts TMJ tissue homeostasis.
Volume: 234
Issue: 4
Pages: 3436-3444
Publication  
First Author: Novais EJ
Year: 2019
Journal: Matrix Biol
Title: p16Ink4a deletion in cells of the intervertebral disc affects their matrix homeostasis and senescence associated secretory phenotype without altering onset of senescence.
Volume: 82
Pages: 54-70
Publication
First Author: Liao L
Year: 2017
Journal: Sci Rep
Title: Deletion of Runx2 in Articular Chondrocytes Decelerates the Progression of DMM-Induced Osteoarthritis in Adult Mice.
Volume: 7
Issue: 1
Pages: 2371
Publication
First Author: Jing Y
Year: 2018
Journal: Int J Biol Sci
Title: Vital Roles of β-catenin in Trans-differentiation of Chondrocytes to Bone Cells.
Volume: 14
Issue: 1
Pages: 1-9
Publication
First Author: Ge X
Year: 2016
Journal: JCI Insight
Title: NFAT restricts osteochondroma formation from entheseal progenitors.
Volume: 1
Issue: 4
Pages: e86254
Publication
First Author: Manning LB
Year: 2016
Journal: Am J Pathol
Title: Discoidin Domain Receptor 2 as a Potential Therapeutic Target for Development of Disease-Modifying Osteoarthritis Drugs.
Volume: 186
Issue: 11
Pages: 3000-3010
Publication
First Author: Alvarez-Garcia O
Year: 2018
Journal: Aging Cell
Title: FOXO are required for intervertebral disk homeostasis during aging and their deficiency promotes disk degeneration.
Volume: 17
Issue: 5
Pages: e12800
Publication
First Author: Heitman N
Year: 2020
Journal: Science
Title: Dermal sheath contraction powers stem cell niche relocation during hair cycle regression.
Volume: 367
Issue: 6474
Pages: 161-166
Publication
First Author: Zhou X
Year: 2021
Journal: Cell Death Dis
Title: Wnt/ß-catenin-mediated p53 suppression is indispensable for osteogenesis of mesenchymal progenitor cells.
Volume: 12
Issue: 6
Pages: 521
Publication
First Author: Chen R
Year: 2015
Journal: Am J Pathol
Title: Attenuation of the progression of articular cartilage degeneration by inhibition of TGF-β1 signaling in a mouse model of osteoarthritis.
Volume: 185
Issue: 11
Pages: 2875-85
Publication
First Author: Shi Y
Year: 2021
Journal: Cell Rep
Title: Gli1+ progenitors mediate bone anabolic function of teriparatide via Hh and Igf signaling.
Volume: 36
Issue: 7
Pages: 109542
Publication  
First Author: Li H
Year: 2020
Journal: Bone
Title: Hypophosphatemic rickets accelerate chondrogenesis and cell trans-differentiation from TMJ chondrocytes into bone cells via a sharp increase in β-catenin.
Volume: 131
Pages: 115151
Publication
First Author: Ono N
Year: 2014
Journal: Nat Cell Biol
Title: A subset of chondrogenic cells provides early mesenchymal progenitors in growing bones.
Volume: 16
Issue: 12
Pages: 1157-67
Publication
First Author: Balani DH
Year: 2017
Journal: J Clin Invest
Title: Parathyroid hormone regulates fates of murine osteoblast precursors in vivo.
Volume: 127
Issue: 9
Pages: 3327-3338
Publication
First Author: Sivaraj KK
Year: 2022
Journal: Nat Commun
Title: Mesenchymal stromal cell-derived septoclasts resorb cartilage during developmental ossification and fracture healing.
Volume: 13
Issue: 1
Pages: 571
Publication
First Author: Lee KI
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: FOXO1 and FOXO3 transcription factors have unique functions in meniscus development and homeostasis during aging and osteoarthritis.
Volume: 117
Issue: 6
Pages: 3135-3143
Publication
First Author: Zhang Y
Year: 2016
Journal: J Bone Miner Res
Title: CCN1 Regulates Chondrocyte Maturation and Cartilage Development.
Volume: 31
Issue: 3
Pages: 549-59
Publication
First Author: Liu NQ
Year: 2022
Journal: Commun Biol
Title: gp130/STAT3 signaling is required for homeostatic proliferation and anabolism in postnatal growth plate and articular chondrocytes.
Volume: 5
Issue: 1
Pages: 64
Publication  
First Author: Shen J
Year: 2017
Journal: JCI Insight
Title: DNA methyltransferase 3b regulates articular cartilage homeostasis by altering metabolism.
Volume: 2
Issue: 12
Publication      
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
Publication      
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
Allele
Name: transgene insertion, Veronique Lefebvre
Allele Type: Transgenic
Attribute String: Inducible, Recombinase, Transactivator
Genotype
Symbol: Sox9/Sox9 Tg(Col2a1/Acan-rtTA,tetO-cre)#Vlf/?
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Lo Cascio L
Year: 2014
Journal: Genesis
Title: Generation of a mouse line harboring a Bi-transgene expressing luciferase and tamoxifen-activatable creER(T2) recombinase in cartilage.
Volume: 52
Issue: 2
Pages: 110-9
Publication
First Author: Liu CF
Year: 2015
Journal: Nucleic Acids Res
Title: The transcription factors SOX9 and SOX5/SOX6 cooperate genome-wide through super-enhancers to drive chondrogenesis.
Volume: 43
Issue: 17
Pages: 8183-203
Publication
First Author: Liu Z
Year: 2019
Journal: PLoS Genet
Title: Dysregulation of STAT3 signaling is associated with endplate-oriented herniations of the intervertebral disc in Adgrg6 mutant mice.
Volume: 15
Issue: 10
Pages: e1008096
Publication
First Author: Karuppaiah K
Year: 2016
Journal: Development
Title: FGF signaling in the osteoprogenitor lineage non-autonomously regulates postnatal chondrocyte proliferation and skeletal growth.
Volume: 143
Issue: 10
Pages: 1811-22
Publication
First Author: Zhang H
Year: 2016
Journal: PLoS Genet
Title: Elevated Fibroblast Growth Factor Signaling Is Critical for the Pathogenesis of the Dwarfism in Evc2/Limbin Mutant Mice.
Volume: 12
Issue: 12
Pages: e1006510
Publication
First Author: Dy P
Year: 2012
Journal: Dev Cell
Title: Sox9 directs hypertrophic maturation and blocks osteoblast differentiation of growth plate chondrocytes.
Volume: 22
Issue: 3
Pages: 597-609
Publication    
First Author: Liu Z
Year: 2021
Journal: Elife
Title: An adhesion G protein-coupled receptor is required in cartilaginous and dense connective tissues to maintain spine alignment.
Volume: 10
Publication  
First Author: Liu Z
Year: 2019
Journal: Dis Model Mech
Title: Regulation of terminal hypertrophic chondrocyte differentiation in Prmt5 mutant mice modeling infantile idiopathic scoliosis.
Volume: 12
Issue: 12
Publication
First Author: Kato K
Year: 2015
Journal: J Bone Miner Res
Title: SOXC Transcription Factors Induce Cartilage Growth Plate Formation in Mouse Embryos by Promoting Noncanonical WNT Signaling.
Volume: 30
Issue: 9
Pages: 1560-71
Publication
First Author: Ramachandran J
Year: 2019
Journal: Dev Biol
Title: PRMT5 is necessary to form distinct cartilage identities in the knee and long bone.
Volume: 456
Issue: 2
Pages: 154-163
Publication
First Author: Ismail HM
Year: 2017
Journal: Arthritis Rheumatol
Title: Rapid Activation of Transforming Growth Factor β-Activated Kinase 1 in Chondrocytes by Phosphorylation and K63 -Linked Polyubiquitination Upon Injury to Animal Articular Cartilage.
Volume: 69
Issue: 3
Pages: 565-575
Allele
Name: aggrecan; targeted mutation 1, Benoit de Crombrugghe
Allele Type: Targeted
Attribute String: Inducible, Recombinase
Strain
Attribute String: congenic, mutant strain, targeted mutation
Allele
Name: transgene insertion 1, George Bou-Gharios
Allele Type: Transgenic
Attribute String: Inducible, Recombinase, Reporter
Allele
Name: aggrecan; targeted mutation 1.1, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Inducible, Recombinase, Reporter
Strain
Attribute String: coisogenic, mutant strain, targeted mutation
Allele
Name: aggrecan; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Inducible, Recombinase
Strain
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
Genotype
Symbol: Acan/Acan
Background: involves: 129S6/SvEvTac * C57BL/6
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Ext1/Ext1 Acan/Acan<+>
Background: involves: 129S5/SvEvBrd * 129S6/SvEvTac * C57BL/6NCrl
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Acan/Acan<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129S4/SvJae * C57BL/6 * FVB
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Acan/Acan<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6Ncr
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Acan-cre/ERT2,-luc)1Gbg/?
Background: involves: 129S4/SvJaeSor
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Rowlands D
Year: 2018
Journal: J Neurosci
Title: Aggrecan Directs Extracellular Matrix-Mediated Neuronal Plasticity.
Volume: 38
Issue: 47
Pages: 10102-10113
Publication
First Author: Yoshida CA
Year: 2014
Journal: J Biol Chem
Title: Overexpression of Galnt3 in chondrocytes resulted in dwarfism due to the increase of mucin-type O-glycans and reduction of glycosaminoglycans.
Volume: 289
Issue: 38
Pages: 26584-96
Publication
First Author: Dupuis LE
Year: 2019
Journal: Arterioscler Thromb Vasc Biol
Title: Adamts5-/- Mice Exhibit Altered Aggrecan Proteolytic Profiles That Correlate With Ascending Aortic Anomalies.
Volume: 39
Issue: 10
Pages: 2067-2081
Publication
First Author: Lauing KL
Year: 2014
Journal: Dev Biol
Title: Aggrecan is required for growth plate cytoarchitecture and differentiation.
Volume: 396
Issue: 2
Pages: 224-36
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Bell L
Year: 1986
Journal: J Hered
Title: A new mutation at the cmd locus in the mouse.
Volume: 77
Issue: 3
Pages: 205-6
Publication
First Author: Krueger RC Jr
Year: 1999
Journal: Mamm Genome
Title: Completion of the mouse aggrecan gene structure and identification of the defect in the cmd-Bc mouse as a near complete deletion of the murine aggrecan gene.
Volume: 10
Issue: 12
Pages: 1119-25
Publication  
First Author: Juriloff DM
Year: 1985
Journal: Mouse News Lett
Title: Agccmd-Bc - cartilage matrix deficiency-British Columbia
Volume: 72
Pages: 95
Publication  
First Author: Rittenhouse E
Year: 1978
Journal: J Embryol Exp Morphol
Title: Cartilage matrix deficiency (cmd): a new autosomal recessive lethal mutation in the mouse.
Volume: 43
Pages: 71-84
Publication
First Author: Kimata K
Year: 1981
Journal: J Biol Chem
Title: Absence of proteoglycan core protein in cartilage from the cmd/cmd (cartilage matrix deficiency) mouse.
Volume: 256
Issue: 13
Pages: 6961-8
Publication
First Author: Houghton MJ
Year: 1989
Journal: Pediatr Pathol
Title: Pulmonary hypoplasia in mice homozygous for the cartilage matrix deficiency (cmd) gene: a model for human congenital disorder.
Volume: 9
Issue: 5
Pages: 501-12
Publication
First Author: Brennan MJ
Year: 1983
Journal: Dev Biol
Title: Immunological evidence for two distinct chondroitin sulfate proteoglycan core proteins: differential expression in cartilage matrix deficient mice.
Volume: 98
Issue: 1
Pages: 139-47