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Search results 1 to 100 out of 287 for Acd

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: rat
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Domain
Type: Family
Description: Adrenocortical dysplasia protein (acd, also known as TPP1) is a component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways []. It also forms a heterodimer with POT1 that increases the activity and processivity of the telomerase core enzyme [].This entry also includes fission yeast TPP1 homologue, Tpz1. Together with Pot1 it forms a complex that protects telomeres and regulates telomere length [].
Publication
First Author: Keegan CE
Year: 2005
Journal: Hum Mol Genet
Title: Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd) mice is caused by a splicing mutation in a novel telomeric regulator.
Volume: 14
Issue: 1
Pages: 113-23
EMAPA Term
Starts At: 11
Ends At: 12
Protein
Organism: Mus musculus/domesticus
Length: 416  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 104  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 136  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 416  
Fragment?: false
Publication
First Author: Wang F
Year: 2007
Journal: Nature
Title: The POT1-TPP1 telomere complex is a telomerase processivity factor.
Volume: 445
Issue: 7127
Pages: 506-10
Publication
First Author: Miyoshi T
Year: 2008
Journal: Science
Title: Fission yeast Pot1-Tpp1 protects telomeres and regulates telomere length.
Volume: 320
Issue: 5881
Pages: 1341-4
Publication  
First Author: Graniel JV
Year: 2022
Journal: Life Sci Alliance
Title: Differential impact of a dyskeratosis congenita mutation in TPP1 on mouse hematopoiesis and germline.
Volume: 5
Issue: 1
Allele  
Name: adrenocortical dysplasia
Allele Type: Spontaneous
Publication
First Author: Else T
Year: 2007
Journal: Chromosome Res
Title: Tpp1/Acd maintains genomic stability through a complex role in telomere protection.
Volume: 15
Issue: 8
Pages: 1001-13
Publication
First Author: Else T
Year: 2009
Journal: Cancer Cell
Title: Genetic p53 deficiency partially rescues the adrenocortical dysplasia phenotype at the expense of increased tumorigenesis.
Volume: 15
Issue: 6
Pages: 465-76
Publication
First Author: O'Connor BC
Year: 2011
Journal: Mamm Genome
Title: Additive effect of TAp63 deficiency on the adrenocortical dysplasia (acd) phenotype.
Volume: 22
Issue: 11-12
Pages: 714-21
Publication
First Author: Beamer WG
Year: 1994
Journal: J Endocrinol
Title: Adrenocortical dysplasia: a mouse model system for adrenocortical insufficiency.
Volume: 141
Issue: 1
Pages: 33-43
Publication
First Author: Vlangos CN
Year: 2009
Journal: Dev Biol
Title: Caudal regression in adrenocortical dysplasia (acd) mice is caused by telomere dysfunction with subsequent p53-dependent apoptosis.
Volume: 334
Issue: 2
Pages: 418-28
MP Term
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication  
First Author: Sweet HO
Year: 1988
Journal: Mouse News Lett
Title: Adrenocortical dysplasia (acd).
Volume: 81
Pages: 69
GXD Expression      
Probe: MGI:3528594
Assay Type: RT-PCR
Annotation Date: 2005-03-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3528595
Age: postnatal
Specimen Label: liver
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3528594
Assay Type: RT-PCR
Annotation Date: 2005-03-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:3528595
Age: postnatal
Specimen Label: spleen
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3528594
Assay Type: RT-PCR
Annotation Date: 2005-03-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:3528595
Age: postnatal
Specimen Label: lung
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3528594
Assay Type: RT-PCR
Annotation Date: 2005-03-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3528595
Age: postnatal
Specimen Label: kidney
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3528594
Assay Type: RT-PCR
Annotation Date: 2005-03-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1738328
Stage: TS28
Assay Id: MGI:3528595
Age: postnatal
Specimen Label: gonad
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3528594
Assay Type: RT-PCR
Annotation Date: 2005-03-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3528595
Age: postnatal
Specimen Label: brain
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:3528594
Assay Type: RT-PCR
Annotation Date: 2005-03-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3557728
Stage: TS28
Assay Id: MGI:3528595
Age: postnatal
Specimen Label: muscle
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:3528594
Assay Type: RT-PCR
Annotation Date: 2005-03-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1842628
Stage: TS28
Assay Id: MGI:3528595
Age: postnatal week 3
Specimen Label: 3wk adr
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:3528594
Assay Type: RT-PCR
Annotation Date: 2005-03-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1842628
Stage: TS28
Assay Id: MGI:3528595
Age: postnatal adult
Specimen Label: adult adr
Detected: true
Specimen Num: 9
GXD Expression      
Probe: MGI:3528594
Assay Type: RT-PCR
Annotation Date: 2005-03-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1842627
Stage: TS27
Assay Id: MGI:3528595
Age: postnatal newborn
Specimen Label: P1 adr
Detected: true
Specimen Num: 10
GXD Expression      
Probe: MGI:3528594
Assay Type: RT-PCR
Annotation Date: 2005-03-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1842628
Stage: TS28
Assay Id: MGI:3528727
Age: postnatal week 3
Specimen Label: 3wk
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3528594
Assay Type: RT-PCR
Annotation Date: 2005-03-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1842628
Stage: TS28
Assay Id: MGI:3528727
Age: postnatal adult
Specimen Label: adult
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3528594
Assay Type: RT-PCR
Annotation Date: 2005-03-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1842627
Stage: TS27
Assay Id: MGI:3528727
Age: postnatal newborn
Specimen Label: P0
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3528594
Assay Type: RT-PCR
Annotation Date: 2005-03-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603910
Stage: TS10
Assay Id: MGI:3528729
Age: embryonic day 7.0
Specimen Label: e7
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3528594
Assay Type: RT-PCR
Annotation Date: 2005-03-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603914
Stage: TS14
Assay Id: MGI:3528729
Age: embryonic day 9.0
Specimen Label: e9
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3528594
Assay Type: RT-PCR
Annotation Date: 2005-03-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603916
Stage: TS16
Assay Id: MGI:3528729
Age: embryonic day 10.0
Specimen Label: e10
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3528594
Assay Type: RT-PCR
Annotation Date: 2005-03-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603918
Stage: TS18
Assay Id: MGI:3528729
Age: embryonic day 11.0
Specimen Label: e11
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3528594
Assay Type: RT-PCR
Annotation Date: 2005-03-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:3528729
Age: embryonic day 12.0
Specimen Label: e12
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:3528594
Assay Type: RT-PCR
Annotation Date: 2005-03-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603921
Stage: TS21
Assay Id: MGI:3528729
Age: embryonic day 13.0
Specimen Label: e13
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:3528594
Assay Type: RT-PCR
Annotation Date: 2005-03-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603922
Stage: TS22
Assay Id: MGI:3528729
Age: embryonic day 14.0
Specimen Label: e14
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:3528594
Assay Type: RT-PCR
Annotation Date: 2005-03-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:3528729
Age: embryonic day 15.0
Specimen Label: e15
Detected: true
Specimen Num: 9
GXD Expression      
Probe: MGI:3528594
Assay Type: RT-PCR
Annotation Date: 2005-03-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603924
Stage: TS24
Assay Id: MGI:3528729
Age: embryonic day 16.0
Specimen Label: e16
Detected: true
Specimen Num: 10
GXD Expression      
Probe: MGI:3528594
Assay Type: RT-PCR
Annotation Date: 2005-03-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603925
Stage: TS25
Assay Id: MGI:3528729
Age: embryonic day 17.0
Specimen Label: e17
Detected: true
Specimen Num: 11
GXD Expression      
Probe: MGI:3528594
Assay Type: RT-PCR
Annotation Date: 2005-03-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603926
Stage: TS26
Assay Id: MGI:3528729
Age: embryonic day 18.0
Specimen Label: e18
Detected: true
Specimen Num: 12
GXD Expression      
Probe: MGI:3528740
Assay Type: RT-PCR
Annotation Date: 2005-03-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1842628
Stage: TS28
Assay Id: MGI:3528743
Age: postnatal
Specimen Label: +/+
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3528740
Assay Type: RT-PCR
Annotation Date: 2005-03-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1842628
Stage: TS28
Assay Id: MGI:3528743
Age: postnatal
Specimen Label: acd/acd
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3528746
Assay Type: RT-PCR
Annotation Date: 2005-03-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1842628
Stage: TS28
Assay Id: MGI:3528747
Age: postnatal
Specimen Label: +/+
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3528746
Assay Type: RT-PCR
Annotation Date: 2005-03-08
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1842628
Stage: TS28
Assay Id: MGI:3528747
Age: postnatal
Specimen Label: acd/acd
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:3528748
Assay Type: RT-PCR
Annotation Date: 2005-03-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1842628
Stage: TS28
Assay Id: MGI:3528750
Age: postnatal
Specimen Label: acd/acd
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3528751
Assay Type: RT-PCR
Annotation Date: 2005-03-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1842628
Stage: TS28
Assay Id: MGI:3528752
Age: postnatal
Specimen Label: acd/acd
Detected: true
Specimen Num: 2
GXD Expression        
Probe: MGI:3528705
Assay Type: Northern blot
Annotation Date: 2005-03-08
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3528735
Age: postnatal adult
Specimen Label: heart
Specimen Num: 2
GXD Expression        
Probe: MGI:3528705
Assay Type: Northern blot
Annotation Date: 2005-03-08
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3528735
Age: postnatal adult
Specimen Label: brain
Specimen Num: 3
GXD Expression        
Probe: MGI:3528705
Assay Type: Northern blot
Annotation Date: 2005-03-08
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3528735
Age: postnatal adult
Specimen Label: liver
Specimen Num: 4
GXD Expression        
Probe: MGI:3528705
Assay Type: Northern blot
Annotation Date: 2005-03-08
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:3528735
Age: postnatal adult
Specimen Label: spleen
Specimen Num: 5
GXD Expression        
Probe: MGI:3528705
Assay Type: Northern blot
Annotation Date: 2005-03-08
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3528735
Age: postnatal adult
Specimen Label: kidney
Specimen Num: 6
GXD Expression        
Probe: MGI:3528705
Assay Type: Northern blot
Annotation Date: 2005-03-08
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:3528735
Age: embryonic day 10.0-11.0
Specimen Label: embryo
Specimen Num: 7
GXD Expression        
Probe: MGI:3528705
Assay Type: Northern blot
Annotation Date: 2005-03-08
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:3528735
Age: postnatal adult
Specimen Label: lung
Specimen Num: 8
GXD Expression        
Probe: MGI:3528705
Assay Type: Northern blot
Annotation Date: 2005-03-08
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:3528735
Age: postnatal adult
Specimen Label: thymus
Specimen Num: 9
GXD Expression        
Probe: MGI:3528705
Assay Type: Northern blot
Annotation Date: 2005-03-08
Strength: Not Specified
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:3528735
Age: postnatal adult
Specimen Label: testis
Specimen Num: 10
GXD Expression        
Probe: MGI:3528705
Assay Type: Northern blot
Annotation Date: 2005-03-08
Strength: Not Specified
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:3528735
Age: postnatal adult
Specimen Label: ovary
Specimen Num: 11
GXD Expression      
Probe: MGI:7266330
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691016
Stage: TS16
Assay Id: MGI:7266389
Age: embryonic day 10.0
Specimen Label: E10
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:7266330
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754420
Stage: TS20
Assay Id: MGI:7266389
Age: embryonic day 12.0
Specimen Label: E12
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:7266330
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754422
Stage: TS22
Assay Id: MGI:7266389
Age: embryonic day 14.0
Specimen Label: E14
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:7266330
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754424
Stage: TS24
Assay Id: MGI:7266389
Age: embryonic day 16.0
Specimen Label: E16
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:7266330
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754426
Stage: TS26
Assay Id: MGI:7266389
Age: embryonic day 18.0
Specimen Label: E18
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:7266330
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754427
Stage: TS27
Assay Id: MGI:7266389
Age: postnatal day 1
Specimen Label: P1
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:7266330
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:7266389
Age: postnatal day 7
Specimen Label: P7
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:7266330
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:7266389
Age: postnatal day 21
Specimen Label: P21
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:7266330
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:7266389
Age: postnatal day 100
Specimen Label: P100
Detected: true
Specimen Num: 9
GXD Expression      
Probe: MGI:7266330
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610516
Stage: TS16
Assay Id: MGI:7266397
Age: embryonic day 10.0
Specimen Label: E10
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:7266330
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610520
Stage: TS20
Assay Id: MGI:7266397
Age: embryonic day 12.0
Specimen Label: E12
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:7266330
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610522
Stage: TS22
Assay Id: MGI:7266397
Age: embryonic day 14.0
Specimen Label: E14
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:7266330
Assay Type: RT-PCR
Annotation Date: 2022-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610524
Stage: TS24
Assay Id: MGI:7266397
Age: embryonic day 16.0
Specimen Label: E16
Detected: true
Specimen Num: 4